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Rongrong Fan

Assistant professor

Department and organisational affiliation:

About me

Keywords:

  • Assistant professor / team leader
  • Integrated research in human and mice
  • State-of-the-art sequencing techniques
  • Obesity (and) metabolic disorders
  • Metabolic inflammation (metaflammation)
  • Transcription factors and coregulators
  • Epigenome
  • Metabolic tissues (adipocytes and liver)
  • Immune cells (monocytes and macrophages)

Research description

One of the most important questions in the metabolic field is how obesity develops into different metabolic disorders (i.e. T2D, CVD and NAFLD). My research aims to find an answer using combinative approaches, starting from analyzing the metabolic tissues (including adipose tissue and liver) from patients with different susceptibility to metabolic stress challenges (i.e. obesity but non-diabetic versus obesity type 2 diabetes) followed with mechanistic studies in mouse and cell disease models using multi-OMICS methodologies.

I have so far analyzed different patient samples in the transcriptomic, cistromic and epigenomic levels and identified a group of interesting candidates involved in species-conserved and disease-relevant regulation of glucose and lipid metabolism. Of particular interest is the transcription factor coregulator GPS2, the dysregulation of which is associated with de-repressed inflammation and impaired lipid oxidation pathways, leading to type 2 diabetes and liver disease progression.

The ongoing research activity involves further investigation of the coregulator-based mechanisms in the genomic and epigenomic level in various disease contexts. Understanding such pathways is crucial for better encrypting disease mechanisms which is ultimately required for identifying novel targets with diagnostic and intervention potential. 

 

Teaching portfolio

  • Co-supervised PhD students: Zhiqiang Huang (2013-2018), Ning Liang (2013-2019).
  • 2020: Molecular biological techniques. Karolinska Institute.
  • 2019: Master thesis evaluation (Klara Lenart). Karolinska Institute.
  • 2019: Genetics, Genomics and Functional Genomics. Karolinska Institute.
  • 2018: Master thesis evaluation (Ingibjörg Sigvaldadóttir). Karolinska Institute.
  • 2017: Methods in molecular biology and proteomics and their application in medical research. Karolinska Institute.
  • 2016: Applied communication in biomedicine 2. Karolinska Institute.
  • 2015: Applied communication in biomedicine 2. Karolinska Institute.
  • 2014: Applied communication in biomedicine 1. Karolinska Institute.

Education

  • 2018 to now: Assistant professor at the Department of Biosciences and Nutrition, Karolinska Institute, Fleminsberg.
  • 2012 to 2017: Postdoctoral Study at the Department of Biosciences and Nutrition, Karolinska Institute, Fleminsberg.
  • 2012: PhD in Medical Sciences, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong.

Academic honours, awards and prizes

Research grants:

  • Swedish research council starting grant.
  • Novo Nordisk Endocrinology and Metabolism project grant.
  • CIMED junior investigator grant.
  • Junior Diabetes Wellness Sverige grant. 
  • EFSD / Lilly research fellowship.
  • KI research grant.

Awards and prizes:

  • Best short talk. 7th Endometrial SRP Diabetes Joint Retreat. Stockholm, 2017.
  • Best Poster Award for completed work. 6th Endometrial SRP Diabetes Joint Retreat. Stockholm, 2016. 
  • Distinguished Young researcher Award at Bayer 2nd Asia-Pacific Diabetes Forum. Taipei, 2010.
  • Distinguished Young Investigator Award at the 5th China Endocrinology Congress. Taipei, 2008.

Commission of trust:

  • Guest editor: Frontiers in Endocrinology 2020.
  • Invited reviewer in: Nature Communications, JBC, FASEB J, Diabetologia, Diabetes, obesity and metabolism, PLoS One, Journal of cellular and molecular medicine, etc.
  • Poster assesment committee: Epigenomics, nuclear receptor and diseases summer school. Spetses, 2019.
  • Poster assesment committee: 7th Endometrial SRP Diabetes Joint Retreat. Stockholm, 2017.
  • Poster assesment committee: Epigenomics, nuclear receptor and diseases summer school. Spetses, 2017.
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