Rune Toftgård

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Articles

Article: TRANSGENIC RESEARCH. 2021;30(5):701-707

Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Krüppel-like factor 5 (Klf5).

Bergström Å; Gerling M; Van Hul N; Fernández Moro C; Rozell B; Toftgård R; Sur I
Article: INTERNATIONAL JOURNAL OF CANCER. 2020;146(4):1125-1138

GLI1-induced mammary gland tumours are transplantable and maintain major molecular features.

Norum JH; Frings O; Kasper M; Bergholtz H; Zell Thime H; Bergström Å; Andersson A; Kuiper R; Fredlund E; Sørlie T; Toftgård R
Article: DEVELOPMENTAL BIOLOGY. 2017;429(1):132-146

Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.

Hoelzl MA; Heby-Henricson K; Gerling M; Dias JM; Kuiper RV; Trünkle C; Bergström Å; Ericson J; Toftgård R; Teglund S
Article: NATURE CELL BIOLOGY. 2016;18(12):1346-1356

Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.

Blaas L; Pucci F; Messal HA; Andersson AB; Josue Ruiz E; Gerling M; Douagi I; Spencer-Dene B; Musch A; Mitter R; Bhaw L; Stone R; Bornhorst D; Sesay AK; Jonkers J; Stamp G; Malanchi I; Toftgård R; Behrens A
Article: NATURE COMMUNICATIONS. 2016;7:12321

Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth.

Gerling M; Büller NVJA; Kirn LM; Joost S; Frings O; Englert B; Bergström Å; Kuiper RV; Blaas L; Wielenga MCB; Almer S; Kühl AA; Fredlund E; van den Brink GR; Toftgård R
Article: EMBO JOURNAL. 2016;35(13):1400-1416

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.

Raducu M; Fung E; Serres S; Infante P; Barberis A; Fischer R; Bristow C; Thézénas M-L; Finta C; Christianson JC; Buffa FM; Kessler BM; Sibson NR; Di Marcotullio L; Toftgård R; D'Angiolella V
Article: NATURE COMMUNICATIONS. 2016;7:11314

FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.

Bosma M; Gerling M; Pasto J; Georgiadi A; Graham E; Shilkova O; Iwata Y; Almer S; Söderman J; Toftgård R; Wermeling F; Boström EA; Boström PA
Article: METHODS IN MOLECULAR BIOLOGY. 2016;1453:123-136

Isolation and Fluorescence-Activated Cell Sorting of Mouse Keratinocytes Expressing β-Galactosidase.

Kasper M; Toftgård R; Jaks V
Article: STEM CELL REPORTS. 2015;5(5):843-855

Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.

Füllgrabe A; Joost S; Are A; Jacob T; Sivan U; Haegebarth A; Linnarsson S; Simons BD; Clevers H; Toftgård R; Kasper M
Article: STEM CELLS AND DEVELOPMENT. 2015;24(21):2547-2560

Suppressor of Fused Plays an Important Role in Regulating Mesodermal Differentiation of Murine Embryonic Stem Cells In Vivo.

Hoelzl MA; Heby-Henricson K; Bilousova G; Rozell B; Kuiper RV; Kasper M; Toftgård R; Teglund S
Article: DEVELOPMENTAL BIOLOGY. 2015;404(2):35-48

A conditional transgenic mouse line for targeted expression of the stem cell marker LGR5.

Norum JH; Bergström Å; Andersson AB; Kuiper RV; Hoelzl MA; Sørlie T; Toftgård R
Article: MOLECULAR CANCER. 2015;14(1):17

β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma.

Zinke J; Schneider FT; Harter PN; Thom S; Ziegler N; Toftgård R; Plate KH; Liebner S
Article: CELL REPORTS. 2014;7(3):747-761

Regulated splicing of the α6 integrin cytoplasmic domain determines the fate of breast cancer stem cells.

Goel HL; Gritsko T; Pursell B; Chang C; Shultz LD; Greiner DL; Norum JH; Toftgard R; Shaw LM; Mercurio AM
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2013;69(Pt 12):2563-2579

Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.

Cherry AL; Finta C; Karlström M; Jin Q; Schwend T; Astorga-Wells J; Zubarev RA; Del Campo M; Criswell AR; de Sanctis D; Jovine L; Toftgård R
Article: IMMUNITY. 2013;39(5):899-911

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice.

Kumari S; Bonnet MC; Ulvmar MH; Wolk K; Karagianni N; Witte E; Uthoff-Hachenberg C; Renauld J-C; Kollias G; Toftgard R; Sabat R; Pasparakis M; Haase I
Article: CELL DEATH AND DIFFERENTIATION. 2013;20(8):1080-1088

Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis.

