Marcus Rafael Lobo Bezerra
PhD Student
Marcus has experience with protein/antibody engineering, molecular biology and biochemistry. His work at Lisa Westerberg's Group involves structural studies of WASp (Wiskott-Aldrich Syndrome protein).
About me
Marcus Rafael Bezerra is an exchange PhD student at Lisa Westerberg's Group. He has a background in Biotechnology, with Master's Degree in Biotechnology from the Federal University of Ceara (Fortaleza/Brazil). He works at the Research Group on Protein Engineering and Solutions for Health at Oswaldo Cruz Foundation (Fiocruz/Ceara) and currently he is in an exchange period at Karolinska Institutet (Stockholm/Sweden).
Research description
Marcus is interested in protein-protein interaction studies. His PhD project aims to understand the influence of antibody-target affinity to therapeutic outcomes in different configuration of antibody-derived molecules (immunoglobulins, Chimeric Antigen Receptors, antibody fragments). Marcus has experience with directed evolution, selection/discovery of molecules by phage display technology, site-directed mutagenesis studies and protein expression/purification. He also works with WASp (Wiskott-Aldrich Syndrome protein) to understand the role of mutations in its structure, interaction with other proteins and ultimately, function in different phenotypes/clinical conditions.