Mats Marshall Heyman

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: BRITISH JOURNAL OF HAEMATOLOGY. 2023;202(2):384-392

The prognostic impact of IKZF1 deletions and UKALL genetic classifiers in paediatric B-cell precursor acute lymphoblastic leukaemia treated according to NOPHO 2008 protocols.

Öfverholm I; Rezayee F; Heyman M; Harila A; Arvidsson L; Schmiegelow K; Norén-Nyström U; Barbany G
Article: HEMASPHERE. 2023;7(5):e875

The Prognostic Effect of IKZF1 Deletions in ETV6::RUNX1 and High Hyperdiploid Childhood Acute Lymphoblastic Leukemia.

Østergaard A; Enshaei A; Pieters R; Vora A; Horstmann MA; Escherich G; Johansson B; Heyman M; Schmiegelow K; Hoogerbrugge PM; den Boer ML; Kuiper RP; Moorman AV; Boer JM; van Leeuwen FN
Journal article: HEMASPHERE. 2023;7(5)

The Prognostic Effect of IKZF1 Deletions in ETV6::RUNX1 and High Hyperdiploid Childhood Acute Lymphoblastic Leukemia

Ostergaard A; Enshaei A; Pieters R; Vora A; Horstmann MA; Escherich G; Johansson B; Heyman M; Schmiegelow K; Hoogerbrugge PM; den Boer ML; Kuiper RP; Moorman AV; Boer JM; van Leeuwen FN
Journal article: HEMASPHERE. 2023;7(5)

Genetic Subtypes and Outcome of Patients Aged 1 to 45 Years Old With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Trial

Noren-Nystrom U; Andersen MK; Barbany G; Dirse V; Eilert-Olsen M; Engvall M; Harila-Saari A; Heyman M; Hovland R; Haikio S; Jonsson JJ; Karhu R; Kjeldsen E; Norberg A; Preiss BS; Pulkkinen K; Quist-Paulsen P; Rasanen H; Schmiegelow K; Seitsonen A; Sjogren H; Tammur P; Johansson B
Article: ACTA PAEDIATRICA. 2022;111(11):2235-2241

High need for intensive care in paediatric acute myeloid leukaemia: A population-based study.

Ranta S; Broman LM; Abrahamsson J; Karlsson L; Norén-Nyström U; Palle J; Svahn JE; Törnudd L; Heyman M; Harila-Saari A
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2022;198(6):1032-1040

Quality of life in mothers and fathers of children treated for acute lymphoblastic leukaemia in Sweden, Finland and Denmark.

Mogensen N; Saaranen E; Olsson E; Klug Albertsen B; Lähteenmäki PM; Kreicbergs U; Heyman M; Harila-Saari A
Article: PEDIATRIC BLOOD & CANCER. 2022;69(7):e29745

Does minimal central nervous system involvement in childhood acute lymphoblastic leukemia increase the risk for central nervous system toxicity?

Anastasopoulou S; Harila-Saari A; Als-Nielsen B; Eriksson MA; Heyman M; Johannsdottir IM; Marquart HV; Niinimäki R; Pronk CJ; Schmiegelow K; Vaitkeviciene G; Thastrup M; Ranta S
Article: BMC CANCER. 2022;22(1):483

Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0-45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol.

Toksvang LN; Als-Nielsen B; Bacon C; Bertasiute R; Duarte X; Escherich G; Helgadottir EA; Johannsdottir IR; Jónsson ÓG; Kozlowski P; Langenskjöld C; Lepik K; Niinimäki R; Overgaard UM; Punab M; Räty R; Segers H; van der Sluis I; Smith OP; Strullu M; Vaitkevičienė G; Wik HS; Heyman M; Schmiegelow K
Article: LEUKEMIA. 2022;36(5):1274-1282

Temporal changes in incidence of relapse and outcome after relapse of childhood acute lymphoblastic leukemia over three decades; a Nordic population-based cohort study.

Jensen KS; Oskarsson T; Lähteenmäki PM; Flaegstad T; Jónsson ÓG; Svenberg P; Schmiegelow K; Heyman M; Norén-Nyström U; Schrøder H; Albertsen BK
Article: BLOOD ADVANCES. 2022;6(7):2275-2289

A somatic UBA2 variant preceded ETV6-RUNX1 in the concordant BCP-ALL of monozygotic twins.

Bang B; Eisfeldt J; Barbany G; Harila-Saari A; Heyman M; Zachariadis V; Taylan F; Nordgren A
Article: BLOOD. 2022;139(12):1785-1793

Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium.

Buchmann S; Schrappe M; Baruchel A; Biondi A; Borowitz M; Campbell M; Cario G; Cazzaniga G; Escherich G; Harrison CJ; Heyman M; Hunger SP; Kiss C; Liu H-C; Locatelli F; Loh ML; Manabe A; Mann G; Pieters R; Pui C-H; Rives S; Schmiegelow K; Silverman LB; Stary J; Vora A; Brown P
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2022;196(5):1239-1247

Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia.

Egnell C; Heyman M; Jónsson ÓG; Raja RA; Niinimäki R; Albertsen BK; Schmiegelow K; Stabell N; Vaitkeviciene G; Lepik K; Harila-Saari A; Ranta S
Article: BLOOD ADVANCES. 2022;6(1):138-147

Asparaginase enzyme activity levels and toxicity in childhood acute lymphoblastic leukemia: a NOPHO ALL2008 study.

Lynggaard LS; Rank CU; Hansen SN; Gottschalk Højfeldt S; Henriksen LT; Jarvis KB; Ranta S; Niinimäki R; Harila-Saari A; Wolthers BO; Frandsen TL; Heyman M; Schmiegelow K; Albertsen BK
Article: INTERNATIONAL JOURNAL OF CANCER. 2021;149(11):1863-1876

Skeletal adverse events in childhood cancer survivors: An Adult Life after Childhood Cancer in Scandinavia cohort study.

Oskarsson T; Duun-Henriksen AK; Bautz A; Montgomery S; Harila-Saari A; Petersen C; Niinimäki R; Madanat-Harjuoja L; Tryggvadóttir L; Holmqvist AS; Hasle H; Heyman M; Winther JF; ALiCCS study group
Article: PEDIATRIC CRITICAL CARE MEDICINE. 2021;22(12):1050-1060

ICU Admission in Children With Acute Lymphoblastic Leukemia in Sweden: Prevalence, Outcome, and Risk Factors.

Ranta S; Broman LM; Abrahamsson J; Berner J; Fläring U; Hed Myrberg I; Kalzén H; Karlsson L; Mellgren K; Nilsson A; Norén-Nyström U; Palle J; von Schewelov K; Svahn JE; Törnudd L; Heyman M; Harila-Saari A
Article: LANCET HAEMATOLOGY. 2021;8(10):e700-e710

Minimal residual disease, long-term outcome, and IKZF1 deletions in children and adolescents with Down syndrome and acute lymphocytic leukaemia: a matched cohort study.

