Sean Rudd profile image

Sean Rudd

Assistant professor

Department and organisational affiliation:

About me

Assistant Professor and Research Team Leader at the Department of Oncology-Pathology, Science For Life Laboratory

Research description

The ultimate goal of our research is to provide cancer patients with better informed treatment options, and we believe this can be achieved by gaining a deeper understanding of the metabolic pathways operating inside cancer cells. In particular, we are interested in those pathways responsible for maintaining the DNA molecule and the DNA precursor pool, both of which play critical roles in cancer biology and the response to cancer therapy. By using a biochemical, molecular, and cell biology-focused approach, we aim to identify potential biomarkers and therapeutic targets involved in these pathways that can then be utilised for the rationale improvement of cancer treatment.

For more information, see our group page.

For further reading see selected publications:

  1. Ribonucleotide Reductase Inhibitors Suppress SAMHD1 ara-CTPase Activity Enhancing Cytarabine Efficacy. 2020. EMBO Mol Med. PMID: 31950591
  2. Targeting SAMHD1 With the Vpx Protein to Improve Cytarabine Therapy for Hematological Malignancies. 2017. Nat Med. PMID: 28067901
  3. Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism. 2018. Cancers. PMID: 30041457
  4. Pathways Controlling dNTP Pools to Maintain Genome Stability. 2016. DNA Repair. PMID: 27311542

 

Teaching portfolio

Main supervisor for undergraduate students (KI Summer School in Medical Research)

Main supervisor for MSc students (Biochemistry, Drug Discovery & Development)

Co-supervisor for PhD student

Education

2013 – 2018: Postdoctoral Research Fellow, Science For Life Laboratory, Karolinska Instituet, Sweden

2009 – 2013: PhD in Biochemistry, Genome Damage & Stability Centre, University of Sussex, UK

2005 – 2008: BSc (Hons) in Biochemistry, University of Manchester, UK

Academic honours, awards and prizes

2019 – Cancerfonden Junior Investigator Award

2018 – Faculty-funded Assistant Professorship from Karolinska Institutet

2018 – Swedish Research Council starting grant within medicine and health

2017 – The Swedish Childhood Cancer Foundation Postdoctoral Fellowship

2014 – EMBO Long-Term Fellowship

 

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