Rochellys Diaz Heijtz

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About me

Dr. Diaz Heijtz is an Associate Professor and group leader in the Department
of Neuroscience.

Articles

Article: CELLS. 2023;12(17):2153

Cognitive Alterations in Old Mice Are Associated with Intestinal Barrier Dysfunction and Induced Toll-like Receptor 2 and 4 Signaling in Different Brain Regions.

Brandt A; Kromm F; Hernández-Arriaga A; Martínez Sánchez I; Bozkir HÖ; Staltner R; Baumann A; Camarinha-Silva A; Heijtz RD; Bergheim I
Article: NEUROPHARMACOLOGY. 2023;234:109562

Characterizing the metabolomic signature of attention-deficit hyperactivity disorder in twins.

Swann JR; Diaz Heijtz R; Mayneris-Perxachs J; Arora A; Isaksson J; Bölte S; Tammimies K
Article: TRANSLATIONAL PSYCHIATRY. 2023;13(1):257

Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder.

Zuffa S; Schimmel P; Gonzalez-Santana A; Belzer C; Knol J; Bölte S; Falck-Ytter T; Forssberg H; Swann J; Diaz Heijtz R
Article: NEUROPHARMACOLOGY. 2023;229:109479

Perturbation of maternal gut microbiota in mice during a critical perinatal window influences early neurobehavioral outcomes in offspring.

Morel C; Martinez Sanchez I; Cherifi Y; Chartrel N; Diaz Heijtz R
Article: METABOLITES. 2020;10(5):E172-172

Developmental Signatures of Microbiota-Derived Metabolites in the Mouse Brain.

Swann JR; Spitzer SO; Diaz Heijtz R
Article: MOLECULAR NEUROBIOLOGY. 2019;56(10):6883-6900

Can Neonatal Systemic Inflammation and Hypoxia Yield a Cerebral Palsy-Like Phenotype in Periadolescent Mice?

Fragopoulou AF; Qian Y; Heijtz RD; Forssberg H
Article: CURRENT OPINION IN PHARMACOLOGY. 2019;48:107-113

Bacterial peptidoglycans as novel signaling molecules from microbiota to brain.

Tosoni G; Conti M; Diaz Heijtz R
Article: BRAIN BEHAVIOR AND IMMUNITY. 2018;69:273-282

Toll-like receptor-4 regulates anxiety-like behavior and DARPP-32 phosphorylation.

Femenia T; Qian Y; Arentsen T; Forssberg H; Diaz Heijtz R
Article: EBIOMEDICINE. 2018;28:162-167

Genetic Variation in the Dopamine System Influences Intervention Outcome in Children with Cerebral Palsy.

Diaz Heijtz R; Almeida R; Eliasson AC; Forssberg H
Article: BRAIN BEHAVIOR AND IMMUNITY. 2018;67:345-354

Sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 knockout mice.

Arentsen T; Khalid R; Qian Y; Diaz Heijtz R
Article: JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS. 2017;47(8):2621-2627

Brief Report: Association Between Autism Spectrum Disorder, Gastrointestinal Problems and Perinatal Risk Factors Within Sibling Pairs.

Isaksson J; Pettersson E; Kostrzewa E; Diaz Heijtz R; Bölte S
Article: MOLECULAR PSYCHIATRY. 2017;22(2):257-266

The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior.

Arentsen T; Qian Y; Gkotzis S; Femenia T; Wang T; Udekwu K; Forssberg H; Diaz Heijtz R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(52):E8472-E8481

Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide.

Barde S; Rüegg J; Prud'homme J; Ekström TJ; Palkovits M; Turecki G; Bagdy G; Ihnatko R; Theodorsson E; Juhasz G; Diaz-Heijtz R; Mechawar N; Hökfelt TGM
Article: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY. 2015;57 Suppl 2:10-14

Translational studies exploring neuroplasticity associated with motor skill learning and the regulatory role of the dopamine system.

Diaz Heijtz R; Forssberg H
Article: MICROBIAL ECOLOGY IN HEALTH AND DISEASE. 2015;26:29719

Host microbiota modulates development of social preference in mice.

