Head of unit
I am a trained biologist, or more accurate animal physiologist from the Agricultural University in Wageningen (NL). I have a PhD in clinical nutrition from the University of Maastricht (NL). After that I did 2 postdoc fellowships; one at the Endocrine Research Unit at the Mayo Clinic in Rochester, Minnesota (USA) and one at the Department of Medicine at the University of Edinburgh (UK). In January 2000 I joined the currenet research group at Karolinska Institutet and located at hthe Department of Anesthesiology and Intensive Care at Karolinska Unversity Hospital in Huddinge. I started here as a assistent professor and head of the analytical lab. Presently I am a professor in experimental anesthesiology and intensive care and together with Professor Jan Wernerman run the ICU metabolism research group (see www.icu.metabolism.se).
The research me and the research group are involved in is to study the metabolic and nutritional problems of critically ill patients. We mainly perform smaller mechanistic physiological studies, but also perfrom smaller intervention studies to elucidate how interventions actually work. The research group is run by me and Pofessor Jan Wernerman and includes clinical researchers (from students up to consultants), basic researchers (from exchange students to associate professors) technical staff and research nurses. Part of metabolism we focus on are:
- Why do critically ill patients waste muscle mass and function so fast?
- Why are gplasma glutamine levels sometime high and sometime low in critically ill patients and how do they handle extra glutamine?
- How much nutritional protein is beneficial for critically ill patients?
- What is causing high lactate levels during sepsis and is this a problem?
- Were does plasma albumin go when we are ill and especially when we are critically ill?
- Should we control glucose levels in the critically ill and peri-operatively?
Details on projects and links to publications can be found on our research group's website.
My teaching activities are mainly at the postgraduate level. I am involved in a local course in researcher and research ethics and my main interest in this course is the researcher ethics; how should be behave us as researchers? Ocassionally I organise a course in Clinical Techniques in the study of Endocrine and Metabolic Disorders; a course that teaches different techniques and approaches to study human subjects and patients.
I am the co-organiser of a International course in Tracer Methodology in Clinical Nutrition and Metabolism. This is an intensive course taking place ones a year in a weekend to teach on the usage of stable isotope labelled metabolites to quantify metabolic fluxes in vivo in humans. For more information look at our website (http://icu-metabolism.se/tracers.html)