Reza Zandi Shafagh
Ph.D in Micro and Nanosystems
Head of Micro and Nanofabrication core facility (MCF)
Reza is a researcher at the Department of Physiology and Pharmacology, karolinska institutet (KI). He holds Ph.D degree in Micro and Nanosystems from Royal Institute of Technology (KTH), Micro and Nanosystems department (MST), Stockholm, Sweden.
Reza's expertise lies in nanoengineering, microfluidics, lab-on-a-chip, and biomicroelectromechanical systems (BioMEMS) for biomedical applications. More specifically during his Ph.D studies, he made the following contributions:
- Establishing novel micro-and nanofabrication methods (micro and nano reaction injection molding- μRIM and NanoRIM), as well as implementing the standard ones (Electron beam lithography and Nanoimprint lithography), for high-resolution structuring of polymer materials (down to 20 nm) and scalable manufacturing of microfluidic devices.
- Introducing facile back-end processing techniques, including direct bonding and sealing, 3D surface energy patterning, and seamless integration of microfluidic devices and sensors.
- Presenting high-resolution protein patterning techniques.
- Developing ultrasensitive biosensing methods.
- Within the framework of the RAPP-ID project, the research included technologies for rapid and ultrasensitive detection of Influenza virus directly from human breath.
- Within the framework of the Norosensor project, the research included technologies for the rapid and ultrasensitive detection of Norovirus in ambient air.
- POSITIVE project aimed at the diagnosis of food allergies via porous silicon-based lab-on-a-chip devices.
Reza is currently the head of Micro and Nanofabrication core facility (MCF) at KI. His ongoing research theme focuses on the fabrication and characterization of organ-on-a-chip devices for drug development purposes. MCF aims to bridge the gap between engineering and biology at Karolinska Institutet and provide common grounds with respect to suitable material of use of modular design and tunable structures for biomedical purposes.
Thiol-ene polymer constitutes an important class of materials with a diverse spectrum of applications in electronics, photonics and biomedicine. As the subclass of these polymers, OSTE/OSTE+ have emerged as promising materials which are especially tuned for lab-on-a-chip and microfluidic applications.
Using the above-mentioned material either standalone or, in combination with other materials (such as silicon, glass, PDMS, etc) when necessary, Reza aims to establish novel and facile techniques for fabrication and characterization of cell matrices, embedded with micro and nanocomponents, to explore fundamental biological questions. Development of suitable platforms for 3D cell culture, manipulation of different cell behaviors on a broad range of nanotopographies, and development of perfused microfluidic platforms for human tissues and organs cross-talk are some examples of the intended research efforts.