Arentsen T; Raith H; Qian Y; Forssberg H; Diaz Heijtz R
Article: PLOS ONE. 2015;10(10):e0140974

Motor Skill Learning Is Associated with Phase-Dependent Modifications in the Striatal cAMP/PKA/DARPP-32 Signaling Pathway in Rodents.

Qian Y; Forssberg H; Diaz Heijtz R
Article: GENES BRAIN AND BEHAVIOR. 2013;12(6):604-614

Genetic variation in dopamine-related gene expression influences motor skill learning in mice.

Qian Y; Chen M; Forssberg H; Diaz Heijtz R
Article: JOURNAL OF PEDIATRICS. 2013;163(2):441-446

Cognitive outcome in adolescents and young adults after repeat courses of antenatal corticosteroids.

Stålnacke J; Diaz Heijtz R; Norberg H; Norman M; Smedler A-C; Forssberg H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(6):E536-E545

Distinct features of neurotransmitter systems in the human brain with focus on the galanin system in locus coeruleus and dorsal raphe.

Le Maître E; Barde SS; Palkovits M; Diaz-Heijtz R; Hökfelt TGM
Article: PLOS ONE. 2012;7(4):e35642

The dopamine D2 receptor gene in lamprey, its expression in the striatum and cellular effects of D2 receptor activation.

Robertson B; Huerta-Ocampo I; Ericsson J; Stephenson-Jones M; Pérez-Fernández J; Bolam JP; Diaz-Heijtz R; Grillner S
Article: ACTA PAEDIATRICA. 2011;100(3):364-369

Antenatal corticosteroids for preterm birth: dose-dependent reduction in birthweight, length and head circumference.

Norberg H; Stålnacke J; Diaz Heijtz R; Smedler A-C; Nyman M; Forssberg H; Norman M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(7):3047-3052

Normal gut microbiota modulates brain development and behavior.

Diaz Heijtz R; Wang S; Anuar F; Qian Y; Björkholm B; Samuelsson A; Hibberd ML; Forssberg H; Pettersson S
Article: BEHAVIORAL AND BRAIN FUNCTIONS. 2010;6:51

Deficits in fine motor skills in a genetic animal model of ADHD.

Qian Y; Lei G; Castellanos FX; Forssberg H; Heijtz RD
Article: BIOLOGICAL PSYCHIATRY. 2010;67(11):1106-1109

Primate early life stress leads to long-term mild hippocampal decreases in corticosteroid receptor expression.

Arabadzisz D; Diaz-Heijtz R; Knuesel I; Weber E; Pilloud S; Dettling AC; Feldon J; Law AJ; Harrison PJ; Pryce CR
Article: BEHAVIORAL AND BRAIN FUNCTIONS. 2010;6:18

Effects of antenatal dexamethasone treatment on glucocorticoid receptor and calcyon gene expression in the prefrontal cortex of neonatal and adult common marmoset monkeys.

Diaz Heijtz R; Fuchs E; Feldon J; Pryce CR; Forssberg H
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2009;12(2):243-255

Effects of repeated treatment of phencyclidine on cognition and gene expression in C57BL/6 mice.

Beraki S; Diaz-Heijtz R; Tai F; Ogren SO
Article: ENDOCRINOLOGY. 2008;149(12):6343-6355

Effects of prenatal dexamethasone treatment on physical growth, pituitary-adrenal hormones, and performance of motor, motivational, and cognitive tasks in juvenile and adolescent common marmoset monkeys.

Hauser J; Knapman A; Zürcher NR; Pilloud S; Maier C; Diaz-Heijtz R; Forssberg H; Dettling A; Feldon J; Pryce CR
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):155-160

Motor inhibitory role of dopamine D1 receptors: implications for ADHD.

Heijtz RD; Kolb B; Forssberg H
Article: BEHAVIORAL AND BRAIN FUNCTIONS. 2007;3:33

Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD.

