About me
I received my PhD training in medical biology from the Department of Pathology, University Medical Center Utrecht, and the Utrecht University, in The Netherlands. I obtained my doctoral degree in 2012 on how cytotoxic lymphocytes can control cytomegalovirus infections.
Research description
My main research focus is on the immunological mechanisms by which cytotoxic lymphocytes can control HIV-1 infection and to find ways to exploit or boost these mechanisms for an improved HIV-1 control. Currently, I am investigating how NK cells could be utilized in a shock-and-kill strategy.
Publications
Furtado Milão J, Love L, Gourgi G, Derhaschnig L, Svensson JP, Sönnerborg A, van Domselaar R. (2022) Natural killer cells induce HIV-1 latency reversal after treatment with pan-caspase inhibitors. Front Immunol. 2022 Dec 6;13:1067767 (PMID: 36561752)
Saccon E, Mikaeloff F, Figueras Ivern P, Végvári Á, Sönnerborg A, Neogi U, van Domselaar R. (2021) Cytotoxic lymphocytes target HIV-1 Gag through granzyme M-mediated cleavage. Front Immunol. 2021 Apr 19;12:669347. (PMID: 33953729)
Sperk M, van Domselaar R, Rodriguez JE, Mikaeloff F, Sá Vinhas B, Saccon E, Sönnerborg A, Singh K, Gupta S, Végvári Á, Neogi U. (2020) Utility of Proteomics in Emerging and Re-Emerging Infectious Diseases Caused by RNA Viruses. J Proteome Res. 2020 Nov 6;19(11):4259-4274. (PMID: 33095583)
van Domselaar R, Njenda DT, Rao R, Sönnerborg A, Singh K, Neogi U. (2019) HIV-1 Subtype C with PYxE Insertion Has Enhanced Binding of Gag-p6 to Host Cell Protein ALIX and Increased Replication Fitness. J Virol. 2019 Apr 17;93(9):e00077-19 (PMID: 30760577)
Sperk M, van Domselaar R, Neogi U. (2018) Immune Checkpoints as the Immune System Regulators and Potential Biomarkers in HIV-1 Infection. Int J Mol Sci. 2018 Jul 9;19(7):2000. (PMID: 29987244)
Zhang W, Ambikan AT, Sperk M, van Domselaar R, Nowak P, Noyan K, Russom A, Sönnerborg A, Neogi U. (2018) Transcriptomics and Targeted Proteomics Analysis to Gain Insights Into the Immune-control Mechanisms of HIV-1 Infected Elite Controllers. EBioMedicine. 2018 Jan;27:40-50 (PMID: 29269040)
van de Ven RAH, de Groot JS, Park D, van Domselaar R, de Jong D, Szuhai K, van der Wall E, Rueda OM, Ali HR, Caldas C, van Diest PJ, Hetzer MW, Sahai E, Derksen PWB. (2016) p120-catenin prevents multinucleation through spatial control of MKLP1-dependent RhoA activity during cytokinesis. Nat Commun. 2016 Dec 22;7:13874 (PMID: 28004812)
de Groot JS, Moelans CB, Elias SG, Fackler MJ, van Domselaar R, Suijkerbuijk KPM, Witkamp AJ, Sukumar S, van Diest PJ, van der Wall E. (2016) DNA promoter hypermethylation in nipple fluid: a potential tool for early breast cancer detection. Oncotarget. 2016 Apr 26;7(17):24778-91 (PMID: 27028854)
Bovenschen N, Spijkers SNM, Wensink AC, Schellens IMM, van Domselaar R, van Baarle D. (2014) Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation. Clin Immunol. 2014 Jan;150(1):1-11 (PMID: 24316590)
van Domselaar R, de Poot SAH, Remmerswaal EBM, Lai KW, ten Berge IJM, Bovenschen N. (2013) Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication. Cell Death Diff. 2013 Mar;20(3):419-29 (PMID: 23099853)
van Domselaar R, Quadir R, van der Made AM, Broekhuizen R, Bovenschen N. (2012) All human granzymes target hnRNP K that is essential for tumor cell viability. J Biol Chem. 2012 Jun 29;287(27):22854-64 (PMID: 22582387)
van Domselaar R, Bovenschen N. (2011) Cell death-independent functions of granzymes: hit viruses where it hurts. Rev Med Virol. 2011 Sep;21(5):301-314 (PMID: 21714121)
van Domselaar R, Philippen LE, Quadir R, Wiertz EJHJ, Kummer JA, Bovenschen N. (2010) Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71. J Immunol. 2010 Dec 15;185(12):7605-13 (PMID: 21059895)
van Domselaar R, de Poot SAH, Bovenschen N. (2010) Proteomic profiling of proteases: tools for granzyme degradomics. Exp Rev Proteomics. 2010 Jun;7(3):347-359 (PMID: 20536307)
Rooijakkers SHM, Wu J, Ruyken M, van Domselaar R, Planken KL, Tzekou A, Ricklin D, Lambris JD, Janssen BJC, van Strijp JAG, Gros P. (2009) Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nat Immunol. 2009 Jul;10(7):721-7 (PMID: 19503103)
Education
2007 - 2012 PhD degree in Life Sciences, University Medical Center Utrecht & Utrecht University, The Netherlands (Fields of expertise: Immunology, Microbiology, Molecular/Cell Biology)
2005 - 2007 MSc degree in Biomedical Sciences, Utrecht University, The Netherlands
2002 - 2005 BSc degree in Biomedical Sciences, Utrecht University, The Netherlands