Olof Rådmark

About me
Publications
Public outreach and news

About me

Affiliated to Chemistry 2, MBB.

Research

Role of coactosin-like protein (CLP) in leukotriene biosynthesis.

Articles

Article: FASEB JOURNAL. 2021;35(2):e21193

Modulation of microRNA processing by 5-lipoxygenase.

Uebbing S; Kreiß M; Scholl F; Häfner A-K; Sürün D; Garscha U; Werz O; Basavarajappa D; Samuelsson B; Rådmark O; Suess B; Steinhilber D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(15):8573-8583

Dicer up-regulation by inhibition of specific proteolysis in differentiating monocytic cells.

Basavarajappa D; Uebbing S; Kreiss M; Lukic A; Suess B; Steinhilber D; Samuelsson B; Rådmark O
Article: CANCER LETTERS. 2019;444:1-8

Exosomes and cells from lung cancer pleural exudates transform LTC4 to LTD4, promoting cell migration and survival via CysLT1.

Lukic A; Wahlund CJE; Gómez C; Brodin D; Samuelsson B; Wheelock CE; Gabrielsson S; Rådmark O
Article: FASEB JOURNAL. 2017;31(10):4370-4381

GM-CSF- and M-CSF-primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures.

Lukic A; Larssen P; Fauland A; Samuelsson B; Wheelock CE; Gabrielsson S; Radmark O
Article: LEUKEMIA & LYMPHOMA. 2017;58(8):1903-1913

Modulation of leukotriene signaling inhibiting cell growth in chronic myeloid leukemia.

Yektaei-Karin E; Zovko A; Nilsson A; Näsman-Glaser B; Kanter L; Rådmark O; Wallvik J; Ekblom M; Dolinska M; Qian H; Stenke L
Article: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2017;1861(8):2099-2111

Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase.

Mittal M; Hasan M; Balagunaseelan N; Fauland A; Wheelock C; Rådmark O; Haeggström JZ; Rinaldo-Matthis A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2017;127(8):3167-3176

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males.

Pace S; Pergola C; Dehm F; Rossi A; Gerstmeier J; Troisi F; Pein H; Schaible AM; Weinigel C; Rummler S; Northoff H; Laufer S; Maier TJ; Rådmark O; Samuelsson B; Koeberle A; Sautebin L; Werz O
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1186-1194

Pulmonary sarcoidosis is associated with exosomal vitamin D-binding protein and inflammatory molecules.

Martinez-Bravo M-J; Wahlund CJE; Qazi KR; Moulder R; Lukic A; Rådmark O; Lahesmaa R; Grunewald J; Eklund A; Gabrielsson S
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1343-1354.e6

Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways.

Dietz K; de Los Reyes Jiménez M; Gollwitzer ES; Chaker AM; Zissler UM; Rådmark OP; Baarsma HA; Königshoff M; Schmidt-Weber CB; Marsland BJ; Esser-von Bieren J
Article: JOURNAL OF LIPID RESEARCH. 2016;57(9):1659-1669

Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4.

Lukic A; Ji J; Idborg H; Samuelsson B; Palmberg L; Gabrielsson S; Rådmark O
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2016;26(15):3547-3551

Kinetic investigation of human 5-lipoxygenase with arachidonic acid.

Mittal M; Kumar RB; Balagunaseelan N; Hamberg M; Jegerschöld C; Rådmark O; Haeggström JZ; Rinaldo-Matthis A
Article: ONCOTARGET. 2016;7(28):44350-44364

Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer.

Terzuoli E; Donnini S; Finetti F; Nesi G; Villari D; Hanaka H; Radmark O; Giachetti A; Ziche M
Article: FASEB JOURNAL. 2016;30(1):276-285

Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes.

Gerstmeier J; Weinigel C; Rummler S; Rådmark O; Werz O; Garscha U
Article: PLOS ONE. 2016;11(3):e0152116

Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs.

