Nina Kronqvist

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Articles

Article: NATURE COMMUNICATIONS. 2024;15(1):965

Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain

Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
Article: TRANSLATIONAL RESEARCH. 2023;262:60-74

Synthetic surfactant with a combined SP-B and SP-C analogue is efficient in rabbit models of adult and neonatal respiratory distress syndrome.

Mikolka P; Kronqvist N; Haegerstrand-Björkman M; Jaudzems K; Kosutova P; Kolomaznik M; Saluri M; Landreh M; Calkovska A; Curstedt T; Johansson J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2023;655:75-81

Display of a naïve affibody library on staphylococci for selection of binders by means of flow cytometry sorting.

Dahlsson Leitao C; Mestre Borras A; Jonsson A; Malm M; Kronqvist N; Fleetwood F; Sandersjöö L; Uhlén M; Löfblom J; Ståhl S; Lindberg H
Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358

Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue.

Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstål H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
Article: NATURE COMMUNICATIONS. 2022;13(1):4695

Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform.

Arndt T; Jaudzems K; Shilkova O; Francis J; Johansson M; Laity PR; Sahin C; Chatterjee U; Kronqvist N; Barajas-Ledesma E; Kumar R; Chen G; Strömberg R; Abelein A; Langton M; Landreh M; Barth A; Holland C; Johansson J; Rising A
Article: STRUCTURE. 2022;30(5):733-742.e7

A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder.

Kaldmäe M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Siau JW; Ng AS; Ghadessy FJ; Sabatier P; Vojtesek B; Sarr M; Sahin C; Österlund N; Ilag LL; Väänänen VA; Sedimbi S; Arsenian-Henriksson M; Zubarev RA; Nilsson L; Koeck PJB; Rising A; Abelein A; Fritz N; Johansson J; Lane DP; Landreh M
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:936887

Solution Structure of Tubuliform Spidroin N-Terminal Domain and Implications for pH Dependent Dimerization.

Šede M; Fridmanis J; Otikovs M; Johansson J; Rising A; Kronqvist N; Jaudzems K
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:927017

Cooperative action of SP-A and its trimeric recombinant fragment with polymyxins against Gram-negative respiratory bacteria.

Coya JM; Fraile-Ágreda V; de Tapia L; García-Fojeda B; Sáenz A; Bengoechea JA; Kronqvist N; Johansson J; Casals C
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:994328

The collectin SP-A and its trimeric recombinant fragment protect alveolar epithelial cells from the cytotoxic and proinflammatory effects of human cathelicidin in vitro.

de Tapia L; García-Fojeda B; Kronqvist N; Johansson J; Casals C
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2406:113-130

A Novel Approach for the Production of Aggregation-Prone Proteins Using the Spidroin-Derived NT* Tag.

Kronqvist N; Rising A; Johansson J
Article: MICROBIAL CELL FACTORIES. 2021;20(1):150

Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E. coli fed-batch culture.

Schmuck B; Chen G; Pelcman J; Kronqvist N; Rising A; Johansson J
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2021;198:113996

The synthesis and characterization of Bri2 BRICHOS coated magnetic particles and their application to protein fishing: Identification of novel binding proteins.

Tigro H; Kronqvist N; Abelein A; Galan-Acosta L; Chen G; Landreh M; Lyashkov A; Aon MA; Ferrucci L; Shimmo R; Johansson J; Moaddel R
Article: BIOCHEMISTRY. 2021;60(9):678-688

Smallest Secondary Nucleation Competent Aβ Aggregates Probed by an ATP-Independent Molecular Chaperone Domain.

Leppert A; Tiiman A; Kronqvist N; Landreh M; Abelein A; Vukojević V; Johansson J
Article: FEBS JOURNAL. 2020;287(13):2823-2833

High intracellular stability of the spidroin N-terminal domain in spite of abundant amyloidogenic segments revealed by in-cell hydrogen/deuterium exchange mass spectrometry.

Kaldmäe M; Leppert A; Chen G; Sarr M; Sahin C; Nordling K; Kronqvist N; Gonzalvo-Ulla M; Fritz N; Abelein A; Laίn S; Biverstål H; Jörnvall H; Lane DP; Rising A; Johansson J; Landreh M
Article: SCIENTIFIC REPORTS. 2020;10(1):235

High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain.

Abelein A; Chen G; Kitoka K; Aleksis R; Oleskovs F; Sarr M; Landreh M; Pahnke J; Nordling K; Kronqvist N; Jaudzems K; Rising A; Johansson J; Biverstål H
Article: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 2019;30(8):1385-1388

Gas-Phase Collisions with Trimethylamine-N-Oxide Enable Activation-Controlled Protein Ion Charge Reduction.

Kaldmäe M; Österlund N; Lianoudaki D; Sahin C; Bergman P; Nyman T; Kronqvist N; Ilag LL; Allison TM; Marklund EG; Landreh M
Article: JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 2018;9(14):4082-4086

Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone.

