Stine Marie Præstholm

Stine Marie Præstholm

Postdoctoral Researcher
Visiting address: Solnavägen 9, Biomedicum C5, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Molekylär och cellulär arbetsfysiologi, 171 77 Stockholm
Part of:

About me

  • Stine Marie Præstholm obtained her PhD from the University of Southern Denmark in April 2021. During her doctoral studies she investigated transcriptional regulation mediated by nuclear receptors: the thyroid hormone receptor and the glucocorticoid receptor, in mouse liver. Specifically, she looked into enhancers regulated by the thyroid hormone receptor identifying different types of enhancers differential bound by coregulators. Later, she studied the role of the glucocorticoid receptor in regulating hepatic gene transcription in the transition from fasting to feeding in a circadian context. PhD | 2021 | Biochemistry and Molecular Biology, University of Southern Denmark MSc | 2018 | Biochemistry and Molecular Biology, University of Southern Denmark BSc | 2015 | Biochemistry and Molecular Biology, University of Southern Denmark

Research

  • In October 2021, I started my SRP Diabetes Postdoctoral Fellowship at Karolinska Institutet under the supervision of Professor Jorge Ruas at the Department of Physiology and Pharmacology. In our project we investigate how a protein, newly discovered to be a major regulator of inflammation, extracellular matrix remodeling and fibrogenesis, called TRAIN, promotes NAFLD/NASH and elucidate the molecular mechanism. Moreover, we will evaluate the TRAIN-driven secretome to identify diagnostic tools for NAFLD/NASH and investigate TRAIN levels and candidate biomarkers in NAFLD/NASH patient samples. The findings of this project could potentially form a basis of a new class of pharmacological therapies for NASH.

Articles

All other publications

News from KI

Events from KI