Sebastian Lewandowski

Senior research specialist

About me

Team Leader at the Department of Clinical Neuroscience.

Research description

Our team studies vascular mechanisms in ALS neurodegeneration and dementia in FTD and AD to find novel therapeutic applications and clinical biomarkers. Our web resource for cell-specific gene expression in ALS:


Publication highlight:

Månberg A. et al. Nature Medicine April 2021 "Altered perivascular fibroblast activity precedes ALS disease onset".

Nature Medicine News and Views April 2021 "Is presymptomatic ALS perivascular?"

Karolinska Institute Press release. "New type of cell contributes to increased understanding of ALS"


We look at how blood vessel dysfunction and vascular remodelling lead to increased severity of Amyotrophic Lateral Sclerosis (ALS) and FTD using bioinformatics, in-vivo rodent models and clinical samples. We collaborate with the leading neurology centres in Europe and US including UZ Leuven in Belgium, Univ. Utrecht in Holland, Ulm Univ. in Germany and UCSD in San Diego. Our results lead to novel off-label drug applications to therapy and biomarkers in neurodegeneration including ALS, stroke and multiple sclerosis.


We offer master student, PhD and Postdoc positions to highly motivated and enthusiastic researchers. For details, send an email to

Teaching portfolio

- PhD course director "The Vascular Brain" 2020 - onwards

- Different types of teaching assignments:

Group discussions (2009-2017), Seminars (2010-2017), Laboratory work (2012-2013), Lecturer (2012-2017), PhD course director (2014)

-Planned, developed and led a new postgraduate course:

Course director (PhD Level) DBRM3: Neurovascular Regenerative Medicine, From Development to Disease - (2014).

- Student supervision. Summer Research School. Dept. of Biosciences and Nutrition. Ksenia Belobordova. Direct supervision in science project concluded in a written and oral report. Summer 2006


2005 – PhD degree in Molecular Biology - Nencki Institute of Experimental Biology, Warsaw, Poland

1997 – MSc degree in Biophysics - Molecular Biology at University of Gdansk, Poland