Chari NS; Romano RA; Koster MI; Jaks V; Roop D; Flores ER; Teglund S; Sinha S; Gruber W; Aberger F; Medeiros LJ; Toftgard R; McDonnell TJ
Journal article: PANCREATOLOGY. 2013;13(3):s19

Detection of hypoxic areas in a syngeneic, orthotopic model of pancreatic ductal adenocarcinoma in mouse by in vivo imaging using photoacoustics

Heuchel R; Gerling M; Zhao Y; Jose J; Norberg J; Toftgård R; Löhr M
Article: EMBO MOLECULAR MEDICINE. 2013;5(4):488-508

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.

Goel HL; Pursell B; Chang C; Shaw LM; Mao J; Simin K; Kumar P; Vander Kooi CW; Shultz LD; Greiner DL; Norum JH; Toftgard R; Kuperwasser C; Mercurio AM
Article: GUT. 2013;62(3):348-357

Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus.

van Dop WA; Rosekrans SL; Uhmann A; Jaks V; Offerhaus GJA; van den Bergh Weerman MA; Kasper M; Heijmans J; Hardwick JCH; Verspaget HW; Hommes DW; Toftgård R; Hahn H; van den Brink GR
Article: BMC CANCER. 2013;13:95

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing.

Longati P; Jia X; Eimer J; Wagman A; Witt M-R; Rehnmark S; Verbeke C; Toftgård R; Löhr M; Heuchel RL
Article: MOLECULAR CARCINOGENESIS. 2012;51(9):754-760

Loss of Trp53 promotes medulloblastoma development but not skin tumorigenesis in Sufu heterozygous mutant mice.

Heby-Henricson K; Bergström A; Rozell B; Toftgård R; Teglund S
Article: AMERICAN JOURNAL OF PATHOLOGY. 2011;179(5):2569-2579

Targeted expression of GLI1 in the salivary glands results in an altered differentiation program and hyperplasia.

Fiaschi M; Kolterud A; Nilsson M; Toftgård R; Rozell B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(10):4099-4104

Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.

Kasper M; Jaks V; Are A; Bergström Å; Schwäger A; Svärd J; Teglund S; Barker N; Toftgård R
Article: PLOS ONE. 2011;6(6):e20580

Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.

Massinen S; Hokkanen M-E; Matsson H; Tammimies K; Tapia-Páez I; Dahlström-Heuser V; Kuja-Panula J; Burghoorn J; Jeppsson KE; Swoboda P; Peyrard-Janvid M; Toftgård R; Castrén E; Kere J
Article: MOLECULAR PHARMACOLOGY. 2010;78(3):486-496

Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels.

Lauth M; Rohnalter V; Bergström A; Kooshesh M; Svenningsson P; Toftgård R
Article: GENES AND CANCER. 2010;1(9):941-951

Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway.

Tostar U; Toftgård R; Zaphiropoulos PG; Shimokawa T
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2010;17(6):718-725

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.

Lauth M; Bergström A; Shimokawa T; Tostar U; Jin Q; Fendrich V; Guerra C; Barbacid M; Toftgård R
Article: SCIENCE. 2010;327(5971):1385-1389

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.

Snippert HJ; Haegebarth A; Kasper M; Jaks V; van Es JH; Barker N; van de Wetering M; van den Born M; Begthel H; Vries RG; Stange DE; Toftgård R; Clevers H
Article: EXPERIMENTAL DERMATOLOGY. 2009;18(12):1044-1052

MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer.

Boyd S; Virolainen S; Pärssinen J; Skoog T; van Hogerlinden M; Latonen L; Kyllönen L; Toftgard R; Saarialho-Kere U
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2009;129(11):2584-2593

Timed NF-kappaB inhibition in skin reveals dual independent effects on development of HED/EDA and chronic inflammation.

Ulvmar MH; Sur I; Mémet S; Toftgård R
Article: DEVELOPMENTAL BIOLOGY. 2009;330(2):452-460

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia.

Jia J; Kolterud A; Zeng H; Hoover A; Teglund S; Toftgård R; Liu A
Article: CANCER RESEARCH. 2009;69(11):4810-4817

Development of mammary tumors by conditional expression of GLI1.

Fiaschi M; Rozell B; Bergström A; Toftgård R
Article: MOLECULAR CARCINOGENESIS. 2009;48(5):408-419

Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice.

Svärd J; Rozell B; Toftgård R; Teglund S
Article: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION. 2009;29(1):44-51

Inhibition of NF-kappaB signaling interferes with phorbol ester-induced growth arrest of keratinocytes in a TNFR1-independent manner.

