Robert Schnell

Publications
CV
Public outreach and news

Articles

Article: ACS CHEMICAL BIOLOGY. 2023;18(4):794-802

Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway.

Artukka E; Schnell R; Palmu K; Rosenqvist P; Szodorai E; Niemi J; Virta P; Schneider G; Metsä-Ketelä M
Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2022;228:113976

Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens.

Varakala SD; Reshma RS; Schnell R; Dharmarajan S
Article: CELL CHEMICAL BIOLOGY. 2021;28(9):1321-1332.e5

N-Thio-β-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis.

Martelli G; Pessatti TB; Steiner EM; Cirillo M; Caso C; Bisognin F; Landreh M; Monte PD; Giacomini D; Schnell R
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2021;143(10):3794-3807

Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase.

Schriever K; Saenz-Mendez P; Rudraraju RS; Hendrikse NM; Hudson EP; Biundo A; Schnell R; Syrén P-O
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2021;30:115898

A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.

Vella P; Rudraraju RS; Lundbäck T; Axelsson H; Almqvist H; Vallin M; Schneider G; Schnell R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2018;430(18 Pt B):3170-3189

Structural and Functional Characterization of the BcsG Subunit of the Cellulose Synthase in Salmonella typhimurium.

Sun L; Vella P; Schnell R; Polyakova A; Bourenkov G; Li F; Cimdins A; Schneider TR; Lindqvist Y; Galperin MY; Schneider G; Römling U
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2018;86(9):912-923

The structure of the N-terminal module of the cell wall hydrolase RipA and its role in regulating catalytic activity.

Steiner EM; Lyngsø J; Guy JE; Bourenkov G; Lindqvist Y; Schneider TR; Pedersen JS; Schneider G; Schnell R
Article: MOLECULAR METABOLISM. 2018;14:108-120

Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification.

Malenczyk K; Szodorai E; Schnell R; Lubec G; Szabó G; Hökfelt T; Harkany T
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017;27(19):4582-4587

Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis.

Brunner K; Steiner EM; Reshma RS; Sriram D; Schnell R; Schneider G
Article: EMBO JOURNAL. 2017;36(14):2107-2125

A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.

Malenczyk K; Girach F; Szodorai E; Storm P; Segerstolpe Å; Tortoriello G; Schnell R; Mulder J; Romanov RA; Borók E; Piscitelli F; Di Marzo V; Szabó G; Sandberg R; Kubicek S; Lubec G; Hökfelt T; Wagner L; Groop L; Harkany T
Article: FEBS JOURNAL. 2017;284(5):725-741

Binding and processing of β-lactam antibiotics by the transpeptidase LdtMt2 from Mycobacterium tuberculosis.

Steiner EM; Schneider G; Schnell R
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2016;59(14):6848-6859

Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.

Brunner K; Maric S; Reshma RS; Almqvist H; Seashore-Ludlow B; Gustavsson A-L; Poyraz Ö; Yogeeswari P; Lundbäck T; Vallin M; Sriram D; Schnell R; Schneider G
Article: ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS. 2016;72(Pt 2):105-111

Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa.

Jacewicz A; Schnell R; Lindqvist Y; Schneider G
Article: ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS. 2015;71(Pt 8):1020-1026

Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form.

Baum B; Lecker LSM; Zoltner M; Jaenicke E; Schnell R; Hunter WN; Brenk R
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2015;71(Pt 3):721-731

Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.

Schmidberger JW; Schnell R; Schneider G
Article: EMBO JOURNAL. 2015;34(1):36-54

A secretagogin locus of the mammalian hypothalamus controls stress hormone release.

Romanov RA; Alpár A; Zhang M-D; Zeisel A; Calas A; Landry M; Fuszard M; Shirran SL; Schnell R; Dobolyi Á; Oláh M; Spence L; Mulder J; Martens H; Palkovits M; Uhlen M; Sitte HH; Botting CH; Wagner L; Linnarsson S; Hökfelt T; Harkany T
Article: PLOS ONE. 2015;10(3):e0121494

Crystal structures of the kinase domain of the sulfate-activating complex in Mycobacterium tuberculosis.

Poyraz Ö; Brunner K; Lohkamp B; Axelsson H; Hammarström LGJ; Schnell R; Schneider G
Article: CEREBRAL CORTEX. 2014;24(12):3277-3288

GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain.