Michels N; Boer JM; Enshaei A; Sutton R; Heyman M; Ebert S; Fiocco M; de Groot-Kruseman HA; van der Velden VHJ; Barbany G; Escherich G; Vora A; Trahair T; Dalla-Pozza L; Pieters R; Zur Stadt U; Schmiegelow K; Moorman AV; Zwaan CM; den Boer ML
Article: SCIENTIFIC REPORTS. 2021;11(1):15988

Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia.

Sayyab S; Lundmark A; Larsson M; Ringnér M; Nystedt S; Marincevic-Zuniga Y; Tamm KP; Abrahamsson J; Fogelstrand L; Heyman M; Norén-Nyström U; Lönnerholm G; Harila-Saari A; Berglund EC; Nordlund J; Syvänen A-C
Article: BRITISH JOURNAL OF CANCER. 2021;125(1):112-118

Number of siblings and survival from childhood leukaemia: a national register-based cohort study from Sweden.

Mogensen H; Modig K; Talbäck M; Erdmann F; Heyman M; Feychting M; Tettamanti G
Article: BLOOD. 2021;137(17):2373-2382

Relapse risk following truncation of pegylated asparaginase in childhood acute lymphoblastic leukemia.

Gottschalk Højfeldt S; Grell K; Abrahamsson J; Lund B; Vettenranta K; Jónsson ÓG; Frandsen TL; Wolthers BO; Marquart HV; Vaitkeviciene G; Lepik K; Heyman M; Schmiegelow K; Albertsen BK
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2020;105(6):797-807

Impact of body mass index on relapse in children with acute lymphoblastic leukemia treated according to Nordic treatment protocols.

Egnell C; Ranta S; Banerjee J; Merker A; Niinimäki R; Lund B; Mogensen PR; Jonsson ÓG; Vaitkeviciene G; Lepik K; Forslund A; Heyman M; Harila-Saari A
Article: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY. 2020;27:72-77

Seizures during treatment of childhood acute lymphoblastic leukemia: A population-based cohort study.

Anastasopoulou S; Heyman M; Eriksson MA; Niinimäki R; Taskinen M; Mikkel S; Vaitkeviciene GE; Johannsdottir IM; Myrberg IH; Jonsson OG; Als-Nielsen B; Schmiegelow K; Banerjee J; Ranta S; Harila-Saari A
Article: BLOOD. 2020;135(17):1438-1446

A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia.

Enshaei A; O'Connor D; Bartram J; Hancock J; Harrison CJ; Hough R; Samarasinghe S; den Boer ML; Boer JM; de Groot-Kruseman HA; Marquart HV; Noren-Nystrom U; Schmiegelow K; Schwab C; Horstmann MA; Escherich G; Heyman M; Pieters R; Vora A; Moppett J; Moorman AV
Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419

Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.

Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CB; Sandhow L; Kutzner J; Hed Myrberg I; Bunten SS; Axelsson H; Zhang SM; Rasti A; Mäkelä P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtiö J; Rassidakis GZ; Pokrovskaja Tamm K; Warpman-Berglund U; Heyman M; Grandér D; Lehmann S; Lundbäck T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
Article: LEUKEMIA & LYMPHOMA. 2020;61(3):604-613

Overexpression of chromatin remodeling and tyrosine kinase genes in iAMP21-positive acute lymphoblastic leukemia.

Ivanov Öfverholm I; Zachariadis V; Taylan F; Marincevic-Zuniga Y; Tran AN; Saft L; Nilsson D; Syvänen A-C; Lönnerholm G; Harila-Saari A; Nordenskjöld M; Heyman M; Nordgren A; Nordlund J; Barbany G
Article: LEUKEMIA. 2020;34(2):347-357

T-cell acute lymphoblastic leukemia in patients 1-45 years treated with the pediatric NOPHO ALL2008 protocol.

Quist-Paulsen P; Toft N; Heyman M; Abrahamsson J; Griškevičius L; Hallböök H; Jónsson ÓG; Palk K; Vaitkeviciene G; Vettenranta K; Åsberg A; Frandsen TL; Opdahl S; Marquart HV; Siitonen S; Osnes LT; Hultdin M; Overgaard UM; Wartiovaara-Kautto U; Schmiegelow K
Article: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(19):1638-1646

Intermittent Versus Continuous PEG-Asparaginase to Reduce Asparaginase-Associated Toxicities: A NOPHO ALL2008 Randomized Study.

Albertsen BK; Grell K; Abrahamsson J; Lund B; Vettenranta K; Jónsson ÓG; Frandsen TL; Wolthers BO; Heyman M; Schmiegelow K
Article: PEDIATRIC BLOOD & CANCER. 2019;66(5):e27594

Posterior reversible encephalopathy syndrome in children with acute lymphoblastic leukemia: Clinical characteristics, risk factors, course, and outcome of disease.

Anastasopoulou S; Eriksson MA; Heyman M; Wang C; Niinimäki R; Mikkel S; Vaitkevičienė GE; Johannsdottir IM; Myrberg IH; Jonsson OG; Als-Nielsen B; Schmiegelow K; Banerjee J; Harila-Saari A; Ranta S
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2019;184(6):982-993

Low burden of minimal residual disease prior to transplantation in children with very high risk acute lymphoblastic leukaemia: The NOPHO ALL2008 experience.

Ifversen M; Turkiewicz D; Marquart HV; Winiarski J; Buechner J; Mellgren K; Arvidson J; Rascon J; Körgvee L-T; Madsen HO; Abrahamsson J; Lund B; Jonsson OG; Heilmann C; Heyman M; Schmiegelow K; Vettenranta K
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2019;184(3):405-417

Genetic predisposition to PEG-asparaginase hypersensitivity in children treated according to NOPHO ALL2008.

Højfeldt SG; Wolthers BO; Tulstrup M; Abrahamsson J; Gupta R; Harila-Saari A; Heyman M; Henriksen LT; Jónsson ÒG; Lähteenmäki PM; Lund B; Pruunsild K; Vaitkeviciene G; Schmiegelow K; Albertsen BK; Nordic Society of Paediatric Haematology Oncology
Article: ACTA PAEDIATRICA. 2019;108(2):361-366

Early central line-associated blood stream infections in children with cancer pose a risk for premature catheter removal.

Moell J; Svenningsson A; Af Sandeberg M; Larsson M; Heyman M; Harila-Saari A; Nilsson A
Article: CANCER MEDICINE. 2019;8(1):311-324

An integrated transcriptome analysis in T-cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression.

