Nicole Marquardt

Publications
Grants
Public outreach and news

Articles

Article: ONCOIMMUNOLOGY. 2023;12(1):2233402

Accumulation of tissue-resident natural killer cells, innate lymphoid cells, and CD8+ T cells towards the center of human lung tumors.

Brownlie D; von Kries A; Valenzano G; Wild N; Yilmaz E; Säfholm J; Al-Ameri M; Alici E; Ljunggren H-G; Schliemann I; Aricak O; Haglund de Flon F; Michaëlsson J; Marquardt N
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195

The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.

Ljunggren H-G; Ask EH; Cornillet M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio A; Dzidic M; Filipovic I; Flodström-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingström J; Kokkinou E; Kvedaraite E; Lourda M; Mjösberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Karolinska KI/K COVID-19 Study Group; Eriksson LI; Aleman S; Malmberg K-J; Strålin K; Björkström NK
Article: CELL REPORTS MEDICINE. 2022;3(2):100508

Autologous NK cells as consolidation therapy following stem cell transplantation in multiple myeloma.

Nahi H; Chrobok M; Meinke S; Gran C; Marquardt N; Afram G; Sutlu T; Gilljam M; Stellan B; Wagner AK; Blomberg P; Holmqvist P-H; Walther-Jallow L; Mellström K; Liwing J; Gustafsson C; Månsson R; Klimkowska M; Gahrton G; Lund J; Ljungman P; Ljunggren H-G; Alici E
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:834862

Comparison of Lung-Homing Receptor Expression and Activation Profiles on NK Cell and T Cell Subsets in COVID-19 and Influenza.

Brownlie D; Rødahl I; Varnaite R; Asgeirsson H; Glans H; Falck-Jones S; Vangeti S; Buggert M; Ljunggren H-G; Michaëlsson J; Gredmark-Russ S; Smed-Sörensen A; Marquardt N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(11):e2016580118

Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood.

Brownlie D; Scharenberg M; Mold JE; Hård J; Kekäläinen E; Buggert M; Nguyen S; Wilson JN; Al-Ameri M; Ljunggren H-G; Marquardt N; Michaëlsson J
Article: IMMUNITY. 2021;54(2):259-275.e7

Distinct developmental pathways from blood monocytes generate human lung macrophage diversity.

Evren E; Ringqvist E; Tripathi KP; Sleiers N; Rives IC; Alisjahbana A; Gao Y; Sarhan D; Halle T; Sorini C; Lepzien R; Marquardt N; Michaëlsson J; Smed-Sörensen A; Botling J; Karlsson MCI; Villablanca EJ; Willinger T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.

Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Hed Myrberg I; Lourda M; Dzidic M; Akber M; Klingström J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Ginhoux F; Björkström NK; Henter J-I; Svensson M; Karolinska KI/K COVID-19 Study Group
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:752104

CD5 Surface Expression Marks Intravascular Human Innate Lymphoid Cells That Have a Distinct Ontogeny and Migrate to the Lung.

Alisjahbana A; Gao Y; Sleiers N; Evren E; Brownlie D; von Kries A; Jorns C; Marquardt N; Michaëlsson J; Willinger T
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306

SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation.

Sandberg JT; Varnaitė R; Christ W; Chen P; Muvva JR; Maleki KT; García M; Dzidic M; Folkesson E; Skagerberg M; Ahlén G; Frelin L; Sällberg M; Eriksson LI; Rooyackers O; Sönnerborg A; Buggert M; Björkström NK; Aleman S; Strålin K; Klingström J; Ljunggren H-G; Blom K; Gredmark-Russ S; Karolinska COVID‐19 Study Group
Article: CELL. 2020;183(1):158-168.e14

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.

Sekine T; Perez-Potti A; Rivera-Ballesteros O; Strålin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgård J; Parrot T; Folkesson E; Karolinska COVID-19 Study Group; Rooyackers O; Eriksson LI; Henter J-I; Sönnerborg A; Allander T; Albert J; Nielsen M; Klingström J; Gredmark-Russ S; Björkström NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670

MAIT cell activation and dynamics associated with COVID-19 disease severity.

Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgård J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Karolinska COVID-19 Study Group; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Björkström NK; Aleman S; Buggert M; Klingström J; Strålin K; Sandberg JK
Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832

Natural killer cell immunotypes related to COVID-19 disease severity.

Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingström J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaëlsson J; Marquardt N; Hammer Q; Strålin K; Björkström NK; Karolinska COVID-19 Study Group
Article: NATURE COMMUNICATIONS. 2019;10(1):3897

NK cells are activated and primed for skin-homing during acute dengue virus infection in humans.

Zimmer CL; Cornillet M; Solà-Riera C; Cheung K-W; Ivarsson MA; Lim MQ; Marquardt N; Leo Y-S; Lye DC; Klingström J; MacAry PA; Ljunggren H-G; Rivino L; Björkström NK
Article: NATURE COMMUNICATIONS. 2019;10(1):3841

Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells.

Marquardt N; Kekäläinen E; Chen P; Lourda M; Wilson JN; Scharenberg M; Bergman P; Al-Ameri M; Hård J; Mold JE; Ljunggren H-G; Michaëlsson J
Article: JOURNAL OF HEPATOLOGY. 2019;71(2):301-312

Chronic hepatitis delta virus infection leads to functional impairment and severe loss of MAIT cells.

Dias J; Hengst J; Parrot T; Leeansyah E; Lunemann S; Malone DFG; Hardtke S; Strauss O; Zimmer CL; Berglin L; Schirdewahn T; Ciesek S; Marquardt N; von Hahn T; Manns MP; Cornberg M; Ljunggren H-G; Wedemeyer H; Sandberg JK; Björkström NK
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1116

Influenza A Virus Infection Induces Hyperresponsiveness in Human Lung Tissue-Resident and Peripheral Blood NK Cells.

Scharenberg M; Vangeti S; Kekäläinen E; Bergman P; Al-Ameri M; Johansson N; Sondén K; Falck-Jones S; Färnert A; Ljunggren H-G; Michaëlsson J; Smed-Sörensen A; Marquardt N
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1321-1330.e4

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69-CD56dim cells.

Marquardt N; Kekäläinen E; Chen P; Kvedaraite E; Wilson JN; Ivarsson MA; Mjösberg J; Berglin L; Säfholm J; Manson ML; Adner M; Al-Ameri M; Bergman P; Orre A-C; Svensson M; Dahlén B; Dahlén S-E; Ljunggren H-G; Michaëlsson J
Article: MUCOSAL IMMUNOLOGY. 2017;10(2):322-331

Composition and dynamics of the uterine NK cell KIR repertoire in menstrual blood.

Ivarsson MA; Stiglund N; Marquardt N; Westgren M; Gidlöf S; Björkström NK
Article: IMMUNITY. 2017;46(2):287-300

CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin.

Cheuk S; Schlums H; Gallais Sérézal I; Martini E; Chiang SC; Marquardt N; Gibbs A; Detlofsson E; Introini A; Forkel M; Höög C; Tjernlund A; Michaëlsson J; Folkersen L; Mjösberg J; Blomqvist L; Ehrström M; Ståhle M; Bryceson YT; Eidsmo L
Article: JOURNAL OF IMMUNOLOGY. 2016;197(8):3069-3075

Fetal CD103+ IL-17-Producing Group 3 Innate Lymphoid Cells Represent the Dominant Lymphocyte Subset in Human Amniotic Fluid.

Marquardt N; Ivarsson MA; Sundström E; Åkesson E; Martini E; Eidsmo L; Mjösberg J; Friberg D; Kublickas M; Ek S; Tegerstedt G; Seiger Å; Westgren M; Michaëlsson J
Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3262-3272

The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education.

Marquardt N; Ivarsson MA; Blom K; Gonzalez VD; Braun M; Falconer K; Gustafsson R; Fogdell-Hahn A; Sandberg JK; Michaëlsson J
Article: JOURNAL OF IMMUNOLOGY. 2015;194(6):2467-2471

Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.

Marquardt N; Béziat V; Nyström S; Hengst J; Ivarsson MA; Kekäläinen E; Johansson H; Mjösberg J; Westgren M; Lankisch TO; Wedemeyer H; Ellis EC; Ljunggren H-G; Michaëlsson J; Björkström NK
Article: CELL COMMUNICATION AND SIGNALING. 2014;12:63

Role of gamma-secretase in human umbilical-cord derived mesenchymal stem cell mediated suppression of NK cell cytotoxicity.

Chatterjee D; Marquardt N; Tufa DM; Beauclair G; Low HZ; Hatlapatka T; Hass R; Kasper C; von Kaisenberg C; Schmidt RE; Jacobs R
Article: FRONTIERS IN IMMUNOLOGY. 2014;5:662

Human Umbilical Cord-Derived Mesenchymal Stem Cells Utilize Activin-A to Suppress Interferon-γ Production by Natural Killer Cells.

