About me

Sirus Rabbani is a medical doctor and Ph.D. student in the Upper GI Surgery group at the Department of Molecular Medicine and Surgery, Karolinska Institutet. In parallel with his medical studies, he pursued a PhD after being granted partial funding from the Karolinska CSTP programme in mid-2018. His research focuses on investigating the aetiology of oesophageal cancer, especially the role of sex hormones. 


Research description

Oesophageal adenocarcinoma (OAC) carries an extremely poor prognosis with an overall 5-year survival lower than 20%. OAC is characterised by a strong and largely unexplained male predominance. Our research is mainly investigating the role of sex hormones on the incidence and prognosis of OAC. 


Rabbani S, Santoni G, Lagergren J, Xie SH. Use of anti-androgenic 5α-reductase inhibitors and risk of oesophageal and gastric cancer by histological type and anatomical sub-site. Br J Cancer. 2022 Sep;127(5):892-897.

Xie SH, Rabbani S, Ness-Jensen E, Lagergren J. Circulating Levels of Inflammatory and Metabolic Biomarkers and Risk of Esophageal Adenocarcinoma and Barrett Esophagus: Systematic Review and Meta-analysis. Cancer Epidemiol Biomarkers Prev. 2020 Nov;29(11):2109-2118. 

Xie SH, Ness-Jensen E, Rabbani S, Langseth H, Gislefoss RE, Mattsson F, Lagergren J. Circulating Sex Hormone Levels and Risk of Esophageal Adenocarcinoma in a Prospective Study in Men. Am J Gastroenterol. 2020 Feb;115(2):216-223. 

Xie SH, Rabbani S, Petrick JL, Cook MB, Lagergren J. Racial and Ethnic Disparities in the Incidence of Esophageal Cancer in the United States, 1992-2013. Am J Epidemiol. 2017 Dec 15;186(12):1341-1351.