Haider Z; Larsson P; Landfors M; Köhn L; Schmiegelow K; Flaegstad T; Kanerva J; Heyman M; Hultdin M; Degerman S
Article: PEDIATRIC BLOOD & CANCER. 2019;66(1):e27437

Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia.

Wolthers BO; Mogensen PR; Frandsen TL; Abrahamsson J; Behrendtz M; Heyman M; Lohi O; Norén-Nyström U; Ruud E; Schmiegelow K
Article: PEDIATRIC BLOOD & CANCER. 2018;65(9):e27249

Late mortality and morbidity among long-term leukemia survivors with Down syndrome: A nationwide population-based cohort study.

Vonasek J; Asdahl P; Heyman M; Källén K; Hasle H
Article: PEDIATRIC BLOOD & CANCER. 2018;65(4)

Treatment-related mortality in relapsed childhood acute lymphoblastic leukemia.

Oskarsson T; Söderhäll S; Arvidson J; Forestier E; Frandsen TL; Hellebostad M; Lähteenmäki P; Jónsson ÓG; Myrberg IH; Heyman M; Nordic Society of Paediatric Haematology and Oncol
Article: LEUKEMIA. 2018;32(3):606-615

Results of NOPHO ALL2008 treatment for patients aged 1-45 years with acute lymphoblastic leukemia.

Toft N; Birgens H; Abrahamsson J; Griškevičius L; Hallböök H; Heyman M; Klausen TW; Jónsson ÓG; Palk K; Pruunsild K; Quist-Paulsen P; Vaitkeviciene G; Vettenranta K; Åsberg A; Frandsen TL; Marquart HV; Madsen HO; Norén-Nyström U; Schmiegelow K
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2018;100(1):53-60

Individualized 6-mercaptopurine increments in consolidation treatment of childhood acute lymphoblastic leukemia: A NOPHO randomized controlled trial.

Tulstrup M; Frandsen TL; Abrahamsson J; Lund B; Vettenranta K; Jonsson OG; Marquart HVH; Albertsen BK; Heyman M; Schmiegelow K
Article: CLINICAL EPIGENETICS. 2018;10:31

DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia.

Borssén M; Nordlund J; Haider Z; Landfors M; Larsson P; Kanerva J; Schmiegelow K; Flaegstad T; Jónsson ÓG; Frost B-M; Palle J; Forestier E; Heyman M; Hultdin M; Lönnerholm G; Degerman S
Article: PEDIATRIC BLOOD & CANCER. 2017;64(12)

Presenting features and imaging in childhood acute myeloid leukemia with central nervous system involvement.

Ranta S; Palomäki M; Levinsen M; Taskinen M; Abrahamsson J; Hasle H; Jahnukainen K; Heyman M; Harila-Saari A; Nordic Society of Pediatric Haematology and Oncolo
Article: PEDIATRIC BLOOD & CANCER. 2017;64(10)

Children with low-risk acute lymphoblastic leukemia are at highest risk of second cancers.

Nielsen SN; Eriksson F; Rosthoej S; Andersen MK; Forestier E; Hasle H; Hjalgrim LL; Aasberg A; Abrahamsson J; Heyman M; Jónsson ÓG; Pruunsild K; Vaitkeviciené GE; Vettenranta K; Schmiegelow K
Article: PEDIATRIC BLOOD & CANCER. 2017;64(10)

Hypertriglyceridemia during asparaginase treatment in children with acute lymphoblastic leukemia correlates with antithrombin activity in adolescents.

Persson L; Harila-Saari A; Hed Myrberg I; Heyman M; Nilsson A; Ranta S
Article: JOURNAL OF HEMATOLOGY & ONCOLOGY. 2017;10(1):148

Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles.

Marincevic-Zuniga Y; Dahlberg J; Nilsson S; Raine A; Nystedt S; Lindqvist CM; Berglund EC; Abrahamsson J; Cavelier L; Forestier E; Heyman M; Lönnerholm G; Nordlund J; Syvänen A-C
Article: CANCER IMMUNOLOGY RESEARCH. 2017;5(8):654-665

Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells.

Liu LL; Béziat V; Oei VYS; Pfefferle A; Schaffer M; Lehmann S; Hellström-Lindberg E; Söderhäll S; Heyman M; Grandér D; Malmberg K-J
Article: BMC CANCER. 2017;17(1):439

Cerebellar mutism syndrome in children with brain tumours of the posterior fossa.

Wibroe M; Cappelen J; Castor C; Clausen N; Grillner P; Gudrunardottir T; Gupta R; Gustavsson B; Heyman M; Holm S; Karppinen A; Klausen C; Lönnqvist T; Mathiasen R; Nilsson P; Nysom K; Persson K; Rask O; Schmiegelow K; Sehested A; Thomassen H; Tonning-Olsson I; Zetterqvist B; Juhler M
Article: CANCER. 2017;123(7):1238-1248

Short-term and long-term effects of childhood cancer on income from employment and employment status: A national cohort study in Sweden.

Lindahl Norberg A; Montgomery SM; Bottai M; Heyman M; Hovén EI
Article: THROMBOSIS RESEARCH. 2017;152:64-68

Venous thrombosis in children and adolescents with Hodgkin lymphoma in Sweden.

Schönning A; Karlén J; Frisk T; Heyman M; Svahn JE; Øra I; Kawan L; Holmqvist B-M; Björklund C; Harila-Saari A; Ranta S
Article: LEUKEMIA. 2017;31(2):325-332

Asparaginase-associated pancreatitis: a study on phenotype and genotype in the NOPHO ALL2008 protocol.

Wolthers BO; Frandsen TL; Abrahamsson J; Albertsen BK; Helt LR; Heyman M; Jónsson ÓG; Kõrgvee LT; Lund B; Raja RA; Rasmussen KK; Taskinen M; Tulstrup M; Vaitkevičienė GE; Yadav R; Gupta R; Schmiegelow K
Article: NATURE MEDICINE. 2017;23(2):256-263

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.

Herold N; Rudd SG; Ljungblad L; Sanjiv K; Myrberg IH; Paulin CBJ; Heshmati Y; Hagenkort A; Kutzner J; Page BDG; Calderón-Montaño JM; Loseva O; Jemth A-S; Bulli L; Axelsson H; Tesi B; Valerie NCK; Höglund A; Bladh J; Wiita E; Sundin M; Uhlin M; Rassidakis G; Heyman M; Tamm KP; Warpman-Berglund U; Walfridsson J; Lehmann S; Grandér D; Lundbäck T; Kogner P; Henter J-I; Helleday T; Schaller T
Article: PEDIATRIC BLOOD & CANCER. 2017;64(2):242-249

The effect of central nervous system involvement and irradiation in childhood acute lymphoblastic leukemia: Lessons from the NOPHO ALL-92 and ALL-2000 protocols.

