Roland Grafström

Publications
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2022;13(1):3798

Biomarkers of nanomaterials hazard from multi-layer data.

Fortino V; Kinaret PAS; Fratello M; Serra A; Saarimäki LA; Gallud A; Gupta G; Vales G; Correia M; Rasool O; Ytterberg J; Monopoli M; Skoog T; Ritchie P; Moya S; Vázquez-Campos S; Handy R; Grafström R; Tran L; Zubarev R; Lahesmaa R; Dawson K; Loeschner K; Larsen EH; Krombach F; Norppa H; Kere J; Savolainen K; Alenius H; Fadeel B; Greco D
Article: NATURE NANOTECHNOLOGY. 2021;16(6):644-654

Towards FAIR nanosafety data.

Jeliazkova N; Apostolova MD; Andreoli C; Barone F; Barrick A; Battistelli C; Bossa C; Botea-Petcu A; Châtel A; De Angelis I; Dusinska M; El Yamani N; Gheorghe D; Giusti A; Gómez-Fernández P; Grafström R; Gromelski M; Jacobsen NR; Jeliazkov V; Jensen KA; Kochev N; Kohonen P; Manier N; Mariussen E; Mech A; Navas JM; Paskaleva V; Precupas A; Puzyn T; Rasmussen K; Ritchie P; Llopis IR; Rundén-Pran E; Sandu R; Shandilya N; Tanasescu S; Haase A; Nymark P
Article: NANOMATERIALS. 2021;11(3):639

Reliable Surface Analysis Data of Nanomaterials in Support of Risk Assessment Based on Minimum Information Requirements.

Radnik J; Kersting R; Hagenhoff B; Bennet F; Ciornii D; Nymark P; Grafström R; Hodoroaba V-D
Article: MATERIALS TODAY COMMUNICATIONS. 2019;20:100548

Safe innovation approach: Towards an agile system for dealing with innovations

Soeteman-Hernandez LG; Apostolova MD; Bekker C; Dekkers S; Grafstrom RC; Groenewold M; Handzhiyski Y; Herbeck-Engel P; Hoehener K; Karagkiozaki V; Kelly S; Kraegeloh A; Logothetidis S; Micheletti C; Nymark P; Oomen A; Oosterwijk T; Rodriguez-LLopis I; Sabella S; Jimenez AS; Sips AJAM; Suarez-Merino B; Tavernaro I; van Engelen J; Wijnhoven SWP; Noorlander CW
Article: TOXICOLOGY IN VITRO. 2019;54:23-32

Integrated analysis of in vitro data and the adverse outcome pathway framework for prioritization and regulatory applications: An exploratory case study using publicly available data on piperonyl butoxide and liver models.

Oki NO; Farcal L; Abdelaziz A; Florean O; Doktorova TY; Exner T; Kohonen P; Grafström R; Hardy B
Article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2018;58(3):543-549

toxFlow: A Web-Based Application for Read-Across Toxicity Prediction Using Omics and Physicochemical Data.

Varsou D-D; Tsiliki G; Nymark P; Kohonen P; Grafström R; Sarimveis H
Article: TOXICOLOGICAL SCIENCES. 2018;162(1):264-275

A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions.

Nymark P; Rieswijk L; Ehrhart F; Jeliazkova N; Tsiliki G; Sarimveis H; Evelo CT; Hongisto V; Kohonen P; Willighagen E; Grafström RC
Article: FRONTIERS IN GENETICS. 2018;9:661

Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials.

Martens M; Verbruggen T; Nymark P; Grafström R; Burgoon LD; Aladjov H; Torres Andón F; Evelo CT; Willighagen EL
Article: SMALL METHODS. 2017;1(11)

Enriching Nanomaterials Omics Data: An Integration Technique to Generate Biological Descriptors

Tsiliki G; Nymark P; Kohonen P; Grafstrom R; Sarimveis H
Article: JOURNAL OF BIOMEDICAL SEMANTICS. 2017;8(1):35

RDFIO: extending Semantic MediaWiki for interoperable biomedical data management.

