Svetlana Bajalica Lagercrantz

About me
Publications
CV
Public outreach and news

About me

Svetlana Bajalica Lagercrantz is an Adjunct Professor of Cancer Genetics,
especially hereditary cancers.
Read more about her research [1]
[1] https://ki.se/en/onkpat/research-team-svetlana-bajalica-lagercrantz

Articles

Article: BIOMEDICINES. 2022;10(5):1004

Whole-Exome Sequencing of Germline Variants in Non-BRCA Families with Hereditary Breast Cancer.

Liu Y; Helgadottir HT; Kharaziha P; Choi J; López-Giráldez F; Mane SM; Höiom V; Juhlin CC; Larsson C; Bajalica-Lagercrantz S
Article: NATURE CANCER. 2022;3(2):251-261

The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Tamborero D; Dienstmann R; Rachid MH; Boekel J; Lopez-Fernandez A; Jonsson M; Razzak A; Braña I; De Petris L; Yachnin J; Baird RD; Loriot Y; Massard C; Martin-Romano P; Opdam F; Schlenk RF; Vernieri C; Masucci M; Villalobos X; Chavarria E; Cancer Core Europe consortium; Balmaña J; Apolone G; Caldas C; Bergh J; Ernberg I; Fröhling S; Garralda E; Karlsson C; Tabernero J; Voest E; Rodon J; Lehtiö J
Article: CANCERS. 2022;14(2):380

Whole-Body MRI Surveillance-Baseline Findings in the Swedish Multicentre Hereditary TP53-Related Cancer Syndrome Study (SWEP53).

Omran M; Tham E; Brandberg Y; Ahlström H; Lundgren C; Paulsson-Karlsson Y; Kuchinskaya E; Silander G; Rosén A; Persson F; Leonhardt H; Stenmark-Askmalm M; Berg J; van Westen D; Bajalica-Lagercrantz S; Blomqvist L; the Swedish Clinical TP53 Study Group (SweClinTP53
Article: EUROPEAN JOURNAL OF MEDICAL GENETICS. 2021;64(12):104350

Overview of hereditary breast and ovarian cancer (HBOC) guidelines across Europe.

Marmolejo DH; Wong MYZ; Bajalica-Lagercrantz S; Tischkowitz M; Balmaña J; extended ERN-GENTURIS Thematic Group 3
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(12):6345

Association between Predicted Effects of TP53 Missense Variants on Protein Conformation and Their Phenotypic Presentation as Li-Fraumeni Syndrome or Hereditary Breast Cancer.

Liu Y; Axell O; van Leeuwen T; Konrat R; Kharaziha P; Larsson C; Wright APH; Bajalica-Lagercrantz S
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(10):1379-1386

Guidelines for the Li-Fraumeni and heritable TP53-related cancer syndromes.

Frebourg T; Bajalica Lagercrantz S; Oliveira C; Magenheim R; Evans DG; European Reference Network GENTURIS
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(10):1387-1393

Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome.

Tischkowitz M; Colas C; Pouwels S; Hoogerbrugge N; PHTS Guideline Development Group; European Reference Network GENTURIS
Article: HEREDITARY CANCER IN CLINICAL PRACTICE. 2020;18:1

Whole-body MRI within a surveillance program for carriers with clinically actionable germline TP53 variants - the Swedish constitutional TP53 study SWEP53.

Omran M; Blomqvist L; Brandberg Y; Pal N; Kogner P; Ståhlbom AK; Tham E; Bajalica-Lagercrantz S
Article: CLINICAL GENETICS. 2019;96(3):216-225

Functional characterization of novel germline TP53 variants in Swedish families.

Kharaziha P; Ceder S; Axell O; Krall M; Fotouhi O; Böhm S; Lain S; Borg Å; Larsson C; Wiman KG; Tham E; Bajalica-Lagercrantz S
Article: FAMILIAL CANCER. 2019;18(2):281-284

Boosting care and knowledge about hereditary cancer: European Reference Network on Genetic Tumour Risk Syndromes.

