Using single-cell transcriptomics to investigate gene regulation, cellular heterogeneity and the specification of cell identities. We are studying gene expression and regulation using a combination of genomic technologies. In particular, we are developing and applying single-cell transcriptomics to better understand how cellular identities are specified at the molecular level during differentiation, in pluripotency and to enable studies of the cellular heterogeneity in tumors. Additionally, we believe that analyses of single-cell level gene expression will unravel general aspects of transcription processes and general rules for the composition of transcriptomes.
Read more at Rickard Sandberg's Group
Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells. Deng Q, Ramsköld D, Reinius B, Sandberg R Science 2014 Jan;343(6167):193-6
Entering the era of single-cell transcriptomics in biology and medicine. Sandberg R Nat. Methods 2014 Jan;11(1):22-4
Tn5 transposase and tagmentation procedures for massively scaled sequencing projects. Picelli S, Björklund AK, Reinius B, Sagasser S, Winberg G, Sandberg R Genome Res. 2014 Dec;24(12):2033-40
Smart-seq2 for sensitive full-length transcriptome profiling in single cells. Picelli S, Björklund ÅK, Faridani OR, Sagasser S, Winberg G, Sandberg R Nat. Methods 2013 Nov;10(11):1096-8
PhD studies, Department of Microbiology, Tumour and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden 2000-2004.
Postdoctoral training, Massachusetts Institute of Technology (MIT), Cambridge, US 2005-2007.
Assistant Professor, Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Sweden 2008-2013.
Associate Professor, Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Sweden 2013-
Academic honours, awards and prizes
Anders Jahre's medical prize for young medical researchers (Nordic prize) 2014
EMBO Young Investigator 2012
Sven and Ebba-Christina Hagbergs Prize 2012