Lampa S; Willighagen E; Kohonen P; King A; Vrandečić D; Grafström R; Spjuth O
Article: NATURE COMMUNICATIONS. 2017;8:15932

A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury.

Kohonen P; Parkkinen JA; Willighagen EL; Ceder R; Wennerberg K; Kaski S; Grafström RC
Article: CELL BIOLOGY AND TOXICOLOGY. 2016;32(4):275-284

Arsenic alters global histone modifications in lymphocytes in vitro and in vivo.

Pournara A; Kippler M; Holmlund T; Ceder R; Grafström R; Vahter M; Broberg K; Wallberg AE
Article: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2015;43(5):325-332

Toward the Replacement of Animal Experiments through the Bioinformatics-driven Analysis of 'Omics' Data from Human Cell Cultures.

Grafström RC; Nymark P; Hongisto V; Spjuth O; Ceder R; Willighagen E; Hardy B; Kaski S; Kohonen P
Article: BEILSTEIN JOURNAL OF NANOTECHNOLOGY. 2015;6:1609-1634

The eNanoMapper database for nanomaterial safety information.

Jeliazkova N; Chomenidis C; Doganis P; Fadeel B; Grafström R; Hardy B; Hastings J; Hegi M; Jeliazkov V; Kochev N; Kohonen P; Munteanu CR; Sarimveis H; Smeets B; Sopasakis P; Tsiliki G; Vorgrimmler D; Willighagen E
Article: ORAL ONCOLOGY. 2014;50(9):832-839

YAP1 is a potential biomarker for cetuximab resistance in head and neck cancer.

Jerhammar F; Johansson A-C; Ceder R; Welander J; Jansson A; Grafström RC; Söderkvist P; Roberg K
Article: METALLOMICS. 2014;6(3):498-504

Arsenic-induced suppression of kidney cell proliferation and the transcriptional coregulator MAML1.

Pournara A; Holmlund T; Lu Y; Ceder R; Putnik M; Grafström R; Vahter M; Wallberg AE
Article: MOLECULAR INFORMATICS. 2013;32(1):47-63

The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing.

Kohonen P; Benfenati E; Bower D; Ceder R; Crump M; Cross K; Grafström RC; Healy L; Helma C; Jeliazkova N; Jeliazkov V; Maggioni S; Miller S; Myatt G; Rautenberg M; Stacey G; Willighagen E; Wiseman J; Hardy B
Article: MOLECULAR PHARMACOLOGY. 2013;83(1):245-255

Requirement of apoptotic protease-activating factor-1 for bortezomib-induced apoptosis but not for Fas-mediated apoptosis in human leukemic cells.

Ottosson-Wadlund A; Ceder R; Preta G; Pokrovskaja K; Grafström RC; Heyman M; Söderhäll S; Grandér D; Hedenfalk I; Robertson JD; Fadeel B
Article: ONCOGENE. 2012;31(16):2075-2089

Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models.

Härmä V; Knuuttila M; Virtanen J; Mirtti T; Kohonen P; Kovanen P; Happonen A; Kaewphan S; Ahonen I; Kallioniemi O; Grafström R; Lötjönen J; Nees M
Article: AMERICAN JOURNAL OF PATHOLOGY. 2012;180(2):457-472

Differentiation-promoting culture of competent and noncompetent keratinocytes identifies biomarkers for head and neck cancer.

Ceder R; Haig Y; Merne M; Hansson A; Zheng X; Roberg K; Nees M; Iljin K; Bloor BK; Morgan PR; Fadeel B; Grafström RC
Article: PLOS ONE. 2012;7(1):e28776

CD44 expression in oro-pharyngeal carcinoma tissues and cell lines.

