Rodrigo Disner profile picture

Rodrigo Disner

Affiliated to research

About me

Rodrigo Disner (alias Geonildo Disner) is a Brazilian biologist with a Ph.D. in Genetics focused on environmental mutagenesis and toxicology.

Disner received a M.Sc. (2014), and a Ph.D. degree (2018) in Genetics at Universidade Federal do Paraná (UFPR), Brazil.

In 2019 he was recruited to the Center of Toxins, Immune-Response and Cell Signaling (CeTICS) housed in the Butantan Institute (São Paulo, Brazil) and joined Monica Lopes-Ferreira's group as a postdoc fellow.

In 2020, he was a trainee member of the American Association of Immunology-AAI. 

In 2021, Disner was granted a Research Internship Abroad by The São Paulo Research Foundation (FAPESP) and started working as a guest researcher in the Unit of System Toxicology of the Institute of Environmental Medicine (IMM), Karolinska Institutet, under Emma Wincent's supervision.

 

Research description

Most of my post-graduate studies were related to the toxicity of emerging contaminants like nanoparticles, pharmaceutical drugs, and PBDEs. Also, I investigated other topics such as the effects of PAHs, ecotoxicology, green toxicology, and alternative methods to animal experimentation.

Since 2019, I have collaborated as a postdoc fellow with the Center for Toxins, Immune Response, and Cellular Signaling- CeTICS (CEPID/FAPESP) and the Zebrafish Platform at the Butantan Institute. Throughout this postdoc, in the Laboratory of Applied Toxinology, I shift a bit from chemical toxicology to its subfield  Toxinology aiming to study toxins from venomous animals, mainly looking forward to identifying molecular targets, immune response, and novel molecules with the potential to treat inflammatory diseases, which was facilitated by the use of the gold-standard model Danio rerio (zebrafish).

In addition to researching the family of proteins Natterin isolated from the venom of the venomous fish Thalassophryne nattereri, I study the role of Aryl hydrocarbon Receptor (AhR) in immunological processes related to epigenetic mechanisms and therapeutic properties of drug candidate biomolecules, such as TnP (a novel peptide with anti-inflammatory and anti-allergic properties).

Right now, my focus is to elucidate the physiological and toxic impact of TnP on AhR signaling through morphometric and transcriptomic profiling using the zebrafish embryo model.

 

Selected publications

Disner GR, Falcão MAP, Lima C, Lopes-Ferreira M. In Silico Target Prediction of Overexpressed microRNAs from LPS-Challenged Zebrafish (Danio rerio) Treated with the Novel Anti-Inflammatory Peptide TnP. Int J Mol Sci. 2021 Jul 1;22(13):7117. doi: 10.3390/ijms22137117. PMID: 34281170; PMCID: PMC8268205.

Disner GR, Lopes-Ferreira M, Lima C. Where the Aryl Hydrocarbon Receptor Meets the microRNAs: Literature Review of the Last 10 Years. Front Mol Biosci. 2021 Oct 21;8:725044. doi: 10.3389/fmolb.2021.725044. PMID: 34746229; PMCID: PMC8566438.

Lima C, Disner GR, Falcão MAP, Seni-Silva AC, Maleski ALA, Souza MM, Reis Tonello MC, Lopes-Ferreira M. The Natterin Proteins Diversity: A Review on Phylogeny, Structure, and Immune Function. Toxins (Basel). 2021 Jul 31;13(8):538. doi: 10.3390/toxins13080538. PMID: 34437409; PMCID: PMC8402412.

Klingelfus T, Disner GR, Voigt CL, Alle LF, Cestari MM, Leme DM. Nanomaterials induce DNA-protein crosslink and DNA oxidation: A mechanistic study with RTG-2 fish cell line and Comet assay modifications. Chemosphere. 2019 Jan;215:703-709. doi: 10.1016/j.chemosphere.2018.10.118. Epub 2018 Oct 17. PMID: 30347365.