Martin Ivarsson

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About me

I lead a small team studying human uterine immunology. For more information
please view my team website (Unit).

Articles

Journal article: SCIENCE IMMUNOLOGY. 2024;9(94):eadj7168

Tissue-specific nonheritable influences drive endometrial immune system variation.

Bister J; Filipovic I; Sun D; Crona-Guterstam Y; Cornillet M; Ponzetta A; Michaëlsson J; Gidlöf S; Ivarsson MA; Strunz B; Björkström NK
Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2023;90(2):e13738

Immune cell profiling of vaginal blood from patients with early pregnancy bleeding.

Guterstam YC; Acharya G; Schott K; Björkström NK; Gidlöf S; Ivarsson MA
Article: MUCOSAL IMMUNOLOGY. 2021;14(2):357-365

Human endometrial MAIT cells are transiently tissue resident and respond to Neisseria gonorrhoeae.

Bister J; Crona Guterstam Y; Strunz B; Dumitrescu B; Haij Bhattarai K; Özenci V; Brännström M; Ivarsson MA; Gidlöf S; Björkström NK
Article: SCIENCE IMMUNOLOGY. 2021;6(56):eabb7800

Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy.

Strunz B; Bister J; Jönsson H; Filipovic I; Crona-Guterstam Y; Kvedaraite E; Sleiers N; Dumitrescu B; Brännström M; Lentini A; Reinius B; Cornillet M; Willinger T; Gidlöf S; Hamilton RS; Ivarsson MA; Björkström NK
Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2021;100(2):339-346

The cytokine profile of menstrual blood.

Crona Guterstam Y; Strunz B; Ivarsson MA; Zimmer C; Melin A-S; Jonasson AF; Björkström NK; Gidlöf SB
Article: CELL. 2020;183(7):1946-1961.e15

The Identity of Human Tissue-Emigrant CD8+ T Cells.

Buggert M; Vella LA; Nguyen S; Wu VH; Chen Z; Sekine T; Perez-Potti A; Maldini CR; Manne S; Darko S; Ransier A; Kuri-Cervantes L; Japp AS; Brody IB; Ivarsson MA; Gorin J-B; Rivera-Ballesteros O; Hertwig L; Antel JP; Johnson ME; Okoye A; Picker L; Vahedi G; Sparrelid E; Llewellyn-Lacey S; Gostick E; Sandberg JK; Björkström N; Bar-Or A; Dori Y; Naji A; Canaday DH; Laufer TM; Wells AD; Price DA; Frank I; Douek DC; Wherry EJ; Itkin MG; Betts MR
Article: NATURE COMMUNICATIONS. 2020;11(1):381

Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy.

Huhn O; Ivarsson MA; Gardner L; Hollinshead M; Stinchcombe JC; Chen P; Shreeve N; Chazara O; Farrell LE; Theorell J; Ghadially H; Parham P; Griffiths G; Horowitz A; Moffett A; Sharkey AM; Colucci F
Article: METHODS IN MOLECULAR BIOLOGY. 2020;2098:71-82

Methods for High-Dimensional Flow Cytometry Analysis of Human MAIT Cells in Tissues and Peripheral Blood.

Strunz B; Zimmer CL; Bister J; Ivarsson MA; Björkström NK
Article: NATURE COMMUNICATIONS. 2019;10(1):3897

NK cells are activated and primed for skin-homing during acute dengue virus infection in humans.

Zimmer CL; Cornillet M; Solà-Riera C; Cheung K-W; Ivarsson MA; Lim MQ; Marquardt N; Leo Y-S; Lye DC; Klingström J; MacAry PA; Ljunggren H-G; Rivino L; Björkström NK
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2692

29-Color Flow Cytometry: Unraveling Human Liver NK Cell Repertoire Diversity.

Filipovic I; Sönnerborg I; Strunz B; Friberg D; Cornillet M; Hertwig L; Ivarsson MA; Björkström NK
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(12):1997-2004

Primary sclerosing cholangitis leads to dysfunction and loss of MAIT cells.

von Seth E; Zimmer CL; Reuterwall-Hansson M; Barakat A; Arnelo U; Bergquist A; Ivarsson MA; Björkström NK
Article: NATURE. 2018;563(7731):347-353

Single-cell reconstruction of the early maternal-fetal interface in humans.