Sur I; Ulvmar M; Jungedal R; Toftgård R
Article: NATURE GENETICS. 2008;40(11):1291-1299

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

Jaks V; Barker N; Kasper M; van Es JH; Snippert HJ; Clevers H; Toftgård R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(21):14345-14354

Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal.

Shimokawa T; Tostar U; Lauth M; Palaniswamy R; Kasper M; Toftgård R; Zaphiropoulos PG
Article: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 2008;73:351-356

Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells.

Barker N; van Es JH; Jaks V; Kasper M; Snippert H; Toftgård R; Clevers H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(49):36090-36101

Targeted expression of GLI1 in the mammary gland disrupts pregnancy-induced maturation and causes lactation failure.

Fiaschi M; Rozell B; Bergström A; Toftgård R; Kleman MI
Article: CELL CYCLE. 2007;6(20):2458-2463

Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy.

Lauth M; Toftgård R
Article: ONCOGENE. 2007;26(35):5163-5168

Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli.

Lauth M; Bergström A; Toftgård R
Article: ONCOGENE. 2007;26(34):4889-4896

Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling.

Shimokawa T; Svärd J; Heby-Henricson K; Teglund S; Toftgård R; Zaphiropoulos PG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(20):8455-8460

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.

Lauth M; Bergström A; Shimokawa T; Toftgård R
Article: NATURE GENETICS. 2006;38(10):1204-1209

Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus.

Lee K; Jeong J; Kwak I; Yu C-T; Lanske B; Soegiarto DW; Toftgard R; Tsai M-J; Tsai S; Lydon JP; DeMayo FJ
Article: JOURNAL OF CELL SCIENCE. 2006;119(Pt 17):3593-3601

Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis.

Sur I; Rozell B; Jaks V; Bergström A; Toftgård R
Article: BIOCHEMICAL JOURNAL. 2006;394(Pt 1):19-26

Inhibition of GLI1 gene activation by Patched1.

Rahnama F; Shimokawa T; Lauth M; Finta C; Kogerman P; Teglund S; Toftgård R; Zaphiropoulos PG
Article: DEVELOPMENTAL CELL. 2006;10(2):187-197

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.

Svärd J; Heby-Henricson K; Persson-Lek M; Rozell B; Lauth M; Bergström A; Ericson J; Toftgård R; Teglund S
Article: JOURNAL OF PATHOLOGY. 2006;208(1):17-25

Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development.

Tostar U; Malm CJ; Meis-Kindblom JM; Kindblom L-G; Toftgård R; Undén AB
Article: BMC GENOMICS. 2004;5(1):49

The FU gene and its possible protein isoforms.

Østerlund T; Everman DB; Betz RC; Mosca M; Nöthen MM; Schwartz CE; Zaphiropoulos PG; Toftgård R
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2004;123(1):101-108

Characterization of the progressive skin disease and inflammatory cell infiltrate in mice with inhibited NF-kappaB signaling.

van Hogerlinden M; Rozell BL; Toftgård R; Sundberg JP
Article: CANCER RESEARCH. 2004;64(8):2699-2704

Ultraviolet irradiation represses PATCHED gene transcription in human epidermal keratinocytes through an activator protein-1-dependent process.

Brellier F; Marionnet C; Chevallier-Lagente O; Toftgard R; Mauviel A; Sarasin A; Magnaldo T
Article: GENE. 2004;330:101-114

Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site.

Agren M; Kogerman P; Kleman MI; Wessling M; Toftgård R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(14):4972-4977

Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition.

Lind MH; Rozell B; Wallin RPA; van Hogerlinden M; Ljunggren H-G; Toftgård R; Sur I
Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 2004;295(11):482-489

Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.

Maijgren S; Sur I; Nilsson M; Toftgård R
Article: BIOCHEMICAL JOURNAL. 2004;378(Pt 2):325-334

Distinct roles of PTCH2 splice variants in Hedgehog signalling.

Rahnama F; Toftgård R; Zaphiropoulos PG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(7):5621-5629

Role for ELOVL3 and fatty acid chain length in development of hair and skin function.

Westerberg R; Tvrdik P; Undén A-B; Månsson J-E; Norlén L; Jakobsson A; Holleran WH; Elias PM; Asadi A; Flodby P; Toftgård R; Capecchi MR; Jacobsson A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(2):1197-1205

Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1.

Bigelow RLH; Chari NS; Unden AB; Spurgers KB; Lee S; Roop DR; Toftgard R; McDonnell TJ
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2003;198(12):1959-1964

The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor.