Heijtz RD; Alexeyenko A; Castellanos FX
Journal article: BEHAVIORAL AND BRAIN FUNCTIONS. 2006;2:18

Differential effects of a selective dopamine D1-like receptor agonist on motor activity and c-fos expression in the frontal-striatal circuitry of SHR and Wistar-Kyoto rats.

Diaz Heijtz R; Castellanos FX
Article: PEDIATRIC RESEARCH. 2005;58(4):779-783

Locomotor effects of a D1R agonist are DARPP-32 dependent in adult but not weanling mice.

Scott L; Forssberg H; Aperia A; Diaz-Heijtz R
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;325(4):1223-1235

Selective brain responses to acute and chronic low-dose X-ray irradiation in males and females.

Silasi G; Diaz-Heijtz R; Besplug J; Rodriguez-Juarez R; Titov V; Kolb B; Kovalchuk O
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2004;19(4):945-956

Alteration of dopamine D1 receptor-mediated motor inhibition and stimulation during development in rats is associated with distinct patterns of c-fos mRNA expression in the frontal-striatal circuitry.

Diaz Heijtz R; Scott L; Forssberg H
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2003;18(12):3394-3399

Can a therapeutic dose of amphetamine during pre-adolescence modify the pattern of synaptic organization in the brain?

Diaz Heijtz R; Kolb B; Forssberg H
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2002;445(1-2):97-104

Sex differences in the motor inhibitory and stimulatory role of dopamine D1 receptors in rats.

Heijtz RD; Beraki S; Scott L; Aperia A; Forssberg H
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2002;446(1):37-45

Calcyon in the rat brain: cloning of cDNA and expression of mRNA.

Zelenin S; Aperia A; Diaz Heijtz R
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2000;392(1-2):35-39

Ontogeny of the motor inhibitory role of dopamine D(3) receptor subtype in rats.

Heijtz RD; Ogren SO; Fuxe K
Article: JOURNAL OF NEUROSCIENCE. 1998;18(7):2570-2580

Distinct ontogeny of glucocorticoid and mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase types I and II mRNAs in the fetal rat brain suggest a complex control of glucocorticoid actions.

Diaz R; Brown RW; Seckl JR
Article: NEUROSCIENCE. 1997;81(1):129-140

Prenatal corticosterone treatment induces long-term changes in spontaneous and apomorphine-mediated motor activity in male and female rats.

Diaz R; Fuxe K; Ogren SO
Article: NEUROSCIENCE LETTERS. 1997;227(2):119-122

Codistribution of the dopamine D3 receptor and glucocorticoid receptor mRNAs during striatal prenatal development in the rat.

Diaz R; Sokoloff P; Fuxe K
Article: NEUROSCIENCE LETTERS. 1996;213(3):169-172

Ibotenic acid in the medial septum increased brain-derived neurotrophic factor mRNA levels in the dorsal rat hippocampal formation.

Mahy N; Diaz R; Andres N; Fuxe K
Article: CELLULAR AND MOLECULAR NEUROBIOLOGY. 1996;16(2):239-258

On the role of glucocorticoid receptors in brain plasticity.

Fuxe K; Diaz R; Cintra A; Bhatnagar M; Tinner B; Gustafsson JA; Ogren SO; Agnati LF
Article: ENDOCRINOLOGY. 1996;137(2):794-797

The ontogeny of 11 beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development.

Brown RW; Diaz R; Robson AC; Kotelevtsev YV; Mullins JJ; Kaufman MH; Seckl JR
Article: DEVELOPMENTAL BRAIN RESEARCH. 1995;86(1-2):227-232

The hormone-sensitive early postnatal periods for sexual differentiation of feminine behavior and luteinizing hormone secretion in male and female rats.

Diaz DR; Fleming DE; Rhees RW
Article: NEUROSCIENCE. 1995;66(2):467-473

Prenatal corticosterone increases spontaneous and d-amphetamine induced locomotor activity and brain dopamine metabolism in prepubertal male and female rats.

Diaz R; Ogren SO; Blum M; Fuxe K
Article: NEUROREPORT. 1995;6(2):375-378

Perinatal asphyxia increases bFGF mRNA levels and DA cell body number in the mesencephalon of rats.