Rajarajan A; Stokes A; Bloor BK; Ceder R; Desai H; Grafström RC; Odell EW
Article: PLOS ONE. 2012;7(9):e46001

MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters: implications for nephrogenesis and the development of renal cancer.

Hansson ML; Behmer S; Ceder R; Mohammadi S; Preta G; Grafström RC; Fadeel B; Wallberg AE
Article: BMC RESEARCH NOTES. 2011;4:487

Computational toxicology using the OpenTox application programming interface and Bioclipse.

Willighagen EL; Jeliazkova N; Hardy B; Grafström RC; Spjuth O
Article: JOURNAL OF ORAL PATHOLOGY & MEDICINE. 2011;40(10):739-746

Combining factors on protein and gene level to predict radioresponse in head and neck cancer cell lines.

Farnebo L; Jerhammar F; Ceder R; Grafström RC; Vainikka L; Thunell L; Grénman R; Johansson A-C; Roberg K
Article: CANCER BIOLOGY & THERAPY. 2010;10(12):1244-1251

Fibronectin 1 is a potential biomarker for radioresistance in head and neck squamous cell carcinoma.

Jerhammar F; Ceder R; Garvin S; Grénman R; Grafström RC; Roberg K
Article: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2010;32(9):1185-1194

Intrinsic differences in cisplatin sensitivity of head and neck cancer cell lines: Correlation to lysosomal pH.

Nilsson C; Roberg K; Grafström RC; Ollinger K
Article: ORAL ONCOLOGY. 2009;45(10):866-871

Matrix metalloproteinase-7 and -13 expression associate to cisplatin resistance in head and neck cancer cell lines.

Ansell A; Jerhammar F; Ceder R; Grafström R; Grénman R; Roberg K
Article: CLINICAL CANCER RESEARCH. 2009;15(19):6070-6078

High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth.

Iljin K; Ketola K; Vainio P; Halonen P; Kohonen P; Fey V; Grafström RC; Perälä M; Kallioniemi O
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;180(1):113-118

Medium-chain fatty acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol dehydrogenase 3.

Staab CA; Hellgren M; Grafström RC; Höög J-O
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2008;233(3):355-359

Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde.

Thompson CM; Subramaniam RP; Grafström RC
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2008;65(22):3653-3663

Serum-responsive expression of carbonyl-metabolizing enzymes in normal and transformed human buccal keratinocytes.

Staab CA; Ceder R; Roberg K; Grafström RC; Höög J-O
Article: DIFFERENTIATION. 2008;76(8):868-880

Multiple genotypic aberrances associate to terminal differentiation-deficiency of an oral squamous cell carcinoma in serum-free culture.

Roberg K; Ceder R; Farnebo L; Norberg-Spaak L; Grafström RC
Article: BIOCHEMICAL JOURNAL. 2008;413(3):493-504

Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors.

Staab CA; Alander J; Brandt M; Lengqvist J; Morgenstern R; Grafström RC; Höög J-O
Article: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES. 2007;71(3):244-248

Mechanistic considerations for formaldehyde-induced bronchoconstriction involving S-nitrosoglutathione reductase.

Thompson CM; Grafström RC
Article: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2007;35(6):621-639

The application of normal, SV40 T-antigen-immortalised and tumour-derived oral keratinocytes, under serum-free conditions, to the study of the probability of cancer progression as a result of environmental exposure to chemicals.

Ceder R; Merne M; Staab CA; Nilsson JA; Höög J-O; Dressler D; Engelhart K; Grafström RC
Article: JOURNAL OF PROTEOME RESEARCH. 2007;6(9):3705-3717

Bioinformatics processing of protein and transcript profiles of normal and transformed cell lines indicates functional impairment of transcriptional regulators in buccal carcinoma.

Staab CA; Ceder R; Jägerbrink T; Nilsson J-A; Roberg K; Jörnvall H; Höög J-O; Grafström RC
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2004;47(24):5894-5911

Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.

