Principal Researcher

Meng Xie

Principal researcher

Email:
meng.xie@ki.se
Organisation:

Research description

My interest is to understand the cellular dynamics that drive the formation of different components of the intervertebral discs during embryonic development, and the plasticity of adipose tissue in response to environmental changes. We mainly use single cell/nucleus RNA sequencing methods combined with genetic lineage tracing to tackle these scientific questions. Our findings will innovate the current research frontier in the fields of developmental and metabolic biology and inspire the develop of novel treatment strategy against spine-related and metabolic disorders.   

Education

2023 - present

Principal Researcher - Karolinska Institutet

2021 - present

Assistant Professor - Peking University, China

2015 - 2020

Postdoctoral Fellow - Karolinska Institutet, Sweden

2009 - 2014

Doctor of Philosophy in Biology – McGill University, Montréal, Canada

2007 - 2008

Master of Philosophy in Biomolecular Science - University of Manchester, Manchester, UK.

2003 - 2007

Bachelor of Science in Pharmacology with Industrial Experience - University of Manchester, Manchester, UK.

Academic honours, awards and prizes

Research Grants

(1) Swedish Research Council (Vetenskapsrådet), Starting Grant

(2) Stiftelsen Frimurare Barnhuset I Stockholm Foundation

(3) Ulla and Gustaf af Uggla Foundation on arthropathic diseases

(4) Foundation for Rheumatology Research from Karolinska Institutet

(5) Loo and Han Osterman Foundation from Karolinska Institutet

(6) Alex and Eva Foundation from Karolinska Institutet

(7）European Molecular Biology Organization, Long-Term Fellowship

 

Selected Publications:

  1. Xie M, Gol'din P, Herdina AN, Estefa J, Medvedeva EV, Li L, Newton PT, Kotova S, Shavkuta B, Saxena A, Shumate LT, Metscher BD, Großschmidt K, Nishimori S, Akovantseva A, Usanova AP, Kurenkova AD, Kumar A, Arregui IL, Tafforeau P, Fried K, Carlström M, Simon A, Gasser C, Kronenberg HM, Bastepe M, Cooper KL, Timashev P, Sanchez S, Adameyko I, Eriksson A, Chagin AS. Secondary ossification center induces and protects growth plate structure. Elife. 2020 Oct 16;9:e55212. doi: 10.7554/eLife.55212.
  2. Xie M, Chagin AS. The epiphyseal secondary ossification center: Evolution, development and function. Bone. 2020 Oct 19:115701. doi: 10.1016/j.bone.2020.115701.
  3. Zhang Y, Annusver K, Sunadome K, Kameneva K, Edwards S, Kasper M, Chagin AS, Adameyko I*, Xie M*. Epiphyseal cartilage formation involves differential dynamics of various cellular populations during embryogenesis. Frontiers in Cell and Developmental Biology. 2020 Mar 5;8:122. doi: 10.3389/fcell.2020.00122. eCollection 2020. *Corresponding authors
  4. Zhang Y, Kameneva P, Annusver K, Kasper M, Chagin AS, Adameyko I*, Xie M*. Cruciate ligament, patellar tendon and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds. Developmental Dynamics. 2020 Jun;249(6):711-722. doi: 10.1002/dvdy.158. * Corresponding authors 
  5. Xie M, Kamenev D, Kaucka M, Kastriti ME, Zhou B, Artemov AV, Storer M, Fried K, Adameyko I, Dyachuk V, Chagin AS. Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15068-15073. doi: 10.1073/pnas.1900038116.
  6. Xie M, Li JP. Heparan sulfate proteoglycan - A common receptor for diverse cytokines. Cell Signal. 2019 Feb;54:115-121. doi: 10.1016/j.cellsig.2018.11.022.
  7. Xie M and Roy R. AMP-Activated Kinase Regulates Lipid Droplet Localization and Stability of Adipose Triglyceride Lipase in C. elegans Dauer Larvae. PLoS One. 2015 Jun 22;10(6):e0130480. doi: 10.1371/journal.pone.0130480.
  8. Xie M and Roy R. The Causative Gene in Chanarian-Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans. PLoS Genetics. 2015 Jun 17;11(6):e1005284. doi: 10.1371/journal.pgen.1005284.
  9. Xie M and Roy R. Increased Levels of Hydrogen Peroxide Induce a HIF-1-dependent Remodelling of Lipid Metabolism in C. elegans. Cell Metabolism. 2012 Sep 5;16(3):322-35.
  10. Xie M, Alonso H and Roujeinikova A. An Improved Procedure for the Purification of Catalytically Active Alkane Hydroxylase from Pseudomonas putida GPo1. Appl Biochem Biotechnol. 2011 Oct;165(3-4):823-3.