Kumar RB; Zhu L; Idborg H; Rådmark O; Jakobsson P-J; Rinaldo-Matthis A; Hebert H; Jegerschöld C
Article: FASEB JOURNAL. 2015;29(12):5029-5043

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein.

Lehmann C; Homann J; Ball A-K; Blöcher R; Kleinschmidt TK; Basavarajappa D; Angioni C; Ferreirós N; Häfner A-K; Rådmark O; Proschak E; Haeggström JZ; Geisslinger G; Parnham MJ; Steinhilber D; Kahnt AS
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2015;100:33-40

Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes.

Mahshid Y; Markoutsa S; Dincbas-Renqvist V; Sürün D; Christensson B; Sander B; Björkholm M; Sorg BL; Rådmark O; Claesson H-E
Article: ENDOCRINE-RELATED CANCER. 2015;22(4):665-678

mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity.

Finetti F; Terzuoli E; Giachetti A; Santi R; Villari D; Hanaka H; Radmark O; Ziche M; Donnini S
Article: NATURE CELL BIOLOGY. 2014;16(12):1180-1191

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.

Friedmann Angeli JP; Schneider M; Proneth B; Tyurina YY; Tyurin VA; Hammond VJ; Herbach N; Aichler M; Walch A; Eggenhofer E; Basavarajappa D; Rådmark O; Kobayashi S; Seibt T; Beck H; Neff F; Esposito I; Wanke R; Förster H; Yefremova O; Heinrichmeyer M; Bornkamm GW; Geissler EK; Thomas SB; Stockwell BR; O'Donnell VB; Kagan VE; Schick JA; Conrad M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1842(10):1538-1547

Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase.

Schröder M; Häfner A-K; Hofmann B; Rådmark O; Tumulka F; Abele R; Dötsch V; Steinhilber D
Article: PHARMACOLOGICAL RESEARCH. 2014;87:1-7

In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis.

Rossi A; Pergola C; Pace S; Rådmark O; Werz O; Sautebin L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(31):11371-11376

Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis.

Basavarajappa D; Wan M; Lukic A; Steinhilber D; Samuelsson B; Rådmark O
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2014;545:179-185

A mutation interfering with 5-lipoxygenase domain interaction leads to increased enzyme activity.

Rakonjac Ryge M; Tanabe M; Provost P; Persson B; Chen X; Funk CD; Rinaldo-Matthis A; Hofmann B; Steinhilber D; Watanabe T; Samuelsson B; Rådmark O
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;133(7):1578-1588

Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation.

Sha W; Olesch C; Hanaka H; Rådmark O; Weigert A; Brüne B
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(2):293-299

Activated LTB4 pathway in muscle tissue of patients with polymyositis or dermatomyositis.

Loell I; Alemo Munters L; Pandya J; Zong M; Alexanderson H; Fasth AE; Ståhl Hallengren C; Rådmark O; Lundberg IE; Jakobsson P-J; Korotkova M
Article: ONCOGENE. 2012;31(29):3457-3466

EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity.

Donnini S; Finetti F; Terzuoli E; Giachetti A; Iñiguez MA; Hanaka H; Fresno M; Rådmark O; Ziche M
Article: ALLERGY. 2012;67(7):911-919

Bronchoalveolar lavage fluid exosomes contribute to cytokine and leukotriene production in allergic asthma.

Torregrosa Paredes P; Esser J; Admyre C; Nord M; Rahman QK; Lukic A; Rådmark O; Grönneberg R; Grunewald J; Eklund A; Scheynius A; Gabrielsson S
Article: FASEB JOURNAL. 2011;25(10):3377-3387

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes.

Pergola C; Rogge A; Dodt G; Northoff H; Weinigel C; Barz D; Rådmark O; Sautebin L; Werz O
Article: FASEB JOURNAL. 2011;25(4):1417-1427

Zymosan suppresses leukotriene C₄ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors.