Markwalder JA; Arnone MR; Benfield PA; Boisclair M; Burton CR; Chang C-H; Cox SS; Czerniak PM; Dean CL; Doleniak D; Grafstrom R; Harrison BA; Kaltenbach RF; Nugiel DA; Rossi KA; Sherk SR; Sisk LM; Stouten P; Trainor GL; Worland P; Seitz SP
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2004;61(5):610-617

Alcohol dehydrogenase 3 transcription associates with proliferation of human oral keratinocytes.

Nilsson JA; Hedberg JJ; Vondracek M; Staab CA; Hansson A; Höög J-O; Grafström RC
Article: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2003;31(6):575-585

Microarray assessment of fibronectin, collagen and integrin expression and the role of fibronectin-collagen coating in the growth of normal, SV40 T-antigen-immortalised and malignant human oral keratinocytes.

Sarang Z; Haig Y; Hansson A; Vondracek M; Wärngård L; Grafström R
Article: EUROPEAN JOURNAL OF ORAL SCIENCES. 2003;111(1):34-41

Analysis of proliferation, apoptosis and keratin expression in cultured normal and immortalized human buccal keratinocytes.

Hansson A; Bloor BK; Sarang Z; Haig Y; Morgan PR; Stark H-J; Fusenig NE; Ekstrand J; Grafström RC
Article: INTERNATIONAL JOURNAL OF CANCER. 2002;99(6):776-782

Transcript profiling of enzymes involved in detoxification of xenobiotics and reactive oxygen in human normal and simian virus 40 T antigen-immortalized oral keratinocytes.

Vondracek M; Weaver DA; Sarang Z; Hedberg JJ; Willey JC; Wärngård L; Grafström RC
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2002;20(5):897-903

Expression of retinoid-related genes in serum-free cultures of normal, immortalized and malignant human oral keratinocytes.

Dressler D; Sarang Z; Szondy Z; Engelhart K; Grafström RC
Article: MOLECULAR DIAGNOSIS & THERAPY. 2001;6(4):217-225

Reproducible gene expression measurement among multiple laboratories obtained in a blinded study using standardized RT (StaRT)-PCR.

Crawford EL; Peters GJ; Noordhuis P; Rots MG; Vondracek M; Grafström RC; Lieuallen K; Lennon G; Zahorchak RJ; Georgeson MJ; Wali A; Lechner JF; Fan PS; Kahaleh MB; Khuder SA; Warner KA; Weaver DA; Willey JC
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2001;58(11):1719-1726

Micro-array chip analysis of carbonyl-metabolising enzymes in normal, immortalised and malignant human oral keratinocytes.

Hedberg JJ; Grafström RC; Vondracek M; Sarang Z; Wärngård L; Höög JO
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2001;11(16):2209-2211

Identification of selective inhibitors of cyclin dependent kinase 4.

Carini DJ; Kaltenbach RF; Liu J; Benfield PA; Boylan J; Boisclair M; Brizuela L; Burton CR; Cox S; Grafstrom R; Harrison BA; Harrison K; Akamike E; Markwalder JA; Nakano Y; Seitz SP; Sharp DM; Trainor GL; Sielecki TM
Article: ORAL ONCOLOGY. 2001;37(5):419-430

Expression of keratins in normal, immortalized and malignant oral epithelia in organotypic culture.

Hansson A; Bloor BK; Haig Y; Morgan PR; Ekstrand J; Grafström RC
Article: CARCINOGENESIS. 2001;22(3):481-488

Cytochrome P450 expression and related metabolism in human buccal mucosa.

Vondracek M; Xi Z; Larsson P; Baker V; Mace K; Pfeifer A; Tjälve H; Donato MT; Gomez-Lechon MJ; Grafström RC
Article: AMERICAN JOURNAL OF PATHOLOGY. 2000;157(5):1745-1755

Expression of alcohol dehydrogenase 3 in tissue and cultured cells from human oral mucosa.