Chatterjee D; Marquardt N; Tufa DM; Hatlapatka T; Hass R; Kasper C; von Kaisenberg C; Schmidt RE; Jacobs R
Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(9):3889-3901

Differentiation and functional regulation of human fetal NK cells.

Ivarsson MA; Loh L; Marquardt N; Kekäläinen E; Berglin L; Björkström NK; Westgren M; Nixon DF; Michaëlsson J
Article: BRAIN BEHAVIOR AND IMMUNITY. 2011;25(6):1233-1241

Human CD8(+) T cells and NK cells express and secrete S100B upon stimulation.

Steiner J; Marquardt N; Pauls I; Schiltz K; Rahmoune H; Bahn S; Bogerts B; Schmidt RE; Jacobs R
Article: TISSUE ENGINEERING PART C-METHODS. 2011;17(4):485-493

Optimization of culture conditions for the expansion of umbilical cord-derived mesenchymal stem or stromal cell-like cells using xeno-free culture conditions.

Hatlapatka T; Moretti P; Lavrentieva A; Hass R; Marquardt N; Jacobs R; Kasper C
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5):1428-1439

Murine CXCR3+CD27bright NK cells resemble the human CD56bright NK-cell population.

Marquardt N; Wilk E; Pokoyski C; Schmidt RE; Jacobs R
Article: JOURNAL OF STEM CELLS AND REGENERATIVE MEDICINE. 2010;6(2):101-102

Shaping the microenvironment of umbilical cord-derived mesenchymal stem cell-like cells.

Hatlapatka T; Lavrentieva A; Moretti P; Hass R; Marquardt N; Jacobs R; Kasper C
Article: ARTHRITIS & RHEUMATOLOGY. 2009;60(12):3563-3571

Depletion of functionally active CD20+ T cells by rituximab treatment.

Wilk E; Witte T; Marquardt N; Horvath T; Kalippke K; Scholz K; Wilke N; Schmidt RE; Jacobs R
Show more

All other publications

Meeting abstract: BLOOD. 2021;138:4796

CD38 Down-Regulation on Ex Vivo Activated and Expanded NK Cells for Cell Therapy Persists after Infusion

Nahi H; Chrobook M; Meinke S; Gran C; Marquardt N; Afram G; Sutlu T; Gilljam M; Stellan B; Wagner AK; Walther-Jallow L; Liwing J; Klimkowska M; Gahrton G; Ljungman P; Ljunggren H-G; Alici E
Preprint: 2021;bioRxiv

Distinct lung-homing receptor expression and activation profiles on NK cell and T cell subsets in COVID-19 and influenza

Brownlie D; Rødahl I; Varnaite R; Asgeirsson H; Glans H; Falck-Jones S; Vangeti S; Buggert M; Ljunggren H-G; Michaëlsson J; Gredmark-Russ S; Smed-Sörensen A; Marquardt N
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:170

Human CD5+innate lymphoid cells are intravascular precursors that migrate into the lung

Alisjahbana A; Gao Y; Sleiers N; Evren E; Brownlie D; Von Kries A; Jorns C; Michaelsson J; Marquardt N; Willinger T
Preprint: 2020;medRxiv

Natural killer cell activation related to clinical outcome of COVID-19

Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Gomez AC; Ask EH; Hull R; Haroun-Izquierdo A; Schaffer M; Klingström J; Folkesson E; Buggert M; Sandberg J; Eriksson L; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaëlsson J; Marquardt N; Hammer Q; Strålin K; Björkström N; Karolinska COVID-19 Study Group
Preprint: 2019;bioRxiv

Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood

Marquardt N; Scharenberg M; Mold JE; Hård J; Kekäläinen E; Buggert M; Nguyen S; Wilson JN; Al-Ameri M; Ljunggren H-G; Michaëlsson J
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(1):318

Reply.

Marquardt N; Ljunggren H-G; Michaëlsson J
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46:67-68

Human lung NK cells are predominantly constituted by highly differentiated hypofunctional CD69^-CD56^dim cells

Marquardt N; Kekalainen E; Wilson JN; Ivarsson MA; Mjosberg J; Safholm J; Manson ML; Adner M; Al-Ameri M; Bergman P; Orre A-C; Dahlen B; Dahlen S-E; Ljunggren H-G; Michaelsson J
Other: ALLERGY. 2015;70(11):1353-1355

Allergy trainees' perspectives on career opportunities: results from a trainee-organized retreat.

