Research description

My research is focused on understanding where different genetic and non-genetic risk factors and drivers of the disease converge to trigger the formation of tau neurofibrillary tangles and early neuronal degeneration in Alzheimer's disease. To achieve this goal I apply a wide variety of cell-specific transcriptomics and proteomics approaches in human post-mortem brain samples and mouse models with relevance for Alzheimer's disease.

Most relevant publications

Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis. Roussarie JP, Yao V, Rodriguez-Rodriguez P, Oughtred R, Rust J, Plautz Z, Kasturia S, Albornoz C, Wang W, Schmidt EF, Dannenfelser R, Tadych A, Brichta L, Barnea-Cramer A, Heintz N, Hof PR, Heiman M, Dolinski K, Flajolet M, Troyanskaya OG, Greengard P Neuron 2020 09;107(5):821-835.e12

Deciphering cell-type specific signal transduction in the brain: Challenges and promises. Roussarie JP, Rodriguez-Rodriguez P Adv Pharmacol 2021 ;90():145-171

Sex difference in flux of 27-hydroxycholesterol into the brain. Parrado-Fernandez C, Leoni V, Saeed A, Rodriguez-Rodriguez P, Sandebring-Matton A, Córdoba-Beldad CM, Bueno P, Gali CC, Panzenboeck U, Cedazo-Minguez A, Björkhem I Br J Pharmacol 2021 08;178(16):3194-3204

27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons. Merino-Serrais P, Loera-Valencia R, Rodriguez-Rodriguez P, Parrado-Fernandez C, Ismail MA, Maioli S, Matute E, Jimenez-Mateos EM, Björkhem I, DeFelipe J, Cedazo-Minguez A Cereb Cortex 2019 01;29(1):429-446

Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons. Rodriguez-Rodriguez P, Sandebring-Matton A, Merino-Serrais P, Parrado-Fernandez C, Rabano A, Winblad B, Ávila J, Ferrer I, Cedazo-Minguez A Brain 2017 Dec;140(12):3269-3285

Aggregation of the Inflammatory S100A8 Precedes Aβ Plaque Formation in Transgenic APP Mice: Positive Feedback for S100A8 and Aβ Productions. Lodeiro M, Puerta E, Ismail MA, Rodriguez-Rodriguez P, Rönnbäck A, Codita A, Parrado-Fernandez C, Maioli S, Gil-Bea F, Merino-Serrais P, Cedazo-Minguez A J Gerontol A Biol Sci Med Sci 2017 03;72(3):319-328

Underestimation of the pentose-phosphate pathway in intact primary neurons as revealed by metabolic flux analysis. Rodriguez-Rodriguez P, Fernandez E, Bolaños JP J Cereb Blood Flow Metab 2013 Dec;33(12):1843-5

Brain energy metabolism in glutamate-receptor activation and excitotoxicity: role for APC/C-Cdh1 in the balance glycolysis/pentose phosphate pathway. Rodriguez-Rodriguez P, Almeida A, Bolaños JP Neurochem Int 2013 Apr;62(5):750-6

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration. Rodriguez-Rodriguez P, Fernandez E, Almeida A, Bolaños JP Cell Death Differ 2012 Oct;19(10):1582-9