Gault J; Lianoudaki D; Kaldmäe M; Kronqvist N; Rising A; Johansson J; Lohkamp B; Laín S; Allison TM; Lane DP; Marklund EG; Landreh M
Article: FEBS JOURNAL. 2018;285(10):1873-1885

A spidroin-derived solubility tag enables controlled aggregation of a designed amyloid protein.

Sarr M; Kronqvist N; Chen G; Aleksis R; Purhonen P; Hebert H; Jaudzems K; Rising A; Johansson J
Article: NATURE COMMUNICATIONS. 2017;8:15504

Efficient protein production inspired by how spiders make silk.

Kronqvist N; Sarr M; Lindqvist A; Nordling K; Otikovs M; Venturi L; Pioselli B; Purhonen P; Landreh M; Biverstål H; Toleikis Z; Sjöberg L; Robinson CV; Pelizzi N; Jörnvall H; Hebert H; Jaudzems K; Curstedt T; Rising A; Johansson J
Article: IMMUNOBIOLOGY. 2017;222(2):111-118

Novel expression of a functional trimeric fragment of human SP-A with efficacy in neutralisation of RSV.

Watson A; Kronqvist N; Spalluto CM; Griffiths M; Staples KJ; Wilkinson T; Holmskov U; Sorensen GL; Rising A; Johansson J; Madsen J; Clark H
Article: CHEMBIOCHEM. 2015;16(12):1720-1724

Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains.

Otikovs M; Chen G; Nordling K; Landreh M; Meng Q; Jörnvall H; Kronqvist N; Rising A; Johansson J; Jaudzems K
Article: PLOS BIOLOGY. 2014;12(8):e1001921

Carbonic anhydrase generates CO2 and H+ that drive spider silk formation via opposite effects on the terminal domains.

Andersson M; Chen G; Otikovs M; Landreh M; Nordling K; Kronqvist N; Westermark P; Jörnvall H; Knight S; Ridderstråle Y; Holm L; Meng Q; Jaudzems K; Chesler M; Johansson J; Rising A
Article: NATURE COMMUNICATIONS. 2014;5:3254

Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation.

Kronqvist N; Otikovs M; Chmyrov V; Chen G; Andersson M; Nordling K; Landreh M; Sarr M; Jörnvall H; Wennmalm S; Widengren J; Meng Q; Rising A; Otzen D; Knight SD; Jaudzems K; Johansson J
Article: PLOS ONE. 2013;8(5):e62791

Inhibiting HER3-mediated tumor cell growth with affibody molecules engineered to low picomolar affinity by position-directed error-prone PCR-like diversification.

Malm M; Kronqvist N; Lindberg H; Gudmundsdotter L; Bass T; Frejd FY; Höidén-Guthenberg I; Varasteh Z; Orlova A; Tolmachev V; Ståhl S; Löfblom J
Article: PROTEIN ENGINEERING DESIGN & SELECTION. 2011;24(4):385-396

Combining phage and staphylococcal surface display for generation of ErbB3-specific Affibody molecules.

Kronqvist N; Malm M; Göstring L; Gunneriusson E; Nilsson M; Höidén Guthenberg I; Gedda L; Frejd FY; Ståhl S; Löfblom J
Article: PROTEIN ENGINEERING DESIGN & SELECTION. 2008;21(4):247-255

A novel affinity protein selection system based on staphylococcal cell surface display and flow cytometry.

Kronqvist N; Löfblom J; Jonsson A; Wernérus H; Ståhl S
Article: FEMS MICROBIOLOGY LETTERS. 2008;278(1):128-136

Simplified characterization through site-specific protease-mediated release of affinity proteins selected by staphylococcal display.

Kronqvist N; Löfblom J; Severa D; Ståhl S; Wernérus H
Article: JOURNAL OF APPLIED MICROBIOLOGY. 2007;102(3):736-747

Optimization of electroporation-mediated transformation: Staphylococcus carnosus as model organism.

Löfblom J; Kronqvist N; Uhlén M; Ståhl S; Wernérus H
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Editorial comment: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(5):101913

The dimerization mechanism of the N-terminal domain of spider silk proteins is conserved despite extensive sequence divergence.

Sarr M; Kitoka K; Walsh-White K-A; Kaldmäe M; Metlāns R; Tārs K; Mantese A; Shah D; Landreh M; Rising A; Johansson J; Jaudzems K; Kronqvist N
Review: JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY. 2013;88(1):25-38

Affinity proteins and their generation

Stahl S; Kronqvist N; Jonsson A; Lofblom J
Review: RECENT PATENTS ON BIOTECHNOLOGY. 2010;4(3):171-182

Staphylococcal surface display in combinatorial protein engineering and epitope mapping of antibodies.

Kronqvist N; Malm M; Rockberg J; Hjelm B; Uhlén M; Ståhl S; Löfblom J

Employments

Senior Research Specialist, Department of Medicine, Huddinge, Karolinska Institutet, 2024-
Senior Research Specialist, Department of Biosciences and Nutrition, Karolinska Institutet, 2022-2024

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