Research description

Using single-cell transcriptomics to investigate gene regulation, cellular heterogeneity and the specification of cell identities. We are studying gene expression and regulation using a combination of genomic technologies. In particular, we are developing and applying single-cell transcriptomics to better understand how cellular identities are specified at the molecular level during differentiation, in pluripotency and to enable studies of the cellular heterogeneity in tumors. Additionally, we believe that analyses of single-cell level gene expression will unravel general aspects of transcription processes and general rules for the composition of transcriptomes.

Read more at Rickard Sandberg's Group

Selected publications:

Single-cell RNA counting at allele and isoform resolution using Smart-seq3

Michael Hagemann-Jensen, Christoph Ziegenhain, Ping Chen, Daniel Ramsköld, Gert-Jan Hendriks, Anton J. M. Larsson, Omid R. Faridani & Rickard Sandberg. Nature Biotechnology 2020.

Genomic encoding of transcriptional burst kinetics

Larsson, AJM; Johnsson, P; Hagemann-Jensen, M; Hartmanis, L; Faridani, OR; Reinius, B; Segerstolpe, Å; Rivera, CM; Ren, B; Sandberg, R. Nature, 2019, 251-254.

NASC-seq monitors RNA synthesis in single cells

Hendriks, GJ; Jung, LA; Larsson, AJM; Lidschreiber, M; Andersson Forsman, O; Lidschreiber, K; Cramer, P; Sandberg, R. Nature communications, 2019.

Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells.

Deng Q, Ramsköld D, Reinius B, Sandberg R Science 2014 Jan;343(6167):193-6

Smart-seq2 for sensitive full-length transcriptome profiling in single cells.

Picelli S, Björklund ÅK, Faridani OR, Sagasser S, Winberg G, Sandberg R Nature Methods 2013 Nov;10(11):1096-8

Education

PhD studies, Department of Microbiology, Tumour and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden 2000-2004.

Postdoctoral training, Massachusetts Institute of Technology (MIT), Cambridge, US 2005-2007.

Assistant Professor, Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Sweden 2008-2013.

Associate Professor, Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Sweden 2013-

Academic honours, awards and prizes

Elected Member of EMBO 2019.

Elected Member of the Nobel Assembly at Karolinska Institutet 2019.

Anders Jahre's medical prize for young medical researchers (Nordic prize) 2014

EMBO Young Investigator 2012

Sven and Ebba-Christina Hagbergs Prize 2012

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