Shane Wright
Postdoctoral Researcher
E-mail: shane.wright@ki.se
Visiting address: Solnavägen 9, Biomedicum, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Individanpassad medicin och läkemedelsutveckling, 171 77 Stockholm
About me
- Shane C. Wright is a postdoctoral researcher supported by the Swedish
Society for Medical Research at the Department of Physiology and
Pharmacology. He has a background in cell and molecular biology and receptor
pharmacology from the University of Toronto (HBSc), the Université Paris VI
(MSc) and Karolinska Institutet (PhD - supervisor: Prof. Gunnar Schulte).
Shane received postdoctoral training at the Institute for Research in
Immunology and Cancer, Université de Montréal (supervisor: Prof. Michel
Bouvier) and has since returned to Karolinska Institutet as a senior
postdoctoral fellow under the supervision of Assoc. Prof. Volker Lauschke.
Postdoctoral fellow (Personalized medicine and drug development)
– Karolinska Institutet (2020 – Present)
Postdoctoral fellow (Biochemistry and Molecular Medicine) – Université de
Montréal (2019 – 2020)
Doctor of Philosophy (Receptor biology and signaling) – Karolinska
Institutet (2013 – 2019)
Master of Science (Cellular and Molecular Biology) – Université Paris VI
(2010 – 2012)
Honours Bachelor of Science (Life sciences) – University of Toronto
(2005 – 2010)
Research
- Shane's research focuses on better understanding the action of drugs on
receptors known as G protein-coupled receptors (GPCRs). Emerging concepts in
receptor pharmacology such as functional selectivity and subcellular
signaling have so far not been explored in the context of drug discovery.
Employing a biosensor-based approach to map signaling events in fine detail
holds great promise for our understanding of drug efficacy and side effects.
Combining these tools with patient-derived material will provide much needed
insight into the individual variability of patients and the potential for
offering better treatments in the future.
Articles
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Article: NATURE COMMUNICATIONS. 2023;14(1):6243
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Article: CURRENT OPINION IN STRUCTURAL BIOLOGY. 2021;69:142-149
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Article: CURRENT OPINION IN PHARMACOLOGY. 2021;59:11-18
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(20):e2025846118
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Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2020;1867(12):118849
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(35):21723-21730
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Article: NATURE COMMUNICATIONS. 2019;10(1):667
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Article: SCIENCE SIGNALING. 2018;11(559):eaar5536
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Article: NATURE COMMUNICATIONS. 2017;8(1):226
All other publications
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Editorial comment: JOURNAL OF PHYSIOLOGY-LONDON. 2023;601(8):1317-1318
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Letter: CELL RESEARCH. 2021;31(12):1311-1314
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Thesis / dissertation: 2018
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Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2018;39(9):828-842
Employments
- Postdoctoral Researcher, Department of Physiology and Pharmacology, Karolinska Institutet, 2021-2024
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Physiology and Pharmacology, Karolinska Institutet, 2019