Nina Heldring

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Articles

Article: STEM CELLS TRANSLATIONAL MEDICINE. 2020;9(10):1190-1202

Treatment of chronic GvHD with mesenchymal stromal cells induces durable responses: A phase II study.

Boberg E; von Bahr L; Afram G; Lindström C; Ljungman P; Heldring N; Petzelbauer P; Garming Legert K; Kadri N; Le Blanc K
Article: GYNECOLOGIC ONCOLOGY. 2020;156(2):293-300

A randomized phase III trial in patients with recurrent platinum sensitive ovarian cancer comparing efficacy and safety of paclitaxel micellar and Cremophor EL-paclitaxel.

Vergote I; Bergfeldt K; Franquet A; Lisyanskaya AS; Bjermo H; Heldring N; Buyse M; Brize A
Article: ADVANCES IN THERAPY. 2019;36(10):2825-2837

Pharmacokinetics of Total and Unbound Paclitaxel After Administration of Paclitaxel Micellar or Nab-Paclitaxel: An Open, Randomized, Cross-Over, Explorative Study in Breast Cancer Patients.

Borgå O; Lilienberg E; Bjermo H; Hansson F; Heldring N; Dediu R
Article: ADVANCES IN THERAPY. 2019;36(5):1150-1163

Maximum Tolerated Dose and Pharmacokinetics of Paclitaxel Micellar in Patients with Recurrent Malignant Solid Tumours: A Dose-Escalation Study.

Borgå O; Henriksson R; Bjermo H; Lilienberg E; Heldring N; Loman N
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2249

The Complement System Is Essential for the Phagocytosis of Mesenchymal Stromal Cells by Monocytes.

Gavin C; Meinke S; Heldring N; Heck KA; Achour A; Iacobaeus E; Höglund P; Le Blanc K; Kadri N
Article: STEM CELLS. 2017;35(3):766-776

Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression.

Davies LC; Heldring N; Kadri N; Le Blanc K
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2016;5(11):1485-1495

Type 1 Diabetes Mellitus Donor Mesenchymal Stromal Cells Exhibit Comparable Potency to Healthy Controls In Vitro.

Davies LC; Alm JJ; Heldring N; Moll G; Gavin C; Batsis I; Qian H; Sigvardsson M; Nilsson B; Kyllonen LE; Salmela KT; Carlsson P-O; Korsgren O; Le Blanc K
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(10):1199-1213

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome.

Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalén M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Hägglund H; Mattsson M; Lehtiö J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Article: CELL DEATH & DISEASE. 2015;6(6):e1793

Tet3 mediates stable glucocorticoid-induced alterations in DNA methylation and Dnmt3a/Dkk1 expression in neural progenitors.

Bose R; Spulber S; Kilian P; Heldring N; Lönnerberg P; Johnsson A; Conti M; Hermanson O; Ceccatelli S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26316

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting.

Wiklander OPB; Nordin JZ; O'Loughlin A; Gustafsson Y; Corso G; Mäger I; Vader P; Lee Y; Sork H; Seow Y; Heldring N; Alvarez-Erviti L; Smith CIE; Le Blanc K; Macchiarini P; Jungebluth P; Wood MJA; Andaloussi SE
Article: STEM CELLS. 2014;32(9):2430-2442

Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?

Moll G; Alm JJ; Davies LC; von Bahr L; Heldring N; Stenbeck-Funke L; Hamad OA; Hinsch R; Ignatowicz L; Locke M; Lönnies H; Lambris JD; Teramura Y; Nilsson-Ekdahl K; Nilsson B; Le Blanc K
Article: NEURO-ONCOLOGY. 2014;16(2):241-249

NCoR controls glioblastoma tumor cell characteristics.

Heldring N; Nyman U; Lönnerberg P; Onnestam S; Herland A; Holmberg J; Hermanson O
Article: PLOS ONE. 2014;9(1):e85040

Do ABO blood group antigens hamper the therapeutic efficacy of mesenchymal stromal cells?

Moll G; Hult A; von Bahr L; Alm JJ; Heldring N; Hamad OA; Stenbeck-Funke L; Larsson S; Teramura Y; Roelofs H; Nilsson B; Fibbe WE; Olsson ML; Le Blanc K
Article: NATURE. 2013;500(7463):468-471

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.

Füllgrabe J; Lynch-Day MA; Heldring N; Li W; Struijk RB; Ma Q; Hermanson O; Rosenfeld MG; Klionsky DJ; Joseph B
Article: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2012;49(3):277-287

Estrogen receptor-α, RBCK1, and protein kinase C β 1 cooperate to regulate estrogen receptor-α gene expression.

