About me
Per Uhlén is Professor of Cell Signaling in the Unit of Molecular Neurobiology at the Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet
Research description
Research Insterests
Per Uhlén’s research group is studying developmental and cancer related processes in various types of cells. The biological platforms that we are applying are tissue slices, primary cell cultures, cell lines and stem cells. To study the processes of cell division, cell differentiation, and neural migration/networking we are applying state-of-the-art imaging techniques and modern genetic tools, such as transgenic animals. Our focus is to shed light on the intracellular cell signaling mechanisms that regulate these vital processes for development and disease. We are particularly interested in calcium signaling and how cells are modulating and decoding the frequency/amplitude of intracellular calcium oscillations.
Selected Publications
Uhlén P†, Laestadius ņ, Jahnukainen T, Söderblom T, Bäckhed F, Celsi G, Brismar H, Normark S, Aperia A, Richter-Dahlfors A ”a-haemolysin of Uropathogenic E.coli Induces Ca2+ Oscillations in Renal Epithelial Cells” Nature 405, 6787, 694-697 (2000)
Uhlén P‡ “Spectral Analysis of Calcium Oscillations” Science STKE Nov 09;(258):pl15 (2004)
Uhlén P‡, Burch P, Ivins Zito C, Estrada M, Ehrlich BE, Bennett AM “Gain-of-Function/Noonan Syndrome SHP-2/Ptpn11 Mutants Enhance Calcium Oscillations and Impair NFAT Signaling” Proc Natl Acad Sci USA Feb 14;103(7):2160-5 (2006)
Desfrere L†, Karlsson M†, Hiyoshi H†, Malmersjö S, Nanou E, Estrada M, Miyakawa A, Lagercrantz H, El Manira A, Lal M, Uhlén P‡ “Na,K-ATPase Signal Transduction Triggers CREB Activation and Dendritic Growth” Proc Natl Acad Sci USA Feb 17;106(7):2212-7 (2009)
Hiyoshi H, Abdelhady S, Segerström L, Sveinbjörnsson B, Nuriya M, Lundberg TK, Desfrere L, Miyakawa A, Yasui M, Kogner P, Johnsen JI, Andäng M‡, Uhlén P‡ “Quiescence and gH2AX in Neuroblastoma are Regulated by Ouabain/Na,K-ATPase” Br J Cancer May 22;106(11):1807-15 (2012)
Malmersjö S†, Rebellato P†, Smedler E†, Planert H, Kanatani S, Liste I, Nanou E, Sunner H, Abdelhady S, Zhang S, Andäng M, El Manira A, Silberberg G, Arenas E, Uhlén P‡ “Neural Progenitors Organize in Small-World Networks to Promote Cell Proliferation” Proc Natl Acad Sci USA Apr 16;110(16):E1524-E1532 (2013)
Mojallal M, Zheng Y, Hultin S, Audebert S, van Harn T, Johnson P, Lenander C, Fritz N, Mieth C, Corcoran M, Hallström M, Hartman J, Mazure N, Weide T, Grandér D, Borg J-P, Uhlén P, Holmgren L “AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion” Nature Communication Aug 1;5:4557 (2014)