Affiliated to research
Ola Olén is a senior consultant at the Department of pediatric gastroenterology and nutrition at Sachs’ children and youth hospital. He is also a senior researcher at the Clinical Epidemiology Division at the Department of Medicine Solna, Karolinska Insitutet.
The aim of my research is to improve healthcare and ultimately quality of life for patients suffering from diseases such as inflammatory bowel disease (IBD) or functional gastrointestinal disorders such as irritable bowel syndrome (IBS).
As a pediatric gastroenterologist, most of my clinical time is devoted to patients with IBD. They are sometimes severely ill and require advanced treatment. I am PI for a large register-based linkage including all IBD patients in Sweden and matched controls. My IBD research is conducted in national and international collaboration and is based on clinical data in national health registers and local biobanks. Important research questions that we explore are for instance: Why do some people get IBD? What is the prognosis for different patient groups with IBD (and especially for patients with childhood onset)? Different treatments for IBD – are they safe? And are they cost effective? I am also a member of the steering committee for the national quality register for IBD care (www.swibreg.se).
Irritable bowel syndrome (IBS) and other types of functional abdominal pain disorders are very common: Approximately 3% of all visits to the general practitioner, 10% of visits to general pediatricians and 25% of visits to a pediatric gastroenterology unit.
It is well known that cognitive behavior therapy is effective for children and adolescents with IBS, but access to trained therapists is very limited. In randomized clinical trials we test if it is possible to treat children and adolescents with IBS or functional abdominal pain via internet (read more on www.ontimagen.nu). I am also trying to understand why so many children suffer from IBS by studying risk factors for disease in birth cohorts (BAMSE, n=4000; ALADDIN, n=500) and national health registers. In these data sources we are studying the effects of genetics, perinatal risk factors, lifestyle, co-morbidity, gut flora and use of antibiotics.
Olén O*, Erichsen R*, Sachs MC, Pedersen L, Halfvarson J, Askling J, Ekbom A, Toft-Sørensen H, Ludvugsson JF. Colorectal cancer in ulcerative colitis: a Scandinavian population-based cohort study. Lancet. 2020
Olén O, Askling J, Sachs MC, Frumento P, Neovius M, Smedby KE, Ekbom A, Malmborg P, Ludvigsson JF. Childhood onset inflammatory bowel disease and risk of cancer: a Swedish nationwide cohort study 1964-2014. BMJ 2017
Olén O, Askling J, Sachs MC, Frumento P, Neovius M, Smedby KE, Ekbom A, Malmborg P, Ludvigsson JF. Increased Mortality of Patients with Childhood-onset Inflammatory Bowel Diseases, Compared With the General Population. Gastroenterology 2018
Everhov ÅH, Halfvarson J, Myrelid P, Sachs MC, Nordenvall C, Söderling J, Ekbom A, Neovius M, Ludvigsson JF, Askling J, Olén O. Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden. Gastroenterology 2018
Khalili H, Granath F, Smedby KE, Ekbom A, Neovius M, Chan AT, Olen O. Association Between Long-term Oral Contraceptive Use and Risk of Crohn's Disease Complications in a Nationwide Study. Gastroenterology. 2016
Shah SC, Khalili H, Gower-Rousseau C, Olen O, Benchimol EI, Lynge E, Nielsen KR, Brassard P, Vutcovici M, Bitton A, Bernstein CN, Leddin D, Tamim H, Stefansson T, Loftus EV Jr, Moum B, Tang W, Ng SC, Gearry R, Sincic B, Bell S, Sands BE, Lakatos PL, Végh Z, Ott C, Kaplan GG, Burisch J, Colombel JF. Sex-based Differences in Incidence of Inflammatory Bowel Diseases-Pooled Analysis of Population-based Studies from Western Countries. Gastroenterology. 2018.
Khalili H, Burke KE, Roelstraete B, Sachs MC, Olén O, Ludvigsson JF. Microscopic Colitis and Risk of Inflammatory Bowel Disease in a Nationwide Cohort Study. Gastroenterology 2020
Olén O, Askling J, Sachs MC, Neovius M, Smedby KE, Ekbom A, Ludvigsson JF. Mortality in adult-onset and elderly-onset IBD: a nationwide register-based cohort study 1964-2014. Gut. 2019
Khalili H, Håkansson N, Chan SS, Chen Y, Lochhead P, Ludvigsson JF, Chan AT, Hart AR, Olén O, Wolk A. Adherence to a Mediterranean diet is associated with a lower risk of later-onset Crohn's disease: results from two large prospective cohort studies. Gut 2020
Ludvigsson JF, Mahl M, Sachs MC, Björk J, Michaelsson K, Ekbom A, Askling J, Backman AS, Olén O. Fracture Risk in Patients With Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study From 1964 to 2014. Am J Gastroenterol. 2019
Khalili H, Neovius M, Ekbom A, Ludvigsson JF, Askling J, Chan AT, Olen O. Oral Contraceptive Use and Risk of Ulcerative Colitis Progression: A Nationwide Study. Am J Gastroenterol. 2016
Bonnert M, Olén O, Lalouni M, Benninga MA, Bottai M, Engelbrektsson J, Hedman E, Lenhard F, Melin B, Simrén M, Vigerland S, Serlachius E, Ljótsson B. Internet-Delivered Cognitive Behavior Therapy for Adolescents With Irritable Bowel Syndrome: A Randomized Controlled Trial. Am J Gastroenterol. 2017
Lalouni M, Ljótsson B, Bonnert M, Ssegonja R, Benninga M, Bjureberg J, Högström J, Sahlin H, Simrén M, Feldman I, Hedman-Lagerlöf E, Serlachius E, Olén O. Clinical and Cost Effectiveness of Online Cognitive Behavioral Therapy in Children with Functional Abdominal Pain Disorders. Clin Gastroenterol Hepatol. 2018
Dr Olén served as the director of studies 2009-2013 for the widely acclaimed Research school in epidemiology for clinicians at the Karolinska Instituet. He is director of a national course in pediatric gastroenterology, hepatology and nutrition, funded by the National Board of Health and Welfare since 2013. Dr Olén is a valued teacher and often engaged as a lecturer regarding inflammatory bowel disease, irritable bowel syndrome, and epidemiology.
Specialist in pediatrics, 2011
PhD, 2008, Karolinska Institutet
Medical degree, 2000, Uppsala University.
2017 – : Senior Consultant, Sachs’ Children’s hospital. Researcher, Karolinska Institutet.
2014 – 2016: Consultant, Sachs’ Children’s hospital. Postdoc, Karolinska Institutet.
2011 – 2013: Specialist in pediatrics, Sachs’ Children’s hospital (0% research)
2002 – 2010: Specialist training, Sachs’ (incl. parental leave and PhD-studies.)
2000 – 2002: Internship, Sunderby Sjukhus
Academic honours, awards and prizes
- Young scholar award 2018, Strategic Research Area Epidemiology (SfoEpi) at Karolinska Institutet
- Clinical researcher award 2017 ("klinisk forskartjänst"), Karolinska Institutet.
- Mag- Tarmfondens stora pris 2016 (”the great prize of the Swedish gastro society”).
- Bengt Ihre research fellowship in gastroenterology 2014-2016 (www.ihrefellowship.se). Awarded by the Swedish medical association to promising future research leaders in gastroenterology. Includes a 2 year grant and networking activities with prominent researchers in gastroenterology during the grant period and afterwards.
- ìShizu Matsumuraîs donation 2013, to prominent pediatric research at KI.