Andersson K; Blum M; Chen Y; Eneroth P; Gross J; Herrera-Marschitz M; Bjelke B; Bolme P; Diaz R; Jamison L
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All other publications

Editorial comment: BRAIN BEHAVIOR AND IMMUNITY. 2023;114:78-79

Early-life sensitive periods for antibiotic-induced shifts in neuro-immune developmental trajectories and vulnerability to brain disorders.

Diaz Heijtz R; Keane L; Koren O
Editorial comment: NATURE REVIEWS IMMUNOLOGY. 2023;23(4):204

Linking the maternal milk microbiota and infant respiratory infections.

Keane L; Diaz Heijtz R
Editorial comment: NATURE MEDICINE. 2022;28(3):448-450

Targeting microbial metabolites to treat autism.

Diaz Heijtz R; Gressens P; Swann JR
Editorial comment: NATURE AGING. 2021;1(8):625-627

Young microbiota rejuvenates the aging brain.

Heijtz RD; Gonzalez-Santana A; Laman JD
Review: TRENDS IN MOLECULAR MEDICINE. 2020;26(8):729-743

Bacterial Peptidoglycans from Microbiota in Neurodevelopment and Behavior.

Gonzalez-Santana A; Diaz Heijtz R
Corrigendum: MOLECULAR NEUROBIOLOGY. 2019;56(10):6901

Correction to: Can Neonatal Systemic Inflammation and Hypoxia Yield a Cerebral Palsy-Like Phenotype in Periadolescent Mice?

Fragopoulou AF; Qian Y; Diaz Heijtz R; Forssberg H
Editorial comment: CURRENT OPINION IN PHARMACOLOGY. 2019;48:x-xii

Editorial overview: CNS diseases and the microbiome.

Diaz Heijtz R; Swann J
Editorial comment: GASTROENTEROLOGY CLINICS OF NORTH AMERICA. 2019;48(3):xi-xii

Preface.

Heijtz RD
Review: FRONTIERS IN NEURAL CIRCUITS. 2018;12:106

Neuropeptide and Small Transmitter Coexistence: Fundamental Studies and Relevance to Mental Illness.

Hökfelt T; Barde S; Xu Z-QD; Kuteeva E; Rüegg J; Le Maitre E; Risling M; Kehr J; Ihnatko R; Theodorsson E; Palkovits M; Deakin W; Bagdy G; Juhasz G; Prud'homme HJ; Mechawar N; Diaz-Heijtz R; Ögren SO
Editorial comment: MOLECULAR PSYCHIATRY. 2017;22(2):161

Pglyrp2 expression in the developing hippocampus.

Arentsen T; Qian Y; Gkotzis S; Femenia T; Wang T; Udekwu K; Forssberg H; Heijtz RD
Review: SEMINARS IN FETAL & NEONATAL MEDICINE. 2016;21(6):410-417

Fetal, neonatal, and infant microbiome: Perturbations and subsequent effects on brain development and behavior.

Diaz Heijtz R
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S18

The galanin system in the human brain and relations with serotonin and noradrenaline neurons

Le Maitre E; Heijtz RD; Palkovits M; Hokfelt T
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S5

Effects of repeated treatment of phencyclidine in cognition, emotional activity and gene expression in C57BL/6J mice

Beraki S; Diaz-Heijtz R; Tai E; Ogren SO
Review: REVISTA DE NEUROLOGIA. 2006;42 Suppl 2:S19-S23

[Alterations in the pattern of dopaminergic markers in attention-deficit/hyperactivity disorder].

Díaz-Heijtz R; Mulas F; Forssberg H
Review: REVISTA DE NEUROLOGIA. 2002;34 Suppl 1:S78-S81

[Biochemical bases and research in attention-deficit hyperactivity disorder].

Díaz-Heijtz R

Employments

Principal Researcher, Department of Neuroscience, Karolinska Institutet, 2022-2024

Degrees and Education

Docent, Karolinska Institutet, 2011

About me

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Employments

Degrees and Education

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