Markus Dagnell

About me
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Research

Redox reactions play a vital role in growth factor cell signaling. It has
been shown in numerous studies that the phosphorylation cascades initiated by
receptor binding involve inactivation of oxidant-sensitive enzymes in the
pathway, the most prominent of these being protein tyrosine phosphatases
(PTPs). However, it is not at all clear how these proteins become oxidized.
The broad aim of my projects is to advance our understanding of how PTPs are
oxidized and regulated, and how this impacts on physiological and
pathological growth factor signaling.

Articles

Article: ELIFE. 2022;11:e74549

Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation.

James J; Chen Y; Hernandez CM; Forster F; Dagnell M; Cheng Q; Saei AA; Gharibi H; Lahore GF; Åstrand A; Malhotra R; Malissen B; Zubarev RA; Arnér ESJ; Holmdahl R
Article: ANTIOXIDANTS. 2021;10(1):111

Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H2O2 Together with Bicarbonate.

Dagnell M; Cheng Q; Arnér ESJ
Article: SCIENCE ADVANCES. 2020;6(12):eaax7945

Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death.

Busker S; Qian W; Haraldsson M; Espinosa B; Johansson L; Attarha S; Kolosenko I; Liu J; Dagnell M; Grandér D; Arnér ESJ; Tamm KP; Page BDG
Article: SCIENCE ADVANCES. 2020;6(1):eaax8358

Control of protein function through oxidation and reduction of persulfidated states.

Dóka É; Ida T; Dagnell M; Abiko Y; Luong NC; Balog N; Takata T; Espinosa B; Nishimura A; Cheng Q; Funato Y; Miki H; Fukuto JM; Prigge JR; Schmidt EE; Arnér ESJ; Kumagai Y; Akaike T; Nagy P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(33):12330-12338

Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades.

Dagnell M; Cheng Q; Rizvi SHM; Pace PE; Boivin B; Winterbourn CC; Arnér ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(35):14371-14380

Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure.

Dagnell M; Pace PE; Cheng Q; Frijhoff J; Östman A; Arnér ESJ; Hampton MB; Winterbourn CC
Article: ANTIOXIDANTS & REDOX SIGNALING. 2015;22(11):938-950

Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.

Hellfritsch J; Kirsch J; Schneider M; Fluege T; Wortmann M; Frijhoff J; Dagnell M; Fey T; Esposito I; Kölle P; Pogoda K; Angeli JPF; Ingold I; Kuhlencordt P; Östman A; Pohl U; Conrad M; Beck H
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2014;92(9):983-994

Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats.

Buschmann I; Hackbusch D; Gatzke N; Dülsner A; Trappiel M; Dagnell M; Ostman A; Hooft van Huijsduijnen R; Kappert K
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;68:268-277

The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation.

Frijhoff J; Dagnell M; Augsten M; Beltrami E; Giorgio M; Östman A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(33):13398-13403

Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling.

Dagnell M; Frijhoff J; Pader I; Augsten M; Boivin B; Xu J; Mandal PK; Tonks NK; Hellberg C; Conrad M; Arnér ESJ; Östman A
Article: CELL COMMUNICATION AND SIGNALING. 2013;11:49

Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice.

Krüger J; Trappiel M; Dagnell M; Stawowy P; Meyborg H; Böhm C; Bhanot S; Ostman A; Kintscher U; Kappert K
Article: BLOOD. 2012;119(19):4499-4511

Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ.

Godfrey R; Arora D; Bauer R; Stopp S; Müller JP; Heinrich T; Böhmer S-A; Dagnell M; Schnetzke U; Scholl S; Östman A; Böhmer F-D
Article: CELLULAR SIGNALLING. 2011;23(5):820-826

Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases.

Sandin A; Dagnell M; Gonon A; Pernow J; Stangl V; Aspenström P; Kappert K; Ostman A
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183(8):1092-1102

Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases.

ten Freyhaus H; Dagnell M; Leuchs M; Vantler M; Berghausen EM; Caglayan E; Weissmann N; Dahal BK; Schermuly RT; Ostman A; Kappert K; Rosenkranz S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(36):15774-15779

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.

Conrad M; Sandin A; Förster H; Seiler A; Frijhoff J; Dagnell M; Bornkamm GW; Rådmark O; Hooft van Huijsduijnen R; Aspenström P; Böhmer F; Ostman A
Article: CANCER RESEARCH. 2007;67(19):9006-9012

FBXW7/hCDC4 is a general tumor suppressor in human cancer.

Akhoondi S; Sun D; von der Lehr N; Apostolidou S; Klotz K; Maljukova A; Cepeda D; Fiegl H; Dafou D; Marth C; Mueller-Holzner E; Corcoran M; Dagnell M; Nejad SZ; Nayer BN; Zali MR; Hansson J; Egyhazi S; Petersson F; Sangfelt P; Nordgren H; Grander D; Reed SI; Widschwendter M; Sangfelt O; Spruck C
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2007;43(1):100-110

Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2.

Weibrecht I; Böhmer S-A; Dagnell M; Kappert K; Ostman A; Böhmer F-D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(23):24152-24162

Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway.

Thyrell L; Hjortsberg L; Arulampalam V; Panaretakis T; Uhles S; Dagnell M; Zhivotovsky B; Leibiger I; Grandér D; Pokrovskaja K

All other publications

Review: FREE RADICAL BIOLOGY AND MEDICINE. 2018;115:484-496

The A to Z of modulated cell patterning by mammalian thioredoxin reductases.

Dagnell M; Schmidt EE; Arnér ESJ
Review: ANTIOXIDANTS & REDOX SIGNALING. 2014;20(13):1994-2010

Regulation of protein tyrosine phosphatase oxidation in cell adhesion and migration.

Frijhoff J; Dagnell M; Godfrey R; Ostman A
KI thesis / dissertation: 2013

Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling

Dagnell, Markus
Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2011;51:S123

FLT3-ITD Mediated Transformation in Acute Myeloid Leukemia Involves Oxidation of the FLT3 Antagonist PTP, DEP-1: a Novel Redox Circuit in Cancer Cells

Godfrey R; Arora D; Bauer R; Stopp S; Heinrich T; Mueller JP; Dagnell M; Scholl S; Oestman A; Boehmer F-D
Corrigendum: CANCER RESEARCH. 2008;68(4):1245

The FBXW7 gene is mutated in a variety of human tumors (vol 67, pg 9006, 2007)

Akhoondi S; Sun D; von der Lehr N; Apostolidou S; Klotz K; Maljukova A; Capeda D; Fiegl H; Dafou D; Marth C; Mueller-Holzner E; Corcoran M; Dagnell M; Nejad SZ; Nayer BN; Zali MR; Hansson J; Egyhazi S; Petersson F; Sangfelt P; Nordgren H; Grander D; Reed SI; Widschwendter M; Sangfelt O; Spruck C

Grants

MOLECULAR MECHANISMS OF REDOX SIGNALING THROUGH PROTEIN TYROSINE PHOSPHATASES

Swedish Research Council

1 July 2014 - 30 June 2017

Employments

Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2019-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2013
Master Of Medical Science, Karolinska Institutet, 2008

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