Keimpema E; Zheng K; Barde SS; Berghuis P; Dobszay MB; Schnell R; Mulder J; Luiten PGM; Xu ZD; Runesson J; Langel Ü; Lu B; Hökfelt T; Harkany T
Article: JOURNAL OF BACTERIOLOGY. 2014;196(19):3410-3420

CysK2 from Mycobacterium tuberculosis is an O-phospho-L-serine-dependent S-sulfocysteine synthase.

Steiner EM; Böth D; Lössl P; Vilaplana F; Schnell R; Schneider G
Article: BIOCHEMICAL JOURNAL. 2014;457(1):33-41

RipD (Rv1566c) from Mycobacterium tuberculosis: adaptation of an NlpC/p60 domain to a non-catalytic peptidoglycan-binding function.

Böth D; Steiner EM; Izumi A; Schneider G; Schnell R
Article: ACS CHEMICAL BIOLOGY. 2013;8(11):2518-2527

Discovery of an allosteric inhibitor binding site in 3-Oxo-acyl-ACP reductase from Pseudomonas aeruginosa.

Cukier CD; Hope AG; Elamin AA; Moynie L; Schnell R; Schach S; Kneuper H; Singh M; Naismith JH; Lindqvist Y; Gray DW; Schneider G
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2013;56(16):6457-6466

Structure-guided design of novel thiazolidine inhibitors of O-acetyl serine sulfhydrylase from Mycobacterium tuberculosis.

Poyraz O; Jeankumar VU; Saxena S; Schnell R; Haraldsson M; Yogeeswari P; Sriram D; Schneider G
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2013;23(5):1182-1186

Discovery of novel inhibitors targeting the Mycobacterium tuberculosis O-acetylserine sulfhydrylase (CysK1) using virtual high-throughput screening.

Jean Kumar VU; Poyraz Ö; Saxena S; Schnell R; Yogeeswari P; Schneider G; Sriram D
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2013;69(Pt 3):432-441

Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis.

Böth D; Steiner EM; Stadler D; Lindqvist Y; Schnell R; Schneider G
Article: PLOS ONE. 2013;8(6):e66936

Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates.

Chen MW; Lohkamp B; Schnell R; Lescar J; Schneider G
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2013;69(Pt 1):25-34

The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.

Moynie L; Schnell R; McMahon SA; Sandalova T; Boulkerou WA; Schmidberger JW; Alphey M; Cukier C; Duthie F; Kopec J; Liu H; Jacewicz A; Hunter WN; Naismith JH; Schneider G
Article: PLOS ONE. 2013;8(5):e63161

Structural insights into the UbiD protein family from the crystal structure of PA0254 from Pseudomonas aeruginosa.

Jacewicz A; Izumi A; Brunner K; Schnell R; Schneider G
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2012;80(12):2799-2803

Crystal structure of NirD, the small subunit of the nitrite reductase NirbD from Mycobacterium tuberculosis at 2.0 Å resolution.

Izumi A; Schnell R; Schneider G
Article: PLOS ONE. 2012;7(2):e31133

Tetrahydrodipicolinate N-succinyltransferase and dihydrodipicolinate synthase from Pseudomonas aeruginosa: structure analysis and gene deletion.

Schnell R; Oehlmann W; Sandalova T; Braun Y; Huck C; Maringer M; Singh M; Schneider G
Article: JOURNAL OF MOLECULAR BIOLOGY. 2011;413(1):247-260

Peptidoglycan remodeling in Mycobacterium tuberculosis: comparison of structures and catalytic activities of RipA and RipB.

Böth D; Schneider G; Schnell R
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2011;67(Pt 10):1184-1188

Structure of PA4019, a putative aromatic acid decarboxylase from Pseudomonas aeruginosa.

Kopec J; Schnell R; Schneider G
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):33-38

Structural enzymology of sulphur metabolism in Mycobacterium tuberculosis.

Schnell R; Schneider G
Article: JOURNAL OF MOLECULAR BIOLOGY. 2009;393(4):966-977

Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis.

Lindqvist Y; Koskiniemi H; Jansson A; Sandalova T; Schnell R; Liu Z; Mäntsälä P; Niemi J; Schneider G
Article: FEBS LETTERS. 2009;583(2):330-336

The C-terminal of CysM from Mycobacterium tuberculosis protects the aminoacrylate intermediate and is involved in sulfur donor selectivity.

