Mtakai Ngara
Postdoctoral Researcher
E-mail: mtakai.ngara@ki.se
Visiting address: Solnavägen 9, Biomedicum, 17165 Solna
Postal address: C1 Mikrobiologi, tumör- och cellbiologi, C1 MTC Nylén Akira Kaneko, 171 77 Stockholm
Research
- Every cell is unique and generates distinct molecular response(s) in disease.
Understanding these perturbations at single cell resolution is critical in
unravelling complex, yet important diseases such as malaria.
In areas of endemic malaria transmission, individuals living in
geographically defined regions often present distinct phenotypes when
infected by the Plasmodium falciparum. I am interested in applying a systems
approach to understanding how immune cells define the three key outcomes of
malaria infection namely: asymptomatic, mild and symptomatic. To this end, we
will adopt single cell RNA-seq and other genome-wide technologies to profile
T lymphocytes derived from a high-resolution longitudinal cohort from Lake
Victoria islands in Kenya. This will provide an opportunity to gain novel
insight(s) into the disease in field transmission context and enhance our
understanding of the main drivers of adoptive response to malaria infection.
Articles
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Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(4):e163612
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Article: SCIENTIFIC REPORTS. 2021;11(1):19809
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Article: EXPERIMENTAL CELL RESEARCH. 2018;371(1):130-138
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Article: PLOS ONE. 2016;11(7):e0154102
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Article: CANCER CELL. 2014;25(6):794-808
All other publications
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Review: DIABETOLOGIA. 2022;65(8):1241-1250
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KI thesis / dissertation: 2019
Employments
- Postdoctoral Researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2022-2025
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2019