Ninib Baryawno
Principal Researcher
| Docent
E-mail: n.baryawno@ki.se
Visiting address: Widerströmska huset, Tomtebodavägen 18A, 17177 STOCKHOLM
Postal address: K6 Kvinnors och barns hälsa, K6 Barnonkologi och Barnkirurgi Kogner/Johnsen Baryawno, 171 77 Stockholm
About me
- The lab focus is to solve problems that limit the ability of cancer therapy
to be used more effectively against deadly forms of pediatric cancers and
adult cancers.
Dr Ninib Baryawno received his PhD diploma at Karolinska Institutet under the
supervision of associate professor John Inge Johnsen and professor Per
Kogner. His thesis work focused on developing novel therapeutics based on
better biological understanding of the childhood brain tumor medulloblastoma.
A disorder of development, arising mostly in the cerebellum during
embryogenesis and is largely dictated by events in stem cell regulatory
signaling pathways. His research was published as a thesis “New Potential
Targets in Medulloblastoma Therapy – Studies on Cellular Mechanisms and
Mediators”, and defended in February 2010.
It was the interest in stem cell based approaches to disease that brought Dr
Baryawno together with professor David Scadden at Harvard University and
Massachusetts General Hospital in 2011. Dr Baryawno was a postdoctoral fellow
in the Scadden lab until 2017 where he applied single-cell RNA-sequencing to
study how the hematopoietic stem cell niche supports the outgrowth of murine
leukemia and human bone metastases.
Dr Baryawno became Assistant professor at Karolinska Institutet in January
2018.
2001-2005, Biomedicine program, Karolinska Institutet.
2005-2010, PhD training, Karolinska Institutet.
2011-2017, Postdoc fellowship, Harvard University/Massachusetts General
Hospital.
2018, Assistant pProfessor, Karolinska Institutet.
2023, Associate Professor (Docent), Karolinska Institutet.
2023, Group leader, Karolinska Institutet.
Research
- The lab focus is to solve problems that limit the ability of cancer therapy
to be used more effectively against deadly forms of pediatric cancers and
adult cancers. We focus our research on pediatric tumors of the nervous
system such as neuroblastoma and medulloblastoma, and bone metastases from
different tumor origin.
Our research is balanced by a commitment to the value of basic and
translational research. This effort is based on the integrated approach of
single-cell technologies, computational modeling, and functional preclinical
testing, directed at understanding the role of the tumor microenvironment in
cancer development, tumor cell dissemination and cancer resistance.
Read more about our work here [1].
[1] http://baryawnolab.com/
Research expertise:
Childhood cancer
Metastatic cancer
Tumor microenvironment (stroma, immune cells)
Basic and translational
Single-cell omics
Preclinical modeling
Articles
-
Journal article: CANCER CELL. 2024;42(2):283-300.e8
-
Article: GENOME MEDICINE. 2024;16(1):1
-
Article: ONCOIMMUNOLOGY. 2023;12(1):2184130
-
Journal article: JCI INSIGHT. 2023;8(17):e167858
-
Article: NATURE COMMUNICATIONS. 2023;14(1):663
-
Article: CELL DEATH & DISEASE. 2022;13(10):916
-
Article: NATURE COMMUNICATIONS. 2022;13(1):5747
-
Article: JCI INSIGHT. 2022;7(17):e153836
-
Article: CELL REPORTS MEDICINE. 2022;3(6):100657
-
Article: SCIENTIFIC REPORTS. 2022;12(1):7519
-
Article: AMERICAN JOURNAL OF CANCER RESEARCH. 2022;12(12):5532-5551
-
Article: ELIFE. 2021;10:e66512
-
Article: CANCER CELL. 2021;39(11):1464-1478.e8
-
Article: CANCERS. 2021;13(21):5493
-
Article: NATURE METHODS. 2021;18(8):912-920
-
Article: NATURE GENETICS. 2021;53(5):694-706
-
Article: BLOOD. 2020;136(11):1303-1316
-
Article: CELL METABOLISM. 2020;32(3):391-403.e6
-
Article: NATURE. 2020;579(7797):111-117
-
Article: CELL STEM CELL. 2019;25(4):570-583.e7
-
Article: CELL. 2019;177(7):1915-1932.e16
-
Article: CANCER RESEARCH. 2018;78(18):5300-5314
-
Article: GENOME BIOLOGY. 2018;19(1):78
-
Journal article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(6):2651
-
Journal article: NEUROLOGY. 2018;90(15_supplement)
-
Article: CURRENT PROTOCOLS IN MOLECULAR BIOLOGY. 2018;122(1):e57
-
Article: CELL. 2018;172(1-2):191-204.e10
-
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(1):281-293
-
Article: SCIENCE. 2017;358(6367):eaal5081
-
Article: JOURNAL OF CLINICAL INVESTIGATION. 2017;127(4):1405-1413
-
Journal article: CELL. 2017;168(5):944-945
-
Journal article: BLOOD. 2016;128(22):430
-
Article: CELL. 2016;167(5):1310-1322.e17
-
Article: CELL STEM CELL. 2016;19(4):530-543
-
Article: MOLECULAR AND CELLULAR ONCOLOGY. 2016;3(2):e1131356
-
Article: NATURE COMMUNICATIONS. 2015;6:8904
-
Journal article: CELL RESEARCH. 2014;24(10):1151-1152
-
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014;450(4):1600-1605
-
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;133(10):2351-2361
-
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;132(7):1516-1524
-
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2013;42(4):1239-1248
-
Article: ONCOTARGET. 2011;2(12):1329-1338
-
Article: INTERNATIONAL JOURNAL OF CANCER. 2011;129(12):2958-2965
-
Article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(10):4043-4055
-
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;411(1):208-212
-
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2011;38(3):843-849
-
Article: CELL CYCLE. 2010;9(13):2548-2554
-
Article: CANCER RESEARCH. 2010;70(1):266-276
-
Article: NEURO-ONCOLOGY. 2008;10(5):661-674
-
Article: FASEB JOURNAL. 2008;22(10):3525-3536
- Show more
All other publications
-
Review: CANCERS. 2023;15(19):4734
-
Editorial comment: CELL STEM CELL. 2017;20(5):590-592
Grants
-
Swedish Research Council1 December 2023 - 30 November 2026
-
Swedish Research Council1 January 2022 - 31 December 2025
-
Swedish Cancer Society1 January 2019
-
Swedish Research Council1 July 2012 - 30 June 2015
Employments
- Principal Researcher, Department of Women's and Children's Health, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2023
- Degree Of Doctor Of Philosophy, Department of Women's and Children's Health, Karolinska Institutet, 2010
- Master Of Medical Science, Karolinska Institutet, 2007