Gustafsson Sheppard N; Heldring N; Dahlman-Wright K
Article: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS. 2012;11(7):884-892

Pitx2 expression promotes p21 expression and cell cycle exit in neural stem cells.

Heldring N; Joseph B; Hermanson O; Kioussi C
Article: MOLECULAR ENDOCRINOLOGY. 2012;26(5):736-747

Estrogen regulates JNK1 genomic localization to control gene expression and cell growth in breast cancer cells.

Sun M; Isaacs GD; Hah N; Heldring N; Fogarty EA; Kraus WL
Article: MOLECULAR ENDOCRINOLOGY. 2011;25(4):564-574

Multiple sequence-specific DNA-binding proteins mediate estrogen receptor signaling through a tethering pathway.

Heldring N; Isaacs GD; Diehl AG; Sun M; Cheung E; Ranish JA; Kraus WL
Article: PLOS ONE. 2010;5(12):e15594

Fatty acids derived from royal jelly are modulators of estrogen receptor functions.

Moutsatsou P; Papoutsi Z; Kassi E; Heldring N; Zhao C; Tsiapara A; Melliou E; Chrousos GP; Chinou I; Karshikoff A; Nilsson L; Dahlman-Wright K
Article: DEVELOPMENTAL BIOLOGY. 2010;348(2):153-166

Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells.

Das D; Lanner F; Main H; Andersson ER; Bergmann O; Sahlgren C; Heldring N; Hermanson O; Hansson EM; Lendahl U
Article: BIOCHEMICAL JOURNAL. 2007;406(2):343-353

Co-planar 3,3',4,4',5-pentachlorinated biphenyl and non-co-planar 2,2',4,6,6'-pentachlorinated biphenyl differentially induce recruitment of oestrogen receptor alpha to aryl hydrocarbon receptor target genes.

Matthews J; Wihlén B; Heldring N; MacPherson L; Helguero L; Treuter E; Haldosén L-A; Gustafsson J-A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(14):10449-10455

Structural insights into corepressor recognition by antagonist-bound estrogen receptors.

Heldring N; Pawson T; McDonnell D; Treuter E; Gustafsson J-A; Pike ACW
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2006;49(25):7357-7365

Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen receptors alpha and beta.

Roelens F; Heldring N; Dhooge W; Bengtsson M; Comhaire F; Gustafsson J-A; Treuter E; De Keukeleire D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(10):3593-3598

Delineation of a unique protein-protein interaction site on the surface of the estrogen receptor.

Kong EH; Heldring N; Gustafsson J-A; Treuter E; Hubbard RE; Pike ACW
Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(8):3445-3459

Identification of tamoxifen-induced coregulator interaction surfaces within the ligand-binding domain of estrogen receptors.

Heldring N; Nilsson M; Buehrer B; Treuter E; Gustafsson J-A
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All other publications

Corrigendum: NATURE. 2017;543(7647):742

Corrigendum: The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.

Füllgrabe J; Lynch-Day MA; Heldring N; Li W; Struijk RB; Ma Q; Hermanson O; Rosenfeld MG; Klionsky DJ; Joseph B
Corrigendum: STEM CELLS TRANSLATIONAL MEDICINE. 2016;5(6):845

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome.

Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalén M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Hägglund H; Mattsson M; Lehtiö J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Review: HUMAN GENE THERAPY. 2015;26(8):506-517

Therapeutic Potential of Multipotent Mesenchymal Stromal Cells and Their Extracellular Vesicles.

Heldring N; Mäger I; Wood MJA; Le Blanc K; Andaloussi SEL
Review: AUTOPHAGY. 2014;10(4):556-561

Cracking the survival code: autophagy-related histone modifications.

Füllgrabe J; Heldring N; Hermanson O; Joseph B
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2013;1830(2):2354-2360

Like a rolling histone: epigenetic regulation of neural stem cells and brain development by factors controlling histone acetylation and methylation.

Lilja T; Heldring N; Hermanson O
Review: PHYSIOLOGICAL REVIEWS. 2007;87(3):905-931

Estrogen receptors: how do they signal and what are their targets.

Heldring N; Pike A; Andersson S; Matthews J; Cheng G; Hartman J; Tujague M; Ström A; Treuter E; Warner M; Gustafsson J-A
Published paper: TOXICOLOGY IN VITRO. 1998;12(5):557-560

Neurite degeneration in differentiated human neuroblastoma cells.

Nordin-Andersson M; Forsby A; Heldring N; Dejongh J; Kjellstrand P; Walum E

Employments

Affiliated to Research, Department of Oncology-Pathology, Karolinska Institutet, 2023-2024

Degrees and Education

Doctor Of Philosophy, Department of Biosciences and Nutrition, Karolinska Institutet, 2006

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