Mikael Kastengren is a doctoral student with the Institution for Molecular Medicine and Surgery in the thoracic surgery research group. He is a resident in cardiology at Karolinska University Hospital. In his future clinical career he plans to go into interventional cardiology.
We aim to establish a fundament for the conduct of studies regarding minimally invasive heart valve surgery by linking pre-, peri-, and postoperative patient-level data. We will investigate differences in morbidity and mortality associated with minimally invasive compared with conventional full sternotomy aortic and mitral valve surgery.
Five sub-studies are planned:
1. Percutaneous plug-based arteriotomy closure device use in minimally invasive mitral valve surgery.
Comparison of conventional surgical cut-down versus a percutaneous plug-based arteriotomy closure device to close large bore vascular incisions in minimally invasive mitral valve surgery.
2. Leaflet thickening and stent geometry in novel bioprosthetic aortic valves used in minimally invasive aortic valve replacement.
50 patients who underwent minimally invasive aortic valve replacement studied by cardiac computed tomography to assess the association between leaflet thickening and stent geometry.
3. Minimally invasive versus conventional mitral valve surgery.
Comparison of 300 patients operated with full sternotomy and 300 patients operated with minithoracotomy before and after the introduction of a minimally invasive mitral valve surgery programme.
4. Surgical trauma after minimally invasive compared with full sternotomy aortic valve replacement.
40 patients randomized 1:1 to ministernotomy or full sternotomy aortic valve replacement assessed for surgically-mediated trauma.
5. A randomized study investigating mortality and morbidity after minimally invasive compared with full sternotomy aortic valve replacement.
100 patients randomized 1:1 to ministernotomy or full sternotomy aortic valve replacement.