Hedberg JJ; Höög JO; Nilsson JA; Xi Z; Elfwing A; Grafström RC
Article: JOURNAL OF DENTAL RESEARCH. 1998;77(11):1896-1903

Toxicity of formaldehyde to human oral fibroblasts and epithelial cells: influences of culture conditions and role of thiol status.

Nilsson JA; Zheng X; Sundqvist K; Liu Y; Atzori L; Elfwing A; Arvidson K; Grafström RC
Article: CARCINOGENESIS. 1998;19(5):765-769

Defining the minimal portion of the retinoblastoma protein that serves as an efficient substrate for cdk4 kinase/cyclin D1 complex.

Pan W; Sun T; Hoess R; Grafstrom R
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 1998;108(3):197-208

Formation of DNA adducts in human buccal epithelial cells exposed to acetaldehyde and methylglyoxal in vitro.

Vaca CE; Nilsson JA; Fang JL; Grafström RC
Article: CARCINOGENESIS. 1997;18(10):1889-1895

O6-methylguanine-DNA methyltransferase activity in human buccal mucosal tissue and cell cultures. Complex mixtures related to habitual use of tobacco and betel quid inhibit the activity in vitro.

Liu Y; Egyhazi S; Hansson J; Bhide SV; Kulkarni PS; Grafström RC
Article: NATURE MEDICINE. 1997;3(6):632-638

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain.

Selivanova G; Iotsova V; Okan I; Fritsche M; Ström M; Groner B; Grafström RC; Wiman KG
Article: NUCLEIC ACIDS RESEARCH. 1996;24(18):3560-3567

The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.

Selivanova G; Iotsova V; Kiseleva E; Ström M; Bakalkin G; Grafström RC; Wiman KG
Article: ANTICANCER RESEARCH. 1996;16(5A):2681-2686

Non-tumorigenic SV40T immortalized human buccal epithelial cells show aneuploidy and genetic instability.

Kulkarni Schmidt-Kastner PS; Heiden T; Tribukait B; Grafström RC
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;7(5):1123-1128

Identification of genes overexpressed in the sqcc/y1 human buccal carcinoma cell-line using the differential display method.

Sundqvist K; Iotsova V; Ziaie S; Wiman K; Hoog C; Grafstrom R
Article: CARCINOGENESIS. 1995;16(10):2515-2521

Characterization of human buccal epithelial cells transfected with the simian virus 40 T-antigen gene.

Kulkarni PS; Sundqvist K; Betsholtz C; Höglund P; Wiman KG; Zhivotovsky B; Bertolero F; Liu Y; Grafström RC
Article: GLYCOBIOLOGY. 1995;5(1):97-104

A 23 kDa membrane glycoprotein bearing NeuNAc alpha 2-3Gal beta 1-3GalNAc O-linked carbohydrate chains acts as a receptor for Streptococcus sanguis OMZ 9 on human buccal epithelial cells.

Neeser JR; Grafström RC; Woltz A; Brassart D; Fryder V; Guggenheim B
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Editorial comment: NATURE NANOTECHNOLOGY. 2022;17(1):19-20

Reply to: Prospects and challenges for FAIR toxicogenomics data.

Grafström R; Haase A; Kohonen P; Jeliazkova N; Nymark P
Review: NANOMATERIALS. 2020;10(5):E903-903

Transcriptomics in Toxicogenomics, Part II: Preprocessing and Differential Expression Analysis for High Quality Data.

Federico A; Serra A; Ha MK; Kohonen P; Choi J-S; Liampa I; Nymark P; Sanabria N; Cattelani L; Fratello M; Kinaret PAS; Jagiello K; Puzyn T; Melagraki G; Gulumian M; Afantitis A; Sarimveis H; Yoon T-H; Grafström R; Greco D
Review: NANOMATERIALS. 2020;10(4):E750-750

Transcriptomics in Toxicogenomics, Part I: Experimental Design, Technologies, Publicly Available Data, and Regulatory Aspects.

