Sophie Erhardt

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About me

Professor of Experimental Psychiatry and research group leader for Neuropsychoimmunology [1] at the Department of Physiology and Pharmacology. [1] http://ki.se/en/fyfa/neuropsychoimmunology

Articles

Journal article: NEUROPSYCHOPHARMACOLOGY. 2024;49(1):307-308

Kynurenic acid: translational perspectives of a therapeutically targetable gliotransmitter.

Pocivavsek A; Erhardt S
Article: PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2023;77(12):665-671

Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first-episode psychosis.

Pils M; Rutsch J; Eren F; Engberg G; Piehl F; Cervenka S; Sellgren C; Troßbach S; Willbold D; Erhardt S; Bannach O; Korth C
Journal article: ACTA NEUROPSYCHIATRICA. 2023;:1-13

Dual administration of lipopolysaccharide induces behavioural changes in rats relevant to psychotic disorders.

Zheng Y-R; Tufvesson-Alm M; Trepci A; Imbeault S; Li X-Q; Schwieler L; Engberg G; Erhardt S
Article: BRAIN BEHAVIOR AND IMMUNITY. 2023;111:376-385

Immunological protein profiling of first-episode psychosis patients identifies CSF and blood biomarkers correlating with disease severity.

Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
Article: SCHIZOPHRENIA RESEARCH. 2023;257:34-40

CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance.

Orhan F; Goiny M; Becklén M; Mathé L; Piehl F; Schwieler L; Fatouros-Bergman H; Farde L; Cervenka S; Sellgren CM; Engberg G; Erhardt S
Article: PSYCHONEUROENDOCRINOLOGY. 2023;153:106110

Lipopolysaccharide-induced changes in the kynurenine pathway and symptoms of sickness behavior in humans.

Balter LJ; Li X; Schwieler L; Erhardt S; Axelsson J; Olsson MJ; Lasselin J; Lekander M
Article: LEUKEMIA. 2023;37(4):888-900

Cognitive impairments correlate with increased central nervous system immune activation after allogeneic haematopoietic stem cell transplantation.

Boberg E; Kadri N; Hagey DW; Schwieler L; El Andaloussi S; Erhardt S; Iacobaeus E; Le Blanc K
Journal article: NEUROSCIENCE APPLIED. 2023;2:103551

Kynurenic acid promotes activity-dependent synaptic pruning and associates with genetic risk variance for schizophrenia

Orhan F; Malwade S; Schwieler L; Tiihonen J; Koistinahu J; Erhardt S; Engberg G; Kent J; Samudyata S; Sellgren C
Article: NATURE COMMUNICATIONS. 2022;13(1):6427

Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia.

Gracias J; Orhan F; Hörbeck E; Holmén-Larsson J; Khanlarkani N; Malwade S; Goparaju SK; Schwieler L; Demirel İŞ; Fu T; Fatourus-Bergman H; Pelanis A; Goold CP; Goulding A; Annerbrink K; Isgren A; Sparding T; Schalling M; Yañez VAC; Göpfert JC; Nilsson J; Brinkmalm A; Blennow K; Zetterberg H; Engberg G; Piehl F; Sheridan SD; Perlis RH; Cervenka S; Erhardt S; Landen M; Sellgren CM
Article: INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS. 2022;10(1):26

A physically active lifestyle is associated with lower long-term incidence of bipolar disorder in a population-based, large-scale study.

Svensson M; Erhardt S; Hållmarker U; James S; Deierborg T
Article: HELIYON. 2022;8(9):e10424

Facial affect recognition in first-episode psychosis is impaired but not associated with psychotic symptoms.

Larsson C; Lee M; Lundgren T; Erhardt S; Sellgren CM; Cervenka S; Borg J; Bölte S; Fatouros-Bergman H
Article: MOLECULAR PSYCHIATRY. 2022;27(8):3247-3261

Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia.

Mätlik K; Garton DR; Montaño-Rodríguez AR; Olfat S; Eren F; Casserly L; Damdimopoulos A; Panhelainen A; Porokuokka LL; Kopra JJ; Turconi G; Schweizer N; Bereczki E; Piehl F; Engberg G; Cervenka S; Piepponen TP; Zhang F-P; Sipilä P; Jakobsson J; Sellgren CM; Erhardt S; Andressoo J-O
Article: BRITISH JOURNAL OF NUTRITION. 2022;:1-8

Two-day fasting affects kynurenine pathway with additional modulation of short-term whole-body cooling: a quasi-randomised crossover trial.

Solianik R; Schwieler L; Trepci A; Erhardt S; Brazaitis M
Article: TRANSLATIONAL PSYCHIATRY. 2022;12(1):229

Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients.

Shang P; Ho AM-C; Tufvesson-Alm M; Lindberg DR; Grant CW; Orhan F; Eren F; Bhat M; Engberg G; Schwieler L; Fatouros-Bergman H; Imbeault S; Iverson RM; Dasari S; Piehl F; Cervenka S; Sellgren CM; Erhardt S; Choi D-S
Article: BRAIN BEHAVIOR AND IMMUNITY. 2022;101:136-145

Peripheral and central kynurenine pathway abnormalities in major depression.

Paul ER; Schwieler L; Erhardt S; Boda S; Trepci A; Kämpe R; Asratian A; Holm L; Yngve A; Dantzer R; Heilig M; Hamilton JP; Samuelsson M
Article: MOLECULAR PSYCHIATRY. 2022;27(2):1233-1240

Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis.

Plavén-Sigray P; Ikonen Victorsson P; Santillo A; Matheson GJ; Lee M; Collste K; Fatouros-Bergman H; Sellgren CM; Erhardt S; Agartz I; Halldin C; Farde L; Cervenka S
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):566

Screening for pathogenic neuronal autoantibodies in serum and CSF of patients with first-episode psychosis.

Theorell J; Ramberger M; Harrison R; Mgbachi V; Jacobson L; Waters P; Erhardt S; Sellgren CM; Cervenka S; Piehl F; Irani SR
Journal article: BRAIN BEHAVIOR AND IMMUNITY. 2021;98:50

Inflammation moderates stress resilience and ketamine response in male antidepressant-resistant rats

Price JB; Walker AJ; Yates C; Erhardt S; Schwieler L; Tye SJ
Article: MOLECULAR PSYCHIATRY. 2021;26(11):6820-6832

GRK3 deficiency elicits brain immune activation and psychosis.

Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schulmann A; Goiny M; Svensson CI; Hökfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landén M; Engberg G; Erhardt S
Article: NPJ SCHIZOPHRENIA. 2021;7(1):46

No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis.

Lee M; Fatouros-Bergman H; Plavén-Sigray P; Ikonen Victorsson P; Sellgren CM; Erhardt S; Flyckt L; Farde L; Cervenka S
Article: ANTIOXIDANTS. 2021;10(9):1443

Vitamin C and E Treatment Blocks Changes in Kynurenine Metabolism Triggered by Three Weeks of Sprint Interval Training in Recreationally Active Elderly Humans.

Wyckelsma VL; Trepci A; Schwieler L; Venckunas T; Brazaitis M; Kamandulis S; Paulauskas H; Gapeyeva H; Pääsuke M; Gastaldello S; Imbeault S; Westerblad H; Erhardt S; Andersson DC
Article: SCIENTIFIC REPORTS. 2021;11(1):7527

Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis.

Becklén M; Orhan F; Piehl F; Cervenka S; Sellgren CM; Flyckt L; Erhardt S; Fatouros-Bergman H
Journal article: ACTA NEUROPSYCHIATRICA. 2021;33(2):111-112

IN MEMORIAM Torgny H. Svensson May 15th 1945-June 12th 2020

Erhardt S; Eriksson E; Engberg G; Wegener G
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2021;43:52-62

Central levels of tryptophan metabolites in subjects with bipolar disorder.

Trepci A; Sellgren CM; Pålsson E; Brundin L; Khanlarkhani N; Schwieler L; Landén M; Erhardt S
Article: SCHIZOPHRENIA RESEARCH. 2021;228:118-123

Disrupted sensorimotor gating in first-episode psychosis patients is not affected by short-term antipsychotic treatment.

Hedberg M; Imbeault S; Karolinska Schizophrenia Project (KaSP) consortium; Erhardt S; Schwieler L
Article: SCIENTIFIC REPORTS. 2021;11(1):1669

Differential effects on blood and cerebrospinal fluid immune protein markers and kynurenine pathway metabolites from aerobic physical exercise in healthy subjects.

Isung J; Granqvist M; Trepci A; Huang J; Schwieler L; Kierkegaard M; Erhardt S; Jokinen J; Piehl F
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2021;14:11786469211041368-117864692110413

Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice.

Imbeault S; Gubert Olivé M; Jungholm O; Erhardt S; Wigström H; Engberg G; Jardemark K
Article: FRONTIERS IN PSYCHIATRY. 2021;12:714014

Physical Activity Is Associated With Lower Long-Term Incidence of Anxiety in a Population-Based, Large-Scale Study.