Regamey A; Hohl D; Liu JW; Roger T; Kogerman P; Toftgard R; Huber M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(7):5116-5122

Characterization of the physical interaction of Gli proteins with SUFU proteins.

Dunaeva M; Michelson P; Kogerman P; Toftgard R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(38):35156-35161

Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1.

Mao J; Maye P; Kogerman P; Tejedor FJ; Toftgard R; Xie W; Wu G; Wu D
Article: ONCOGENE. 2002;21(39):6007-6016

Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein.

Kogerman P; Krause D; Rahnama F; Kogerman L; Undén AB; Zaphiropoulos PG; Toftgård R
Article: ONCOGENE. 2002;21(32):4969-4977

Inhibition of Rel/Nuclear Factor-kappaB signaling in skin results in defective DNA damage-induced cell cycle arrest and Ha-ras- and p53-independent tumor development.

van Hogerlinden M; Auer G; Toftgård R
Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2002;81(6):323-334

Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles.

Sur I; Undén AB; Toftgård R
Article: ONCOGENE. 2001;20(53):7770-7778

PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer.

Ling G; Ahmadian A; Persson A; Undén AB; Afink G; Williams C; Uhlén M; Toftgård R; Lundeberg J; Pontén F
Article: FEBS LETTERS. 2001;505(1):13-17

Genomic organization and embryonic expression of Suppressor of Fused, a candidate gene for the split-hand/split-foot malformation type 3.

Grimm T; Teglund S; Tackels D; Sangiorgi E; Gurrieri F; Schwartz C; Toftgård R
Article: BRITISH JOURNAL OF DERMATOLOGY. 2000;143(4):709-719

Retinoids induce apoptosis in cultured keratinocytes.

Islam TC; Skarin T; Sumitran S; Toftgård R
Article: MOLECULAR CELL BIOLOGY RESEARCH COMMUNICATIONS. 2000;3(6):367-373

Repression of transcription by HoxC11 upon phorbol ester stimulation.

Sur IP; Toftgård R
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2000;16(5):943-949

Patched 2, located in 1p32-34, is not mutated in high stage neuroblastoma tumors.

Jögi A; Abel F; Sjöberg RM; Toftgård R; Zaphiropoulos PG; Påhlman S; Martinsson T; Axelson H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(7):3438-3443

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1.

Nilsson M; Undèn AB; Krause D; Malmqwist U; Raza K; Zaphiropoulos PG; Toftgård R
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 1999;122(2):89-106

Protection against 12-O-tetradecanoylphorbol-13-acetate induced skin-hyperplasia and tumor promotion, in a two-stage carcinogenesis mouse model, by the 2,3-dimethyl-6(2-dimethylaminoethyl)-6H-indolo-[2,3-b]quinoxaline analogue of ellipticine.

Skarin T; Rozell BL; Bergman J; Toftgård R; Möller L
Article: NATURE CELL BIOLOGY. 1999;1(5):312-319

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1.

Kogerman P; Grimm T; Kogerman L; Krause D; Undén AB; Sandstedt B; Toftgård R; Zaphiropoulos PG
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 1999;21(2):177-184

Cis-acting sequences from the rat cytochrome P450 2B1 gene confer pulmonary and phenobarbital-inducible expression in transgenic mice.

Skarin T; Becher R; Bucht A; Duvefelt K; Bohm S; Ranneberg-Nilsen T; Lilleaas EM; Schwarze PE; Toftgârd R
Article: CANCER RESEARCH. 1999;59(14):3299-3303

Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling.

van Hogerlinden M; Rozell BL; Ahrlund-Richter L; Toftgård R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(19):13511-13518

Repression of dioxin signal transduction in fibroblasts. Identification Of a putative repressor associated with Arnt.

Gradin K; Toftgârd R; Poellinger L; Berghard A
Article: EUROPEAN JOURNAL OF CANCER. 1999;35(5):711-713

The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations.

Vorechovský I; Benediktsson KP; Toftgård R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(6):2880-2884

GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization.

Shin SH; Kogerman P; Lindström E; Toftgárd R; Biesecker LG
Article: CANCER RESEARCH. 1999;59(4):787-792

PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas.

Zaphiropoulos PG; Undén AB; Rahnama F; Hollingsworth RE; Toftgård R
Article: CLINICAL GENETICS. 1998;54(3):239-241

Dinucleotide repeat polymorphism within the tumor suppressor gene PTCH at 9q22.

Louhelainen J; Lindström E; Hemminki K; Toftgård R
Article: BRITISH JOURNAL OF DERMATOLOGY. 1998;139(2):271-275

Treatment of venous leg ulcers with cryopreserved cultured allogeneic keratinocytes: a prospective open controlled study.

