Research description

I am interested in investigating the associations of lifestyle and nutritional factors with diabetes, cardiovascular disease, and gastrointestinal disorder by using epidemiological and genetic approaches. My Ph.D. projects focus on venous thromboembolism and peripheral vascular disease. 

Education

PhD candidate in Epidemiology, Karolinska Institutet

Master of Medical Science in Epidemiology, Karolinska Institutet

Academic honours, awards and prizes

Selected Publications

# Diabetes

Yuan S, Larsson SC. An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study. Diabetologia. 2020;63(11):2359-2371.

Tang B*, Yuan S*, Xiong Y, He Q, Larsson SC. Major depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study. Diabetologia. 2020;63(7):1305-1311.

Yuan S, Larsson SC. Association of genetic variants related to plasma fatty acids with type 2 diabetes mellitus and glycaemic traits: a Mendelian randomisation study. Diabetologia. 2020;63(1):116-123.

Yuan S, Jiang X, Michaëlsson K, Larsson SC. Genetic Prediction of Serum 25-Hydroxyvitamin D, Calcium, and Parathyroid Hormone Levels in Relation to Development of Type 2 Diabetes: A Mendelian Randomization Study. Diabetes Care. 2019;42(12):2197-2203.

Yuan S, Kar S, Carter P, Vithayathil M, Mason AM, Burgess S, Larsson SC. Is Type 2 Diabetes Causally Associated With Cancer Risk? Evidence From a Two-Sample Mendelian Randomization Study. Diabetes. 2020;69(7):1588-1596.

Yuan S, Mason AM, Burgess S, Larsson SC. Differentiating Associations of Glycemic Traits With Atherosclerotic and Thrombotic Outcomes: Mendelian Randomization Investigation. Diabetes. 2022;71(10):2222-2232.

Yuan S, Larsson SC. A causal relationship between cigarette smoking and type 2 diabetes mellitus: A Mendelian randomization study. Sci Rep. 2019;9(1):19342.

# Venous thromboembolism

Yuan S, Bruzelius M, Xiong Y, Håkansson N, Åkesson A, Larsson SC. Overall and abdominal obesity in relation to venous thromboembolism. J Thromb Haemost. 2021;19(2):460-469. 

Yuan S, Bruzelius M, Håkansson N, Åkesson A, Larsson SC. Lifestyle factors and venous thromboembolism in two cohort studies. Thromb Res. 2021;202:119-124.

Yuan S, Bruzelius M, Damrauer SM, Håkansson N, Wolk A, Åkesson A, Larsson SC. Anti-inflammatory diet and venous thromboembolism: Two prospective cohort studies. Nutr Metab Cardiovasc Dis. 2021;31(10):2831-2838.

# Peripheral artery disease

Yuan S, Damrauer SM, Håkansson N, Åkesson A, Larsson SC. A Prospective Evaluation of Modifiable Lifestyle Factors in Relation to Peripheral Artery Disease Risk. Eur J Vasc Endovasc Surg. 2022;64(1):83-91.

Yuan S, Bruzelius M, Damrauer SM, Håkansson N, Wolk A, Åkesson A, Larsson SC. Anti-inflammatory diet and incident peripheral artery disease: Two prospective cohort studies. Clin Nutr. 2022;41(6):1191-1196.

Yuan S, Titova OE, Damrauer SM, Åkesson A, Larsson SC. Swedish snuff (snus) dipping, cigarette smoking, and risk of peripheral artery disease: a prospective cohort study. Sci Rep. 2022;12(1):12139. 

# Gastrointestinal disease

Yuan S, Chen J, Dan L, Xie Y, Sun Y, Li X, Larsson SC. Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation. Am J Clin Nutr. 2022:nqac285. doi: 10.1093/ajcn/nqac285. Epub ahead of print.

Yuan S, Larsson SC. Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2022:S1542-3565(22)00075-1.

Yuan S, Chen J, Li X, Fan R, Arsenault B, Gill D, Giovannucci EL, Zheng JS, Larsson SC. Lifestyle and metabolic factors for nonalcoholic fatty liver disease: Mendelian randomization study. Eur J Epidemiol. 2022;37(7):723-733. 

Yuan S, Larsson SC. Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study. Eur J Epidemiol. 2022;37(7):747-754. 

Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC. Genetically predicted circulating B vitamins in relation to digestive system cancers. Br J Cancer. 2021;124(12):1997-2003.

Yuan S, Mason AM, Titova OE, Vithayathil M, Kar S, Chen J, Li X, Burgess S, Larsson SC. Morning chronotype and digestive tract cancers: Mendelian randomization study. Int J Cancer. 2022. doi: 10.1002/ijc.34284. Epub ahead of print.

Yuan S, Gill D, Giovannucci EL, Larsson SC. Obesity, Type 2 Diabetes, Lifestyle Factors, and Risk of Gallstone Disease: A Mendelian Randomization Investigation. Clin Gastroenterol Hepatol. 2022;20(3):e529-e537.

Yuan S, Sun Y, Tan X, Geng J, Sun J, Chen X, Yu L, Wang J, Zhou X, Hesketh T, Larsson SC, Chen J, Wang X, Li X, Liu Z. Sleep duration and daytime napping in relation to incident inflammatory bowel disease: a prospective cohort study. Aliment Pharmacol Ther. 2022. doi: 10.1111/apt.17285. Epub ahead of print.

Sun Y*, Yuan S*, Chen X, et al. The contribution of genetic risk and lifestyle factors in the development of adult-onset inflammatory bowel disease: a prospective cohort study. The American College of Gastroenterology. 2022: 10.14309.