Maria Bruzelius

Publications
Grants
CV
Public outreach and news

Selected publications

Article: THROMBOSIS AND HAEMOSTASIS. 2024;124(1):32-39

Clinical Implications of Discrepancy between One-Stage Clotting and Chromogenic Factor IX Activity in Hemophilia B.

Schmidt DE; Truedsson Å; Strålfors A; Hojbjerg JA; Soutari N; Holmström M; Ranta S; Letelier A; Bowyer A; Ljung R; Antovic J; Bruzelius M
Letter: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2023;61(12):e248-e250

Laboratory response to paradigm change in hemophilia treatment.

Shafaati Lambert M; Bruzelius M; Mahmoud Hourani Soutari N; Ranta S; Antovic JP
Article: RESUSCITATION PLUS. 2021;8:100178

In-hospital cardiac arrest due to pulmonary embolism - Treatment and outcomes in a Swedish cohort study.

Henriksson CE; Frithiofsson J; Bruchfeld S; Bendz E; Bruzelius M; Djärv T
Article: THROMBOSIS AND HAEMOSTASIS. 2021;121(12):1610-1621

Platelet Count Rose While D-Dimer Levels Dropped as Deaths and Thrombosis Declined-An Observational Study on Anticoagulation Shift in COVID-19.

Sjöström A; Wersäll JD; Warnqvist A; Farm M; Magnusson M; Oldner A; Ågren A; Antovic J; Bruzelius M
Article: SEMINARS IN THROMBOSIS AND HEMOSTASIS. 2021;47(5):506-511

Impaired Fibrinolysis in the Antiphospholipid Syndrome.

Antovic A; Bruzelius M
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2021;19(2):460-469

Overall and abdominal obesity in relation to venous thromboembolism.

Yuan S; Bruzelius M; Xiong Y; Håkansson N; Åkesson A; Larsson SC
Article: THROMBOSIS AND HAEMOSTASIS. 2021;121(1):27-35

Genetics and Hemostatic Potential in Persons with Mild to Moderate Hemophilia A with a Discrepancy between One-Stage and Chromogenic FVIII Assays.

Strålfors A; Mikovic D; Schmidt D; Onelöv L; Soutari NMH; Berndtson M; Chaireti R; Holmström M; Antovic JP; Bruzelius M
Article: BLOOD. 2017;130(15):1706-1712

Management of rivaroxaban- or apixaban-associated major bleeding with prothrombin complex concentrates: a cohort study.

Majeed A; Ågren A; Holmström M; Bruzelius M; Chaireti R; Odeberg J; Hempel E-L; Magnusson M; Frisk T; Schulman S
Article: BLOOD. 2016;128(23):e59-e66

PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study.

Bruzelius M; Iglesias MJ; Hong M-G; Sanchez-Rivera L; Gyorgy B; Souto JC; Frånberg M; Fredolini C; Strawbridge RJ; Holmström M; Hamsten A; Uhlén M; Silveira A; Soria JM; Smadja DM; Butler LM; Schwenk JM; Morange P-E; Trégouët D-A; Odeberg J
Article: THROMBOSIS AND HAEMOSTASIS. 2016;115(2):406-414

F11 is associated with recurrent VTE in women. A prospective cohort study.

Bruzelius M; Ljungqvist M; Bottai M; Bergendal A; Strawbridge RJ; Holmström M; Silveira A; Kieler H; Hamsten A; Lärfars G; Odeberg J
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2015;13(2):219-227

Predicting venous thrombosis in women using a combination of genetic markers and clinical risk factors.

Bruzelius M; Bottai M; Sabater-Lleal M; Strawbridge RJ; Bergendal A; Silveira A; Sundström A; Kieler H; Hamsten A; Odeberg J
Article: THROMBOSIS RESEARCH. 2014;134(2):426-432

Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism.