Lindgren C; Marcusson JA; Toftgård R
Article: MOLECULAR CARCINOGENESIS. 1998;21(2):87-92

Mutation analysis of the human homologue of Drosophila patched and the xeroderma pigmentosum complementation group A genes in squamous cell carcinomas of the skin.

Eklund LK; Lindström E; Undén AB; Lundh-Rozell B; Ståhle-Bäckdahl M; Zaphiropoulos PG; Toftgård R; Söderkvist P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(2):565-569

UVB-induced association of tumor necrosis factor (TNF) receptor 1/TNF receptor-associated factor-2 mediates activation of Rel proteins.

Tobin D; van Hogerlinden M; Toftgård R
Article: CANCER RESEARCH. 1997;57(21):4731-4735

Patched (ptch)-associated preferential expression of smoothened (smoh) in human basal cell carcinoma of the skin.

Kallassy M; Toftgård R; Ueda M; Nakazawa K; Vorechovský I; Yamasaki H; Nakazawa H
Article: CANCER RESEARCH. 1997;57(21):4677-4681

Trichoepitheliomas contain somatic mutations in the overexpressed PTCH gene: support for a gatekeeper mechanism in skin tumorigenesis.

Vorechovský I; Undén AB; Sandstedt B; Toftgård R; Ståhle-Bäckdahl M
Article: MOLECULAR CANCER RESEARCH. 1997;8(8):913-920

Characterization of a nuclear factor that binds juxtaposed with ATF3/Jun on a composite response element specifically mediating induced transcription in response to an epidermal growth factor/Ras/Raf signaling pathway.

Nilsson M; Ford J; Bohm S; Toftgård R
Article: ONCOGENE. 1997;15(3):361-366

Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours.

Vorechovský I; Tingby O; Hartman M; Strömberg B; Nister M; Collins VP; Toftgård R
Article: CANCER RESEARCH. 1997;57(12):2336-2340

Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma.

Undén AB; Zaphiropoulos PG; Bruce K; Toftgård R; Ståhle-Bäckdahl M
Article: CYTOGENETIC AND GENOME RESEARCH. 1997;76(3-4):208-213

Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: placement of a novel zinc finger gene within the NBCCS and ESS1 region.

Levanat S; Chidambaram A; Wicking C; Bray-Ward P; Pressman C; Toftgard R; Gailani MR; Myers JC; Wainwright B; Dean M; Bale AE
Article: ACTA DERMATO-VENEREOLOGICA. 1997;77(1):4-9

Fine mapping of the locus for nevoid basal cell carcinoma syndrome on chromosome 9q.

Undén AB; Ståhle-Bäckdahl M; Holmberg E; Larsson C; Toftgård R
Article: DNA AND CELL BIOLOGY. 1996;15(12):1049-1056

cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region.

Zaphiropoulos PG; Toftgård R
Article: CANCER RESEARCH. 1996;56(20):4562-4565

Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.

Unden AB; Holmberg E; Lundh-Rozell B; Stähle-Bäckdahl M; Zaphiropoulos PG; Toftgård R; Vorechovsky I
Article: MOLECULAR AND CELLULAR BIOLOGY. 1996;16(10):5221-5231

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.

Gradin K; McGuire J; Wenger RH; Kvietikova I; fhitelaw ML; Toftgård R; Tora L; Gassmann M; Poellinger L
Article: BRITISH JOURNAL OF CANCER. 1996;74(2):246-250

Differential allele loss on chromosome 9q22.3 in human non-melanoma skin cancer.

Holmberg E; Rozell BL; Toftgård R
Article: CELL. 1996;85(6):841-851

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.

Hahn H; Wicking C; Zaphiropoulous PG; Gailani MR; Shanley S; Chidambaram A; Vorechovsky I; Holmberg E; Unden AB; Gillies S; Negus K; Smyth I; Pressman C; Leffell DJ; Gerrard B; Goldstein AM; Dean M; Toftgard R; Chenevix-Trench G; Wainwright B; Bale AE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(21):12125-12128

A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities.

Hahn H; Christiansen J; Wicking C; Zaphiropoulos PG; Chidambaram A; Gerrard B; Vorechovsky I; Bale AE; Toftgard R; Dean M; Wainwright B
Article: ONCOGENE. 1996;12(4):785-793

Ras-independent activation of Rel-family transcription factors by UVB and TPA in cultured keratinocytes.

Tobin D; Nilsson M; Toftgård R
Article: IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL. 1995;31(10):790-795

Role of protein kinase C in growth stimulation of primary mouse colonic epithelial cells.