Esser J; Gehrmann U; Salvado MD; Wetterholm A; Haeggström JZ; Samuelsson B; Gabrielsson S; Scheynius A; Rådmark O
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;126(5):1032-1040.e4

Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration.

Esser J; Gehrmann U; D'Alexandri FL; Hidalgo-Estévez AM; Wheelock CE; Scheynius A; Gabrielsson S; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(36):15774-15779

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.

Conrad M; Sandin A; Förster H; Seiler A; Frijhoff J; Dagnell M; Bornkamm GW; Rådmark O; Hooft van Huijsduijnen R; Aspenström P; Böhmer F; Ostman A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):105-110

Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis.

Rådmark O; Samuelsson B
Article: JOURNAL OF MOLECULAR BIOLOGY. 2010;395(4):884-896

Calcitriol upregulates open chromatin and elongation markers at functional vitamin D response elements in the distal part of the 5-lipoxygenase gene.

Stoffers KL; Sorg BL; Seuter S; Rau O; Rådmark O; Steinhilber D
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1801(1):49-57

Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity.

Katryniok C; Schnur N; Gillis A; von Knethen A; Sorg BL; Looijenga L; Rådmark O; Steinhilber D
Article: BIOCHEMICAL JOURNAL. 2009;425(1):265-274

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.

Esser J; Rakonjac M; Hofmann B; Fischer L; Provost P; Schneider G; Steinhilber D; Samuelsson B; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(44):18757-18762

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.

Hanaka H; Pawelzik S-C; Johnsen JI; Rakonjac M; Terawaki K; Rasmuson A; Sveinbjörnsson B; Schumacher MC; Hamberg M; Samuelsson B; Jakobsson P-J; Kogner P; Rådmark O
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2009;66(16):2759-2771

Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.

Feisst C; Pergola C; Rakonjac M; Rossi A; Koeberle A; Dodt G; Hoffmann M; Hoernig C; Fischer L; Steinhilber D; Franke L; Schneider G; Rådmark O; Sautebin L; Werz O
Article: JOURNAL OF LIPID RESEARCH. 2009;50 Suppl(Suppl):S40-S45

5-Lipoxygenase: mechanisms of regulation.

Rådmark O; Samuelsson B
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1789(2):99-108

Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.

Dincbas-Renqvist V; Pépin G; Rakonjac M; Plante I; Ouellet DL; Hermansson A; Goulet I; Doucet J; Samuelsson B; Rådmark O; Provost P
Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(3):R83

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.

Gheorghe KR; Korotkova M; Catrina AI; Backman L; af Klint E; Claesson H-E; Rådmark O; Jakobsson P-J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(50):19881-19886

ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma.

Pergola C; Dodt G; Rossi A; Neunhoeffer E; Lawrenz B; Northoff H; Samuelsson B; Rådmark O; Sautebin L; Werz O
Article: CELL METABOLISM. 2008;8(3):237-248

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.

Seiler A; Schneider M; Förster H; Roth S; Wirth EK; Culmsee C; Plesnila N; Kremmer E; Rådmark O; Wurst W; Bornkamm GW; Schweizer U; Conrad M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1771(10):1271-1282

The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes.

Schnur N; Seuter S; Katryniok C; Rådmark O; Steinhilber D
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1771(7):864-872

Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene.

Seuter S; Väisänen S; Rådmark O; Carlberg C; Steinhilber D
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2007;83(3):162-174

5-lipoxygenase: regulation and possible involvement in atherosclerosis.

Rådmark O; Samuelsson B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(35):13150-13155

Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production.

Rakonjac M; Fischer L; Provost P; Werz O; Steinhilber D; Samuelsson B; Rådmark O
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2006;1761(7):686-697

Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site.

Sorg BL; Klan N; Seuter S; Dishart D; Rådmark O; Habenicht A; Carlberg C; Werz O; Steinhilber D
Article: CELL CALCIUM. 2006;39(6):529-537

Arachidonic acid is a physiological activator of the ryanodine receptor in pancreatic beta-cells.

