About me


Research description

My research is mainly focused on understanding the immune mechanisms underlying periodontal disease and its interplay with other chronic diseases. Another line of investigation relates to the identification of salivary biomarkers for monitoring of chronic inflammatory diseases.


Association of salivary TREM-1 and PGLYRP1 inflammatory markers with non-communicable diseases.
Silbereisen A, Lira-Junior R, Åkerman S, Klinge B, Boström EA, Bostanci N
J Clin Periodontol 2023 Jul;():

Inflammatory markers in saliva and urine reflect disease activity in patients with systemic lupus erythematosus.
Ruacho G, Lira-Junior R, Gunnarsson I, Svenungsson E, Boström EA
Lupus Sci Med 2022 Mar;9(1):

Colony-stimulating factor-1 receptor blockade attenuates inflammation in inflamed gingival tissue explants.
Clark R, Lira-Junior R, Johannsen G, Boström EA
J Periodontal Res 2021 Dec;56(6):1141-1153

Levels of myeloid-related proteins in saliva for screening and monitoring of periodontal disease.
Lira-Junior R, Bissett SM, Preshaw PM, Taylor JJ, Boström EA
J Clin Periodontol 2021 Nov;48(11):1430-1440

Impact of chronic gingivitis management on the cytokine and anti-PPAD expressions in juvenile systemic lupus erythematosus: A six-month follow-up.
Sete MRC, Carlos JC, Mello-Neto JM, Lira-Junior R, Brito F, Bostrom EA, Sztajnbok FR, Figueredo CM
J Periodontal Res 2021 Dec;56(6):1132-1140

What is the future of Periodontal Medicine?
Fischer RG, Gomes Filho IS, Cruz SSD, Oliveira VB, Lira-Junior R, Scannapieco FA, Rego RO
Braz Oral Res 2021 ;35(Supp 2):e102

Periodontitis is associated to increased systemic inflammation in postmyocardial infarction patients.
Lira-Junior R, Boström EA, Gustafsson A,
Open Heart 2021 08;8(2):

Peri-implant treatment reduces the salivary levels of Colony stimulator factor-1 and S100A8/A9.
de Mello-Neto JM, Teixeira MKS, Teixeira GS, Lourenço EJV, Telles DM, Lira-Junior R, Ipe D, Nair RG, Boström EA, Figueredo CM
Odontology 2021 Apr;109(2):540-546

Adjunctive Antiseptic Irrigation of Periodontal Pockets: Effects on Microbial and Cytokine Profiles.
Vitt A, Babenka A, Boström EA, Gustafsson A, Lira Junior R, Slizen V, et al
Dent J (Basel) 2020 Nov;8(4):

Salivary and Serum Inflammatory Profiles Reflect Different Aspects of Inflammatory Bowel Disease Activity.
Majster M, Lira-Junior R, Höög CM, Almer S, Boström EA
Inflamm Bowel Dis 2020 Sep;26(10):1588-1596

Periodontal disease and its impact on general health in Latin America. Section V: Treatment of periodontitis.
Fischer RG, Lira Junior R, Retamal-Valdes B, Figueiredo LC, Malheiros Z, Stewart B, et al
Braz Oral Res 2020 ;34(supp1 1):e026

S100A12 Expression Is Modulated During Monocyte Differentiation and Reflects Periodontitis Severity.
Lira-Junior R, Holmström SB, Clark R, Zwicker S, Majster M, Johannsen G, et al
Front Immunol 2020 ;11():86

Clinical, immunological and microbial gingival profile of juvenile systemic lupus erythematosus patients.
Sete MRC, Carlos JC, Lira-Junior R, Boström EA, Sztajnbok FR, Figueredo CM
Lupus 2019 Feb;28(2):189-198

MMP-12 and S100s in saliva reflect different aspects of periodontal inflammation.
Holmström SB, Lira-Junior R, Zwicker S, Majster M, Gustafsson A, Åkerman S, et al
Cytokine 2019 01;113():155-161

Salivary microbial profiles in relation to age, periodontal, and systemic diseases.
Lira-Junior R, Åkerman S, Klinge B, Boström EA, Gustafsson A
PLoS ONE 2018 ;13(3):e0189374

Oral-gut connection: one step closer to an integrated view of the gastrointestinal tract?
Lira-Junior R, Boström EA
Mucosal Immunol 2018 03;11(2):316-318

Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases.
Lira-Junior R, Åkerman S, Gustafsson A, Klinge B, Boström EA
Sci Rep 2017 08;7(1):7280

Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis.
Lira-Junior R, Öztürk VÖ, Emingil G, Bostanci N, Boström EA
J. Periodontol. 2017 12;88(12):1339-1347


2018 - PhD in Periodontology, UERJ (Brazil)

2014 - MDSc in Periodontology, UERJ (Brazil)

2011 - Dentistry, UFPB (Brazil)