Branting C; Toftgård R; Hällström IP; Rafter J
Article: MOLECULAR PHARMACOLOGY. 1995;48(4):610-615

Differential effects of a topoisomerase I inhibitor on dioxin inducibility and high-level expression of the cytochrome P450IA1 gene.

Gradin K; Toftgård R; Berghard A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(20):12210-12218

Activated Ha-Ras but not TPA induces transcription through binding sites for activating transcription factor 3/Jun and a novel nuclear factor.

Nilsson M; Toftgård R; Bohm S
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1994;269(38):23800-23807

A tyrosine kinase-dependent pathway regulates ligand-dependent activation of the dioxin receptor in human keratinocytes.

Gradin K; Whitelaw ML; Toftgård R; Poellinger L; Berghard A
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1994;203(1):545-552

Nuclear orphan receptor-binding retinoic acid response elements in keratinocytes.

Islam TC; Toftgård R
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1994;201(3):1495-1501

Genetic instability of microsatellite markers in region q22.3-q31 of chromosome 9 in skin squamous cell carcinomas.

Zaphiropoulos PG; Söderkvist P; Hedblad MA; Toftgård R
Journal article: CARCINOGENESIS. 1993;14(8):1723-1725

Lack of initiating capacity of the genotoxic air pollutant 2-nitrofluorene in the mouse skin two-stage carcinogenesis system.

Möller L; Zeisig M; Toftgård R
Journal article: TOXICOLOGY. 1992;75(3):199-208

A subpopulation of 12-O-tetradecanoylphorbol-13-acetate-induced papillomas is not inhibited by retinoic acid.

Islam TC; Toftgård R
Journal article: ACTA CHIRURGICA SCANDINAVICA. 1991;:57-70

AIR-POLLUTANTS - A POSSIBLE FACTOR IN GASTROINTESTINAL CANCER

MOLLER L; TORNQUIST S; TOFTGARD R; RAFTER J; MIDTVEDT T; GUSTAFSSON JA
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1990;265(34):21086-21090

Serum and extracellular calcium modulate induction of cytochrome P-450IA1 in human keratinocytes.

Berghard A; Gradin K; Toftgård R
Journal article: CARCINOGENESIS. 1990;11(8):1249-1254

2-Nitrofluorene metabolism in the rat lung. Pharmacokinetic and metabolic effects of beta-naphthoflavone treatment.

Törnquist S; Möller L; Gabrielsson J; Gustafsson JA; Toftgård R
Journal article: CANCER RESEARCH. 1990;50(5):1626-1633

Isolation and characterization of complementary DNA clones corresponding to genes induced in mouse epidermis in vivo by tumor promoters.

Bohm S; Berghard A; Pereswetoff-Morath C; Toftgård R
Journal article: MOLECULAR INFORMATICS. 1989;8(2):83-89

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) ANALYSIS USING THE PARTIAL LEAST-SQUARES (PLS) METHOD - THE BINDING OF POLYCYCLIC AROMATIC-HYDROCARBONS (PAH) TO THE RAT-LIVER 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) RECEPTOR

JOHNELS D; GILLNER M; NORDEN B; TOFTGARD R; GUSTAFSSON JA
Journal article: CARCINOGENESIS. 1988;9(12):2209-2214

Age dependent expression of cytochrome P-450b and metabolism of the potent carcinogen 2-nitrofluorene in the rat lung.

Törnquist S; Sundin M; Möller L; Gustafsson JA; Toftgård R
Journal article: CANCER RESEARCH. 1988;48(11):3045-3049

Differential expression of the cytochrome P-450c and P-450d genes in the rat ventral prostate and liver.

Söderkvist P; Poellinger L; Toftgård R; Gustafsson JA
Journal article: TOXICOLOGY. 1986;39(3):225-231

Rat lung and liver cytochrome P-450 isozymes involved in the hydroxylation of m-xylene.

Toftgård R; Haaparanta T; Halpert J
Journal article: CANCER RESEARCH. 1985;45(11 Pt 2):5845-5850

Keratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate.

Toftgard R; Yuspa SH; Roop DR
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1985;54(2):185-198

Investigation of absorption, metabolism kinetics and DNA-binding of intratracheally administered benzo[a]pyrene in the isolated, perfused rat lung: a comparative study between microcrystalline and particulate adsorbed benzo[a]pyrene.

Törnquist S; Wiklund L; Toftgård R
Journal article: CARCINOGENESIS. 1985;6(4):655-657

Proto-oncogene expression during two-stage carcinogenesis in mouse skin.