Woolcott OO; Gustafsson AJ; Dzabic M; Pierro C; Tedeschi P; Sandgren J; Bari MR; Nguyen KH; Bianchi M; Rakonjac M; Rådmark O; Ostenson C-G; Islam MS
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1738(1-3):37-47

GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site.

Dishart D; Schnur N; Klan N; Werz O; Steinhilber D; Samuelsson B; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(37):13164-13169

Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells.

Werz O; Tretiakova I; Michel A; Ulke-Lemee A; Hörnig M; Franke L; Schneider G; Samuelsson B; Rådmark O; Steinhilber D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):26913-26921

1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the N-terminal C2-like domain.

Hörnig C; Albert D; Fischer L; Hörnig M; Rådmark O; Steinhilber D; Werz O
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1749(1):123-131

Mutation analysis of the human 5-lipoxygenase C-terminus: support for a stabilizing C-terminal loop.

Okamoto H; Hammarberg T; Zhang Y-Y; Persson B; Watanabe T; Samuelsson B; Rådmark O
Article: PROTEIN AND PEPTIDE LETTERS. 2005;12(3):295-297

C-terminus of p47(phox) is required for interaction with leukocyte type rat 12-lipoxygenase.

Tanabe M; Kamitani H; Watanabe T; Rådmark O
Article: LIPIDS. 2005;40(3):249-257

Novel oxylipins formed from docosahexaenoic acid by potato lipoxygenase--10(S)-hydroxydocosahexaenoic acid and 10,20-dihydroxydocosahexaenoic acid.

Butovich IA; Hamberg M; Rådmark O
Article: MITOCHONDRIAL DNA. 2005;16(1):65-68

Cloning of rat p47phox and comparison with human p47phox.

Tanabe M; Rådmark O; Watanabe T; Shiose A; Sumimoto H
Article: JOURNAL OF BIOMOLECULAR NMR. 2004;30(3):353-356

NMR structure of human coactosin-like protein.

Liepinsh E; Rakonjac M; Boissonneault V; Provost P; Samuelsson B; Rådmark O; Otting G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(44):42846-42853

The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1.

Bürkert E; Arnold C; Hammarberg T; Rådmark O; Steinhilber D; Werz O
Article: NATURE. 2003;425(6956):415-419

The nuclear RNase III Drosha initiates microRNA processing.

Lee Y; Ahn C; Han J; Choi H; Kim J; Yim J; Lee J; Provost P; Rådmark O; Kim S; Kim VN
Article: FASEB JOURNAL. 2003;17(8):949-951

Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors.

Fischer L; Szellas D; Rådmark O; Steinhilber D; Werz O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(3):1238-1243

Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis.

Spanbroek R; Grabner R; Lotzer K; Hildner M; Urbach A; Ruhling K; Moos MPW; Kaiser B; Cohnert TU; Wahlers T; Zieske A; Plenz G; Robenek H; Salbach P; Kuhn H; Radmark O; Samuelsson B; Habenicht AJR
Article: PROTEIN JOURNAL. 2003;22(2):177-181

Thr94 in bovine myelin basic protein is a second phosphorylation site for 42-kDa mitogen-activated protein kinase (ERK2).

Hirschberg D; Rådmark O; Jörnvall H; Bergman T
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2003;73(1):191-200

Cell type-dependent activation of 5-lipoxygenase by arachidonic acid.

Bürkert E; Szellas D; Rådmark O; Steinhilber D; Werz O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(26):16648-16653

Dicer is required for chromosome segregation and gene silencing in fission yeast cells.

Provost P; Silverstein RA; Dishart D; Walfridsson J; Djupedal I; Kniola B; Wright A; Samuelsson B; Radmark O; Ekwall K
Article: EMBO JOURNAL. 2002;21(21):5864-5874

Ribonuclease activity and RNA binding of recombinant human Dicer.