Svensson M; Brundin L; Erhardt S; Hållmarker U; James S; Deierborg T
Article: JOURNAL OF NEUROIMMUNOLOGY. 2020;349:577401

Repeated administration of LPS exaggerates amphetamine-induced locomotor response and causes learning deficits in mice.

Tufvesson-Alm M; Imbeault S; Liu X-C; Zheng Y; Faka A; Choi D-S; Schwieler L; Engberg G; Erhardt S
Article: BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING. 2020;5(12):1095-1103

Brain Age Prediction Reveals Aberrant Brain White Matter in Schizophrenia and Bipolar Disorder: A Multisample Diffusion Tensor Imaging Study.

Tønnesen S; Kaufmann T; de Lange A-MG; Richard G; Doan NT; Alnæs D; van der Meer D; Rokicki J; Moberget T; Maximov II; Agartz I; Aminoff SR; Beck D; Barch DM; Beresniewicz J; Cervenka S; Fatouros-Bergman H; Craven AR; Flyckt L; Gurholt TP; Haukvik UK; Hugdahl K; Johnsen E; Jönsson EG; Karolinska Schizophrenia Project; Kolskår KK; Kroken RA; Lagerberg TV; Løberg E-M; Nordvik JE; Sanders A-M; Ulrichsen K; Andreassen OA; Westlye LT
Article: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 2020;270(7):933-938

Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.

Johansson V; Erhardt S; Engberg G; Kegel M; Bhat M; Schwieler L; Blennow K; Zetterberg H; Cannon TD; Wetterberg L; Hultman CM; Landén M
Article: NATURE COMMUNICATIONS. 2020;11(1):4016

The genetic architecture of human brainstem structures and their involvement in common brain disorders.

Elvsåshagen T; Bahrami S; van der Meer D; Agartz I; Alnæs D; Barch DM; Baur-Streubel R; Bertolino A; Beyer MK; Blasi G; Borgwardt S; Boye B; Buitelaar J; Bøen E; Celius EG; Cervenka S; Conzelmann A; Coynel D; Di Carlo P; Djurovic S; Eisenacher S; Espeseth T; Fatouros-Bergman H; Flyckt L; Franke B; Frei O; Gelao B; Harbo HF; Hartman CA; Håberg A; Heslenfeld D; Hoekstra PJ; Høgestøl EA; Jonassen R; Jönsson EG; Karolinska Schizophrenia Project (KaSP) consortium; Kirsch P; Kłoszewska I; Lagerberg TV; Landrø NI; Le Hellard S; Lesch K-P; Maglanoc LA; Malt UF; Mecocci P; Melle I; Meyer-Lindenberg A; Moberget T; Nordvik JE; Nyberg L; Connell KSO; Oosterlaan J; Papalino M; Papassotiropoulos A; Pauli P; Pergola G; Persson K; de Quervain D; Reif A; Rokicki J; van Rooij D; Shadrin AA; Schmidt A; Schwarz E; Selbæk G; Soininen H; Sowa P; Steen VM; Tsolaki M; Vellas B; Wang L; Westman E; Ziegler GC; Zink M; Andreassen OA; Westlye LT; Kaufmann T
Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(12):1756-1761

Synthesis and Preclinical Evaluation of 6-[18F]Fluorine-α-methyl-l-tryptophan, a Novel PET Tracer for Measuring Tryptophan Uptake.

Krasikova R; Kondrashov M; Avagliano C; Petukhov M; Vazquez-Romero A; Revunov E; Johnström P; Tari L; Tóth M; Häggkvist J; Erhardt S; Cervenka S; Schou M
Article: IBRO REPORTS. 2020;8:136-142

CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects.

Xu C; Sellgren CM; Fatouros-Bergman H; Piehl F; Blennow K; Zetterberg H; Brinkmalm A; Santillo AF; Lundgren S; Cervenka S; Engberg G; Erhardt S; Karolinska Schizophrenia Project (KaSP) Consortium
Article: BIOANALYSIS. 2020;12(6):379-392

A novel, robust method for quantification of multiple kynurenine pathway metabolites in the cerebrospinal fluid.

Schwieler L; Trepci A; Krzyzanowski S; Hermansson S; Granqvist M; Piehl F; Venckunas T; Brazaitis M; Kamandulis S; Lindqvist D; Jones AD; Erhardt S; Brundin L
Article: ACTA NEUROPSYCHIATRICA. 2020;32(1):43-53

Effects of IDO1 and TDO2 inhibition on cognitive deficits and anxiety following LPS-induced neuroinflammation.

Imbeault S; Goiny M; Liu X; Erhardt S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2020;13:1178646920978241-117864692097824

Quantification of Plasma Kynurenine Metabolites Following One Bout of Sprint Interval Exercise.

Trepci A; Imbeault S; Wyckelsma VL; Westerblad H; Hermansson S; Andersson DC; Piehl F; Venckunas T; Brazaitis M; Kamandulis S; Brundin L; Erhardt S; Schwieler L
Article: PSYCHIATRY RESEARCH. 2019;281:112546

Long distance ski racing is associated with lower long-term incidence of depression in a population based, large-scale study.

Svensson M; Brundin L; Erhardt S; Madaj Z; Hållmarker U; James S; Deierborg T
Article: NATURE NEUROSCIENCE. 2019;22(10):1617-1623

Common brain disorders are associated with heritable patterns of apparent aging of the brain.

Kaufmann T; van der Meer D; Doan NT; Schwarz E; Lund MJ; Agartz I; Alnæs D; Barch DM; Baur-Streubel R; Bertolino A; Bettella F; Beyer MK; Bøen E; Borgwardt S; Brandt CL; Buitelaar J; Celius EG; Cervenka S; Conzelmann A; Córdova-Palomera A; Dale AM; de Quervain DJF; Di Carlo P; Djurovic S; Dørum ES; Eisenacher S; Elvsåshagen T; Espeseth T; Fatouros-Bergman H; Flyckt L; Franke B; Frei O; Haatveit B; Håberg AK; Harbo HF; Hartman CA; Heslenfeld D; Hoekstra PJ; Høgestøl EA; Jernigan TL; Jonassen R; Jönsson EG; Karolinska Schizophrenia Project (KaSP); Kirsch P; Kłoszewska I; Kolskår KK; Landrø NI; Le Hellard S; Lesch K-P; Lovestone S; Lundervold A; Lundervold AJ; Maglanoc LA; Malt UF; Mecocci P; Melle I; Meyer-Lindenberg A; Moberget T; Norbom LB; Nordvik JE; Nyberg L; Oosterlaan J; Papalino M; Papassotiropoulos A; Pauli P; Pergola G; Persson K; Richard G; Rokicki J; Sanders A-M; Selbæk G; Shadrin AA; Smeland OB; Soininen H; Sowa P; Steen VM; Tsolaki M; Ulrichsen KM; Vellas B; Wang L; Westman E; Ziegler GC; Zink M; Andreassen OA; Westlye LT
Article: SCHIZOPHRENIA RESEARCH. 2019;210:221-227

Increased peripheral levels of TARC/CCL17 in first episode psychosis patients.

Malmqvist A; Schwieler L; Orhan F; Fatouros-Bergman H; Bauer M; Flyckt L; Cervenka S; Engberg G; Piehl F; Karolinska Schizophrenia Project (KaSP) consortium; Erhardt S
Article: JAMA PSYCHIATRY. 2019;76(7):739-748

Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk.

Alnæs D; Kaufmann T; van der Meer D; Córdova-Palomera A; Rokicki J; Moberget T; Bettella F; Agartz I; Barch DM; Bertolino A; Brandt CL; Cervenka S; Djurovic S; Doan NT; Eisenacher S; Fatouros-Bergman H; Flyckt L; Di Giorgio A; Haatveit B; Jönsson EG; Kirsch P; Lund MJ; Meyer-Lindenberg A; Pergola G; Schwarz E; Smeland OB; Quarto T; Zink M; Andreassen OA; Westlye LT; Karolinska Schizophrenia Project Consortium
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):37

Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls.

Sellgren CM; Gracias J; Jungholm O; Perlis RH; Engberg G; Schwieler L; Landen M; Erhardt S
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):12

Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder.

Schwarz E; Doan NT; Pergola G; Westlye LT; Kaufmann T; Wolfers T; Brecheisen R; Quarto T; Ing AJ; Di Carlo P; Gurholt TP; Harms RL; Noirhomme Q; Moberget T; Agartz I; Andreassen OA; Bellani M; Bertolino A; Blasi G; Brambilla P; Buitelaar JK; Cervenka S; Flyckt L; Frangou S; Franke B; Hall J; Heslenfeld DJ; Kirsch P; McIntosh AM; Nöthen MM; Papassotiropoulos A; de Quervain DJ-F; Rietschel M; Schumann G; Tost H; Witt SH; Zink M; Meyer-Lindenberg A; IMAGEMEND Consortium, Karolinska Schizophrenia Pro
Article: EMBO REPORTS. 2019;20(1):e46224

TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress.

