High doses of estradiol (E2) are well known to decrease longitudinal bone growth in extremely tall adolescents. However, this treatment has been shown to clearly decrease fertility later in life and there is also a fear of increased cancer risk. There is a great medical need for an alternative medical treatment with fewer side effects. The estrogen receptors ERα, ERβ and GPER1 are widely expressed in the human and murine growth plates. Thus, selective estrogen receptor modulators (SERMs) have the potential to more specifically modulate bone growth while reducing the side effects.
- 2012 registered as a Ph.D. student at the Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden.
- 2011 awarded M.Sc. in Molecular Nutrition, Stockholm University, Stockholm, Sweden.