Reza Zandi Shafagh
Research Specialist
E-mail: reza.zandi.shafagh@ki.se
Visiting address: Solnavägen 9, Biomedicum, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Individanpassad medicin och läkemedelsutveckling, 171 77 Stockholm
About me
- Ph.D in Micro and Nanosystems
Head of Biofabrication and Tissue Engineering core Facility (Biofab)
Reza is a research specialist and currently the head of Biofabrication and
Tissue Engineering core Facility (Biofab) [1] at the Department of Physiology
and Pharmacology [2 [3], karolinska institutet [4] (KI). He holds Ph.D
degree in Micro and Nanosystems from Royal Institute of Technology
[5](KTH), Micro and Nanosystems department [6] (MST), Stockholm,
Sweden.
Reza's expertise lies in nanoengineering, microfluidics, lab-on-a-chip, and
biomicroelectromechanical systems (BioMEMS) for biomedical applications. More
specifically during his Ph.D studies, he made the following contributions:
* Establishing novel micro-and nanofabrication methods (micro and nano
reaction injection molding- μRIM and NanoRIM), as well as implementing
the standard ones (Electron beam lithography and Nanoimprint lithography),
for high-resolution structuring of polymer materials (down to 20 nm) and
scalable manufacturing of microfluidic devices.
* Introducing facile back-end processing techniques, including direct
bonding and sealing, 3D surface energy patterning, and seamless
integration of microfluidic devices and sensors.
* Presenting high-resolution protein patterning techniques.
* Developing ultrasensitive biosensing methods.
He was also previously involved in three European IMI and EU FP7 projects ,
"RAPP-ID [7]" and "Norosensor [8]" and "POSITIVE [9]":
* Within the framework of the RAPP-ID [10] project, the research
included technologies for rapid and ultrasensitive detection of Influenza
virus directly from human breath.
* Within the framework of the Norosensor [11] project, the research
included technologies for the rapid and ultrasensitive detection of
Norovirus in ambient air.
* POSITIVE [12]project aimed at the diagnosis of food allergies
via porous silicon-based lab-on-a-chip devices.
Reza is currently the head of Biofabrication and Tissue Engineering core
Facility (Biofab) [13] at KI. Biofab aims to bridge the gap between
engineering and biology at Karolinska Institutet and provide common grounds
with respect to suitable material of use of modular design and tunable
structures for biomedical purposes.
[1] https://ki.se/en/fyfa/biofabrication-and-tissue-engineering-biofab-facility
[2] https://ki.se/en/fyfa/department-of-physiology-and-pharmacology
[3] https://ki.se/en/fyfa/department-of-physiology-and-pharmacology?_ga=2.197737199.1739688656.1584358795-1051791297.1578605044
[4] https://ki.se/
[5] https://www.kth.se/
[6] https://www.kth.se/mst
[7] https://www.imi.europa.eu/projects-results/project-factsheets/rapp-id
[8] https://cordis.europa.eu/project/rcn/110979/factsheet/en
[9] https://www.kth.se/mst/research/micro-and-nanofluidi/projects/previous-projects/positive-1.66472
[10] https://www.imi.europa.eu/projects-results/project-factsheets/rapp-id
[11] https://cordis.europa.eu/project/rcn/110979/factsheet/en
[12] https://www.kth.se/mst/research/micro-and-nanofluidi/projects/previous-projects/positive-1.66472
[13] https://ki.se/en/fyfa/biofabrication-and-tissue-engineering-biofab-facility
Research
- * *Microphysiological systems to mimic organ-to-organ
crosstalk*: Microphysiological systems, also coined as Organ-on-a-Chip
devices, offer exciting possibilities to bioengineer tissue-tissue
interaction for disease modeling or drug development purposes.
Reza's research interest lies in developing suitable materials and
engineering solutions in the noted research field.
* *Mechanobiological control of human cells using
bioinspired nanostructures*: Development of suitable platforms for 3D
cell culture and manipulation of different cell behaviors on a broad range
of nanotopographies to alter mechanosensing of human cells are some
other examples of the intended research efforts.
Articles
-
Article: ADVANCED MATERIALS INTERFACES. 2024
-
Article: ADVANCED HEALTHCARE MATERIALS. 2023;:e2303561
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Article: ADVANCED SCIENCE. 2022;9(34):e2203368
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Article: ADVANCED SCIENCE. 2021;8(16):e2100106
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Article: FASEB JOURNAL. 2021;35(3):e21305
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Article: ACS APPLIED BIO MATERIALS. 2020;3(12):8757-8767
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Article: MICROSYSTEMS & NANOENGINEERING. 2019;5:25
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Article: ACS NANO. 2018;12(10):9940-9946
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Article: JOURNAL OF MICROMECHANICS AND MICROENGINEERING. 2017;27(12):124001
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Article: ACS APPLIED MATERIALS & INTERFACES. 2017;9(36):30267-30272
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Article: OPTICS LETTERS. 2017;42(11):2157-2160
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Article: ACS APPLIED MATERIALS & INTERFACES. 2017;9(12):10418-10426
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Article: PLOS ONE. 2016;11(12):e0166330
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Article: JOURNAL OF MICROMECHANICS AND MICROENGINEERING. 2015;25(7):075002
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Article: OPTICS EXPRESS. 2013;21(18):21293-21298
All other publications
-
Review: PHARMACOLOGICAL REVIEWS. 2022;74(1):141-206
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Review: CHEMICAL RESEARCH IN TOXICOLOGY. 2020;33(1):38-60
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Review: BIOTECHNOLOGY JOURNAL. 2019;14(7):e1800347
Grants
-
KI core-facility grant1 January 2022 - 1 January 2024
-
An “on-chip” platform for 3D cell co-culture, tissue-tissue interaction and “in-situ” drug screeningTORE NILSON'S FOUNDATION FOR MEDICAL RESEARCH1 January 2021 - 1 January 2022