Lafarga V; Sung H-M; Haneke K; Roessig L; Pauleau A-L; Bruer M; Rodriguez-Acebes S; Lopez-Contreras AJ; Gruss OJ; Erhardt S; Mendez J; Fernandez-Capetillo O; Stoecklin G
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2019;12:1178646919891169-117864691989116

Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice.

Peyton L; Oliveros A; Tufvesson-Alm M; Schwieler L; Starski P; Engberg G; Erhardt S; Choi D-S
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2018;138(5):432-440

Increased number of monocytes and plasma levels of MCP-1 and YKL-40 in first-episode psychosis.

Orhan F; Schwieler L; Fatouros-Bergman H; Malmqvist A; Cervenka S; Collste K; Flyckt L; Farde L; Sellgren CM; Piehl F; Karolinska Schizophrenia Project (KaSP) Consortium; Engberg G; Erhardt S
Article: BIOLOGICAL PSYCHIATRY. 2018;84(9):644-654

Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.

van Erp TGM; Walton E; Hibar DP; Schmaal L; Jiang W; Glahn DC; Pearlson GD; Yao N; Fukunaga M; Hashimoto R; Okada N; Yamamori H; Bustillo JR; Clark VP; Agartz I; Mueller BA; Cahn W; de Zwarte SMC; Hulshoff Pol HE; Kahn RS; Ophoff RA; van Haren NEM; Andreassen OA; Dale AM; Doan NT; Gurholt TP; Hartberg CB; Haukvik UK; Jørgensen KN; Lagerberg TV; Melle I; Westlye LT; Gruber O; Kraemer B; Richter A; Zilles D; Calhoun VD; Crespo-Facorro B; Roiz-Santiañez R; Tordesillas-Gutiérrez D; Loughland C; Carr VJ; Catts S; Cropley VL; Fullerton JM; Green MJ; Henskens FA; Jablensky A; Lenroot RK; Mowry BJ; Michie PT; Pantelis C; Quidé Y; Schall U; Scott RJ; Cairns MJ; Seal M; Tooney PA; Rasser PE; Cooper G; Shannon Weickert C; Weickert TW; Morris DW; Hong E; Kochunov P; Beard LM; Gur RE; Gur RC; Satterthwaite TD; Wolf DH; Belger A; Brown GG; Ford JM; Macciardi F; Mathalon DH; O'Leary DS; Potkin SG; Preda A; Voyvodic J; Lim KO; McEwen S; Yang F; Tan Y; Tan S; Wang Z; Fan F; Chen J; Xiang H; Tang S; Guo H; Wan P; Wei D; Bockholt HJ; Ehrlich S; Wolthusen RPF; King MD; Shoemaker JM; Sponheim SR; De Haan L; Koenders L; Machielsen MW; van Amelsvoort T; Veltman DJ; Assogna F; Banaj N; de Rossi P; Iorio M; Piras F; Spalletta G; McKenna PJ; Pomarol-Clotet E; Salvador R; Corvin A; Donohoe G; Kelly S; Whelan CD; Dickie EW; Rotenberg D; Voineskos AN; Ciufolini S; Radua J; Dazzan P; Murray R; Reis Marques T; Simmons A; Borgwardt S; Egloff L; Harrisberger F; Riecher-Rössler A; Smieskova R; Alpert KI; Wang L; Jönsson EG; Koops S; Sommer IEC; Bertolino A; Bonvino A; Di Giorgio A; Neilson E; Mayer AR; Stephen JM; Kwon JS; Yun J-Y; Cannon DM; McDonald C; Lebedeva I; Tomyshev AS; Akhadov T; Kaleda V; Fatouros-Bergman H; Flyckt L; Karolinska Schizophrenia Project; Busatto GF; Rosa PGP; Serpa MH; Zanetti MV; Hoschl C; Skoch A; Spaniel F; Tomecek D; Hagenaars SP; McIntosh AM; Whalley HC; Lawrie SM; Knöchel C; Oertel-Knöchel V; Stäblein M; Howells FM; Stein DJ; Temmingh HS; Uhlmann A; Lopez-Jaramillo C; Dima D; McMahon A; Faskowitz JI; Gutman BA; Jahanshad N; Thompson PM; Turner JA
Article: NEUROPHARMACOLOGY. 2018;138:130-139

Importance of kynurenine 3-monooxygenase for spontaneous firing and pharmacological responses of midbrain dopamine neurons: Relevance for schizophrenia.

Tufvesson-Alm M; Schwieler L; Schwarcz R; Goiny M; Erhardt S; Engberg G
Article: MOLECULAR PSYCHIATRY. 2018;23(5):1244-1250

CSF GABA is reduced in first-episode psychosis and associates to symptom severity.

Orhan F; Fatouros-Bergman H; Goiny M; Malmqvist A; Piehl F; Karolinska Schizophrenia Project (KaSP) Consortium; Cervenka S; Collste K; Victorsson P; Sellgren CM; Flyckt L; Erhardt S; Engberg G
Article: PSYCHOLOGICAL MEDICINE. 2018;48(1):82-94

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium.

Walton E; Hibar DP; van Erp TGM; Potkin SG; Roiz-Santiañez R; Crespo-Facorro B; Suarez-Pinilla P; van Haren NEM; de Zwarte SMC; Kahn RS; Cahn W; Doan NT; Jørgensen KN; Gurholt TP; Agartz I; Andreassen OA; Westlye LT; Melle I; Berg AO; Morch-Johnsen L; Færden A; Flyckt L; Fatouros-Bergman H; Karolinska Schizophrenia Project Consortium (KaSP); Jönsson EG; Hashimoto R; Yamamori H; Fukunaga M; Jahanshad N; De Rossi P; Piras F; Banaj N; Spalletta G; Gur RE; Gur RC; Wolf DH; Satterthwaite TD; Beard LM; Sommer IE; Koops S; Gruber O; Richter A; Krämer B; Kelly S; Donohoe G; McDonald C; Cannon DM; Corvin A; Gill M; Di Giorgio A; Bertolino A; Lawrie S; Nickson T; Whalley HC; Neilson E; Calhoun VD; Thompson PM; Turner JA; Ehrlich S
Article: JOURNAL OF NEUROIMMUNOLOGY. 2017;313:1-9

LPS-induced cortical kynurenic acid and neurogranin-NFAT signaling is associated with deficits in stimulus processing during Pavlovian conditioning.

Oliveros A; Wininger K; Sens J; Larsson MK; Liu XC; Choi S; Faka A; Schwieler L; Engberg G; Erhardt S; Choi DS
Article: BIOLOGICAL PSYCHIATRY. 2017;82(10):756-765

Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders.

Erhardt S; Pocivavsek A; Repici M; Liu X-C; Imbeault S; Maddison DC; Thomas MAR; Smalley JL; Larsson MK; Muchowski PJ; Giorgini F; Schwarcz R
Article: MOLECULAR PSYCHIATRY. 2017;22(6):850-856

Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28.

Collste K; Plavén-Sigray P; Fatouros-Bergman H; Victorsson P; Schain M; Forsberg A; Amini N; Aeinehband S; Karolinska Schizophrenia Project (KaSP) consortium; Erhardt S; Halldin C; Flyckt L; Farde L; Cervenka S
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2017;135(5):439-447

Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium.

Walton E; Hibar DP; van Erp TGM; Potkin SG; Roiz-Santiañez R; Crespo-Facorro B; Suarez-Pinilla P; Van Haren NEM; de Zwarte SMC; Kahn RS; Cahn W; Doan NT; Jørgensen KN; Gurholt TP; Agartz I; Andreassen OA; Westlye LT; Melle I; Berg AO; Mørch-Johnsen L; Faerden A; Flyckt L; Fatouros-Bergman H; Karolinska Schizophrenia Project Consortium (KaSP); Jönsson EG; Hashimoto R; Yamamori H; Fukunaga M; Preda A; De Rossi P; Piras F; Banaj N; Ciullo V; Spalletta G; Gur RE; Gur RC; Wolf DH; Satterthwaite TD; Beard LM; Sommer IE; Koops S; Gruber O; Richter A; Krämer B; Kelly S; Donohoe G; McDonald C; Cannon DM; Corvin A; Gill M; Di Giorgio A; Bertolino A; Lawrie S; Nickson T; Whalley HC; Neilson E; Calhoun VD; Thompson PM; Turner JA; Ehrlich S
Article: ACTA NEUROPSYCHIATRICA. 2017;29(1):54-58

Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression.

Liu X-C; Erhardt S; Goiny M; Engberg G; Mathé AA
Article: NEUROPSYCHIATRIC DISEASE AND TREATMENT. 2017;13:967-972

Twelve-week physical exercise does not have a long-lasting effect on kynurenines in plasma of depressed patients.

Millischer V; Erhardt S; Ekblom Ö; Forsell Y; Lavebratt C
Article: PSYCHIATRY RESEARCH. 2017;247:105-112

Kynurenic acid and psychotic symptoms and personality traits in twins with psychiatric morbidity.