Bruzelius M; Strawbridge RJ; Trégouët D-A; Wiggins KL; Gertow K; Sabater-Lleal M; Öhrvik J; Bergendal A; Silveira A; Sundström A; Kieler H; Syvänen A-C; Smith NL; Morange P-E; Odeberg J; Hamsten A

Articles

Article: HAEMOPHILIA. 2024;30(1):98-105

Health-related quality of life and physical activity in Nordic patients with moderate haemophilia A and B (the MoHem study).

Måseide RJ; Berntorp E; Astermark J; Olsson A; Bruzelius M; Frisk T; Nummi V; Lassila R; Tjønnfjord GE; Holme PA
Article: CLINICAL NUTRITION. 2023;42(8):1268-1275

Ultra-processed food intake and incident venous thromboembolism risk: Prospective cohort study.

Yuan S; Chen J; Fu T; Li X; Bruzelius M; Åkesson A; Larsson SC
Article: HAEMOPHILIA. 2023;29(4):987-996

No difference in quality of life between persons with severe haemophilia A and B.

Kihlberg K; Baghaei F; Bruzelius M; Funding E; Andre Holme P; Lassila R; Nummi V; Ranta S; Gretenkort Andersson N; Berntorp E; Astermark J
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2023;201(4):783-792

Plasma protein and venous thromboembolism: prospective cohort and mendelian randomisation analyses.

Yuan S; Titova OE; Zhang K; Gou W; Schillemans T; Natarajan P; Chen J; Li X; Åkesson A; Bruzelius M; Klarin D; Damrauer SM; Larsson SC
Article: BMC MEDICAL RESEARCH METHODOLOGY. 2023;23(1):99

Association of ABO blood groups with venous thrombosis recurrence in middle-aged patients: insights from a weighted Cox analysis dedicated to ambispective design.

Munsch G; Goumidi L; van Hylckama Vlieg A; Ibrahim-Kosta M; Bruzelius M; Deleuze J-F; Rosendaal FR; Jacqmin-Gadda H; Morange P-E; Trégouët D-A
Article: THROMBOSIS RESEARCH. 2022;217:22-32

Factor IX antibodies and tolerance in hemophilia B in the Nordic countries - The impact of F9 variants and complications.

Kihlberg K; Baghaei F; Bruzelius M; Funding E; Holme PA; Lassila R; Martin M; Nummi V; Ranta S; Strandberg K; Andersson NG; Berntorp E; Astermark J
Article: NUTRIENTS. 2022;14(16):3354

Plasma Phospholipid Fatty Acids and Risk of Venous Thromboembolism: Mendelian Randomization Investigation.

Yuan S; Li X; Morange P-E; Bruzelius M; Larsson SC; On Behalf Of The Invent Consortium
Article: CLINICAL NUTRITION. 2022;41(6):1191-1196

Anti-inflammatory diet and incident peripheral artery disease: Two prospective cohort studies.

Yuan S; Bruzelius M; Damrauer SM; Håkansson N; Wolk A; Åkesson A; Larsson SC
Article: PLOS ONE. 2022;17(7):e0270865

Markers of neutrophil activation and neutrophil extracellular traps in diagnosing patients with acute venous thromboembolism: A feasibility study based on two VTE cohorts.

Smith P; Rosell A; Farm M; Bruzelius M; Aguilera Gatica K; Mackman N; Odeberg J; Thålin C
Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2022;53(1):43-50

Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation.

Yuan S; Bruzelius M; Larsson SC
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2021;10(21):e022286

Cardiometabolic, Lifestyle, and Nutritional Factors in Relation to Varicose Veins: A Mendelian Randomization Study.

Yuan S; Bruzelius M; Damrauer SM; Larsson SC
Article: THROMBOSIS AND HAEMOSTASIS. 2021;121(10):1299-1309

The Complex Relationship between C4b-Binding Protein, Warfarin, and Antiphospholipid Antibodies.

