About me

I am a researcher at the Institute of Environmental Medicine at Karolinska Institutet with a background in genetics, cancer and toxicology. In recent years, my main focus has turned towards development of Adverse Outcome Pathways (AOPs) and New Approach Methodologies (NAMs), as well as their application in risk assessment and in safe and sustainable development of new technologies. Coupled to this focus, I also have a broad interest making data FAIR (Findable, Accessible, Interoperable and Reusable). In addition to research, I currently function as coordinator within the Swedish platform for Nanosafety, SweNanoSafe.

Ongoing projects and involvements:

Toward risk assessment without animals: Development of Adverse Outcome Pathways for lung cancer

Application of the Adverse Outcome Pathway concept and bioinformatics for mechanistic understanding of COVID-19

Gov4Nano - Implementation of Risk Governance: meeting the needs of nanotechnology

HARMLESS - Advanced high aspect ratio multicomponent materials: towards comprehensive intelligent testing and safe by design strategies

Selected previous projects and involvements:

eNanoMapper - A Database and Ontology Framework for Nanomaterials Design and Safety Assessment

NANoREG - A common European approach to the regulatory testing of nanomaterials

NANOSOLUTIONS - Biological Foundation for the Safety Classification of Engineered Nanomaterials (ENM): Systems Biology Approaches to Understand Interactions of ENM with Living Organisms and the Environment

NanoReg2 - Development and implementation of Grouping and Safe-by-Design approaches within regulatory frameworks

caLIBRAte - Performance testing, calibration and implementation of a next generation system-of-systems Risk Governance Framework for nanomaterials

PATROLS – Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment

NanoSolveIT – Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology

miRNAno - Toxicogenomic studies on engineered carbon nanomaterials

Research description

Selected publications:

Jeliazkova N, Apostolova MD, Andreoli C, Barone F, Barrick A, Battistelli C, Bossa C, Botea-Petcu A, Châtel A, De Angelis I, Dusinska M, El Yamani N, Gheorghe D, Giusti A, Gómez-Fernández P, Grafström R, Gromelski M, Jacobsen NR, Jeliazkov V, Jensen KA, Kochev N, Kohonen P, Manier N, Mariussen E, Mech A, Navas JM, Paskaleva V, Precupas A, Puzyn T, Rasmussen K, Ritchie P, Llopis IR, Rundén-Pran E, Sandu R, Shandilya N, Tanasescu S, Haase A, Nymark P. Towards FAIR nanosafety data. Nat Nanotechnol. 2021 May 20. doi: 10.1038/s41565-021-00911-6.

Nymark P, Karlsson HL, Halappanavar S, Vogel U. Adverse Outcome Pathway development for assessment of lung carcinogenicity by nanoparticles. Frontiers in Toxicology, 29 April 2021. doi: 10.3389/ftox.2021.653386

Nymark P, Sachana M, Batista-Leite S, Sund J, Krebs C.E., Sullivan K, Edwards S, Viviani L, Willett K, Landesmann B, Wittwehr C. Systematic Organization of COVID-19 Data Supported by the Adverse Outcome Pathway Framework. Frontiers in Public Health, 19 May 2021, doi: 10.3389/fpubh.2021.638605

Halappanavar S, van den Brule S, Nymark P, Gaté L, Seidel C, Valentino S, Zhernovkov V, Høgh Danielsen P, De Vizcaya A, Wolff H, Stöger T, Boyadziev A, Poulsen SS, Sørli JB, Vogel U. Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale.  Part Fibre Toxicol. 2020 May 25;17(1):16. doi: 10.1186/s12989-020-00344-4.

Nymark P, Bakker M, Dekkers S, Franken R, Fransman W, García-Bilbao A, Greco D, Gulumian M, Hadrup N, Halappanavar S, Hongisto V, Hougaard KS, Jensen KA, Kohonen P, Koivisto AJ, Dal Maso M, Oosterwijk T, Poikkimäki M, Rodriguez-Llopis I, Stierum R, Sørli JB, Grafström R. Toward Rigorous Materials Production: New Approach Methodologies Have Extensive Potential to Improve Current Safety Assessment Practices. Small. 2020 Feb;16(6):e1904749. doi: 10.1002/smll.201904749. Epub 2020 Jan 8.

Soeteman-Hernandez LG, Apostolova MD, Bekker C, Dekkers S, Grafström RC, Groenewold M, Handzhiyski Y, Herbeck-Engel P, Hoehener K, Karagkiozaki V, Kelly S, Kraegeloh A, Logothetidis S, Micheletti C, Nymark P, Oomen A, Oosterwijk T, Rodríguez-LLopis I, Sabella S, Sanchez Jiménez A, Sips A, Suarez-Merino B, Tavernaro I, van Engelen J, Wijnhoven SWP, Noorlander CW. Safe innovation approach: Towards an agile system for dealing with innovations. Materials Today Communications, Volume 20, 2019, 100548, ISSN 2352-4928, doi: 10.1016/j.mtcomm.2019

Giusti A, Atluri R, Tsekovska R, Gajewicz A, Apostolova MD, Battistelli CL, Bleeker EAJ, Bossa C, Bouillard j, Dusinska M, Gómez-Fernández P, Grafström R, Gromelski M, Handzhiyski Y, Jacobsen NR, Jantunen P, Jensen KA, Mech A, Navas JM, Nymark P, Oomen AG, Puzyn T, Rasmussen K, Riebeling C, Rodriguez-Llopis I, Sabella S, Riego Sintes J, Suarez-Merino B, Tanasescu S, Wallin H, Haase A. Nanomaterial grouping: Existing approaches and future recommendations. NanoImpact, Volume 16, 2019, 100182, ISSN 2452-0748, doi: 10.1016/j.impact.2019.100182

Nymark P, Kohonen P, Hongisto V, Grafström RC. Toxic and Genomic Influences of Inhaled Nanomaterials as a Basis for Predicting Adverse Outcome. Ann Am Thorac Soc. 2018 Apr;15(Suppl 2):S91-S97. doi: 10.1513/AnnalsATS.201706-478MG.

Nymark P, Rieswijk L, Ehrhart F, Jeliazkova N, Tsiliki G, Sarimveis H, Evelo CT, Hongisto V, Kohonen P, Willighagen E, Grafström RC. A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions. Toxicol Sci. 2018 Mar 1;162(1):264-275. doi: 10.1093/toxsci/kfx252.

Nymark P, Wijshoff P, Cavill R, van Herwijnen M, Coonen ML, Claessen S, Catalán J, Norppa H, Kleinjans JC, Briedé JJ. Extensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carbon nanotubes in human lung cells. Nanotoxicology, 2015. 9(5): p. 624-635. doi: 10.3109/17435390.2015.1017022

Nymark P, Guled M, Borze I, Faisal A, Lahti L, Salmenkivi K, Kettunen E, Anttila S, Knuutila S. Integrative Analysis of microRNA, mRNA and aCGH Data Reveals Asbestos-Related Changes in Non-Small Cell Lung Cancer. Genes, Chromosom. Cancer, 2011. 50(8):585-97. doi: 10.1002/gcc.20880

Nymark P, Wikman H, Hienonen-Kempas T, Anttila S. Molecular and genetic changes in asbestos-related lung cancer. Cancer Lett. 2008. 265(1):1-15. Doi: 10.1016/j.canlet.2008.02.043

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