Kinaret PAS; Serra A; Federico A; Kohonen P; Nymark P; Liampa I; Ha MK; Choi J-S; Jagiello K; Sanabria N; Melagraki G; Cattelani L; Fratello M; Sarimveis H; Afantitis A; Yoon T-H; Gulumian M; Grafström R; Puzyn T; Greco D
Review: NANOMATERIALS. 2020;10(4):E708-708

Transcriptomics in Toxicogenomics, Part III: Data Modelling for Risk Assessment.

Serra A; Fratello M; Cattelani L; Liampa I; Melagraki G; Kohonen P; Nymark P; Federico A; Kinaret PAS; Jagiello K; Ha MK; Choi J-S; Sanabria N; Gulumian M; Puzyn T; Yoon T-H; Sarimveis H; Grafström R; Afantitis A; Greco D
Review: SMALL. 2020;16(6):e1904749

Toward Rigorous Materials Production: New Approach Methodologies Have Extensive Potential to Improve Current Safety Assessment Practices.

Nymark P; Bakker M; Dekkers S; Franken R; Fransman W; García-Bilbao A; Greco D; Gulumian M; Hadrup N; Halappanavar S; Hongisto V; Hougaard KS; Jensen KA; Kohonen P; Koivisto AJ; Dal Maso M; Oosterwijk T; Poikkimäki M; Rodriguez-Llopis I; Stierum R; Sørli JB; Grafström R
Review: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2020;18:583-602

NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment.

Afantitis A; Melagraki G; Isigonis P; Tsoumanis A; Varsou DD; Valsami-Jones E; Papadiamantis A; Ellis L-JA; Sarimveis H; Doganis P; Karatzas P; Tsiros P; Liampa I; Lobaskin V; Greco D; Serra A; Kinaret PAS; Saarimäki LA; Grafström R; Kohonen P; Nymark P; Willighagen E; Puzyn T; Rybinska-Fryca A; Lyubartsev A; Alstrup Jensen K; Brandenburg JG; Lofts S; Svendsen C; Harrison S; Maier D; Tamm K; Jänes J; Sikk L; Dusinska M; Longhin E; Rundén-Pran E; Mariussen E; El Yamani N; Unger W; Radnik J; Tropsha A; Cohen Y; Leszczynski J; Ogilvie Hendren C; Wiesner M; Winkler D; Suzuki N; Yoon TH; Choi J-S; Sanabria N; Gulumian M; Lynch I
Review: NANOIMPACT. 2019;16:100182

Nanomaterial grouping: Existing approaches and future recommendations

Giusti A; Atluri R; Tsekovska R; Gajewicz A; Apostolova MD; Battistelli CL; Bleeker EAJ; Bossa C; Bouillard J; Dusinska M; Gomez-Fernandez P; Grafstrom R; Gromelski M; Handzhiyski Y; Jacobsen NR; Jantunen P; Jensen KA; Mech A; Navas JM; Nymark P; Oomen AG; Puzyn T; Rasmussen K; Riebeling C; Rodriguez-Llopis I; Sabella S; Sintes JR; Suarez-Merino B; Tanasescu S; Wallin H; Haase A
Review: NANOTOXICOLOGY. 2019;13(1):119-141

Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation.

Mech A; Rasmussen K; Jantunen P; Aicher L; Alessandrelli M; Bernauer U; Bleeker EAJ; Bouillard J; Di Prospero Fanghella P; Draisci R; Dusinska M; Encheva G; Flament G; Haase A; Handzhiyski Y; Herzberg F; Huwyler J; Jacobsen NR; Jeliazkov V; Jeliazkova N; Nymark P; Grafström R; Oomen AG; Polci ML; Riebeling C; Sandström J; Shivachev B; Stateva S; Tanasescu S; Tsekovska R; Wallin H; Wilks MF; Zellmer S; Apostolova MD
Published conference paper: ANNALS OF THE AMERICAN THORACIC SOCIETY. 2018;15(Suppl 2):S91-S97

Toxic and Genomic Influences of Inhaled Nanomaterials as a Basis for Predicting Adverse Outcome.