Grosso G; Sandholm K; Antovic A; Gunnarsson I; Zickert A; Vikerfors A; Truedsson L; Bruzelius M; Nilsson B; Nilsson-Ekdahl K; Svenungsson E
Article: NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. 2021;31(10):2831-2838

Anti-inflammatory diet and venous thromboembolism: Two prospective cohort studies.

Yuan S; Bruzelius M; Damrauer SM; Håkansson N; Wolk A; Åkesson A; Larsson SC
Article: THROMBOSIS RESEARCH. 2021;202:119-124

Lifestyle factors and venous thromboembolism in two cohort studies.

Yuan S; Bruzelius M; Håkansson N; Åkesson A; Larsson SC
Article: HAEMOPHILIA. 2021;27(3):366-374

Treatment outcomes in persons with severe haemophilia B in the Nordic region: The B-NORD study.

Kihlberg K; Baghaei F; Bruzelius M; Funding E; Andre Holme P; Lassila R; Nummi V; Ranta S; Osooli M; Berntorp E; Astermark J
Article: HAEMOPHILIA. 2021;27(2):e253-e259

Haemophilia early arthropathy detection with ultrasound and haemophilia joint health score in the moderate haemophilia (MoHem) study.

Måseide RJ; Berntorp E; Astermark J; Hansen J; Olsson A; Bruzelius M; Frisk T; Aspdahl M; Nummi V; Tjønnfjord GE; Holme PA
Article: HAEMOPHILIA. 2020;26(5):891-897

Joint health and treatment modalities in Nordic patients with moderate haemophilia A and B - The MoHem study.

Måseide RJ; Berntorp E; Astermark J; Olsson A; Bruzelius M; Frisk T; Nummi V; Lassila R; Tjønnfjord GE; Holme PA
Article: EBIOMEDICINE. 2020;59:102956

Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study.

Yuan S; Carter P; Bruzelius M; Vithayathil M; Kar S; Mason AM; Lin A; Burgess S; Larsson SC
Article: NUTRIENTS. 2019;11(12):E3001-3001

Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.

Yuan S; Bäck M; Bruzelius M; Mason AM; Burgess S; Larsson S
Article: THROMBOSIS RESEARCH. 2019;178:34-40

Correlation of thromboelastography and thrombin generation assays in warfarin-treated patients.

Schmidt DE; Chaireti R; Bruzelius M; Holmström M; Antovic J; Ågren A
Article: THROMBOSIS RESEARCH. 2017;158:168-173

Thrombin activatable fibrinolysis inhibitor (TAFI) - A possible link between coagulation and complement activation in the antiphospholipid syndrome (APS).

Grosso G; Vikerfors A; Woodhams B; Adam M; Bremme K; Holmström M; Ågren A; Eelde A; Bruzelius M; Svenungsson E; Antovic A
Article: THROMBOSIS AND HAEMOSTASIS. 2017;117(8):1528-1533

Whole blood ristocetin-activated platelet impedance aggregometry (Multiplate) for the rapid detection of Von Willebrand disease.

Schmidt DE; Bruzelius M; Majeed A; Odeberg J; Holmström M; Ågren A
Article: HAEMOPHILIA. 2017;23(2):309-318

A prospective diagnostic accuracy study evaluating rotational thromboelastometry and thromboelastography in 100 patients with von Willebrand disease.

Schmidt DE; Majeed A; Bruzelius M; Odeberg J; Holmström M; Ågren A
Article: THROMBOSIS RESEARCH. 2014;133(5):936-944

Studies of fibrin formation and fibrinolytic function in patients with the antiphospholipid syndrome.

Vikerfors A; Svenungsson E; Ågren A; Mobarrez F; Bremme K; Holmström M; Eelde A; Bruzelius M; Elgue G; Wallén H; Antovic A
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2012;32(8):2008-2016

A genome-wide association study identifies KNG1 as a genetic determinant of plasma factor XI Level and activated partial thromboplastin time.