Toftgard R; Roop DR; Yuspa SH
Journal article: ENVIRONMENT INTERNATIONAL. 1985;11(2-4):369-374

CHARACTERIZATION OF TCDD-RECEPTOR LIGANDS PRESENT IN EXTRACTS OF URBAN PARTICULATE MATTER

TOFTGARD R; FRANZEN B; GUSTAFSSON JA; LOFROTH G
Journal article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1985;455:426-435

The use of cDNA clones and monospecific antibodies as probes to monitor keratin gene expression.

Roop DR; Cheng CK; Toftgard R; Stanley JR; Steinert PM; Yuspa SH
Journal article: ENVIRONMENT INTERNATIONAL. 1985;11(2-4):347-354

PHARMACOKINETIC INVESTIGATION OF THE FATE OF PARTICLE ADSORBED POLYCYCLIC AROMATIC-HYDROCARBONS IN THE ISOLATED, PERFUSED AND VENTILATED RAT LUNG .1. DNA-BINDING, DOSE-DEPENDENT METABOLISM, AND BIOAVAILABILITY, USING BENZO(A)PYRENE AS THE MODEL-COMPOUND

TORNQUIST S; TOFTGARD R; WICKLUND L
Journal article: CARCINOGENESIS. 1984;5(7):925-930

Short-term bioassays of nitro derivatives of benzo[a]pyrene and perylene.

Löfroth G; Toftgård R; Nilsson L; Agurell E; Gustafsson JA
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1983;46(3):335-346

Compounds in urban air compete with 2,3,7,8-tetrachlorodibenzo-p-dioxin for binding to the receptor protein.

Toftgård R; Löfroth G; Carlstedt-Duke J; Kurl R; Gustafsson JA
Journal article: ARCHIVES OF TOXICOLOGY. 1982;50(1):1-10

Phthalate esters I: Effects on cytochrome P-450 mediated metabolism in rat liver and lung, serum enzymatic activities and serum protein levels.

Walseth F; Toftgård R; Nilsen OG
Journal article: TOXICOLOGY LETTERS. 1982;10(1):61-69

Induction of cytochrome P-450 related metabolic activities in the rat ventral prostate.

Söderkvist P; Toftgard R; Gustafsson JA
Journal article: TOXICOLOGY. 1982;23(2-3):197-212

Effects of xylene and xylene isomers on cytochrome P-450 and in vitro enzymatic activities in rat liver, kidney and lung.

Toftgård R; Nilsen OG
Journal article: ARCHIVES OF TOXICOLOGY. 1981;49(1):1-13

Effects of chlorinated paraffins on rat liver microsomal activities and morphology. Importance of the length and the degree of chlorination of the carbon chain.

Nilsen OG; Toftgård R; Glaumann H
Journal article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 1981;60(3):535-548

Production of discrete changes in dopamine and noradrenaline levels and turnover in various parts of the rat brain following exposure to xylene, ortho-, meta-, and para-xylene, and ethylbenzene.

Andersson K; Fuxe K; Nilsen OG; Toftgård R; Eneroth P; Gustafsson JA
Journal article: ACTA PHARMACOLOGICA ET TOXICOLOGICA. 1981;48(5):369-376

Regio-selectivity of purified forms of rabbit liver microsomal cytochrome P-450 in the metabolism of benzo(a)pyrene, n-hexane and 7-ethoxyresorufin.

Nilsen OG; Toftgård R; Eng L; Gustafsson JA
Journal article: SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH. 1981;7(1):31-37

Changes in rat liver microsomal cytochrome P-450 and enzymatic activities after the inhalation of n-hexane, xylene, methyl ethyl ketone and methylchloroform for four weeks.

Toftgård R; Nilsen OG; Gustafsson JA
Journal article: ARCHIVES OF TOXICOLOGY. 1981;47(1):1-11

Effects of polychlorinated terphenyls and paraffins on rat liver microsomal cytochrome P-450 and in vitro metabolic activities.

Nilsen OG; Toftgård R
Journal article: DEV TOXICOL ENVIRON SCI. 1980;8:525-528

Changes in rat liver morphology and metabolic activities after exposure to chlorinated paraffins.

Nilsen OG; Toftgård R; Glaumann H
Journal article: ACTA PHARMACOLOGICA ET TOXICOLOGICA. 1978;43(4):299-305

Qualitative alterations of cytochrome P-450 in mouse liver microsomes after administration of acrylamide and methylmethacrylate.

Nilsen OG; Toftgård R; Ingelman-Sundberg M; Gustafsson JA
Journal article: ANALYTICA CHIMICA ACTA. 1978;99(2):383-385

Fluorimetric determination of lactate with immobilized lactate dehydrogenase

Toftgård R; Anfält T; Granéli A
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All other publications

Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2021;289(5):601-603

The origin of cancer.