Vento-Tormo R; Efremova M; Botting RA; Turco MY; Vento-Tormo M; Meyer KB; Park J-E; Stephenson E; Polański K; Goncalves A; Gardner L; Holmqvist S; Henriksson J; Zou A; Sharkey AM; Millar B; Innes B; Wood L; Wilbrey-Clark A; Payne RP; Ivarsson MA; Lisgo S; Filby A; Rowitch DH; Bulmer JN; Wright GJ; Stubbington MJT; Haniffa M; Moffett A; Teichmann SA
Article: JOURNAL OF IMMUNOLOGY. 2018;201(9):2593-2601

High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia.

Huhn O; Chazara O; Ivarsson MA; Retière C; Venkatesan TC; Norman PJ; Hilton HG; Jayaraman J; Traherne JA; Trowsdale J; Ito M; Kling C; Parham P; Ghadially H; Moffett A; Sharkey AM; Colucci F
Article: PLOS GENETICS. 2018;14(1):e1007163

Identification of an elaborate NK-specific system regulating HLA-C expression.

Li H; Ivarsson MA; Walker-Sperling VE; Subleski J; Johnson JK; Wright PW; Carrington M; Björkström NK; McVicar DW; Anderson SK
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1321-1330.e4

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69-CD56dim cells.

Marquardt N; Kekäläinen E; Chen P; Kvedaraite E; Wilson JN; Ivarsson MA; Mjösberg J; Berglin L; Säfholm J; Manson ML; Adner M; Al-Ameri M; Bergman P; Orre A-C; Svensson M; Dahlén B; Dahlén S-E; Ljunggren H-G; Michaëlsson J
Article: MUCOSAL IMMUNOLOGY. 2017;10(2):322-331

Composition and dynamics of the uterine NK cell KIR repertoire in menstrual blood.

Ivarsson MA; Stiglund N; Marquardt N; Westgren M; Gidlöf S; Björkström NK
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:298

Modulation of Human Leukocyte Antigen-C by Human Cytomegalovirus Stimulates KIR2DS1 Recognition by Natural Killer Cells.

van der Ploeg K; Chang C; Ivarsson MA; Moffett A; Wills MR; Trowsdale J
Article: JOURNAL OF IMMUNOLOGY. 2016;197(11):4292-4300

Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy.

Kennedy PR; Chazara O; Gardner L; Ivarsson MA; Farrell LE; Xiong S; Hiby SE; Colucci F; Sharkey AM; Moffett A
Article: JOURNAL OF IMMUNOLOGY. 2016;197(8):3069-3075

Fetal CD103+ IL-17-Producing Group 3 Innate Lymphoid Cells Represent the Dominant Lymphocyte Subset in Human Amniotic Fluid.

Marquardt N; Ivarsson MA; Sundström E; Åkesson E; Martini E; Eidsmo L; Mjösberg J; Friberg D; Kublickas M; Ek S; Tegerstedt G; Seiger Å; Westgren M; Michaëlsson J
Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3026-3032

Tissue-Specific Education of Decidual NK Cells.

Sharkey AM; Xiong S; Kennedy PR; Gardner L; Farrell LE; Chazara O; Ivarsson MA; Hiby SE; Colucci F; Moffett A
Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3262-3272

The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education.

Marquardt N; Ivarsson MA; Blom K; Gonzalez VD; Braun M; Falconer K; Gustafsson R; Fogdell-Hahn A; Sandberg JK; Michaëlsson J
Article: JOURNAL OF IMMUNOLOGY. 2015;194(6):2467-2471

Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.

Marquardt N; Béziat V; Nyström S; Hengst J; Ivarsson MA; Kekäläinen E; Johansson H; Mjösberg J; Westgren M; Lankisch TO; Wedemeyer H; Ellis EC; Ljunggren H-G; Michaëlsson J; Björkström NK
Article: MUCOSAL IMMUNOLOGY. 2014;7(5):1233-1243

Invariant natural killer T cells developing in the human fetus accumulate and mature in the small intestine.

Loh L; Ivarsson MA; Michaëlsson J; Sandberg JK; Nixon DF
Article: PLOS PATHOGENS. 2014;10(7):e1004251

T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.

