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otto stackelberg

Otto Stackelberg

Affiliated to research

About me

Resident Vascular Surgeon with an interest for epidemiology and biostatistics. Withheld a PhD for my project investigating the potential impact of modifiable lifestyle related factors on risk of developing abdominal aortic aneurysm (AAA). Affiliated to the Unit of Cardiovascular and Nutritional Epidemiology (Institute of Environmental Medicine, Karolinska Institutet), and the Unit for Vascular Surgery at Stockholm South General Hospital (SOSVASC). Engaged in several studies on epidemiological aspects of abdominal aortic aneurysm, and evaluation of endovascular treatments of AAA.

Research description

Lifestyle and risk of abdominal aortic aneurysm

My PhD-Project aimed to investigate how modifiable lifestyle related factors, such as adiposity, diet and physical activity, may affect the risk of developing an abdominal aortic aneurysm. To prospectively assess this risk, I utilize two large cohorts of middle-aged and elderly men and women from Sweden: the Swedish Mammography Cohort (SMC) and the Cohort of Swedish Men (COSM).

Abdominal aortic aneurysm is a pathological dilatation of the abdominal aorta and associated with high mortality if this dilatation keeps growing to eventually rupture. Since the development of the disease is usually asymptomatic and the best way to detect it is by ultrasound screening, it is important to identify people at risk of the disease, making surgery to prevent rupture possible. The findings of lifestyle related factors affecting the risk of disease may also act as future recommendations for patients with detected abdominal aortic aneurysm. Smoking is heavily associated with the disease but other lifestyle related exposures that possibly could affect inflammation and oxidative stress in the aortic wall, are scarcely investigated. We observed an inverse assocation between higher intake of fruits, moderate intake of beer and wine, and higher levels of physical activity, and risk of the disease. We also observed a higher risk of the disease amongst those with larger waist circumference.

After my dissertation, we have continued to investigate other modifiable factors associated with the disease, e.g. different types of physical activity, hormone replacement therapy, and anti-inflammatory dietary index.

http://ki.se/en/imm/unit-of-nutritional-epidemiology

Thesis for doctoral degree (Ph.D.): Lifestyle and Risk of Abdominal Aortic Aneurysm

 

Endovascular treatment of aortic disease

Abdominal aortic aneurysm can be treated with different endovascular methods. These methods became popular in the 1990's and, with technical innovation, we are now able to treat more and more complex aneurysms in the thoracic and abdominal aorta. Follow-up of new methods are important in order to secure the safety of our patients. Amongst other, we have evaulated how different types of endovascular treatments do in comparison with others, and how treatment of complex endovascular aortic disease in Sweden compares internationally. To do these studies, we collaborate with other vascular surgical centers in Sweden, such as Karolinska University Hospital and Uppsala University Hospital.

http://ki.se/kisos/sosvasc

Education

Doctoral Programme in Medical Science (June 2012 – May 2016)

Unit of Nutritional Epidemiology, IMM, Karolinska Institutet, Stockholm

 

Medical Doctors Programme (Aug 2006 – Jan 2012)

Karolinska Institutet, Stockholm, Sweden

Academic honours, awards and prizes

3rd prize oral presentation at the annual conference for the European Society of Vascular Surgery (ESVS) 2018

Best poster abstract award at the Munich Vascular Conference 2015

Winner of the Swedvasc prize for best article in vascular surgery research 2015

Winner of the best oral presentation of vascular surgical research at the annual national conference for Swedish surgeons 2013

Winner of the IMM poster awards 2013

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