About me

Sirus Rabbani is a medical doctor and Ph.D. student in the Upper GI Surgery group at the Department of Molecular Medicine and Surgery, Karolinska Institutet. In parallel with his medical studies, he pursued a PhD after being granted partial funding from the Karolinska CSTP programme in mid-2018. His research focuses on investigating the aetiology of oesophageal cancer, especially the role of sex hormones. 


Research description

Oesophageal adenocarcinoma (OAC) carries an extremely poor prognosis with an overall 5-year survival lower than 20%. OAC is characterised by a strong and largely unexplained male predominance. Our research is mainly investigating the role of sex hormones on the incidence and prognosis of OAC. 


1. Xie SH, Rabbani S, Ness-Jensen E, Lagergren J. Circulating Levels of Inflammatory and Metabolic Biomarkers and Risk of Esophageal Adenocarcinoma and Barrett Esophagus: Systematic Review and Meta-analysis. Cancer Epidemiol Biomarkers Prev. 2020 Nov;29(11):2109-2118. 

2. Xie SH, Ness-Jensen E, Rabbani S, Langseth H, Gislefoss RE, Mattsson F, Lagergren J. Circulating Sex Hormone Levels and Risk of Esophageal Adenocarcinoma in a Prospective Study in Men. Am J Gastroenterol. 2020 Feb;115(2):216-223. 

3. Xie SH, Rabbani S, Petrick JL, Cook MB, Lagergren J. Racial and Ethnic Disparities in the Incidence of Esophageal Cancer in the United States, 1992-2013. Am J Epidemiol. 2017 Dec 15;186(12):1341-1351.