Taskinen M; Oskarsson T; Levinsen M; Bottai M; Hellebostad M; Jonsson OG; Lähteenmäki P; Schmiegelow K; Heyman M
Article: PEDIATRIC BLOOD & CANCER. 2017;64(1):64-70

Role of neuroimaging in children with acute lymphoblastic leukemia and central nervous system involvement at diagnosis.

Ranta S; Palomäki M; Levinsen M; Taskinen M; Abrahamsson J; Mellgren K; Niinimäki R; Schmiegelow K; Heyman M; Harila-Saari A; Nordic Society of Pediatric Hematology and Oncolog
Article: PEDIATRIC BLOOD & CANCER. 2016;63(12):2104-2111

Maintenance therapy of childhood acute lymphoblastic leukemia revisited-Should drug doses be adjusted by white blood cell, neutrophil, or lymphocyte counts?

Schmiegelow K; Nersting J; Nielsen SN; Heyman M; Wesenberg F; Kristinsson J; Vettenranta K; Schrøeder H; Weinshilboum R; Jensen KL; Grell K; Rosthoej S
Article: ONCOTARGET. 2016;7(39):64071-64088

Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes.

Lindqvist CM; Lundmark A; Nordlund J; Freyhult E; Ekman D; Carlsson Almlöf J; Raine A; Övernäs E; Abrahamsson J; Frost B-M; Grandér D; Heyman M; Palle J; Forestier E; Lönnerholm G; Berglund EC; Syvänen A-C
Article: LEUKEMIA & LYMPHOMA. 2016;57(9):2161-2170

Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia.

Ivanov Öfverholm I; Tran AN; Olsson L; Zachariadis V; Heyman M; Rudd E; Syk Lundberg E; Nordenskjöld M; Johansson B; Nordgren A; Barbany G
Article: PEDIATRIC BLOOD & CANCER. 2016;63(7):1185-1192

DNA Methylation Adds Prognostic Value to Minimal Residual Disease Status in Pediatric T-Cell Acute Lymphoblastic Leukemia.

Borssén M; Haider Z; Landfors M; Norén-Nyström U; Schmiegelow K; Åsberg AE; Kanerva J; Madsen HO; Marquart H; Heyman M; Hultdin M; Roos G; Forestier E; Degerman S
Article: PEDIATRIC BLOOD & CANCER. 2016;63(5):865-871

Parents' and Adolescents' Preferences for Intensified or Reduced Treatment in Randomized Lymphoblastic Leukemia Trials.

Tulstrup M; Larsen HB; Castor A; Rossel P; Grell K; Heyman M; Abrahamsson J; Söderhäll S; Åsberg A; Jonsson OG; Vettenranta K; Frandsen TL; Albertsen BK; Schmiegelow K; Nordic Society of Paediatric Haematology, and Onco
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2016;96(2):160-169

Toxicity profile and treatment delays in NOPHO ALL2008-comparing adults and children with Philadelphia chromosome-negative acute lymphoblastic leukemia.

Toft N; Birgens H; Abrahamsson J; Griškevičius L; Hallböök H; Heyman M; Klausen TW; Jónsson ÓG; Palk K; Pruunsild K; Quist-Paulsen P; Vaitkeviciene G; Vettenranta K; Asberg A; Helt LR; Frandsen T; Schmiegelow K
Article: HAEMATOLOGICA. 2016;101(1):68-76

Relapsed childhood acute lymphoblastic leukemia in the Nordic countries: prognostic factors, treatment and outcome.

Oskarsson T; Söderhäll S; Arvidson J; Forestier E; Montgomery S; Bottai M; Lausen B; Carlsen N; Hellebostad M; Lähteenmäki P; Saarinen-Pihkala UM; Jónsson ÓG; Heyman M; Nordic Society of Paediatric Haematology and Oncol
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2015;170(6):847-858

The clinical impact of IKZF1 deletions in paediatric B-cell precursor acute lymphoblastic leukaemia is independent of minimal residual disease stratification in Nordic Society for Paediatric Haematology and Oncology treatment protocols used between 1992 and 2013.

Olsson L; Ivanov Öfverholm I; Norén-Nyström U; Zachariadis V; Nordlund J; Sjögren H; Golovleva I; Nordgren A; Paulsson K; Heyman M; Barbany G; Johansson B
Article: PEDIATRIC BLOOD & CANCER. 2015;62(6):951-956

Detection of central nervous system involvement in childhood acute lymphoblastic leukemia by cytomorphology and flow cytometry of the cerebrospinal fluid.

Ranta S; Nilsson F; Harila-Saari A; Saft L; Tani E; Söderhäll S; Porwit A; Hultdin M; Noren-Nyström U; Heyman M
Article: PEDIATRIC BLOOD & CANCER. 2015;62(3):427-433

PEG-asparaginase allergy in children with acute lymphoblastic leukemia in the NOPHO ALL2008 protocol.

Henriksen LT; Harila-Saari A; Ruud E; Abrahamsson J; Pruunsild K; Vaitkeviciene G; Jónsson ÓG; Schmiegelow K; Heyman M; Schrøder H; Albertsen BK; Nordic Society of Paediatric Haematology and Oncol
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2015;168(4):547-552

Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology.

Ranta S; Tuckuviene R; Mäkipernaa A; Albertsen BK; Frisk T; Tedgård U; Jónsson ÓG; Pruunsild K; Gretenkort Andersson N; Winther Gunnes M; Saulyte Trakymiene S; Frandsen T; Heyman M; Ruud E; Helgestad J
Article: HUMAN MUTATION. 2015;36(1):118-128

The mutational landscape in pediatric acute lymphoblastic leukemia deciphered by whole genome sequencing.

Lindqvist CM; Nordlund J; Ekman D; Johansson A; Moghadam BT; Raine A; Övernäs E; Dahlberg J; Wahlberg P; Henriksson N; Abrahamsson J; Frost B-M; Grandér D; Heyman M; Larsson R; Palle J; Söderhäll S; Forestier E; Lönnerholm G; Syvänen A-C; Berglund EC
Article: PEDIATRIC BLOOD & CANCER. 2014;61(8):1416-1421

Clinical features and early treatment response of central nervous system involvement in childhood acute lymphoblastic leukemia.

Levinsen M; Taskinen M; Abrahamsson J; Forestier E; Frandsen TL; Harila-Saari A; Heyman M; Jonsson OG; Lähteenmäki PM; Lausen B; Vaitkevičienė G; Asberg A; Schmiegelow K; Nordic Society of Paediatric Haematology and Oncol
Article: PEDIATRIC BLOOD & CANCER. 2014;61(5):797-802

Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: influence on cure rates and risk of second cancer.