Kegel ME; Johansson V; Wetterberg L; Bhat M; Schwieler L; Cannon TD; Schuppe-Koistinen I; Engberg G; Landén M; Hultman CM; Erhardt S
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2016;84(5):262-271

Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes.

Orhan F; Bhat M; Sandberg K; Ståhl S; Piehl F; Karolinska Schizophrenia Project (KaSP) consortium; Svensson C; Erhardt S; Schwieler L
Article: MOLECULAR PSYCHIATRY. 2016;21(10):1342-1350

A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder.

Sellgren CM; Kegel ME; Bergen SE; Ekman CJ; Olsson S; Larsson M; Vawter MP; Backlund L; Sullivan PF; Sklar P; Smoller JW; Magnusson PKE; Hultman CM; Walther-Jallow L; Svensson CI; Lichtenstein P; Schalling M; Engberg G; Erhardt S; Landén M
Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2016;32(7):754-761

Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes.

Mudry JM; Alm PS; Erhardt S; Goiny M; Fritz T; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
Article: PSYCHONEUROENDOCRINOLOGY. 2016;71:189-196

Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects.

Coccaro EF; Lee R; Fanning JR; Fuchs D; Goiny M; Erhardt S; Christensen K; Brundin L; Coussons-Read M
Article: NEUROCHEMICAL RESEARCH. 2016;41(9):2243-2255

Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice.

Larsson MK; Faka A; Bhat M; Imbeault S; Goiny M; Orhan F; Oliveros A; Ståhl S; Liu XC; Choi DS; Sandberg K; Engberg G; Schwieler L; Erhardt S
Article: TRANSLATIONAL PSYCHIATRY. 2016;6(8):e865

An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation.

Brundin L; Sellgren CM; Lim CK; Grit J; Pålsson E; Landén M; Samuelsson M; Lundgren K; Brundin P; Fuchs D; Postolache TT; Traskman-Bendz L; Guillemin GJ; Erhardt S
Article: FEBS LETTERS. 2016;590(14):2063-2075

EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway.

Mutz CN; Schwentner R; Kauer MO; Katschnig AM; Kromp F; Aryee DNT; Erhardt S; Goiny M; Alonso J; Fuchs D; Kovar H
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2016;310(10):C836-C840

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans.

Schlittler M; Goiny M; Agudelo LZ; Venckunas T; Brazaitis M; Skurvydas A; Kamandulis S; Ruas JL; Erhardt S; Westerblad H; Andersson DC
Article: JOURNAL OF AFFECTIVE DISORDERS. 2016;193:349-354

The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.

Ventorp F; Barzilay R; Erhardt S; Samuelsson M; Träskman-Bendz L; Janelidze S; Weizman A; Offen D; Brundin L
Article: NEUROPHARMACOLOGY. 2016;102:42-47

Inhibition of kynurenine aminotransferase II reduces activity of midbrain dopamine neurons.

Linderholm KR; Alm MT; Larsson MK; Olsson SK; Goiny M; Hajos M; Erhardt S; Engberg G
Article: JOURNAL OF NEUROINFLAMMATION. 2016;13(1):51

Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients.

Schwieler L; Samuelsson M; Frye MA; Bhat M; Schuppe-Koistinen I; Jungholm O; Johansson AG; Landén M; Sellgren CM; Erhardt S
Article: BRAIN BEHAVIOR AND IMMUNITY. 2016;51:47-55

Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms.

Aeinehband S; Brenner P; Ståhl S; Bhat M; Fidock MD; Khademi M; Olsson T; Engberg G; Jokinen J; Erhardt S; Piehl F
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2015;131(4):269-278

Low IL-8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels.

Janelidze S; Suchankova P; Ekman A; Erhardt S; Sellgren C; Samuelsson M; Westrin A; Minthon L; Hansson O; Träskman-Bendz L; Brundin L
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2015;40(2):126-133

Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway.

Schwieler L; Larsson MK; Skogh E; Kegel ME; Orhan F; Abdelmoaty S; Finn A; Bhat M; Samuelsson M; Lundberg K; Dahl M-L; Sellgren C; Schuppe-Koistinen I; Svensson C; Erhardt S; Engberg G
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2015;8:49-52

Chronic Antipsychotic Treatment in the Rat - Effects on Brain Interleukin-8 and Kynurenic Acid.

Larsson MK; Schwieler L; Goiny M; Erhardt S; Engberg G
Article: BRAIN BEHAVIOR AND IMMUNITY. 2015;43:110-117

A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality.

Bay-Richter C; Linderholm KR; Lim CK; Samuelsson M; Träskman-Bendz L; Guillemin GJ; Erhardt S; Brundin L
Article: CELL. 2014;159(1):33-45

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.

Agudelo LZ; Femenía T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Article: MOLECULAR PSYCHIATRY. 2014;19(3):334-341

The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression.

Lavebratt C; Olsson S; Backlund L; Frisén L; Sellgren C; Priebe L; Nikamo P; Träskman-Bendz L; Cichon S; Vawter MP; Osby U; Engberg G; Landén M; Erhardt S; Schalling M
Article: BRAIN BEHAVIOR AND IMMUNITY. 2014;36:80-89

Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid.

Liu X-C; Holtze M; Powell SB; Terrando N; Larsson MK; Persson A; Olsson SK; Orhan F; Kegel M; Asp L; Goiny M; Schwieler L; Engberg G; Karlsson H; Erhardt S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2014;7:1-7

Kynurenic Acid levels in cerebrospinal fluid from patients with Alzheimer's disease or dementia with lewy bodies.

Wennström M; Nielsen HM; Orhan F; Londos E; Minthon L; Erhardt S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2014;7:15-22

Imbalanced kynurenine pathway in schizophrenia.

Kegel ME; Bhat M; Skogh E; Samuelsson M; Lundberg K; Dahl M-L; Sellgren C; Schwieler L; Engberg G; Schuppe-Koistinen I; Erhardt S
Article: PSYCHONEUROENDOCRINOLOGY. 2013;38(6):853-862

Altered chemokine levels in the cerebrospinal fluid and plasma of suicide attempters.

Janelidze S; Ventorp F; Erhardt S; Hansson O; Minthon L; Flax J; Samuelsson M; Traskman-Bendz L; Brundin L
Article: NEUROPSYCHOPHARMACOLOGY. 2013;38(5):743-752

Connecting inflammation with glutamate agonism in suicidality.

Erhardt S; Lim CK; Linderholm KR; Janelidze S; Lindqvist D; Samuelsson M; Lundberg K; Postolache TT; Träskman-Bendz L; Guillemin GJ; Brundin L
Article: PSYCHIATRY RESEARCH. 2013;205(1-2):165-167

CSF kynurenic acid and suicide risk in schizophrenia spectrum psychosis.

Carlborg A; Jokinen J; Jönsson EG; Erhardt S; Nordström P
Journal article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2012;28(&NA;):e42

Working memory performance in bipolar disorder

Sellgren C; Engberg G; Erhardt S; Lichtenstein P; Landèn M
Journal article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2012;28(&NA;):e41-e42

The Kynurenine pathway and cognitive performance in Euthymic bipolar disorder

Sellgren C; Olsson S; Erhardt S; Engberg G; Lichtenstein P; Landèn M
Journal article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2012;28(&NA;):e25

Genome-wide study of CSF kynurenic acid in bipolar disorder implicates a molecular pathway underlying psychosis

Sellgren C; Kegel M; Ekman C; Olsson S; Svensson C; Hultman C; Lichtenstein P; Purcell S; Sullivan P; Sklar P; Engberg G; Erhardt S; Landèn M
Journal article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2012;28(&NA;):e4

Can routinely collected data be used for research on bipolar disorder? data from the St. Göran bipolar project

Landén M; Rydén E; Johansson A; Wetterberg L; Jakobsson J; Pålsson E; Ekman CJ; Sellgren C; Olsson S; Erhardt S; Båve U
Article: BIPOLAR DISORDERS. 2012;14(7):719-726

Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients with bipolar I disorder.

Olsson SK; Sellgren C; Engberg G; Landén M; Erhardt S
Article: SCHIZOPHRENIA BULLETIN. 2012;38(3):426-432

Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia.

Linderholm KR; Skogh E; Olsson SK; Dahl M-L; Holtze M; Engberg G; Samuelsson M; Erhardt S
Journal article: NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH. 2012;18(2):62

Low chemokine levels in the cerebrospinal fluid of suicide attempters

Janelidze S; Ventorp F; Erhardt S; Hansson O; Minthon L; Samuelsson M; Traskman-Bendz L; Brundin L
Article: JOURNAL OF NEURAL TRANSMISSION. 2012;119(2):155-163

Subchronic elevation of brain kynurenic acid augments amphetamine-induced locomotor response in mice.

Olsson SK; Larsson MK; Erhardt S
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2012;37(1):53-57

Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls.

