Mirco Martino
Postdoctoral Researcher
E-mail: mirco.martino@ki.se
Visiting address: J6:20 BioClinicum, Akademiska stråket 1, 17164 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Göndör, 171 77 Stockholm
About me
- A curious and ambitious scientist with a passion for unraveling the intricacies of nature. My Ph.D. equipped me with specialized knowledge in 3D nuclear architecture, nuclear organization, and circadian cycle. I cultivated a critical mindset, honed my analytical skills, and refined my communication abilities. Additionally, my roles as a scout leader and student representative enabled me to foster leadership, teamwork, and effective liaison with stakeholders.
* Doctorate of Philosophy, Medical Science 2016-2023
Marie S. Curie PhD Fellowship, Chromatin3D consortium
Karolinska Institutet, Solna, Sweden
Supervisors: Anita Göndör, Barbara Scholz, Galina Selivanova, Andreas Lennartsson
Doctoral Thesis Title: The odyssey of the MYC transcript from the nucleus to the cytoplasm: the molecular mechanism of the gene gating in human cancer cells. Defended: 2023-06-16
* Master's degree, Genetic Sciences and Technologies 2012-2014
Joint Programme between University of Sannio, Federico II of Naples, Bari, Foggia and the Research Center BIOGEM
Master’s thesis project carried out in the Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, supported by Erasmus Programme
Title: Effect of bexarotene and Aβ in microglia and macrophage TREM2expression and M1/M2 polarization
*Bachelor's degree, Biotechnologies 2009-2012
Biotechnologies Program, University of Modena and Reggio Emilia, Modena, Italy
Bachelor’s thesis title: Identification and characterization of isolated bacteria from natural mineral waters in bottle
Research
- My research focuses on understanding the mechanisms behind this interconnection between deregulated 3D nuclear architecture and cancer development.
In our group, we have observed and studied the molecular mechanisms of the MYC gene-gating: a nuclear export pathway that was never observed in mammal cells until now.
I have recently graduated with a thesis titled "The odyssey of MYC transcript from the nucleus to the cytoplasm: the molecular mechanism of the gene gating in human cancer cells".
I'm now continuing the work as a postdoctoral researcher, studying the role of the enhancer RNA, CCAT1, in the MYC nuclear export pathways.
Articles
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Article: NATURE COMMUNICATIONS. 2022;13(1):204
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Article: NATURE GENETICS. 2019;51(12):1723-1731
All other publications
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Corrigendum: NATURE GENETICS. 2020;52(11):1265
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Book chapter: CHROMATIN REGULATION AND DYNAMICS. 2017;p. 1-34
Employments
- Postdoctoral Researcher, Department of Oncology-Pathology, Karolinska Institutet, 2023-2025
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2023