Santhilal Subhash

Santhilal Subhash

Postdoctoral researcher

My current post-doctoral research work focuses on evaluating somatic mutations associated with the vascular wall of age-related cardiovascular disease (CVD).

About me

I am a postdoctoral researcher at Prof. Maria Eriksson's lab. My current research focuses on evaluating somatic mutations associated with the vascular wall of age-related cardiovascular disease (CVD). I completed my Ph.D. in Medical Science at the University of Gothenburg. I previously worked on identifying chromatin-associated long noncoding in cancer using various transcriptome and chromatin-based high-throughput sequencing datasets. 

My overall objective is to work with the health care industry to benefit the general public. I have experience in data analysis, designing pipelines, and statistical inference of complex data. I am familiar with SLURM workload manager, LINUX, High-Performance Computing (HPC), and cloud computing. Expert in performing integrative analysis of multi-layered biological datasets and advanced visualization.

★ Analyzed transcriptome and chromatin-based datasets from cell lines and tumors

★ Handled larger datasets from The Cancer Genome Atlas (TCGA), GTEx, ENCODE and dbGAP

★ Performed integrative approaches by combining multiple datasets such as

- Methylation-based (Methyl-seq, RRBS-seq, MBD-seq-seq, MEDIP-seq)

- RNA-based (RNA-seq, scRNA-seq, Microarray)

- Protein-based (Proteome array)

- Chromatin-based (ChIP-seq, ChRIP-seq, ChOP-seq)

- Sequence-based (Motif analysis, promoter-proximity analysis, conservation analysis)

★ Designing computational tools to address problems in functional genomics (GeneSCF). 

Research description

 

Current Interests (Postdoc: Erikssonlab)

Keen to address molecular mechanisms involved in disease prognosis by integrating datasets from various high-throughput techniques. My current postdoctoral project work involves identifying somatic mutations in the vascular wall of age-related cardiovascular disease (CVD). 

Brief description of my doctoral research work (Kandurilab)

I have experience in the field of cancer, noncoding RNAs, epigenetics, and chromatin biology. During my Ph.D., I worked with transcriptome (nascent and stable RNAs), chromatin immunoprecipitation (DNA and RNA), and genome (methylome) based high-throughput sequencing datasets. By analyzing genome-wide chromatin profiles, I have proposed distinct mechanisms of active and repressive chromatin-associated RNA molecules. Moreover, with an integrative approach using chromatin and transcriptome datasets of mammalian gametes, early-late developmental stages, somatic, and cancer tissues, I have identified a unique set of sperm-specific long noncoding RNAs (lncRNAs) having a role in multiple cancer. Additionally, using the nascent RNA sequencing approach and PAN-cancer datasets (transcriptome and methylome) from The Cancer Genome Project (TCGA), I have identified cell-cycle associated oncogenic and tumor suppressor lncRNAs in multiple cancers. 

Education

 

Ph.D. in Medical Science

July 2014 – December 2020.

Department of Medical Biochemistry & Cell Biology, University of Gothenburg, Sweden.

Titel: Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach.

Ph.D. Supervisor: Prof. Chandrasekhar Kanduri 

Co-supervisors: Prof. Erik Larsson Lekholm and Dr. Tanmoy Mondal.

Link to Thesis

 

Bachelor of Technology (B.Tech.) in Bioinformatics

March 2004 - May 2008

Department of Bioinformatics, School of Bio-engineering, SRM University, India

Academic honours, awards and prizes

 

Swedish Society For Medical Research (SSMF)

Type: Three-year grant for post-doctoral studies in medical science

Grant amount: 2,340,000 SEK

Period: July 2021- June 2023

ProjectIdentification of somatic mutations in the vascular wall – new risk factors and targets for age-related cardiovascular disease.

 

The Royal Swedish Academy Of Sciences (KVA)

Type: Post-doctoral project grant for research in Biosciences.

Grant amount: 100,000 SEK

Period: April 2021- April 2022

Project: The contribution of somatic mutations to misregulated regulation of LINE elements in aging.

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