Holtze M; Saetre P; Engberg G; Schwieler L; Werge T; Andreassen OA; Hall H; Terenius L; Agartz I; Jönsson EG; Schalling M; Erhardt S
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2011;124(1):52-61

CSF biomarkers in suicide attempters--a principal component analysis.

Lindqvist D; Janelidze S; Erhardt S; Träskman-Bendz L; Engström G; Brundin L
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2011;36(2):114-118

Elevation of cerebrospinal fluid interleukin-1ß in bipolar disorder.

Söderlund J; Olsson SK; Samuelsson M; Walther-Jallow L; Johansson C; Erhardt S; Landén M; Engberg G
Article: JOURNAL OF NEUROINFLAMMATION. 2010;7:44

Acyclovir inhibition of IDO to decrease Tregs as a glioblastoma treatment adjunct.

Söderlund J; Erhardt S; Kast RE
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2010;13(4):475-485

Neonatal infection with neurotropic influenza A virus induces the kynurenine pathway in early life and disrupts sensorimotor gating in adult Tap1-/- mice.

Asp L; Holtze M; Powell SB; Karlsson H; Erhardt S
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2010;35(3):195-199

Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder.

Olsson SK; Samuelsson M; Saetre P; Lindström L; Jönsson EG; Nordin C; Engberg G; Erhardt S; Landén M
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2010;3:1-12

Role of the NMDA-receptor in Prepulse Inhibition in the Rat.

Linderholm K; Powell S; Olsson E; Holtze M; Snodgrass R; Erhardt S
Article: BIOLOGICAL PSYCHIATRY. 2009;66(3):287-292

Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity.

Lindqvist D; Janelidze S; Hagell P; Erhardt S; Samuelsson M; Minthon L; Hansson O; Björkqvist M; Träskman-Bendz L; Brundin L
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2009;12(4):501-512

Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia.

Olsson SK; Andersson AS; Linderholm KR; Holtze M; Nilsson-Todd LK; Schwieler L; Olsson E; Larsson K; Engberg G; Erhardt S
Article: ENDOCRINOLOGY. 2008;149(12):6356-6365

Prenatal dexamethasone impairs behavior and the activation of the BDNF exon IV promoter in the paraventricular nucleus in adult offspring.

Hossain A; Hajman K; Charitidi K; Erhardt S; Zimmermann U; Knipper M; Canlon B
Article: LIFE SCIENCES. 2008;83(5-6):170-175

Clozapine interacts with the glycine site of the NMDA receptor: electrophysiological studies of dopamine neurons in the rat ventral tegmental area.

Schwieler L; Linderholm KR; Nilsson-Todd LK; Erhardt S; Engberg G
Journal article: SCHIZOPHRENIA RESEARCH. 2008;102(1-3):94

KYNURENIC ACID IN CEREBROSPINAL FLUID AND BRAIN TISSUE LOSSES IN PATIENTS WITH FIRST-ONSET SCHIZOPHRENIA

Schröder J; Thomann P; Heuser M; Essig M; Holtze M; Erhardt S; Engberg G; Karlsson H
Journal article: JOURNAL OF PROTEOMICS AND BIOINFORMATICS. 2008;01(02):090-097

Comparative Proteome Analysis of Thalamus and Cortex from Rats Subchronically Treated with Kynurenine and Probenecid

Paulson L; Nilsson- Todd LK; Linderholm KR; Brinkmalm A; Eriksson PS; Engberg G; Erhardt S
Article: NEUROPHARMACOLOGY. 2007;53(8):918-924

Activation of rat ventral tegmental area dopamine neurons by endogenous kynurenic acid: a pharmacological analysis.

Linderholm KR; Andersson A; Olsson S; Olsson E; Snodgrass R; Engberg G; Erhardt S
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):203-209

The kynurenic acid hypothesis of schizophrenia.

Erhardt S; Schwieler L; Nilsson L; Linderholm K; Engberg G
Article: ACTA NEUROPSYCHIATRICA. 2007;19(1):45-52

Cerebrospinal fluid kynurenic acid in male patients with schizophrenia - correlation with monoamine metabolites.

Nilsson-Todd LK; Nordin C; Jönsson EG; Skogh E; Erhardt S
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2007;41(1-2):144-151

Cerebrospinal fluid kynurenic acid in male and female controls - correlation with monoamine metabolites and influences of confounding factors.

Nilsson LK; Nordin C; Jönsson EG; Engberg G; Linderholm KR; Erhardt S
Article: JOURNAL OF NEURAL TRANSMISSION. 2006;113(5):557-571

Subchronic treatment with kynurenine and probenecid: effects on prepulse inhibition and firing of midbrain dopamine neurons.

Nilsson LK; Linderholm KR; Erhardt S
Article: SYNAPSE. 2006;59(5):290-298

Effects of COX-1 and COX-2 inhibitors on the firing of rat midbrain dopaminergic neurons--possible involvement of endogenous kynurenic acid.

Schwieler L; Erhardt S; Nilsson L; Linderholm K; Engberg G
Article: SCHIZOPHRENIA RESEARCH. 2005;80(2-3):315-322

Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia.

Nilsson LK; Linderholm KR; Engberg G; Paulson L; Blennow K; Lindström LH; Nordin C; Karanti A; Persson P; Erhardt S
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2005;8(3):329-339

Activation of noradrenergic locus coeruleus neurons by clozapine and haloperidol: involvement of glutamatergic mechanisms.

Nilsson LK; Schwieler L; Engberg G; Linderholm KR; Erhardt S
Article: JOURNAL OF NEURAL TRANSMISSION. 2005;112(7):863-872

Prostaglandin-mediated control of rat brain kynurenic acid synthesis--opposite actions by COX-1 and COX-2 isoforms.

Schwieler L; Erhardt S; Erhardt C; Engberg G
Article: BIOLOGICAL PSYCHIATRY. 2004;56(4):255-260

Endogenous kynurenic acid disrupts prepulse inhibition.

Erhardt S; Schwieler L; Emanuelsson C; Geyer M
Article: SYNAPSE. 2004;52(2):114-122

Clozapine modulates midbrain dopamine neuron firing via interaction with the NMDA receptor complex.

Schwieler L; Engberg G; Erhardt S
Article: NEUROPSYCHOPHARMACOLOGY. 2003;28(10):1770-1777

Inhibitory action of clozapine on rat ventral tegmental area dopamine neurons following increased levels of endogenous kynurenic acid.

Schwieler L; Erhardt S
Article: LIFE SCIENCES. 2003;72(24):2793-2801

The anaesthetic agent propofol interacts with GABA(B)-receptors: an electrophysiological study in rat.

Schwieler L; Delbro DS; Engberg G; Erhardt S
Article: ACTA PHYSIOLOGICA. 2002;175(1):45-53

Increased phasic activity of dopaminergic neurones in the rat ventral tegmental area following pharmacologically elevated levels of endogenous kynurenic acid.

Erhardt S; Engberg G
Article: SYNAPSE. 2002;43(4):227-237

Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine.

Erhardt S; Schwieler L; Engberg G
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2002;365(3):173-180

GABA(B) receptor-mediated modulation of the firing pattern of ventral tegmental area dopamine neurons in vivo.

Erhardt S; Mathé JM; Chergui K; Engberg G; Svensson TH
Article: NEUROSCIENCE LETTERS. 2001;313(1-2):96-98

Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia.

Erhardt S; Blennow K; Nordin C; Skogh E; Lindström LH; Engberg G
Article: AMINO ACIDS. 2001;20(4):353-362

Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons.

Erhardt S; Oberg H; Mathé JM; Engberg G
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2001;363(1):21-27

Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neurons.

Erhardt S; Oberg H; Engberg G
Article: LIFE SCIENCES. 2000;67(15):1901-1911

Excitation of nigral dopamine neurons by the GABA(A) receptor agonist muscimol is mediated via release of glutamate.

Erhardt S; Engberg G
Article: SYNAPSE. 2000;37(2):104-108

Nicotine-induced excitation of locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid.

Erhardt S; Hajos M; Lindberg A; Engberg G
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2000;362(1):41-45

Nicotine inhibits firing activity of dorsal raphe 5-HT neurones in vivo.

Engberg G; Erhardt S; Sharp T; Hajós M
Article: JOURNAL OF NEURAL TRANSMISSION. 1999;106(5-6):383-394

Activation of nigral dopamine neurons by the selective GABA(B)-receptor antagonist SCH 50911.

Erhardt S; Nissbrandt H; Engberg G
Article: NEUROSCIENCE LETTERS. 1998;255(2):115-118

Oxytocin increases locus coeruleus alpha 2-adrenoreceptor responsiveness in rats.

Petersson M; Uvnäs-Moberg K; Erhardt S; Engberg G
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1998;357(6):611-619

Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by gamma-hydroxybutyric acid (GHBA) are specifically induced by activation of GABA(B) receptors.