Sabater-Lleal M; Martinez-Perez A; Buil A; Folkersen L; Souto JC; Bruzelius M; Borrell M; Odeberg J; Silveira A; Eriksson P; Almasy L; Hamsten A; Soria JM
Article: LUPUS. 2012;21(7):802-805

Studies of microparticles in patients with the antiphospholipid syndrome (APS).

Vikerfors A; Mobarrez F; Bremme K; Holmström M; Ågren A; Eelde A; Bruzelius M; Antovic A; Wallén H; Svenungsson E
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All other publications

Preprint: 2021;medRxiv

Modelling of time-to-events in an ambispective study: illustration with the analysis of ABO blood groups on venous thrombosis recurrence

Munsch G; Goumidi L; van Hylckama Vlieg A; Ibrahim-Kosta M; Bruzelius M; Deleuze J-F; Rosendaal FR; Jacqmin-Gadda H; Morange P-E; Trégouët D-A
Book chapter: LECTURE NOTES IN COMPUTER SCIENCE. 2021;p. 108-121

Explainable Artificial Neural Network for Recurrent Venous Thromboembolism Based on Plasma Proteomics

Razzaq M; Goumidi L; Iglesias M-J; Munsch G; Bruzelius M; Ibrahim-Kosta M; Butler L; Odeberg J; Morange P-E; Tregouet DA
KI thesis / dissertation: 2015

Exploration of novel mechanisms and biomarkers for venous thromboembolism : a genetics and proteomics study

Bruzelius, Maria
Book chapter: 2013;p. 56-61

Critical bleeding

Bruzelius M; Ågren A; Johnsson H
Letter: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2012;10(8):1693-1695

Lack of association of non-synonymous FUT2 and ALPL polymorphisms with venous thrombosis.

Tregouet D-A; Sabater-Lleal M; Bruzelius M; Emmerich J; Amouyel P; Dartigues J-F; Kieler H; Morange P-E

Grants

Increased risk for thrombotic complications in patients with rheumatic diseases -from register data to individual patient and biomarkers

Stockholm County Council and Karolinska Institutet (ALF)

1 January 2024 - 31 December 2025

Employments

Affiliated To Research, K2 Department of Medicine, Solna, Karolinska Institutet, 2023-
Senior Consultant, Coagulation Unit, ME Hematologi, Karolinska Universitetssjukhuset, 2020-
Clinical Post Doctor, Karolinska Instutet/Region Stockholm, 2018-2021

Degrees and Education

Docent, Assocaited Professor, Internal Medicine, Department of Medicine, Karolinska Institutet, 2023
Docent, Associated Professor, Internal Medicine, Karolinska Institutet, 2023
Doctor of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2015
Specialist in Coagulation and bleeding disorders, National Board of Health and Welfare, 2009
Specialist in Internal Medicine, National Board of Health and Welfare, 2006
Doctor of Medicine, Lund University, 1998

Supervisor

Natali Karandyszowska, Diagnostic and therapeutic challenges in patients with antiphospholipid syndrome, 2021
Emma Bendz, Pulmonary embolism as the cause of out of hospital cardiac arrest in women - A Swedish population-based register study, 2021
Shuai Yuan, Modifiable Risk Factors, Blood Proteins and Venous Thromboembolism, https://openarchive.ki.se/xmlui/handle/10616/48888, 2020
Ann Sjöström, Severe COVID-19 and routine biomarker pattern, http://hdl.handle.net/10616/48787, 2019

Thesis evaluation

Fridtjof Balteskard Rinde, Opponent, University of Tromsø, D-dimer for diagnosis and risk assessment first and recurrent venous Thromboembolism, https://hdl.handle.net/10037/29270, 2023
Joakim Knutsen Sejrup, Opponent, University of Tromsø, Risk Factors and Triggers of Venous Thromboembolism in Patients with Myocardial Infarction, https://hdl.handle.net/10037/25377, 2022

Selected publications

Articles

All other publications

Grants

Employments

Degrees and Education

Supervisor

Thesis evaluation

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