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Sean Rudd

Assistant professor

Department and organisational affiliation:

About me

Assistant Professor at the Department of Oncology-Pathology

Research Team Leader at Science For Life Laboratory

Research description

My research team is focused upon gaining a better understanding of the chemotherapies currently employed in cancer treatment. In particular, we are interested in the metabolic processes within cancer cells, such as those responsible for maintaining genome stability, and how we can exploit these to enhance the efficacy of existing cancer therapies. In our current work, funded by a starting grant from the Swedish Research Council, we are focused upon a group of common chemotherapies, called nucleobase and nucleoside analogues, and how the efficacy of these therapies can be modulated by nucleotide metabolic enzymes, such as the deoxynucleoside triphosphate triphosphohydrolase SAMHD1.

For further reading see selected publications:

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.

SAMHD1 protects cancer cells from various nucleoside-based antimetabolites.

SAMHD1 is a barrier to antimetabolite-based cancer therapies.

Pathways controlling dNTP pools to maintain genome stability.

Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism.

Teaching portfolio

Main supervisor for undergraduate students (KI Summer School in Medical Research)

Main supervisor for MSc students (Biochemistry, Drug Discovery & Development)

Co-supervisor for PhD student

Education

2013 – 2018: Postdoctoral Research Fellow, Science For Life Laboratory, Karolinska Instituet, Sweden

2009 – 2013: PhD in Biochemistry, Genome Damage & Stability Centre, University of Sussex, UK

2005 – 2008: BSc (Hons) in Biochemistry, University of Manchester, UK

Academic honours, awards and prizes

2019 – Cancerfonden Junior Investigator Award

2018 – Faculty-funded Assistant Professorship from Karolinska Institutet

2018 – Swedish Research Council starting grant within medicine and health

2017 – The Swedish Childhood Cancer Foundation Postdoctoral Fellowship

2014 – EMBO Long-Term Fellowship

 

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