Agren D; Schnell R; Schneider G
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2008;64(Pt 12):1096-1100

1.9 A structure of the signal receiver domain of the putative response regulator NarL from Mycobacterium tuberculosis.

Schnell R; Agren D; Schneider G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(46):31567-31574

Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria.

Agren D; Schnell R; Oehlmann W; Singh M; Schneider G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(32):23473-23481

Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis. Crystal structures of the enzyme alpha-aminoacrylate intermediate and an enzyme-inhibitor complex.

Schnell R; Oehlmann W; Singh M; Schneider G
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2006;62(Pt 10):1196-1207

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens.

Fogg MJ; Alzari P; Bahar M; Bertini I; Betton JM; Burmeister WP; Cambillau C; Canard B; Corrondo MA; Coll M; Daenke S; Dym O; Egloff MP; Enguita FJ; Geerlof A; Haouz A; Jones TA; Ma Q; Manicka SN; Migliardi M; Nordlund P; Owens RJ; Peleg Y; Schneider G; Schnell R; Stuart DI; Tarbouriech N; Unge T; Wilkinson AJ; Wilmanns M; Wilson KS; Zimhony O; Grimes JM
Article: BMC BIOCHEMISTRY. 2005;6:16

Analysis of Escherichia coli nicotinate mononucleotide adenylyltransferase mutants in vivo and in vitro.

Stancek M; Schnell R; Rydén-Aulin M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):27319-27328

Siroheme- and [Fe4-S4]-dependent NirA from Mycobacterium tuberculosis is a sulfite reductase with a covalent Cys-Tyr bond in the active site.

Schnell R; Sandalova T; Hellman U; Lindqvist Y; Schneider G
Article: FEBS LETTERS. 2003;538(1-3):139-144

Functional EF-Tu with large C-terminal extensions in an E coli strain with a precise deletion of both chromosomal tuf genes.

Schnell R; Abdulkarim F; Kálmán M; Isaksson LA
Article: JOURNAL OF BACTERIOLOGY. 2002;184(17):4930-4932

The metD D-methionine transporter locus of Escherichia coli is an ABC transporter gene cluster.

Gál J; Szvetnik A; Schnell R; Kálmán M
Article: BIOLOGIA FUTURA. 2002;53(4):445-464

Visual event related potentials. The origin of wave P300. A computer model.

Fehér O; Schnell R
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2001;1544(1-2):378-385

Ribosomes with large synthetic N-terminal extensions of protein S15 are active in vivo.

Walles-Granberg A; Schnell R; Isaksson LA; Rydén-Aulin M
Article: ANALYTICAL BIOCHEMISTRY. 2000;282(1):156-158

Polymerase dependence of autosticky polymerase chain reaction.

Gál J; Schnell R; Kálmán M
Article: ANALYTICAL BIOCHEMISTRY. 1999;266(2):235-238

A positive selection cloning system based on the gltS gene of Escherichia coli.

Gál J; Szekeres S; Schnell R; Pongor S; Simoncsits A; Kálmán M
Article: MOLECULAR GENETICS AND GENOMICS. 1999;260(6):569-573

Directional cloning of native PCR products with preformed sticky ends (autosticky PCR).

Gál J; Schnell R; Szekeres S; Kálmán M
Show more

All other publications

Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1854(9):1175-1183

Pyridoxal-phosphate dependent mycobacterial cysteine synthases: Structure, mechanism and potential as drug targets.

Schnell R; Sriram D; Schneider G
Corrigendum: PLOS ONE. 2015;10(4):e0127016

Correction: Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium tuberculosis.

PLOS ONE Staff
Corrigendum: ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY. 2006;62:1571

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens (vol 62, pg 1196, 2006)

Fogg MJ; Alzari P; Bahar M; Bertini I; Betton J-M; Burmeister WP; Cambillau C; Canard B; Carrondo MA; Coll M; Daenke S; Dym O; Egloff M-P; Enguita FJ; Geerlof A; Haouz A; Jones TA; Qingjun M; Manicka SN; Migliardi M; Nordlund P; Owens RJ; Peleg Y; Schneider G; Schnell R; Stuart DI; Tarbouriech N; Unge T; Wilkinson AJ; Wilmanns M; Wilson KS; Zimhony O; Grimes JM

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI