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Shireen

Shireen Sindi

Assistant professor

About me

Shireen Sindi, PhD is Assistant Professor at Karolinska Institute (Sweden), Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics. She completed her former studies at McGill University (Canada), with a Bachelor’s degree in psychology, and a doctoral degree at McGill’s Integrated Program in Neuroscience.

Research description

Her research focuses on risk factors for cognitive decline and dementia, including stress, sleep and biological markers, with evidence from normal ageing to Alzheimer’s disease. More recently she developed an expertise on dementia lifestyle preventive interventions, and published on the underlying biological mechanisms (telomere length) in a multidomain lifestyle intervention (the FINGER trial). She has established and leads the following projects: 1)Multi-Center Sleep Study. 2) The Microbiome-Gut-Brain Axis in Prodromal Alzheimer's disease study. 

She is also scientific & research coordinator for: 1) Multimodal preventive trials for Alzheimer's Disease (MIND-AD); 2) Multimodal strategies to promote a healthy brain in aging: Innovative evidence-based tools (EIT-Health MULTI-MODE); 3) Cortisol & Stress in Alzheimer’s disease (Co-STAR) projects.

She is also actively involved in supervision, teaching & several academic activities. She is Assistant Professors Representative at the NVS Department Council and Junior Faculty Representative at the KI Faculty Council. She is also Vice Chair within KI Junior Faculty, and Leader of the Junior Faculty Mentorship Program.

Selected publications:

1. Sindi S, Darin-Mattsson, A, Kåreholt, I, Kulmala, J, Ngandu, T, Laatikainen, T, Soininen, H, Kivipelto, M. Midlife improvements in financial situation are associated with a reduced dementia risk later in life: The C AIDE 30-Year Study. International Psychogeriatrics 2019, 1-8.

2. Udeh-Momoh CT, Su B, Evans S, Zheng B, Sindi S, Tzoulaki I, Perneczky R, Middleton LT, Alzheimer’s Disease Neuroimaging Initiative. Cortisol, Amyloid-β, and Reserve Predicts Alzheimer’s Disease Progression for Cognitively Normal Older Adults. Journal of Alzheimer's Disease. 2019 Jan 1(Preprint):1-0.

3. Sindi, S, Kåreholt, I, Eskelinen, M, Hooshmand, B, Lehtisalo, J, Soininen, H, Ngandu, T, Kivipelto, M. Healthy dietary changes in midlife are associated with reduced dementia risk later in life. 2018 Nov 3;10(11):1649.

4. Sindi, S, Kåreholt, I, Johansson, L, Skoog, J, Sjöberg, L, Wang, H-X, Johansson, B, Fratiglioni, F, Soininen, H, Solomon, A, Skoog, I, Kivipelto, M. Sleep disturbances and dementia risk: a multi-centre study. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018. 14(10) pp.1235-1242.

5. Sindi, S, Ngandu, T, Hovatta, I, Kareholt, I, Antikainen, R, Hanninen, T, . . . group, F s, Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on C ognition: The FINGER Randomized C ontrolled Trial. Journal of Alzheimer's disease : JAD, 2017. 59(4): p. 1459-70.

6. Sindi, S, Johansson, L., Skoog, J., Mattsson, AD., Sjöberg, L., Wang, HX., Fratiglioni, L., Kulmala, J., Soininen, H., Solomon, A., Johansson, B. Skoog, I., Kivipelto, M., Kåreholt, I., Sleep disturbances and later cognitive status: A multi-centre study. Sleep Medicine Sleep medicine, 2018. 52, 26-33.

8. Sindi, S, Kareholt, I, Solomon, A, Hooshmand, B, Soininen, H, and Kivipelto, M, Midlife work-related stress is associated with late-life cognition. Journal of neurology, 2017. 1;264(9):1996-2002.

9. Sindi, S, Kareholt, I, Spulber G, Soininen H, Kivipelto M, Solomon A, Midlife Work-Related Stress is Associated with Late-Life Gray Matter Volume Atrophy. Journal of Alzheimer's Disease Reports 2017. 1(1): p. 219-27.

10. Sindi, S, Hagman, G, Hakansson, K, Kulmala, J, Nilsen, C , Kareholt, I, . . . Kivipelto, M, Midlife Work-Related Stress Increases Dementia Risk in Later Life: The C AIDE 30-Year Study. The journals of gerontology. Series B, Psychological sciences and social sciences, 2016. 27059705, 10.1093/geronb/gbw043,

11. Sindi, S, C alov, E, Fokkens, J, Ngandu, T, Soininen, H, Tuomilehto, J, and Kivipelto, M, The C AIDE Dementia Risk Score App: The development of an evidence-based mobile application to predict the risk of dementia. Alzheimer's & dementia, 2015. 1(3): p. 328-33.

12. Sindi, S, Mangialasche, F, and Kivipelto, M, Advances in the prevention of Alzheimer's Disease. F1000prime reports, 2015. P7-50.

13. Sindi, S, Fiocco, A J, Juster, R P, Lord, C, Pruessner, J, and Lupien, S J, Now you see it, now you don't: Testing environments modulate the association between hippocampal volume and cortisol levels in young and older adults. Hippocampus, 2014. 24(12): p. 1623-32. 

14.  Sindi, S, Fiocco, A J, Juster, R P, Pruessner, J, and Lupien, S J, When we test, do we stress? Impact of the testing environment on cortisol secretion and memory performance in older adults. Psychoneuroendocrinology, 2013. 38(8): p. 1388-96. 

15. Sindi, S, Juster, R P, Wan, N, Nair, N P, Ying Kin, N, and Lupien, S J, Depressive symptoms, cortisol, and cognition during human aging: the role of negative aging perceptions. Stress, 2012. 15(2): p. 130-7. 

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