Nymark P; Kohonen P; Hongisto V; Grafström RC
Review: WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY. 2017;9(1):e1413

High throughput toxicity screening and intracellular detection of nanomaterials.

Collins AR; Annangi B; Rubio L; Marcos R; Dorn M; Merker C; Estrela-Lopis I; Cimpan MR; Ibrahim M; Cimpan E; Ostermann M; Sauter A; Yamani NE; Shaposhnikov S; Chevillard S; Paget V; Grall R; Delic J; de-Cerio FG; Suarez-Merino B; Fessard V; Hogeveen KN; Fjellsbø LM; Pran ER; Brzicova T; Topinka J; Silva MJ; Leite PE; Ribeiro AR; Granjeiro JM; Grafström R; Prina-Mello A; Dusinska M
Review: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION. 2016;56(4):614-634

Consumption of Red/Processed Meat and Colorectal Carcinoma: Possible Mechanisms Underlying the Significant Association.

Hammerling U; Bergman Laurila J; Grafström R; Ilbäck N-G
Review: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2014;115(1):50-58

Cancer biology, toxicology and alternative methods development go hand-in-hand.

Kohonen P; Ceder R; Smit I; Hongisto V; Myatt G; Hardy B; Spjuth O; Grafström R
Letter: LEUKEMIA. 2011;25(5):868-872

HAX-1 expression in human B lymphoma.

Kwiecinska A; Ottosson-Wadlund A; Ceder R; Grafström RC; Björck E; Nordenskjöld M; Porwit A; Fadeel B
Letter: TOXICOLOGICAL SCIENCES. 2011;120(1):230-232

Considerations for the implausibility of leukemia induction by formaldehyde.

Thompson CM; Grafström RC
Editorial comment: TOXICOLOGY LETTERS. 2010;193(1):1-3

Formaldehyde dehydrogenase: beyond phase I metabolism.

Thompson CM; Ceder R; Grafström RC
Editorial comment: ENVIRONMENTAL HEALTH. 2009;8:53

Commentary: mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma.

Thompson CM; Grafström RC
Review: DRUG METABOLISM AND DISPOSITION. 2009;37(8):1565-1571

The ontogeny, distribution, and regulation of alcohol dehydrogenase 3: implications for pulmonary physiology.

Thompson CM; Sonawane B; Grafström RC
Review: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION. 2009;49(7):626-669

Comparative hazard characterization in food toxicology.

Hammerling U; Tallsjö A; Grafström R; Ilbäck N-G
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;178(1-3):29-35

The Janus face of alcohol dehydrogenase 3.

Staab CA; Alander J; Morgenstern R; Grafström RC; Höög J-O
Published conference paper: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2004;32(4):401-405

Modelling of normal and premalignant oral tissue by using the immortalised cell line, SVpgC2a: a review of the value of the model.

Staab CA; Vondracek M; Custodio H; Johansson K; Nilsson JA; Morgan P; Höög J-O; Cotgreave I; Grafström RC
Published conference paper: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2001;29(3):325-333

Uniform expression of alcohol dehydrogenase 3 in epithelia regenerated with cultured normal, immortalised and malignant human oral keratinocytes.

Hedberg JJ; Hansson A; Nilsson JA; Höög JO; Grafström RC
Review: RECENT RESULTS IN CANCER RESEARCH. 1997;143:275-306

Growth and transformation of human oral epithelium in vitro.

Grafström RC; Norén UG; Zheng X; Elfwing A; Sundqvist K
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