Protudjer JLP; Binnmyr J; Grundström J; Manson ML; Marquardt N; Säfholm J; Ullemar V
Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:173.17

Function and regulation of human NK cells in an acute viral infection model

Marquardt N; Ivarsson M; Blom K; Braun M; Gonzalez V; Falconer K; Sandberg J; Michaelsson J
Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:52.46

Differential education of human fetal natural killer cells provides a mechanism for fetal-maternal tolerance.

Ivarsson M; Loh L; Marquardt N; Bjorkstrom N; Westgren M; Nixon D; Michaelsson J
Conference publication: IMMUNOLOGY. 2012;137:92

Human mesenchymal stem cell mediated suppression of NK cell effector functions

Chatterjee D; Hass R; Marquardt N; Kasper C; Schmidt RE; Jacobs R
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:180

Human CD8+T cells and NK cells express and secrete S100B upon stimulation

Steiner J; Marquardt N; Pauls I; Schiltz K; Bogerts B; Schmidt R-E; Jacobs R
Conference publication: TISSUE ENGINEERING PART A. 2011;17(3-4):575

Shaping the Microenvironment of Umbilical Cord-derived Mesenchymal Stem Cell-like Cells

Hatlapatka T; Kasper C; Lavrentieva A; Hass R; Marquardt N; Jacobs R
Letter: ARTHRITIS & RHEUMATOLOGY. 2010;62(8):2563-2565

CD3+CD20+cells may be an artifact of flow cytometry: comment on the article by Wilk et al Reply

Wilk E; Witte T; Marquardt N; Hennig C; Hansen G; Schmidt RE; Jacobs R
Conference publication: WIENER KLINISCHE WOCHENSCHRIFT. 2008;120:107

CXCR3 expression patterns on murine NK cells characterize phenotypic and functional homologs to human NK cell subsets

Marquardt N; Wilk E; Schmidt RE; Jacobs R

Grants

Induction of cytotoxic NK cells with a tissue-resident phenotype for treatment against human lung tumors

Magnus Bergvalls Stiftelse

1 January 2024 - 31 December 2024
Harnessing human adaptive-like tissue-resident Natural Killer cells for treatment of lung cancer

The Swedish Cancer Society

1 January 2023 - 31 December 2025
Modifiera lunginfiltration av NK-celler i luftvägsinfektioner för att förhindra lungvävnadsskada

KI Research Foundation

1 January 2022 - 31 December 2023
Mapping NK cell heterogeneity and functions in human lung tissues in health and disease

KID

1 January 2022 - 31 December 2025
Identifying and harnessing NK cell subsets in the human lung for treatment of lung cancer.

Swedish Research Council

1 January 2022 - 31 December 2024
Understanding and preventing NK cell-mediated lung tissue-damage upon severe respiratory viral infections

Swedish Research Council

1 December 2021 - 30 November 2024
Prevention of NK cell-induced lung tissue-damage upon severe respiratory viral infections (SARS-CoV-2, Influenza A virus)

Centrum för innovativ medicin (CIMED)

1 January 2021 - 31 December 2023
Stiftelsen Tornspiran

1 January 2021 - 31 December 2021
Harnessing intratumoral tissue-resident NK cells for treatment of lung cancer with inhibitory checkpoint blockade

Centrum för innovativ medicin

1 January 2021 - 31 December 2023
Metabolic regulation of tumor-infiltrating NK cells in human sarcoma

Magnus Bergvalls Stiftelse

1 January 2020 - 31 December 2020
Human lung NK cells in severe respiratory viral infections

Stiftelsen Clas Groschinskys Minnesfond

1 January 2020 - 31 December 2021
Humana NK cellers funktion och reglering vid infekction med influensavirus

KI Research Foundation

1 January 2019 - 31 December 2020
Funktion och manipulering av naturliga killer celler i virusinfektion i human lunga

Stiftelsen Tornspiran

1 January 2019 - 31 December 2019
Role and manipulation of human lung NK cells in influenza infection

Åke Wibergs Stiftelse

1 January 2019 - 31 December 2019
Development, regulation and function of human natural killer cells in healthy and virus infected individuals

Deutsche Forschungsgemeinschaft

1 January 2011 - 31 December 2013

Articles

All other publications

Grants

News from KI

Events from KI