About me
Stine Marie Præstholm obtained her PhD from the University of Southern Denmark in April 2021. During her doctoral studies she investigated transcriptional regulation mediated by nuclear receptors: the thyroid hormone receptor and the glucocorticoid receptor, in mouse liver. Specifically, she looked into enhancers regulated by the thyroid hormone receptor identifying different types of enhancers differential bound by coregulators. Later, she studied the role of the glucocorticoid receptor in regulating hepatic gene transcription in the transition from fasting to feeding in a circadian context.
Research description
In October 2021, I started my SRP Diabetes Postdoctoral Fellowship at Karolinska Institutet under the supervision of Professor Jorge Ruas at the Department of Physiology and Pharmacology. In our project we investigate how a protein, newly discovered to be a major regulator of inflammation, extracellular matrix remodeling and fibrogenesis, called TRAIN, promotes NAFLD/NASH and elucidate the molecular mechanism. Moreover, we will evaluate the TRAIN-driven secretome to identify diagnostic tools for NAFLD/NASH and investigate TRAIN levels and candidate biomarkers in NAFLD/NASH patient samples. The findings of this project could potentially form a basis of a new class of pharmacological therapies for NASH.
Education
PhD | 2021 | Biochemistry and Molecular Biology, University of Southern Denmark
MSc | 2018 | Biochemistry and Molecular Biology, University of Southern Denmark
BSc | 2015 | Biochemistry and Molecular Biology, University of Southern Denmark