Research description

Redox reactions play a vital role in growth factor cell signaling. It has been shown in numerous studies that the phosphorylation cascades initiated by receptor binding involve inactivation of oxidant-sensitive enzymes in the pathway, the most prominent of these being protein tyrosine phosphatases (PTPs). However, it is not at all clear how these proteins become oxidized. The broad aim of my projects is to advance our understanding of how PTPs are oxidized and regulated, and how this impacts on physiological and pathological growth factor signaling.