Levinsen M; Rotevatn EØ; Rosthøj S; Nersting J; Abrahamsson J; Appell ML; Bergan S; Bechensteen A-G; Harila-Saari A; Heyman M; Jonsson OG; Maxild JBC; Niemi M; Söderhäll S; Schmiegelow K; Nordic Society of Paediatric Haematology, Oncology
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2014;165(1):126-133

Asparaginase-associated pancreatitis in children with acute lymphoblastic leukaemia in the NOPHO ALL2008 protocol.

Raja RA; Schmiegelow K; Albertsen BK; Prunsild K; Zeller B; Vaitkeviciene G; Abrahamsson J; Heyman M; Taskinen M; Harila-Saari A; Kanerva J; Frandsen TL; Nordic Society of Paediatric Haematology and Oncol
Article: PEDIATRIC BLOOD & CANCER. 2014;61(4):653-658

The circadian schedule for childhood acute lymphoblastic leukemia maintenance therapy does not influence event-free survival in the NOPHO ALL92 protocol.

Clemmensen KKB; Christensen RH; Shabaneh DN; Harila-Saari A; Heyman M; Jonsson OG; Wesenberg F; Rosthøj S; Schmiegelow K; Nordic Society of Pediatric Hematology, Oncology (
Article: PEDIATRIC BLOOD & CANCER. 2014;61(3):424-430

Prognostic implications of mutations in NOTCH1 and FBXW7 in childhood T-ALL treated according to the NOPHO ALL-1992 and ALL-2000 protocols.

Fogelstrand L; Staffas A; Wasslavik C; Sjögren H; Söderhäll S; Frost B-M; Forestier E; Degerman S; Behrendtz M; Heldrup J; Karrman K; Johansson B; Heyman M; Abrahamsson J; Palmqvist L
Article: EUROPEAN JOURNAL OF CANCER. 2014;50(2):251-259

Complying with the European Clinical Trials directive while surviving the administrative pressure - an alternative approach to toxicity registration in a cancer trial.

Frandsen TL; Heyman M; Abrahamsson J; Vettenranta K; Åsberg A; Vaitkeviciene G; Pruunsild K; Toft N; Birgens H; Hallböök H; Quist-Paulsen P; Griškevičius L; Helt L; Hansen BV; Schmiegelow K
Article: GENOME BIOLOGY. 2013;14(9):r105

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia.

Nordlund J; Bäcklin CL; Wahlberg P; Busche S; Berglund EC; Eloranta M-L; Flaegstad T; Forestier E; Frost B-M; Harila-Saari A; Heyman M; Jónsson OG; Larsson R; Palle J; Rönnblom L; Schmiegelow K; Sinnett D; Söderhäll S; Pastinen T; Gustafsson MG; Lönnerholm G; Syvänen A-C
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2013;90(5):404-412

Risk group assignment differs for children and adults 1-45 yr with acute lymphoblastic leukemia treated by the NOPHO ALL-2008 protocol.

Toft N; Birgens H; Abrahamsson J; Bernell P; Griškevičius L; Hallböök H; Heyman M; Holm MS; Hulegårdh E; Klausen TW; Marquart HV; Jónsson OG; Nielsen OJ; Quist-Paulsen P; Taskinen M; Vaitkeviciene G; Vettenranta K; Åsberg A; Schmiegelow K
Article: LEUKEMIA. 2013;27(4):866-870

Physicians compliance during maintenance therapy in children with Down syndrome and acute lymphoblastic leukemia.

Bohnstedt C; Levinsen M; Rosthøj S; Zeller B; Taskinen M; Hafsteinsdottir S; Björgvinsdóttir H; Heyman M; Schmiegelow K; Nordic Society of Pediatric Hematology and Oncolog
Article: MOLECULAR PHARMACOLOGY. 2013;83(1):245-255

Requirement of apoptotic protease-activating factor-1 for bortezomib-induced apoptosis but not for Fas-mediated apoptosis in human leukemic cells.

Ottosson-Wadlund A; Ceder R; Preta G; Pokrovskaja K; Grafström RC; Heyman M; Söderhäll S; Grandér D; Hedenfalk I; Robertson JD; Fadeel B
Article: LEUKEMIA & LYMPHOMA. 2012;53(10):2041-2050

Involvement of miR17 pathway in glucocorticoid-induced cell death in pediatric acute lymphoblastic leukemia.

Harada M; Pokrovskaja-Tamm K; Söderhäll S; Heyman M; Grander D; Corcoran M
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2012;366(15):1371-1381

Outcomes after induction failure in childhood acute lymphoblastic leukemia.

Schrappe M; Hunger SP; Pui C-H; Saha V; Gaynon PS; Baruchel A; Conter V; Otten J; Ohara A; Versluys AB; Escherich G; Heyman M; Silverman LB; Horibe K; Mann G; Camitta BM; Harbott J; Riehm H; Richards S; Devidas M; Zimmermann M
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2011;155(2):244-247

Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study.

Frandsen TL; Abrahamsson J; Lausen B; Vettenranta K; Heyman M; Behrentz M; Castor A; Wehner PS; Frost B-M; Andersen EW; Schmiegelow K
Article: BLOOD CANCER JOURNAL. 2011;1(7):e31

Glucocorticoid-induced cell death is mediated through reduced glucose metabolism in lymphoid leukemia cells.

Buentke E; Nordström A; Lin H; Björklund A-C; Laane E; Harada M; Lu L; Tegnebratt T; Stone-Elander S; Heyman M; Söderhäll S; Porwit A; Ostenson C-G; Shoshan M; Tamm KP; Grandér D
Article: PEDIATRIC BLOOD & CANCER. 2011;56(4):551-559

Risk factors for treatment related mortality in childhood acute lymphoblastic leukaemia.

Lund B; Åsberg A; Heyman M; Kanerva J; Harila-Saari A; Hasle H; Söderhäll S; Jónsson ÓG; Lydersen S; Schmiegelow K; Nordic Society of Paediatric Haematology and Oncol
Article: LEUKEMIA. 2011;25(4):622-628

The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial.

Zachariadis V; Gauffin F; Kuchinskaya E; Heyman M; Schoumans J; Blennow E; Gustafsson B; Barbany G; Golovleva I; Ehrencrona H; Cavelier L; Palmqvist L; Lönnerholm G; Nordenskjöld M; Johansson B; Forestier E; Nordgren A; Nordic Society of Pediatric Hematology, Oncology (; Swedish Cytogenetic Leukemia Study Group (SCLSG)
Article: LEUKEMIA RESEARCH. 2011;35(4):472-478

In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia.

