Research description
Alterations of the nuclear envelope components, including nuclear pore complexes (NPCs) and nuclear lamina, cause a spectrum of human diseases such as autoimmune dysfunctions, premature aging syndromes, neurological disorders, and cancer.
However, a comprehensive understanding of the highly complex nuclear envelope environment, its dynamics, and functions of the individual proteins are lacking.
Currently, my particular focus is to provide molecular insights into the role of nuclear envelope components in three fundamental cellular processes:
- maintenance of genome integrity
- translation of external physical forces into intracellular signaling pathways (mechanotransduction)
- response to oncogene activation
In the long-term, my work aims to understand the involvement of the nuclear envelope in disease processes, especially cancer development. The main goal is to discover novel targets and biomarkers for personalized cancer treatment.
Education
Ph.D. degree in Molecular and Cell Biology, Genetics and Virology; Faculty of Medicine, Charles University, Czech Republic
M.Sc. degree in Molecular Biology and Genetics; Masaryk University, Czech Republic
M.Sc. degree in Upper Secondary School Teacher Training in Biology; Masaryk University, Czech Republic
M.Sc. degree in Systematic Biology and Ecology; Masaryk University, Czech Republic
B.Sc. degree in Systematic Biology and Ecology; Masaryk University, Czech Republic
Professional experience
Research
2015- 2020: Postdoctoral researcher at the Institute of Molecular Oncology (IFOM), Italy
2010-2014: Ph.D. training at the Danish Cancer Society Research Center, Denmark
Grant evaluation
Independent expert for the evaluation of the research and innovation project proposals, Research Executive Agency, European Commission
Academic honours, awards and prizes
2020: Fondazione Umberto Veronesi Postdoctoral Fellowship in Oncology (awarded by The Umberto Veronesi Foundation, Italy; duration 12 months)
2019: Fondazione Umberto Veronesi Postdoctoral Fellowship in Oncology (awarded by The Umberto Veronesi Foundation, Italy; duration 12 months)
2016: Marie Sklodowska-Curie Individual Fellowship (awarded by the European Commission; duration 24 months)
2013: The Lundbeck Foundation travel grant (awarded by The Lundbeck Foundation, Denmark)