Buggert M; Tauriainen J; Yamamoto T; Frederiksen J; Ivarsson MA; Michaëlsson J; Lund O; Hejdeman B; Jansson M; Sönnerborg A; Koup RA; Betts MR; Karlsson AC
Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(9):3889-3901

Differentiation and functional regulation of human fetal NK cells.

Ivarsson MA; Loh L; Marquardt N; Kekäläinen E; Berglin L; Björkström NK; Westgren M; Nixon DF; Michaëlsson J
Article: BLOOD. 2013;121(14):2678-2688

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.

Béziat V; Liu LL; Malmberg J-A; Ivarsson MA; Sohlberg E; Björklund AT; Retière C; Sverremark-Ekström E; Traherne J; Ljungman P; Schaffer M; Price DA; Trowsdale J; Michaëlsson J; Ljunggren H-G; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2013;190(5):2150-2158

Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response.

Blom K; Braun M; Ivarsson MA; Gonzalez VD; Falconer K; Moll M; Ljunggren H-G; Michaëlsson J; Sandberg JK
Article: SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES. 2011;25(12):3755-3760

Bowel obstruction after laparoscopic and open colon resection for cancer: results of 5 years of follow-up in a randomized trial.

Schölin J; Buunen M; Hop W; Bonjer J; Anderberg B; Cuesta M; Delgado S; Ibarzabal A; Ivarsson M-L; Janson M; Lacy A; Lange J; Påhlman L; Skullman S; Haglind E
Article: PLOS ONE. 2011;6(5):e20261

IgE immune complexes stimulate an increase in lung mast cell progenitors in a mouse model of allergic airway inflammation.

Dahlin JS; Ivarsson MA; Heyman B; Hallgren J
Article: BLOOD. 2010;116(19):3853-3864

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education.

Björkström NK; Riese P; Heuts F; Andersson S; Fauriat C; Ivarsson MA; Björklund AT; Flodström-Tullberg M; Michaëlsson J; Rottenberg ME; Guzmán CA; Ljunggren H-G; Malmberg K-J
Article: BLOOD. 2010;115(6):1166-1174

Education of human natural killer cells by activating killer cell immunoglobulin-like receptors.

Fauriat C; Ivarsson MA; Ljunggren H-G; Malmberg K-J; Michaëlsson J
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All other publications

Conference publication: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY. 2022;270:E94

Human endometrial mait cells are transiently tissue resident and respond to neisseria gonorrhoeae

Guterstam YC; Bister J; Strunz B; Dumitrescu B; Bhattarai KH; Ozenci V; Brannstrom M; Ivarsson M; Gidlof S; Bjorkstrom N
Preprint: BIORXIV. 2020

The identity of human tissue-emigrant CD8⁺T cells

Buggert M; Vella L; Nguyen S; Wu V; Sekine T; Perez-Potti A; Maldini C; Manne S; Darko S; Ransier A; Kuri-Cervantes L; Japp AS; Brody IB; Ivarsson M; Hertwig L; Antel J; Johnson M; Okoye A; Picker L; Vahedi G; Sparrelid E; Llewellyn-Lacey S; Gostick E; Björkström N; Bar-Or A; Dori Y; Naji A; Canaday D; Laufer T; Wells A; Price D; Frank I; Douek D; Wherry J; Itkin M; Betts M
Book chapter: ENCYCLOPEDIA OF REPRODUCTION. 2018;p. 462-468

Uterine Natural Killer (NK) Cells

Moffett A; Ivarsson MA
Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(7):2192-2196

Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation.

Béziat V; Traherne J; Malmberg J-A; Ivarsson MA; Björkström NK; Retière C; Ljunggren H-G; Michaëlsson J; Trowsdale J; Malmberg K-J
Thesis / dissertation: 2014

The ontogeny and regulation of human natural killer cells

Ivarsson, Martin A
Review: FRONTIERS IN IMMUNOLOGY. 2014;5:184-9

Activating killer cell Ig-like receptors in health and disease.

Ivarsson MA; Michaëlsson J; Fauriat C

Grants

Mapping the dynamics of human uterine natural killer cells for development of personalized care in female reproductive medicine

Swedish Research Council

1 January 2021 - 31 December 2024

Employments

Senior Research Specialist, Department of Medicine, Huddinge, Karolinska Institutet, 2023-
Assistant Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2018-2023

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medicine, Huddinge, Karolinska Institutet, 2014

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