Lönnerholm G; Thörn I; Sundström C; Frost B-M; Flaegstad T; Heyman M; Jonsson OG; Harila-Saari A; Madsen HO; Porwit A; Schmiegelow K; Söderhäll S; Wesenberg F; Vettenranta K; Larsson R; Forestier E
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2011;152(5):615-622

Interphase fluorescent in situ hybridization deletion analysis of the 9p21 region and prognosis in childhood acute lymphoblastic leukaemia (ALL): results from a prospective analysis of 519 Nordic patients treated according to the NOPHO-ALL 2000 protocol.

Kuchinskaya E; Heyman M; Nordgren A; Söderhäll S; Forestier E; Wehner P; Vettenranta K; Jonsson O; Wesenberg F; Sahlén S; Nordenskjöld M; Blennow E
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2011;86(1):38-46

High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL-92 and ALL-2000 studies.

Vaitkevičienė G; Forestier E; Hellebostad M; Heyman M; Jonsson OG; Lähteenmäki PM; Rosthoej S; Söderhäll S; Schmiegelow K; Nordic Society of Paediatric Haematology and Oncol
Article: LEUKEMIA. 2010;24(4):715-720

The degree of myelosuppression during maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia predicts risk of relapse.

Schmiegelow K; Heyman M; Gustafsson G; Lausen B; Wesenberg F; Kristinsson J; Vettenranta K; Schroeder H; Forestier E; Rosthoej S; Nordic Society of Paediatric Haematology and Oncol
Article: BLOOD. 2010;115(6):1214-1225

DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia.

Milani L; Lundmark A; Kiialainen A; Nordlund J; Flaegstad T; Forestier E; Heyman M; Jonmundsson G; Kanerva J; Schmiegelow K; Söderhäll S; Gustafsson MG; Lönnerholm G; Syvänen A-C
Article: LEUKEMIA. 2010;24(2):345-354

Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia.

Schmiegelow K; Forestier E; Hellebostad M; Heyman M; Kristinsson J; Söderhäll S; Taskinen M; Nordic Society of Paediatric Haematology and Oncol
Article: GENES CHROMOSOMES & CANCER. 2009;48(9):795-805

Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: rare T-cell receptor gene rearrangements are associated with poor outcome.

Karrman K; Forestier E; Heyman M; Andersen MK; Autio K; Blennow E; Borgström G; Ehrencrona H; Golovleva I; Heim S; Heinonen K; Hovland R; Johannsson JH; Kerndrup G; Nordgren A; Palmqvist L; Johansson B; Nordic Society of Pediatric Hematology, Oncology (; Swedish Cytogenetic Leukemia Study Group (SCLSG); NOPHO Leukemia Cytogenetic Study Group (NLCSG)
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2009;146(5):521-530

Vascular density in childhood acute lymphoblastic leukaemia correlates to biological factors and outcome.

Norén-Nyström U; Heyman M; Frisk P; Golovleva I; Sundström C; Porwit A; Roos G; Bergh A; Forestier E
Article: CELL DEATH AND DIFFERENTIATION. 2009;16(7):1018-1029

Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy.

Laane E; Tamm KP; Buentke E; Ito K; Kharaziha P; Oscarsson J; Corcoran M; Björklund A-C; Hultenby K; Lundin J; Heyman M; Söderhäll S; Mazur J; Porwit A; Pandolfi PP; Zhivotovsky B; Panaretakis T; Grandér D
Article: BLOOD. 2009;113(24):6077-6084

Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.

Schmiegelow K; Al-Modhwahi I; Andersen MK; Behrendtz M; Forestier E; Hasle H; Heyman M; Kristinsson J; Nersting J; Nygaard R; Svendsen AL; Vettenranta K; Weinshilboum R; Nordic Society for Paediatric Haematology and Onco
Article: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. 2009;31(6):385-392

Oral methotrexate/6-mercaptopurine may be superior to a multidrug LSA2L2 Maintenance therapy for higher risk childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.

Schmiegelow K; Heyman M; Kristinsson J; Mogensen UB; Rosthøj S; Vettenranta K; Wesenberg F; Saarinen-Pihkala U; Nordic Society of Paediatric Haematology and Oncol
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2008;142(4):616-621

Vincristine pharmacokinetics is related to clinical outcome in children with standard risk acute lymphoblastic leukemia.

Lönnerholm G; Frost B-M; Abrahamsson J; Behrendtz M; Castor A; Forestier E; Heyman M; Uges DRA; de Graaf SSN
Article: LEUKEMIA & LYMPHOMA. 2008;49(3):477-487

Characterization of 6q deletions in mature B cell lymphomas and childhood acute lymphoblastic leukemia.

Thelander EF; Ichimura K; Corcoran M; Barbany G; Nordgren A; Heyman M; Berglund M; Mungall A; Rosenquist R; Collins VP; Grandér D; Larsson C; Lagercrantz S
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2008;140(5):572-577

Array-CGH reveals hidden gene dose changes in children with acute lymphoblastic leukaemia and a normal or failed karyotype by G-banding.

Kuchinskaya E; Heyman M; Nordgren A; Schoumans J; Staaf J; Borg A; Söderhäll S; Grandér D; Nordenskjöld M; Blennow E
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2008;140(6):665-672

Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival.

Forestier E; Heyman M; Andersen MK; Autio K; Blennow E; Borgström G; Golovleva I; Heim S; Heinonen K; Hovland R; Johannsson JH; Kerndrup G; Nordgren A; Rosenquist R; Swolin B; Johansson B; Nordic Society of Paediatric Haematology, Oncology; Swedish Cytogenetic Leukaemia Study Group (SCLSG); NOPHO Leukaemia Cytogenetic Study Group (NLCSG)
Article: LEUKEMIA. 2008;22(3):504-510

Bone marrow fibrosis in childhood acute lymphoblastic leukemia correlates to biological factors, treatment response and outcome.

Norén-Nyström U; Roos G; Bergh A; Botling J; Lönnerholm G; Porwit A; Heyman M; Forestier E
Article: CLINICAL INFECTIOUS DISEASES. 2008;46(4):528-536

Parvovirus B19 infection in children with acute lymphoblastic leukemia is associated with cytopenia resulting in prolonged interruptions of chemotherapy.

Lindblom A; Heyman M; Gustafsson I; Norbeck O; Kaldensjö T; Vernby A; Henter J-I; Tolfvenstam T; Broliden K
Article: HAEMATOLOGICA. 2007;92(11):1460-1469

Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members.

Laane E; Panaretakis T; Pokrovskaja K; Buentke E; Corcoran M; Söderhäll S; Heyman M; Mazur J; Zhivotovsky B; Porwit A; Grandér D
Article: EXPERIMENTAL CELL RESEARCH. 2007;313(14):3141-3152

Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines.

