About me

Mattias Carlström is Professor of Cardiorenal Physiology and group leader for Reactive oxygen species and nitric oxide signaling in Reno-Cardio-Metabolic Regulation at the Department of Physiology and Pharmacology.

Link: https://ki.se/en/fyfa/mattias-carlstrom-group-research

 

Doctoral thesis

Carlström M.  Development of salt-sensitive hypertension in hydronephrosis.  Acta Universitatis Upsaliensis; Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 324; 2008 (ISBN 978-91-554-7137-8)

Research description

Emerging evidence suggests that renal oxidative stress and nitric oxide (NO) deficiency is linked to cardiovascular disease and diabetic complications. Mechanisms are not clear, but exaggerated NADPH oxidase- and mitochondria-derived superoxide production and NO deficiency may impair vascular function and lead to impairment of renal autoregulation. Using a translational design, our projects aim to characterize the mechanisms for superoxide and NO formation, interaction and influence on renal, cardiovascular and metabolic functions in health and disease. Novel dietary and pharmacological therapeutic strategies, focusing on dampening of vascular oxidative stress, are investigated and characterized in experimental disease models and in patients with reno-cardio-metabolic disorders, including chronic kidney disease, hypertension and type 2 diabetes. 

https://ki.se/en/fyfa/mattias-carlstrom-group-research

Education

- Professor of Cardiorenal Physiology, Karolinska Institutet, Dept. of Physiology & Pharmacology (2022-)

- Associate Professor of Physiology, Karolinska Institutet, Dept. of Physiology & Pharmacology (2015-2022)

- Adjunct Assistant Professor, Georgetown University, Washington DC, Dept. of Medicine, Div of Nephrology & Hypertension (2011-)

- Postdoc: Georgetown University, Div. of Nephrology & Hypertension, DC,USA, (2009-2011)

- Postdoc: Karolinska Institutet, Dept. of Physiology & Pharmacology (2008-2009)

- PhD Medicine, Dept. of Medical Cell Biology, Uppsala University (2008)

- Degree of Master of Science in Pharmacy, Uppsala University (2003)

-Degree of Master of Science in Pharmaceutical Science, Uppsala University (2002)

Academic honours, awards and prizes

2022: SRP Diabetes - The Rolf Luft Grant for Instrumentation  

2019: Novo Nordisk Foundation (5 years) – Ascending Investigator Grant - Endocrinology & Metabolism

2019: Distinguished Professor, Weifang Medical University, China

2019. Senior Research Award (2 years), Karolinska Institutet

2017: Heart and Lung Foundation (3 years) – Prince Daniel’s Award, Sweden

2015: Fo-Ass Research Grant (4 years), Karolinska Institutet

2012: Lewis T. Preston Research Achievement Award, Georgetown University, USA

2012: Top Young Investigator Award, ASN, Kidney Week, Philadelphia, USA

2011: Lewis T. Preston Research Achievement Award, Georgetown University, USA

2011: Fellows Forum Presentation Winner, National Kidney Foundation, NIH, USA

2010: Young Investigator Award – Society Free Radical Biology Meeting, Orlando, USA

2010: Fellows Forum Presentation Winner, National Kidney Foundation, NIH, USA

2009: Young Investigator Award – 3rd Int. Meeting on the Role of Nitrite in Physiology, Pathophysiology, and Therapeutics, Sweden

2007: Young Investigator Award - Scand. Physiol. Society Annual Meeting, Norway