Mikael Lindström

Mikael Lindström

Researcher | Docent
Visiting address: Tomtebodavägen 23A, 17165 Solna
Postal address: C2 Medicinsk biokemi och biofysik, C2 Genome biology Bartek, 171 77 Stockholm
Part of:

About me

  • PhD degree (Experimental Oncology) 2004, and Docent in Experimental Pathology
    obtained 2012 at Karolinska Institutet i Stockholm, Sweden (Assoc Prof
    equivalent). At present researcher at the Department of Medical Biochemistry and
    Biophysics, KI, SciLifeLab in Stockholm. Besides being involved research I am also active in teaching medical students (former DFM1, now known as BV2), foreign medical doctors aiming for license, and students at the Biomedicine program (course Biochemistry). I´m also supervising postdoctoral fellows, PhD students and master students. Several tasks in peer review, editorial board, and serving on expert panels.


    Fellowships and grants

    Swedish Research Council (VR), Young Researcher grant, 2012-2014
    Postdoctoral fellowship awarded by the Swedish Cancer Society (Cancerfonden), 2007 - 2010.
    Postdoctoral fellowship awarded by the Swedish Research Council (VR), 2005-2006.
    Grants from among others: Swedish Research Council, Radiumhemmets funds, Magnus Bergvall foundation, Åke Wiberg foundation, 2008-2009.

Research

  • We are specifically interested in molecular mechanisms underlying the
    regulation of ribosome biogenesis, how the cell senses errors in the complex
    process of ribosome biogenesis and how these processes in turn can be used in
    the development of novel anti-cancer therapies.

    To investigate ribosome biogenesis and nucleolar structure, the team uses
    various microscopy technologies, ribosome profiling, rDNA assays,
    transcriptomics, translatomics, and proteomics. We also work a lot with small
    molecules and functional screens.

    Main lines and interests of research:

    1. Characterization of ribosome biogenesis regulatory proteins and
    potential role in cancer development, biomarker discovery for precision /
    personalized cancer medicine.
    2. Regulation of ribosome biogenesis and protein synthesis in normal
    CNS cells and in glioma, including heterogeneity of ribosome in relation to
    glioma cellular diversity.
    3. Targeting of ribosome biogenesis or mature ribosome function in
    cancer.
    4. Functional studies of ribosomal proteins.

Teaching

  • Supervision of PhD students

    Main supervisor for Dr KM Goudarzi, PhD 2018-04-27 KI
    Dr A Zisi, PhD, 2022-10-28 KI
    Co-supervisor: Dr T Elsir, PhD 2010-06-04 KI, Dr I Nazarenko,
    PhD 2011-09-30 KI Dr K Holmberg-Olausson, PhD 2015-06-01 KI

    Pre-examination of 16 doctoral dissertations between 2009 and 2023 at SU, KI, and UU.

    Half time review of 20 doctoral student projects between 2013 and 2024 at KI and UU.

    Chairman of 6 PhD defenses

    Faculty opponent for Amir Nematollani Mahani KI Dept LabMed 2018-06-20

    Examiner Master or Bachelor of Science thesis, approx 15 during 2012-2018, KI

    Courses

    Basic pedagogics for university lecturers GHPH09 2009 KI 5 weeks
    Postgraduate supervisor training course KI 1 week
    Leadership education UGL KI 2 days

    Over 600 teaching hours in cell biology, oncology, and biochemistry, for undergraduate and graduate students mostly medical and biomedical students (KI)

Articles

All other publications

Grants

Employments

  • Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2015-
  • Researcher, Department of Oncology-Pathology, Karolinska Institutet, 2013-2015
  • Assistant Professor, Department of Oncology-Pathology, Karolinska Institutet, 2009-2013
  • Postdoctoral Researcher, Department of Oncology-Pathology, Karolinska Institutet, 2007-2009
  • Phd Student, Department of Oncology-Pathology, Karolinska Institutet, 2001-2004

Degrees and Education

  • Docent, Karolinska Institutet, 2012
  • Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2004
  • Master Of Medical Science, Karolinska Institutet, 1999

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