Erhardt S; Andersson B; Nissbrandt H; Engberg G
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All other publications

Letter: BRAIN BEHAVIOR AND IMMUNITY. 2023;114:163-164

Preanalytic handling of clinical blood samples in assessing immunological proteins - Role of storage duration.

Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
Preprint: 2023;bioRxiv

Kynurenic acid promotes activity-dependent synaptic pruning in schizophrenia

Orhan F; Malwade S; Khanlarkhani N; Gkoga A; Jungholm O; Koskuvi M; Lehtonen Š; Schwieler L; Jardemark K; Tiihonen J; Koistinaho J; Erhardt S; Engberg G; Samudyata S; Sellgren CM
Conference publication: BIOLOGICAL PSYCHIATRY. 2023;93(9):S24

Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression

Tye S; Price J; Walker A; Sutor S; Erhardt S; Schwieler L; Cullen K; Voort JV; Frye M; Bobo W; Shiroma P
Conference publication: BIOLOGICAL PSYCHIATRY. 2023;93(9):S24

Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression

Voort JV; Singh B; Riva-Posse P; Erhardt S; Schwieler L; Pazdernik V; Frye M; Tye S
Preprint: 2023;medRxiv

Disrupted-in-schizophrenia 1 (DISC1) protein aggregates in cerebrospinal fluid are elevated in first-episode psychosis patients

Pils M; Rutsch J; Eren F; Engberg G; Piehl F; Cervenka S; Sellgren C; Troßbach S; Willbold D; Erhardt S; Bannach O; Korth C
Review: BRAIN SCIENCES. 2023;13(3):505

Biological Factors Underpinning Suicidal Behaviour: An Update.

Abou Chahla MN; Khalil MI; Comai S; Brundin L; Erhardt S; Guillemin GJ
Corrigendum: MOLECULAR PSYCHIATRY. 2022;27(3):1855

Correction: GRK3 deficiency elicits brain immune activation and psychosis.

Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schulmann A; Goiny M; Svensson CI; Hökfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landén M; Engberg G; Erhardt S
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:290-291

Dysregulation of the Kynurenine Pathway is Related to Persistent Cognitive Impairments After Tick Borne Encephalitis (TBE)

Schwieler L; Weidenfors JA; Griska V; Li X; Piehl F; Mickiene A; Erhardt S
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:378-379

Proteomic Plasma Profiling of Patients With First-Episode Psychosis Identifies Inflammatory Markers Associated With Illness Severity

Erhardt S; Schwieler L; Sellgren CM; Eren F; Cervenka S; Piehl F; Bergman HF; Orhan F; Engberg G
Preprint: 2021;medRxiv

Cerebrospinal fluid concentration of complement component 4A is increased in first-episode schizophrenia

Gracias J; Orhan F; Hörbeck E; Holmén-Larsson J; Khanlarkani N; Malwade S; Goparaju SK; Schwieler L; Fatourus-Bergman H; Pelanis A; Goold CP; Goulding A; Annerbrink K; Isgren A; Sparding T; Schalling M; Yañez VAC; Göpfert JC; Nilsson J; Brinkmalm A; Blennow K; Zetterberg H; Engberg G; Piehl F; Sheridan SD; Perlis RH; Cervenka S; Erhardt S; Landen M; Sellgren CM
Letter: SCHIZOPHRENIA RESEARCH. 2019;208:490-492

Neurogranin as a potential synaptic marker in the cerebrospinal fluid of patients with a first episode psychosis.

Santillo AF; Lundgren S; Xu C; Orhan F; Fatouros-Bergman H; Blennow K; Zetterberg H; Portelius E; Karolinska Schizophrenia Project (KaSP) Consortium; Cervenka S; Jönsson EG; Erhardt S; Engberg G
Letter: BIOLOGICAL PSYCHIATRY. 2019;85(7):e35-e39

Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

van Erp TGM; Walton E; Hibar DP; Schmaal L; Jiang W; Glahn DC; Pearlson GD; Yao N; Fukunaga M; Hashimoto R; Okada N; Yamamori H; Clark VP; Mueller BA; de Zwarte SMC; Ophoff RA; van Haren NEM; Andreassen OA; Gurholt TP; Gruber O; Kraemer B; Richter A; Calhoun VD; Crespo-Facorro B; Roiz-Santiañez R; Tordesillas-Gutiérrez D; Loughland C; Catts S; Fullerton JM; Green MJ; Henskens F; Jablensky A; Mowry BJ; Pantelis C; Quidé Y; Schall U; Scott RJ; Cairns MJ; Seal M; Tooney PA; Rasser PE; Cooper G; Shannon Weickert C; Weickert TW; Hong E; Kochunov P; Gur RE; Gur RC; Ford JM; Macciardi F; Mathalon DH; Potkin SG; Preda A; Fan F; Ehrlich S; King MD; De Haan L; Veltman DJ; Assogna F; Banaj N; de Rossi P; Iorio M; Piras F; Spalletta G; Pomarol-Clotet E; Kelly S; Ciufolini S; Radua J; Murray R; Marques TR; Simmons A; Borgwardt S; Schönborn-Harrisberger F; Riecher-Rössler A; Smieskova R; Alpert KI; Bertolino A; Bonvino A; Di Giorgio A; Neilson E; Mayer AR; Yun J-Y; Cannon DM; Lebedeva I; Tomyshev AS; Akhadov T; Kaleda V; Fatouros-Bergman H; Flyckt L; Karolinska Schizophrenia Project; Rosa PGP; Serpa MH; Zanetti MV; Hoschl C; Skoch A; Spaniel F; Tomecek D; McIntosh AM; Whalley HC; Knöchel C; Oertel-Knöchel V; Howells FM; Stein DJ; Temmingh HS; Uhlmann A; Lopez-Jaramillo C; Dima D; Faskowitz JI; Gutman BA; Jahanshad N; Thompson PM; Turner JA
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2019;44(SUPPL 1):490-491

Role of GRK3 in Brain Immune Activation and Psychosis

Erhardt S; Sellgren CM; Schwieler L; Imbeault S; Engberg G
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2019;44(SUPPL 1):169-170

Synaptic Elimination in First-Episode Psychosis Subjects

Engberg G; Xu C; Sellgren C; Fatouros-Bergman H; Blennow K; Zetterberg H; Brinkmalm A; Erhardt S
Letter: SCHIZOPHRENIA RESEARCH. 2018;199:438-441

Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients.

Checa A; Malmqvist A; Flyckt L; Schwieler L; Samuelsson M; Skogh E; Cervenka S; Dahl M-L; Piehl F; Karolinska Schizophrenia Project (KaSP) Consortium; Erhardt S; Wheelock CE
Review: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2018;90:212-220

Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression.

Price JB; Bronars C; Erhardt S; Cullen KR; Schwieler L; Berk M; Walder K; McGee SL; Frye MA; Tye SJ
Letter: SCHIZOPHRENIA RESEARCH. 2018;195:406-408

First-episode psychosis patients display increased plasma IL-18 that correlates with cognitive dysfunction.

Orhan F; Fatouros-Bergman H; Schwieler L; Cervenka S; Flyckt L; Sellgren CM; Karolinska Schizophrenia Project (KaSP) consortium; Engberg G; Erhardt S
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:S722

Associations between central chemokine levels and glial activation in first episode psychosis - a positron emission tomography study

Collste K; Orhan F; Erhardt S; Schwieler L; Flyckt L; Farde L; Engberg G; Cervenka S
Preprint: 2017;bioRxiv