Dohda T; Maljukova A; Liu L; Heyman M; Grandér D; Brodin D; Sangfelt O; Lendahl U
Article: CANCER RESEARCH. 2007;67(12):5611-5616

The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

Malyukova A; Dohda T; von der Lehr N; Akhoondi S; Corcoran M; Heyman M; Spruck C; Grandér D; Lendahl U; Sangfelt O
Article: CANCER. 2006;107(7):1551-1561

Treatment outcome in young adults and children >10 years of age with acute lymphoblastic leukemia in Sweden: a comparison between a pediatric protocol and an adult protocol.

Hallböök H; Gustafsson G; Smedmyr B; Söderhäll S; Heyman M; Swedish Adult Acute Lymphocytic Leukemia Group; Swedish Childhood Leukemia Group
Article: DANISH MEDICAL BULLETIN. 2006;53(1):76-79

Acute lymphoblastic leukemia in adolescents between 10 and 19 years of age in Denmark--secondary publication.

Schrøder H; Kjeldahl M; Boesen AM; Nielsen OJ; Schmidt K; Johnsen HE; Gregersen H; Heyman M; Gustafsson G
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2005;131(1):50-58

Treatment-related death in childhood acute lymphoblastic leukaemia in the Nordic countries: 1992-2001.

Christensen MS; Heyman M; Möttönen M; Zeller B; Jonmundsson G; Hasle H; Nordic Society of Paediatric Haematology and Oncol
Article: MOLECULAR BIOLOGY OF THE CELL. 2005;16(8):3821-3831

Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.

Panaretakis T; Laane E; Pokrovskaja K; Björklund A-C; Moustakas A; Zhivotovsky B; Heyman M; Shoshan MC; Grandér D
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2005;74(6):466-480

Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles.

Kuchinskaya E; Heyman M; Grandér D; Linderholm M; Söderhäll S; Zaritskey A; Nordgren A; Porwit-Macdonald A; Zueva E; Pawitan Y; Corcoran M; Nordenskjöld M; Blennow E
Article: LEUKEMIA. 2002;16(10):2037-2045

Deletion of the Ink4-locus (the p16ink4a, p14ARF and p15ink4b genes) predicts relapse in children with ALL treated according to the Nordic protocols NOPHO-86 and NOPHO-92.

Calero Moreno TM; Gustafsson G; Garwicz S; Grandér D; Jonmundsson GK; Frost B-M; Mäkipernaa A; Rasool O; Savolainen E-R; Schmiegelow K; Söderhäll S; Vettenranta K; Wesenberg F; Einhorn S; Heyman M
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2002;68(1):31-41

Spectral karyotyping and interphase FISH reveal abnormalities not detected by conventional G-banding. Implications for treatment stratification of childhood acute lymphoblastic leukaemia: detailed analysis of 70 cases.

Nordgren A; Heyman M; Sahlén S; Schoumans J; Söderhäll S; Nordenskjöld M; Blennow E
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2001;112(3):680-690

In vitro drug resistance and prognostic impact of p16INK4A/P15INK4B deletions in childhood T-cell acute lymphoblastic leukaemia.

Ramakers-van Woerden NL; Pieters R; Slater RM; Loonen AH; Beverloo HB; van Drunen E; Heyman M; Moreno TC; Rots MG; van Wering ER; Kamps WA; Janka-Schaub GE; Veerman AJ
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2000;65(6):390-398

Inverse correlation between Ink4-locus deletions and ICM-DNA hyperdiploidy in childhood acute lymphoblastic leukaemia, relation to clinical characteristics and outcome.

Moreno TC; Widell S; Czader M; Grandér D; Söderhäll S; Gustafsson G; Einhorn S; Porwit A; Heyman M
Article: MOLECULAR CANCER RESEARCH. 1999;10(8):575-582

Interferon-alpha inhibits proliferation in human T lymphocytes by abrogation of interleukin 2-induced changes in cell cycle-regulatory proteins.

Erickson S; Sangfelt O; Castro J; Heyman M; Einhorn S; Grandér D
Article: ONCOGENE. 1998;17(5):595-602

Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence.

Erickson S; Sangfelt O; Heyman M; Castro J; Einhorn S; Grandér D
Article: BLOOD. 1998;91(9):3397-3400

6q deletions in acute lymphoblastic leukemia and non-Hodgkin's lymphomas.

Merup M; Moreno TC; Heyman M; Rönnberg K; Grandér D; Detlofsson R; Rasool O; Liu Y; Söderhäll S; Juliusson G; Gahrton G; Einhorn S
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1997;98(1):147-150

Inverse correlation between loss of heterozygosity of the short arm of chromosome 12 and p15ink4B/p16ink4 gene inactivation in childhood acute lymphoblastic leukaemia.

Heyman M; Calero Moreno T; Liu Y; Grandér D; Rasool O; Borgonova-Brandter L; Merup M; Söderhäll S; Einhorn S
Article: LEUKEMIA. 1996;10(5):909-917

A T cell lymphoblastic lymphoma patient with two malignant cell populations carrying different 9p deletions including the p16INK4 and p15INK4B genes: Clinical response to interferon-alpha therapy in one of the subclones.

Heyman M; Nordgren A; Jeddi-Tehrani M; Rasool O; Liu Y; Grander D; Ost A; Wallberg B; Johansson B
Article: JOURNAL OF CLINICAL ONCOLOGY. 1996;14(5):1512-1520

Prognostic importance of p15INK4B and p16INK4 gene inactivation in childhood acute lymphocytic leukemia.

Heyman M; Rasool O; Borgonovo Brandter L; Liu Y; Grandér D; Söderhäll S; Gustavsson G; Einhorn S
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 1996;56(5):313-318

p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.

Borgonovo Brandter L; Heyman M; Rasool O; Liu Y; Grandér D; Einhorn S
Article: BLOOD. 1995;86(5):1911-1915

13q deletions in lymphoid malignancies.

Liu Y; Hermanson M; Grandér D; Merup M; Wu X; Heyman M; Rasool O; Juliusson G; Gahrton G; Detlofsson R; Nikiforova N; Buys C; Söderhäll S; Yankovsky N; Zabarovsky E; Einhorn S
Article: BLOOD. 1995;85(12):3431-3436

p15ink4B and p16ink4 gene inactivation in acute lymphocytic leukemia.

Rasool O; Heyman M; Brandter LB; Liu Y; Grandér D; Söderhäll S; Einhorn S
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Alla övriga publikationer

Review: COCHRANE DATABASE OF SYSTEMATIC REVIEWS. 2023;5(5):CD014570

PEG-asparaginase treatment regimens for acute lymphoblastic leukaemia in children: a network meta-analysis.

