About me
My educational background is Clinical Medicine/General Surgery and I worked as a hepatobiliary surgeon in my country. I was registered as a PhD student at Professor Torkel B. Brismar Group in June 2018 and defended in May 2022. I stay at the same group and work as a postdoctoral researcher.
Research fields: liver growth/liver function; hepatocellular carcinoma; radiomics & machine learning; gadoxetic acid-enhanced MRI; fibrosis/cirrhosis.
Research description
My PhD study is centered around how to accurately evaluate the liver function, especially the future liver remnant part, in patients with hepatocellular carcinoma before liver resection. We aim to establish non-invasive, accurate and reliable imaging biomarkers to evaluate (regional) liver function quantitatively based on preoperative gadoxetic acid enhanced MRI. With an ever-growing progress of artificial intelligence in the medical field, my current research is also making an attempt to apply machine learning approach (such as radiomics) to evaluate liver function, for instance to predict post-hepatectomy liver failure. We expect our research findings can supply a comprehensive estimation of the liver function for patients before liver resection, increase the number of patients as candidates for liver resection and assist to provide a safer and successful operation.
Publications
Hu X, Wang Q#, Huang G, He X, Sparrelid E, Brismar TB, Fan Y. Gadoxetic Acid-Enhanced MRI-Based Radiomics Signature: A Potential Imaging Biomarker for Identifying Cytokeratin 19-Positive Hepatocellular Carcinoma. Computational and Mathematical Methods in Medicine. 2023 Feb 9;2023:5424204. doi: 10.1155/2023/5424204.
Hu X, Li C, Wang Q, Wu X, Chen Z, Xia F, Cai P, Zhang L, Fan Y, Ma K. Development and External Validation of a Radiomics Model Derived from Preoperative Gadoxetic Acid-Enhanced MRI for Predicting Histopathologic Grade of Hepatocellular Carcinoma. Diagnostics (Basel). 2023 Jan 23;13(3):413. doi: 10.3390/diagnostics13030413.
Wang Q#*, Xu J, Wang A, Chen Y, Wang T, Chen D, Zhang J, Brismar TB. Systematic review of machine learning-based radiomics approach for predicting microsatellite instability status in colorectal cancer. La Radiologia Medica. 2023 Jan 17. doi: 10.1007/s11547-023-01593-x.
Wang Q#, Wang A, Li Z, Sparrelid E, Brismar TB. Impact of sarcopenia on the future liver remnant growth after portal vein embolization and associating liver partition and portal vein ligation for staged hepatectomy in patients with liver cancer: A systematic review. Frontiers in Oncology. 2022 Nov 24;12:1064785. doi: 10.3389/fonc.2022.1064785.
Wang Q*, Brismar TB, Gilg S, Jonas E, Nilsson H, Tzortzakakis A, Isaksson B, Axelsson R, Sparrelid E. Multimodal perioperative assessment of liver function and volume in patients undergoing hepatectomy for colorectal liver metastasis: a comparison of the indocyanine green retention test, 99mTc mebrofenin hepatobiliary scintigraphy and gadoxetic acid enhanced MRI. British Journal of Radiology. 2022 Sep 16:20220370. doi: 10.1259/bjr.20220370.
Qu C, Wang Q*, Li C, Xie Q, Cai P, Yan X, Sparrelid E, Zhang L, Ma K, Brismar TB. A Radiomics Model Based on Gd-EOB-DTPA-Enhanced MRI for the Prediction of Microvascular Invasion in Solitary Hepatocellular Carcinoma ≤ 5 cm. Frontiers in Oncology. 2022 May 19;12:831795. doi: 10.3389/fonc.2022.831795.
Wang Q*, Kesen S, Liljeroth M, Nilsson H, Zhao Y, Sparrelid E, Brismar TB. Quantitative evaluation of liver function with gadoxetic acid enhanced MRI: Comparison among signal intensity-, T1-relaxometry-, and dynamic-hepatocyte-specific-contrast-enhanced MRI- derived parameters. Scandinavian Journal of Gastroenterology. 2022 Feb 2:1-8. doi: 10.1080/00365521.2022.2032321.
Chen Y, Chen D, Wang Q, Xu Y, Huang X, Haglund F, Su H. Immunological Classification of Pancreatic Carcinomas to Identify Immune Index and Provide a Strategy for Patient Stratification. Frontiers in Immunology. 2022 Jan 17;12:719105. doi: 10.3389/fimmu.2021.719105.
Wang Q*, Li C, Zhang J, Hu X, Fan Y, Ma K, Sparrelid E, Brismar TB. Radiomics Models for Predicting Microvascular Invasion in Hepatocellular Carcinoma: A Systematic Review and Radiomics Quality Score Assessment. Cancers (Basel). 2021 Nov 22;13(22):5864. doi: 10.3390/cancers13225864.
Wang Q#, Ji Y, Brismar TB, Chen S, Li C, Jiang J, Mu W, Zhang L, Sparrelid E, Ma K. Sequential Portal Vein Embolization and Percutaneous Radiofrequency Ablation for Future Liver Remnant Growth: A Minimally Invasive Alternative to ALPPS Stage-1 in Treatment of Hepatocellular Carcinoma. Frontiers in Surgery. 2021 Sep 30;8:741352. doi: 10.3389/fsurg.2021.741352.
Wang Q, Wang A, Sparrelid E, Zhang J, Zhao Y, Ma K, Brismar TB. Predictive value of gadoxetic acid-enhanced MRI for posthepatectomy liver failure: a systematic review. European Radiology. 2021 Sep 25. doi: 10.1007/s00330-021-08297-8.
Wang Q#, Chen S, Yan J, Brismar T, Sparrelid E, Qu C, Ji Y, Chen S, Ma K. Rescue radiofrequency ablation or percutaneous ethanol injection: a strategy for failed RALPPS stage-1 in patients with cirrhosis-related hepatocellular carcinoma. BMC Surgery. 2021 May 18;21(1):246. doi: 10.1186/s12893-021-01241-z.
Note: # co-first author; * corresponding author.
Academic honours, awards and prizes
Medicinsk Diagnostik Karolinska Kliniknära FoU 2022.
Analytic Imaging Diagnostics Arena (AIDA) of Clinical fellowship project 2022.
Member of National Clinical Research School in Chronic Inflammatory Diseases (NCRSCID) (2020-2022).