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

Kong X-Z; Mathias S; Guadalupe T; Abé C; Agartz I; Akudjedu T; Andre A; Saud A; Allen N; Ames D; Andreassen O; Arias Vasquez A; Armstrong N; Bergo F; Bastin M; Batalla A; Bauer J; Baune B; Baur R; Biederman J; Blaine S; Boedhoe P; Bøen E; Bose A; Bralten J; Brandeis D; Brem S; Brodaty H; Bröhl H; Brooks S; Buitelaar J; Bürger C; Bülow R; Calhoun V; Calvo A; Canales-Rodríguez EJ; Canive J; Cannon D; Caparelli E; Castellanos F; Cavalleri G; Cendes F; Chaim-Avancini TM; Chantiluke K; Chen Q-L; Chen X; Cheng Y; Christakou A; Clark V; Coghill D; Connolly C; Conzelmann A; Cόrdova-Palomera A; Cousijn J; Crow T; Cubillo A; Dannlowski U; de Bruttopilo SA; Zeeuw PD; Deary I; Delanty N; Demeter D; Martino AD; Dickie E; Dietsche B; Doan T; Doherty C; Doyle A; Durston S; Earl E; Ehrlich S; Ekman CJ; Elvsåshagen T; Epstein J; Fair D; Faraone S; Fatouros-Bergman H; Fernndez G; Busatto Filho G; Flyckt L; Forster K; Jean-Paul F; Foxe J; Fuentes-Claramonte P; Fullerton J; Garavan H; Garcia DDS; Gotlib I; Goudriaan A; Jorgen Grabe H; Groenewold N; Grotegerd D; Gruber O; Gurholt T; Haavik J; Hahn T; Hansell N; Harris M; Hartman C; Hernandez MDCV; Heslenfeld D; Hester R; Hibar DP; Ho B-C; Ho T; Hoekstra P; van Holst R; Hoogman M; Hovik M; Howells F; Hugdahl K; Huyser C; Ingvar M; Irwin L; Ishikawa A; James A; Jahanshad N; Jernigan T; Jonsson E; Kahler C; Kaleda V; Kelly C; Kerich M; Keshavan M; Khadka S; Kircher T; Kohls G; Konrad K; Korucuoglu O; Kramer B; Krug A; Kwon JS; Lambregts-Rommelse N; Landen M; Lazaro L; Lebedeva I; Lenroot R; Lesch K-P; Li Q; Lim K; Liu J; Lochner C; London E; Lonning V; Lorenzetti V; Luciano M; Luijten M; Lundervold A; Mackey S; MacMaster F; Maingault S; Malpas C; Malt U; Mataix-Cols D; Martin-Santos R; Mayer A; McCarthy H; Mitchell P; Mueller B; Maniega SM; Mazoyer B; McDonald C; McLellan Q; McMahon K; McPhilemy G; Momenan R; Morales A; Narayanaswamy J; Moreira JCV; Nerland S; Nestor L; Nigg J; Nordvik J-E; Novotny S; Oberwelland E; O'Gorman R; Oosterlaan J; Oranje B; Orr C; Overs B; Pauli P; Paulus M; Plessen K; von Polier G; Pomarol-Clotet E; Qiu J; Radua J; Ramos-Quiroga JA; Reddy YCJ; Reif A; Roberts G; Rosa P; Rubia K; Sacchet M; Sachdev P; Salvador R; Schmaal L; Schweren L; Seidman L; Seitz J; Serpa MH; Shaw P; Shumskaya E; Silk T; Simmons A; Simulionyte E; Sinha R; Sjoerds Z; Smelror RE; Soliva JC; Solowij N; Sponheim S; Stein D; Stein E; Stevens M; Strike L; Sudre G; Sui J; Tamm L; Temmingh H; Thoma R; Tomyshev A; Tronchin G; Turner J; Uhlmann A; van Erp TGM; van den Heuvel O; van der Meer D; van Eijk L; Vance A; Veer I; Dic
Conference publication: BIOLOGICAL PSYCHIATRY. 2017;81(10):S266-S267

Metformin Enhances Antidepressant Response Rate to Ketamine in a Rodent Model of Antidepressant Treatment Resistance

Price J; He C; Erhardt S; Schwieler L; Frye M; Tye S
Review: NEUROPHARMACOLOGY. 2017;112(Pt B):297-306

The kynurenine pathway in schizophrenia and bipolar disorder.

Erhardt S; Schwieler L; Imbeault S; Engberg G
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2017;42:S220-S221

First-Episode Psychosis Patients Display Increased Plasma IL-18 That Correlates With Cognitive Dysfunctions

Schwieler L; Orhan F; Fatouros-Bergman H; Cervenka S; Flyckt L; Farde L; Sellgren CM; Engberg G; Erhardt S
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;44:S522

Radiosynthesis of 6-[¹⁸F]Fluoro-α-methyl-L-tryptophan - a prospective tracer for in vivo studies of tryptophan metabolism

Vazquez-Romero A; Revunov E; Krasikova R; Moein MM; Cervenka S; Erhardt S; Halldin C; Schou M
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2017;37:234

Reduced TSPO levels in drug-naive first episode psychosis patients as measured using PET and [¹¹C]PBR28

Collste K; Plaven-Sigray P; Fatouros-Bergman H; Victorsson P; Schain M; Forsberg A; Amini N; Aeinehband S; Erhardt S; Halldin C; Flyckt L; Farde L; Cervenka S
Conference publication: BIOLOGICAL PSYCHIATRY. 2016;79(9):338S-339S

An Enzyme in the Kynurenine Pathway That Governs Vulnerability to Develop Suicidal Behavior

Brundin L; Sellgren C; Lim C; Grit J; Palsson E; Landen M; Brundin P; Fuchs D; Postolache T; Traskman-Bendz L; Guillemin G; Erhardt S
Review: LAKARTIDNINGEN. 2015;112:DH34

[New findings about schizophrenia can provide new diagnostics and treatment].

Schalling M; Engberg G; Andreassen O; Erhardt S; Cunningham J; Agartz I; Petrovic P; Cervenka S; Fatouros-Bergman H
Review: ACTA PSYCHIATRICA SCANDINAVICA. 2015;132(3):192-203

The role of inflammation in suicidal behaviour.

Brundin L; Erhardt S; Bryleva EY; Achtyes ED; Postolache TT
Conference publication: CANCER RESEARCH. 2015;75:1162

Investigating the NAD metabolome in Ewing Sarcoma

Mutz CN; Schwentner R; Kauer MO; Ban J; Aryee DNT; Erhardt S; Fuchs D; Heitger A; Kovar H
Meeting abstract: EUROPEAN PSYCHIATRY. 2015;30:277

Cognitive Performance in Drug-naive First Episode Schizophrenia (FES) Patients

Fatouros-Bergman H; Cervenka C; Flyckt L; Edman G; Schwieler L; Ikonen P; Collste K; Piehl F; Agartz I; Engberg G; Erhardt S; Farde L
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2015;21:351-352

Cerebrospinal fluid kynurenines in multiple sclerosis: relation to disease course and neurocognitive symptoms

Stahl S; Aeinehband S; Brenner P; Bhat M; Fidock MD; Khademi M; Olsson T; Engberg G; Jokinen J; Erhardt S; Piehl F
Conference publication: DIABETOLOGIA. 2015;58:S300

Acute exercise impacts kynurenine metabolism in type 2 diabetic and healthy people

Mudry JM; Ruas JL; Erhardt S; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
Corrigendum: CELL. 2015;160(1-2):351

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression (vol 159, pg 33, 2014)

Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson A; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Conference publication: BIPOLAR DISORDERS. 2014;16:65

An inflammatory pathway linked to psychosis in bipolar disorder

Sellgren C; Kegel ME; Bergen SE; Ekman CJ; Olsson S; Larsson M; Sullivan PF; Sklar P; Purcell S; Smoller JW; Magnusson PKE; Hultman CM; Walther-Jallow L; Svensson CI; Lichtenstein P; Engberg G; Erhardt S; Landen M
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23:S14-S15

Intracerebroventricular administration of interleukin-1β elevates brain kynurenic acid and disrupts prepulse inhibition in C57BL/6 mice

Larsson M; Schwieler L; Engberg G; Powell SB; Erhardt S
Conference publication: BIOLOGICAL PSYCHIATRY. 2013;73(9):152S

Il-8 is Associated with Anxiety in Suicide Attempters

Janelidze S; Suchankova P; Ekman A; Erhardt S; Samuelsson M; Westrin A; Minthon L; Hansson O; Traeskman-Bendz L; Brundin L
Conference publication: BIOLOGICAL PSYCHIATRY. 2013;73(9):34S

The Role of CD44-Hyaluronic Acid Signaling in Response to Stress in Mice and in Suicidal Behavior in Humans

Barzilay R; Ventorp F; Segal H; Aharoni I; Globus R; Weizman A; Naor D; Erhardt S; Lipton J; Traskman-Bendz L; Offen D; Brundin L
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:128-129

Endogenous kynurenic acid induces a reduction in parvalbumin immunoreactivity in the rat frontal cortex

Orhan F; Kegel M; Larsson M; Schwieler L; Erhardt S
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:134

Central interleukin-6 activation in patients with chronic schizophrenia

Schwieler L; Skogh E; Samuelsson M; Kegel M; Erhardt S; Engberg G
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:128

Kynurenic acid in cerebrospinal fluid, plasma and urine of healthy male volunteers

Olsson S; Samuelsson M; Erhardt S
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:228

Association between IL-8 and anxiety in suicidal patients

Janelidze S; Suchankova P; Ekman A; Erhardt S; Westrin A; Traskman-Bendz L; Brundin L
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:180

CSF biomarkers in suicide attempters - inflammation biomarkers and monoamine metabolites

Lindqvist D; Janelidze S; Erhardt S; Traskman-Bendz L; Engstrom G; Brundin L
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:179

IL-1β induces TDO and provokes the release of kynurenic acid from human astrocytes in vitro

Kegel ME; Svensson CI; Erhardt S
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:28

Inflammation as a cause of suicidality?

Brundin L; Erhardt S; Traskman-Bendz L
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:117

Significance of elevated brain kynurenic acid following neonatal influenza A infection

Holtze M; Powell SB; Asp L; Karlsson H; Erhardt S
Letter: SCHIZOPHRENIA RESEARCH. 2011;127(1-3):270-272

Kynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: an association study.

