reilly_marie

Marie Reilly

Professor

Department and organisational affiliation:

About me

Marie Reilly, BSc, MSc, PhD

Ph.D. in Biostatistics (1991).University of Washington, Seattle, U.S.A. 

Biostatistician at the Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm. Professor from 2003.

Research description

Epidemiologic Design

(text book in progress "Controlled Epidemiological Studies")

Statistical methods for extended design and analysis of "controlled" epidemiological studies, including:

  • Re-use of case-control data for studying new outcomes
  • Estimation of absolute risk from nested case-control data
  • Variations of nested case-control designs using "extreme" sampling
  • Hybrid designs that superimpose subsampling on traditional designs.

Maternal Screening

  • Investigation of prevalence for maternal alloimmunization with specific antibodies from the Rhesus and non-Rhesus systems
  • Studies of the association of blood group with maternal outcome, including preeclampsia, pregnancy-associated hypertension and pregnancy-associated DVT/PE
  • Investigation of the effect of maternal alloimmunization on pregnancy and neonatal outcomes using population registers and clinical cohort data
  • Development of prediction models for risk-stratification of pregnant women with regard to alloimmunization and identification of an at-risk group of alloimmunized pregnancies that could benefit from earlier care.

Infectious Diseases/Immunology

  • Studies of mother-to-child transmission of HIV, focusing on peptide responses from Elispot assays and Flow Cytometry data;
  • Phase I/II randomized clinical trials of candidate HIV-vaccines in infants and adults
  • Studies of the effect of maternal antiretroviral treatment for HIV on passive transfer of antibodies to infants and on infant immunity to common infections (measles, rotavirus, pneumonia)
  • Investigation of growth curves of HIV-exposed uninfected infants before and after administration of an experimental vaccine, with a focus on role of breastfeeding and maternal antiretroviral treatment.  
  • Development of statistical methodology to analyze Elispot responses, including (i) estimation of individual peptide effects from pooled peptide data and (ii) analysis of repeated Elispot assays from the same individual controlling for false discovery rate
  • Design of software tools for exploring flow cytometry data

Family Data

  • Investigation of the impact of truncated register data on epidemiological analyses of familial disease risk, with applications to the Swedish Inpatient Register and MultiGeneration Register.
  • Development of statistical models for joint estimation of risk to different  family members of patients, and investigation of patterns of these familial risks over time.
  • Methods and software for smoothed hazard estimation

 

Teaching portfolio

I have been actively involved in there design and delivery of biostatistics courses to undergraduate medical students

Education

  • PhD (Biostatistics, University of Washington, Seattle, USA, 1991)
  • MSc. (Mathematics & Statistics, University College Galway, Ireland, 1977)
  • BSc (Physics, University College Galway, Ireland, 1975)

Academic honours, awards and prizes

Best non-US Paper Prize, Obs & Gyn journal, March 2013.

Best Paper Prize from International Society of Blood Transfusion, 2010

School of Public Health Outstanding Student Award (University of Washington, Seattle, 1989)

Donovan Thompson Graduate Student Award (University of Washington, 1988)

Sir Joseph Larmor Faculty Prize (National University of  Ireland, Galway, 1975)

 

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