Mohammad Alzrigat

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Grants
Public outreach and news

Articles

Article: CANCERS. 2023;15(18):4599

Target Genes of c-MYC and MYCN with Prognostic Power in Neuroblastoma Exhibit Different Expressions during Sympathoadrenal Development.

Yuan Y; Alzrigat M; Rodriguez-Garcia A; Wang X; Bexelius TS; Johnsen JI; Arsenian-Henriksson M; Liaño-Pons J; Bedoya-Reina OC
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(9):8141

MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma.

Agarwal P; Glowacka A; Mahmoud L; Bazzar W; Larsson L-G; Alzrigat M
Article: NATURE COMMUNICATIONS. 2022;13(1):5093

HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection.

Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(3):182-201

MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner.

Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickström M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(2):110-130

MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding.

Massó-Vallés D; Beaulieu M-E; Jauset T; Giuntini F; Zacarías-Fluck MF; Foradada L; Martínez-Martín S; Serrano E; Martín-Fernández G; Casacuberta-Serra S; Castillo Cano V; Kaur J; López-Estévez S; Morcillo MÁ; Alzrigat M; Mahmoud L; Luque-García A; Escorihuela M; Guzman M; Arribas J; Serra V; Larsson L-G; Whitfield JR; Soucek L
Article: CELL CYCLE. 2021;20(1):23-38

Pharmacological inactivation of CDK2 inhibits MYC/BCL-XL-driven leukemia in vivo through induction of cellular senescence.

Bazzar W; Bocci M; Hejll E; Högqvist Tabor V; Hydbring P; Grandien A; Alzrigat M; Larsson L-G
Article: METHODS IN MOLECULAR BIOLOGY. 2021;2318:241-254

Methods to Study Myc-Regulated Cellular Senescence: An Update.

Zhang F; Bazzar W; Alzrigat M; Larsson L-G
Article: EPIGENOMES. 2018;2(3):16

Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity.

Alzrigat M; Jernberg-Wiklund H; Licht JD
Article: ONCOTARGET. 2017;8(61):103731-103743

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains.

Alzrigat M; Párraga AA; Majumder MM; Ma A; Jin J; Österborg A; Nahi H; Nilsson K; Heckman CA; Öberg F; Kalushkova A; Jernberg-Wiklund H
Article: ONCOTARGET. 2017;8(6):10213-10224

EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat M; Párraga AA; Agarwal P; Zureigat H; Österborg A; Nahi H; Ma A; Jin J; Nilsson K; Öberg F; Kalushkova A; Jernberg-Wiklund H
Article: RNA & DISEASE. 2017;4(2):e1529

The miR-125a and miR-320c are potential tumor suppressor microRNAs epigenetically silenced by the polycomb repressive complex 2 in multiple myeloma.

Alzrigat M; Jernberg-Wiklund H
Article: ONCOTARGET. 2016;7(6):6809-6823

Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

Agarwal P; Alzrigat M; Párraga AA; Enroth S; Singh U; Ungerstedt J; Österborg A; Brown PJ; Ma A; Jin J; Nilsson K; Öberg F; Kalushkova A; Jernberg-Wiklund H
Article: JOURNAL OF CELL BIOLOGY. 2012;199(1):49-63

PML promotes MHC class II gene expression by stabilizing the class II transactivator.

Ulbricht T; Alzrigat M; Horch A; Reuter N; von Mikecz A; Steimle V; Schmitt E; Krämer OH; Stamminger T; Hemmerich P

All other publications

Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023

Supplementary Materials and Methods, Figures 1-6 from MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner

Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickström M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023

Supplementary Materials and Methods, Figures 1-6 from MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner

Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickström M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023

Data from MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner

Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickström M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023

Data from MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner

Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickström M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
Corrigendum: NATURE COMMUNICATIONS. 2022;13(1):6545

Publisher Correction: HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection.

Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
Review: SEMINARS IN CANCER BIOLOGY. 2018;51:101-115

Epigenetics in multiple myeloma: From mechanisms to therapy.

Alzrigat M; Párraga AA; Jernberg-Wiklund H
Conference publication: BLOOD. 2014;124(21):2192

An Epigenomic Map of Multiple Myeloma Reveals the Importance of Polycomb Gene Silencing for the Malignancy

Agarwal P; Kalushkova A; Enroth S; Alzrigat M; Osterborg A; Nilsson K; Oberg F; Jernberg-Wiklund H

Grants

The Role of NSD2 Methyltransferase in Refractory Acute Lymphocytic Leukemia

American Association For Cancer Research

1 July 2018 - 23 October 2018

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