Affiliated to research
My research is focused on understanding mechanisms and improving means for diagnosis of autoimmune disease.
Autoantibodies as markers of disease. We are using proteome arrays to characterize autoantibody responses and to identify biomarkers. We are also developing targeted antigen panels to support clinical diagnostics of autoimmune disorders.
One of the autoantigens we have identified, transglutaminase 4, is a prostate-specific member of the transglutaminase protein family. Previous studies have identified other members of this protein family as autoantigens in distinct autoimmune disorders. Inspired by this, we now pursue remaining transglutaminases as candidate autoantigens.
Sex differences in immunity and disease. Women face a four-fold higher risk of developing an autoimmune disorder compared to men. As a means to understand the role of sex hormones, we follow men and women undergoing sex change with blood and fecal sampling before and at different time points during cross-sex hormone therapy. Multiple omics technologies are combined to achieve a broad view of how male and female hormones regulate the immune system.
Swedish Research Council
Karolinska Institutet doctoral student funding (KID)
Swedish Society of Medicine
Swedish Society for Medical Research
Swedish Association of Endocrinologists
Åke Wiberg foundation
Marcus Borgström foundation
Magnus Bergvall foundation
Tore Nilson foundation
Licenced physician 2018
PhD 2015, Uppsala University
MD 2011, Uppsala University
Academic honours, awards and prizes
Swedish Research Council postdoc-grant
Swedish Society for Medical Research Postdoctoral Fellowship, 2018
The Swedish Association of Endocrinologists’ Research Stipend of the Year, 2017
The Crafoord Stipend, 2016
Benzeliusbelöning, from the Royal Society of Sciences in Uppsala, 2015
Best Thesis award from the Department of Medical Sciences, Uppsala University, 2015
Thesis of the Year from The Swedish Association of Endocrinologists, 2015
SciLifeLab Scientific Highlight, recognizing Landegren et al. Science Translational Medicine 2015
Swedish Society for Medical Research Travel grant for exchange to Stanford University, 2012