Provost P; Dishart D; Doucet J; Frendewey D; Samuelsson B; Rådmark O
Article: FASEB JOURNAL. 2002;16(11):1441-1443

Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes.

Werz O; Bürkert E; Fischer L; Szellas D; Dishart D; Samuelsson B; Rådmark O; Steinhilber D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;295(4):985-991

Monocyte-derived soluble protein confers 5-lipoxygenase activity Ca2+-dependent.

Bürkert E; Rådmark O; Steinhilber D; Werz O
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(17):14793-14800

Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

Werz O; Szellas D; Steinhilber D; Rådmark O
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2002;71(3):477-486

Hypertonicity suppresses ionophore-induced product formation and translocation of 5-lipoxygenase in human leukocytes.

Bürkert E; Rådmark O; Samuelsson B; Steinhilber D; Werz O
Article: BLOOD. 2002;99(3):1044-1052

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes.

Werz O; Bürkert E; Samuelsson B; Rådmark O; Steinhilber D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;290(2):783-789

Molecular cloning and functional characterization of mouse coactosin-like protein.

Doucet J; Provost P; Samuelsson B; Rådmark O
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2001;70(5):830-838

p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line.

Werz O; Klemm J; Rådmark O; Samuelsson B
Article: BIOCHEMICAL JOURNAL. 2001;359(Pt 2):255-263

Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75.

Provost P; Doucet J; Stock A; Gerisch G; Samuelsson B; Rådmark O
Article: BIOCHEMISTRY. 2001;40(21):6371-6378

EPR investigation of the active site of recombinant human 5-lipoxygenase: inhibition by selenide.

Hammarberg T; Kuprin S; Rådmark O; Holmgren A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(19):16520-16527

5-Lipoxygenase interacts with coactosin-like protein.

Provost P; Doucet J; Hammarberg T; Gerisch G; Samuelsson B; Radmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(9):5152-5157

IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression.

Spanbroek R; Hildner M; Köhler A; Müller A; Zintl F; Kühn H; Rådmark O; Samuelsson B; Habenicht AJ
Article: BLOOD. 2001;97(8):2487-2495

Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes.

Werz O; Klemm J; Samuelsson B; Rådmark O
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(49):38787-38793

The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity.

Hammarberg T; Provost P; Persson B; Rådmark O
Article: BLOOD. 2000;96(12):3857-3865

5-lipoxygenase expression in dendritic cells generated from CD34(+) hematopoietic progenitors and in lymphoid organs.

Spanbroek R; Hildner M; Steinhilber D; Fusenig N; Yoneda K; Rådmark O; Samuelsson B; Habenicht AJ
Article: BIOCHEMICAL JOURNAL. 2000;351 Pt 3(Pt 3):697-707

Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labelling: binding characteristics and amino acid sequences.

Zhang YY; Hammarberg T; Radmark O; Samuelsson B; Ng CF; Funk CD; Loscalzo J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(10):5261-5266

5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases.

Werz O; Klemm J; Samuelsson B; Rådmark O
Article: BIOCHEMISTRY. 2000;39(7):1840-1848

Mg2+ activates 5-lipoxygenase in vitro: dependency on concentrations of phosphatidylcholine and arachidonic acid.

Reddy KV; Hammarberg T; Rådmark O
Article: BIOCHEMISTRY. 1999;38(14):4441-4447

5-lipoxygenase binds calcium.

Hammarberg T; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(5):1881-1885

Interaction of 5-lipoxygenase with cellular proteins.

Provost P; Samuelsson B; Rådmark O
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 1998;19(2):316-323

Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants.

Silverman ES; Du J; De Sanctis GT; Rådmark O; Samuelsson B; Drazen JM; Collins T
Article: FEBS JOURNAL. 1998;254(2):275-281

Calcitriol and transforming growth factor-beta upregulate 5-lipoxygenase mRNA expression by increasing gene transcription and mRNA maturation.