Holtze M; Saetre P; Erhardt S; Schwieler L; Werge T; Hansen T; Nielsen J; Djurovic S; Melle I; Andreassen OA; Hall H; Terenius L; Agartz I; Engberg G; Jönsson EG; Schalling M
Conference publication: BIPOLAR DISORDERS. 2011;13:87

Plasticity related gene 5, kynurenic acid, and psychotic features in bipolar disorder

Sellgren C; Olsson S; Lichtenstein P; Erhardt S; Engberg G; Grankvist A; Landen M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2010;20:S40

Neonatal influenza A infection potentiates amphetamine induced increase in locomotor activity in the adult mouse

Holtze M; Asp L; Karlsson H; Erhardt S
Letter: MOLECULAR PSYCHIATRY. 2009;14(12):1069-1071

Activation of brain interleukin-1beta in schizophrenia.

Söderlund J; Schröder J; Nordin C; Samuelsson M; Walther-Jallow L; Karlsson H; Erhardt S; Engberg G
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S178

Do virus infections cause schizophrenia?

Karlsson H; Asp L; Ogren SO; Erhardt S; Holtze M; Kristensson K; Dalman C
Review: CNS DRUGS. 2009;23(2):91-101

Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders.

Erhardt S; Olsson SK; Engberg G
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2008;11:180

Kynurenic acid levels are increased in the cerebrospinal fluid of patients with bipolar disorder

Olsson S; Erhardt S; Engberg G; Landen M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S422-S423

Enhanced amphetamine-induced dopamine release in rat nucleus accumbens following subchronic elevation of kynurenic acid

Andersson LA; Nilsson LK; Schwieler L; Holtze M; Olsson SK; Olsson E; Linderholm K; Engberg G; Erhardt S
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S419-S420

Subchronic elevation of endogenous levels of kynurenic acid increase dopamine release in rat nucleus accumbens

Nilsson-Todd LK; Andersson LA; Schwieler L; Engberg G; Holtze M; Linderholm KR; Olsson E; Olsson SK; Erhardt S
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S219

Endogenous kynurenate regulates dopaminergic activity: implications for schizophrenia research

Erhardt S; Schwieler L; Nilsson LK; Andersson LA; Linderholm KR; Holtze M; Olsson E; Olsson SK; Engberg G
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S264-S265

Increased midbrain dopaminergic firing by the competitive N-methyl-D-aspartate receptor antagonist SDZ 220-581

Olsson SK; Linderholm K; Erhardt S; Engberg G
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S435-S436

The response of clozapine on midbrain dopamine neurons depends on endogenous concentration of kynurenic acid

Schwieler L; Linderholm KR; Nilsson LK; Engberg G; Erhardt S
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S377

Correlations between cerebrospinal fluid kynurenic acid and monoamine metabolites in male patients with schizophrenia

Erhardt S; Nordin C; Skogh E; Jonsson EG; Nilsson LK
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2006;31:S126

Changes in brain kynurenic acid levels alter the response of clozapine on midbrain dopamine neurons

Engberg G; Erhardt S; Linderholm K; Nilsson L; Schwieler L
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2006;31:S45

Role of endogenous kynurenic acid in the control of dopaminergic neurotransmission

Erhardt S; Schwieler L; Linderholm K; Nilsson L; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2006;60(4):334

Changes in brain kynurenic acid levels alter the response of clozapine on midbrain dopamine neurons

Linderholm KR; Erhardt S; Nilsson LK; Schwieler L; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2006;60(4):321

Kynurenic acid in schizophrenia

Erhardt S
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2006;31:S45-S46

Developing a model of kynurenic acid effects on information processing

Powell SB; Erhardt S; Nilsson LK; Linderholm KR; Swerdlow NR; Geyer MA
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2006;60(4):328-329

In situ produced 7-chlorokynurenic acid increase phasic activity of dopaminergic neurons in the rat ventral tegmental area

Andersson LA; Linderholm KR; Eggertson CJ; Schwarcz R; Engberg G; Erhardt S
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15:S34-S35

Rats reared in social isolation display disrupted ppi and elevated levels of kynurenic acid in the hippocampus

Erhardt S; Powell SB; Nilsson LK; Linderholm KR; Swerdlow NR; Geyer MA
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2005;59(5):409

Kynurenate tonically modulates midbrain dopamine neurons

Erhardt S; Schwieler L; Linderholm KR; Nilsson LK; Engberg G
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15:S320

Rats reared in social isolation display disrupted PPI and elevated levels of kynurenic acid in the hippocampus

Erhardt S; Swerdlow NR; Powell SB; Nilsson LK; Linderholm KR; Geyer MA
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2005;59(5):416-417

Kynurenic acid levels in cerebrospinal fluid from schizophrenic patients.

Nilsson LK; Linderholm KR; Sedvall G; Engberg G; Erhardt S
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2005;59(5):414

Increased kynurenate in the brain of rats reared in social isolation.

Linderholm KR; Erhardt S; Powell SB; Nilsson LK; Swerdlow N; Geyer MA
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2004;58(2):106-107

Prostaglandin-mediated control of rat brain kynurenic acid synthesis - opposite actions by COX-1 and COX-2 isoforms

Schwieler L; Erhardt S; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2004;58(2):102

Clozapine affects noradrenergic locus coerulcus neurons via interactions with the NMDA receptor

Erhardt S; Nilsson LK; Schwieler L; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2004;58(2):94

Elevation of the endogenous NMDA-receptor antagonist kynurenic acid disrupts prepulse inhibition

Erhardt S; Schwieler L; Geyer M
Published paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2003;527:155-165

Kynurenic acid and schizophrenia.

Erhardt S; Schwieler L; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2001;55(2):90

Excitatory and inhibitory effects of nicotine on neuronal firing of A10 dopamine neurons are mediated via glutamate-and GABA-release, respectively

Erhardt S; Schwieler LH; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2001;55(2):89

The intravenous anesthetic agent propofol induces regularization of the firing pattern and prevents burst activity of nigral dopamine neurons via a GABAB-receptor agonistic action

Engberg G; Erhardt S; Schwieler LH
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2000;54(2):93

Endogenous kynurenic acid blocks nicotine-induced activation of brain dopaminergic and noradrenergic neurons

Erhardt S; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 1999;53(2):110

Increased tiring rate and burst activity of nigral dopamine neurons by the gamma-butyric acid receptor antagonist SCH 50911

Erhardt S; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 1998;52(2):135

γ-hydroxybutyric acid inhibits firing rate and regularizes firing pattern of nigral dopamine neurons specifically by activation of gamma-aminobutyric acid β-receptors

Erhardt S; Engberg G
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Grants

Integrated understanding of the pathophysiology in severe psychiatric disorders – a translational approach with focus on immune activation.

Swedish Research Council

1 January 2022 - 31 December 2024
The effect of psilocybin on depression symptom severity, peripheral biomarkers and synaptic density – a single dose randomized double blind, placebo-controlled phase 2 PET study

Swedish Research Council

1 January 2022 - 31 December 2024
A novel immunological approach in the treatment of schizophrenia – drug development, clinical and experimental evaluations

Swedish Research Council

1 January 2020 - 31 December 2023
61st Annual Meeting of Scandinavian College of Neuropsychopharmacology (SCNP)

Swedish Research Council

1 November 2019 - 30 November 2019
Unraveling the Complexity of Psychiatric disorders

Swedish Research Council

1 January 2018 - 31 December 2021
MRI brain morphology and connectivity in schizophrenia; translational studies of four cohorts; importance of genetic and non-genetic risk factors for brain development and clinical outcome

Swedish Research Council

1 January 2018 - 31 December 2020
Affective disorders- A translational and prospective approach to dimensional etiology and treatment response

Swedish Research Council

1 January 2017 - 31 December 2019
Unraveling the Immune Architecture of Schizophrenia

Swedish Research Council

1 January 2014 - 31 December 2017
Towards an understanding of gliotransmission in psychiatric disorders - role of neuroimmunology

Swedish Research Council

1 January 2012 - 31 December 2013
Brain immune activation in schizophrenia - functional investigations of a novel antipsychotic drug target

Swedish Research Council

1 January 2012 - 31 December 2013
Towards an understanding of gliotransmission in psychiatric disorders - Role of neuroimmunology

Swedish Research Council

1 September 2010 - 31 August 2016
Towards an understanding of gliotransmission in psychiatric disorders - Role of neuroimmunology

Swedish Research Council

1 September 2010 - 31 August 2016
Towards an understanding of gliotransmission in psychiatric disorders - role of neuroimmunology

Swedish Research Council

1 January 2010 - 31 December 2011
Brain Immune actvation in schizophrenia

Swedish Research Council

1 January 2009 - 31 December 2012

Employments

Professor, Department of Physiology and Pharmacology, Karolinska Institutet, 2016-

Degrees and Education

Docent, Karolinska Institutet, 2006
Doctor Of Philosophy, Department of Physiology and Pharmacology, Karolinska Institutet, 2001

Leadership and responsibility assignments

Head of department, C3 Department of Physiology and Pharmacology, Karolinska Institutet, 2022-

About me

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