Lynggaard LS; Rank CU; Als-Nielsen B; Hoejfeldt SG; Heyman M; Schmiegelow K; Albertsen BK
Letter: HEMASPHERE. 2023;7(5):e883

Genetic Subtypes and Outcome of Patients Aged 1 to 45 Years Old With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Trial.

Norén-Nyström U; Andersen MK; Barbany G; Dirse V; Eilert-Olsen M; Engvall M; Harila-Saari A; Heyman M; Hovland R; Häikiö S; Jónsson JJ; Karhu R; Kjeldsen E; Norberg A; Preiss BS; Pulkkinen K; Quist-Paulsen P; Räsänen H; Schmiegelow K; Seitsonen A; Sjögren H; Tammur P; Johansson B
Letter: LEUKEMIA. 2021;35(3):863-866

Acute lymphoblastic leukemia and down syndrome: 6-mercaptopurine and methotrexate metabolites during maintenance therapy.

Østergaard A; Bohnstedt C; Grell K; Degn M; Zeller B; Taskinen M; Hafsteinsdottir S; Björgvinsdóttir H; Heyman M; Hoogerbrugge P; Schmiegelow K; Nordic Society of Paediatric Haematology and Oncol
Letter: CLINICAL CHEMISTRY. 2019;65(2):345-347

Somatic Structural Alterations in Childhood Leukemia Can Be Backtracked in Neonatal Dried Blood Spots by Use of Whole-Genome Sequencing and Digital PCR.

Taylan F; Bang B; Öfverholm II; Tran A-N; Heyman M; Barbany G; Zachariadis V; Nordgren A
Review: FRONTIERS IN ONCOLOGY. 2018;8:485

Survival After Childhood Cancer-Social Inequalities in High-Income Countries.

Mogensen H; Modig K; Tettamanti G; Erdmann F; Heyman M; Feychting M
Published conference paper: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. 2018;40(1):e13-e18

Posterior Reversible Encephalopathy Syndrome: Risk Factors and Impact on the Outcome in Children With Acute Lymphoblastic Leukemia Treated With Nordic Protocols.

Banerjee JS; Heyman M; Palomäki M; Lähteenmäki P; Arola M; Riikonen PV; Möttönen MI; Lönnqvist T; Taskinen MH; Harila-Saari AH
Letter: HAEMATOLOGICA. 2016;101(1):e20-e23

PAX5-ESRRB is a recurrent fusion gene in B-cell precursor pediatric acute lymphoblastic leukemia.

Marincevic-Zuniga Y; Zachariadis V; Cavelier L; Castor A; Barbany G; Forestier E; Fogelstrand L; Heyman M; Abrahamsson J; Lönnerholm G; Nordgren A; Syvänen A-C; Nordlund J
Letter: LAKARTIDNINGEN. 2014;111(11):494-495

[23 physicians comments on circumcision of small boys: The Swedish Medical Association should take a more humble approach].

Altman M; Altman D; Fischler B; Björkstén B; Bruchfeld A; Böhm F; Chrapkowska C; Finder M; Finkel Y; Halmin M; Heyman M; Ilicki A; Kahn R; Karpman D; Katz-Salamon M; Lagercrantz H; Mårtensson T; Nisell H; Rosling H; Sarman I; Wackernagel D; Wennergren G; Wilczek M
Letter: LEUKEMIA & LYMPHOMA. 2013;54(12):2742-2744

The ETV6/RUNX1 fusion transcript is not detected in RNA isolated from neonatal dried blood spots from children later diagnosed with the corresponding leukemia.

Barbany G; Gauffin F; Öfverholm I; Karlsson H; Thörn I; Arvidson J; Heyman M; Gustafsson B; Nordgren A
Letter: LEUKEMIA. 2013;27(11):2259-2262

Early morbidity and mortality in childhood acute lymphoblastic leukemia with very high white blood cell count.

Vaitkeviciene G; Heyman M; Jonsson OG; Lausen B; Harila-Saari A; Stenmarker M; Taskinen M; Zvirblis T; Åsberg A; Groth-Pedersen L; Rageliene L; Schmiegelow K
Letter: LEUKEMIA. 2013;27(9):1936-1939

Impact of IKZF1 deletions and PAX5 amplifications in pediatric B-cell precursor ALL treated according to NOPHO protocols.

Ofverholm I; Tran AN; Heyman M; Zachariadis V; Nordenskjöld M; Nordgren A; Barbany G
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2012;159(4):488-491

Homozygous deletions of CDKN2A are present in all dic(9;20)(p13·2;q11·2)-positive B-cell precursor acute lymphoblastic leukaemias and may be important for leukaemic transformation.

Zachariadis V; Schoumans J; Barbany G; Heyman M; Forestier E; Johansson B; Nordenskjöld M; Nordgren A
Review: GENES CHROMOSOMES & CANCER. 2008;47(2):149-158

Clinical and cytogenetic features of pediatric dic(9;20)(p13.2;q11.2)-positive B-cell precursor acute lymphoblastic leukemias: a Nordic series of 24 cases and review of the literature.

Forestier E; Gauffin F; Andersen MK; Autio K; Borgström G; Golovleva I; Gustafsson B; Heim S; Heinonen K; Heyman M; Hovland R; Johannsson JH; Kerndrup G; Rosenquist R; Schoumans J; Swolin B; Johansson B; Nordgren A; Nordic Society of Pediatric Hematology and Oncolog; Swedish Cytogenetic Leukemia Study Group; NOPHO Leukemia Cytogenetic Study Group
Letter: LEUKEMIA. 2007;21(6):1327-1330

Tiling-resolution array-CGH reveals the pattern of DNA copy number alterations in acute lymphoblastic leukemia with 21q amplification: the result of telomere dysfunction and breakage/fusion/breakage cycles?

Kuchinskaya E; Nordgren A; Heyman M; Schoumans J; Corcoran M; Staaf J; Borg A; Söderhäll S; Grandér D; Nordenskjöld M; Blennow E
Meeting abstract: BLOOD. 2006;108(11):1853

Risk of second malignant neoplasm is related to TPMT activity and duration of MTX/6MP maintenance therapy of ALL.

Schmiegelow K; Al-Modhawi I; Berendtz M; Forestier E; Hasle H; Heyman M; Kristinsson J; Nygaard R; Vettenranta K
Review: LEUKEMIA & LYMPHOMA. 1996;23(3-4):235-245

Inactivation of the p15INK4B and p16INK4 genes in hematologic malignancies.

Heyman M; Einhorn S
Letter: BLOOD. 1996;87(4):1657-1658

Exclusive p15INK4B gene deletions in acute lymphocytic leukemia include the E1 beta exon of the p16INK4 gene.

Heyman M; Rasool O; Brandter LB; Liu Y; Grandér D; Einhorn S; Söderhäll S

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