Härle D; Rådmark O; Samuelsson B; Steinhilber D
Article: BIOCHEMICAL PHARMACOLOGY. 1998;55(6):863-871

Effects of 1-chloro-2,4,6-trinitrobenzene on 5-lipoxygenase activity and cellular leukotriene synthesis.

Larsson PK; Hammarberg T; Johnsson T; Lindgren JA; Rådmark O; Claesson HE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(2):663-668

5-Lipoxygenase expression in Langerhans cells of normal human epidermis.

Spanbroek R; Stark HJ; Janssen-Timmen U; Kraft S; Hildner M; Andl T; Bosch FX; Fusenig NE; Bieber T; Rådmark O; Samuelsson B; Habenicht AJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(15):6966-6970

Expression of 5-lipoxygenase in differentiating human skin keratinocytes.

Janssen-Timmen U; Vickers PJ; Wittig U; Lehmann WD; Stark HJ; Fusenig NE; Rosenbach T; Rådmark O; Samuelsson B; Habenicht AJ
Article: FEBS JOURNAL. 1995;230(2):401-407

Mutations at the C-terminal isoleucine and other potential iron ligands of 5-lipoxygenase.

Hammarberg T; Zhang YY; Lind B; Radmark O; Samuelsson B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(1):107-111

Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor beta and 1,25-dihydroxyvitamin D3.

Brungs M; Rådmark O; Samuelsson B; Steinhilber D
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Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1851(4):331-339

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease.

Rådmark O; Werz O; Steinhilber D; Samuelsson B
Published paper: JOURNAL OF INTERNAL MEDICINE. 2010;268(1):5-14

Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer.

Rådmark O; Samuelsson B
Review: TRENDS IN BIOCHEMICAL SCIENCES. 2007;32(7):332-341

5-Lipoxygenase: regulation of expression and enzyme activity.

Rådmark O; Werz O; Steinhilber D; Samuelsson B
Review: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;338(1):102-110

Regulation of 5-lipoxygenase enzyme activity.

Rådmark O; Samuelsson B
Editorial comment: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2003;23(7):1140-1142

5-lipoxygenase-derived leukotrienes: mediators also of atherosclerotic inflammation.

Rådmark O
Review: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2002;68-69:211-234

Arachidonate 5-lipoxygenase.

Rådmark O
Published paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2002;507:117-121

Calcium binding to 5-lipoxygenase.

Hammarberg T; Reddy KV; Persson B; Rådmark O
Published paper: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2000;161(2 Pt 2):S11-S15

The molecular biology and regulation of 5-lipoxygenase.

Rådmark OP
Published paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1999;469:105-111

Transcriptional and posttranscriptional regulation of 5-lipoxygenase mRNA expression in the human monocytic cell line Mono Mac 6 by transforming growth factor-beta and 1,25-dihydroxyvitamin D3.

Härle D; Rådmark O; Samuelsson B; Steinhilber D
Published paper: JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING. 1995;12(2-3):171-184

Arachidonate 5-lipoxygenase.

Rådmark O
Published paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:449-451

Transforming growth factor-beta and 1,25-dihydroxyvitamin D3 induce 5-lipoxygenase activity during myeloid cell maturation.

Steinhilber D; Brungs M; Rådmark O; Samuelsson B
Published paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:329-331

5-lipoxygenase expression in cultured human keratinocytes.

Janssen-Timmen U; Vickers P; Beilecke U; Lehmann WD; Stark HJ; Fusenig NE; Rosenbach T; Goerig M; Rådmark O; Samuelsson B
Published paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:1-9

5-lipoxygenase: structure and stability of recombinant enzyme, regulation in Mono Mac 6 cells.

Rådmark O; Zhang YY; Hammarberg T; Lind B; Hamberg M; Brungs M; Steinhilber D; Samuelsson B

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