Toftgård R
Corrigendum: NATURE COMMUNICATIONS. 2016;7:12936

Erratum: Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth.

Gerling M; Büller NVJA; Kirn LM; Joost S; Frings O; Englert B; Bergström Å; Kuiper RV; Blaas L; Wielenga MCB; Almer S; Kühl AA; Fredlund E; van den Brink GR; Toftgård R
Other: CELL DEATH AND DIFFERENTIATION. 2015;22(6):887

Alberto Gulino MD, PhD (1952-2014).

Toftgård R; Ruiz I Altaba A
Editorial comment: DEVELOPMENTAL CELL. 2014;31(1):1-2

Think inside the BOCs: a mechanism underlying medulloblastoma progression.

Lauth M; Toftgard R
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2013;274(2):102-104

Breast cancer biology and the future of tailored therapies. Introduction.

Bergh J; Hall P; Östman A; Toftgård R
Letter: ACTA ONCOLOGICA. 2013;52(4):862-866

Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma.

Asklund T; Henriksson R; Axelsson J; Bergström Å; Kasper M; Ögren M; Toftgård R; Riklund KÅ
Editorial comment: CANCER CELL. 2013;23(1):3-5

Smoothing out drug resistance.

Kasper M; Toftgård R
Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(14):5548

Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes (vol 108, pg 4099, 2011)

Kasper M; Jaks V; Are A; Bergstrom A; Schwager A; Svard J; Teglund S; Barker N; Toftgard R
Review: JOURNAL OF CLINICAL INVESTIGATION. 2012;122(2):455-463

Basal cell carcinoma - molecular biology and potential new therapies.

Kasper M; Jaks V; Hohl D; Toftgård R
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2011;110:1-17

Hedgehog signaling and pancreatic tumor development.

Lauth M; Toftgård R
Editorial comment: NATURE MEDICINE. 2011;17(6):669

Rune Toftgard

Toftgard R
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1422-1428

The hair follicle-a stem cell zoo.

Jaks V; Kasper M; Toftgård R
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1805(2):181-208

Hedgehog beyond medulloblastoma and basal cell carcinoma.

Teglund S; Toftgård R
Editorial comment: NATURE MEDICINE. 2009;15(9):994-996

Two sides to cilia in cancer.

Toftgård R
Review: CARCINOGENESIS. 2009;30(6):903-911

Hedgehog signalling in breast cancer.

Kasper M; Jaks V; Fiaschi M; Toftgård R
Editorial comment: NATURE GENETICS. 2008;40(9):1040-1041

Hedgehog in Wnterland.

Roop D; Toftgård R
Review: INTERNATIONAL REVIEWS OF IMMUNOLOGY. 2008;27(4):205-223

The two-faced NF-kappaB in the skin.

Sur I; Ulvmar M; Toftgård R
Editorial comment: JOURNAL OF HEPATOLOGY. 2007;47(6):860-867

Tumour suppressors in liver carcinogenesis.

Dufour J-F; Huber O; Kozma SC; Lu X; Toftgård R
Review: CURRENT OPINION IN INVESTIGATIONAL DRUGS. 2007;8(6):457-461

The Hedgehog pathway as a drug target in cancer therapy.

Lauth M; Toftgård R
Review: HUMAN MUTATION. 2006;27(3):215-219

PTCH mutations: distribution and analyses.

Lindström E; Shimokawa T; Toftgård R; Zaphiropoulos PG
Corrigendum: DEVELOPMENTAL CELL. 2006;10(3):409

Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway (vol 10, pg 187, 2006)

Svärd J; Heby-Henricson K; Persson-Lek M; Rozell B; Lauth M; Bergström A; Ericson J; Toftgård R; Teglund S
Published conference paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100 Suppl 1(Suppl 1):11873-11880

Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis.

Niemann C; Unden AB; Lyle S; Zouboulis CC; Toftgård R; Watt FM
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2000;57(12):1720-1731

Hedgehog signalling in cancer.

Toftgård R
Letter: NATURE GENETICS. 1996;14(1):78-81

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.

Gailani MR; Ståhle-Bäckdahl M; Leffell DJ; Glynn M; Zaphiropoulos PG; Pressman C; Undén AB; Dean M; Brash DE; Bale AE; Toftgård R
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Employments

Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2024
Professor, Department of Biosciences and Nutrition, Karolinska Institutet, 2020-2024

Degrees and Education

Docent, Karolinska Institutet, 1985

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