Vos JR; Giepmans L; Röhl C; Geverink N; Hoogerbrugge N; ERN GENTURIS
Article: INTERNATIONAL JOURNAL OF CANCER. 2019;144(5):1195-1204

Prevalence of BRCA1 and BRCA2 pathogenic variants in a large, unselected breast cancer cohort.

Li J; Wen WX; Eklund M; Kvist A; Eriksson M; Christensen HN; Torstensson A; Bajalica-Lagercrantz S; Dunning AM; Decker B; Allen J; Luccarini C; Pooley K; Simard J; Dorling L; Easton DF; Teo S-H; Hall P; Borg Å; Grönberg H; Czene K
Article: PATHOBIOLOGY. 2018;85(4):211-219

Proteomic Profiling of Diffuse Large B-Cell Lymphomas.

Kwiecińska A; Porwit A; Souchelnytskyi N; Kaufeldt A; Larsson C; Bajalica-Lagercrantz S; Souchelnytskyi S
Article: ONCOTARGET. 2016;7(24):35703-35723

Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells.

Pellegrini P; Dyczynski M; Sbrana FV; Karlgren M; Buoncervello M; Hägg-Olofsson M; Ma R; Hartman J; Bajalica-Lagercrantz S; Grander D; Kharaziha P; De Milito A
Article: JOURNAL OF OVARIAN RESEARCH. 2016;9(1):27

Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer.

Fransson Å; Glaessgen D; Alfredsson J; Wiman KG; Bajalica-Lagercrantz S; Mohell N
Article: ONCOTARGET. 2015;6(34):36894-36902

Alterations of biomarker profiles after neoadjuvant chemotherapy in breast cancer: tumor heterogeneity should be taken into consideration.

Zhou X; Zhang J; Yun H; Shi R; Wang Y; Wang W; Lagercrantz SB; Mu K
Article: ANNALS OF DIAGNOSTIC PATHOLOGY. 2015;19(4):243-248

A standardized method for quantifying proliferation by Ki-67 and cyclin A immunohistochemistry in breast cancer.

Mu K; Li L; Yang Q; Yun H; Kharaziha P; Ye D-W; Auer G; Lagercrantz SB; Zetterberg A
Article: LANCET. 2015;386(9992):433-443

Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial.

Gnant M; Pfeiler G; Dubsky PC; Hubalek M; Greil R; Jakesz R; Wette V; Balic M; Haslbauer F; Melbinger E; Bjelic-Radisic V; Artner-Matuschek S; Fitzal F; Marth C; Sevelda P; Mlineritsch B; Steger GG; Manfreda D; Exner R; Egle D; Bergh J; Kainberger F; Talbot S; Warner D; Fesl C; Singer CF; Austrian Breast and Colorectal Cancer Study Group
Article: GENES CHROMOSOMES & CANCER. 2014;53(9):750-768

Amplification of 2p as a genomic marker for transformation in lymphoma.

Kwiecinska A; Ichimura K; Berglund M; Dinets A; Sulaiman L; Collins VP; Larsson C; Porwit A; Lagercrantz SB
Article: PLOS ONE. 2014;9(11):e111125

Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma.

Xu L-D; Muller S; Thoppe SR; Hellborg F; Kanter L; Lerner M; Zheng B; Lagercrantz SB; Grandér D; Wallin KL; Wiman KG; Larsson C; Andersson S
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(5):1190-1195

Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy.

Daneshmanesh AH; Mikaelsson E; Jeddi-Tehrani M; Bayat AA; Ghods R; Ostadkarampour M; Akhondi M; Lagercrantz S; Larsson C; Osterborg A; Shokri F; Mellstedt H; Rabbani H
Article: LEUKEMIA & LYMPHOMA. 2008;49(3):477-487

Characterization of 6q deletions in mature B cell lymphomas and childhood acute lymphoblastic leukemia.

Thelander EF; Ichimura K; Corcoran M; Barbany G; Nordgren A; Heyman M; Berglund M; Mungall A; Rosenquist R; Collins VP; Grandér D; Larsson C; Lagercrantz S
Article: LEUKEMIA RESEARCH. 2007;31(9):1219-1230

Detailed assessment of copy number alterations revealing homozygous deletions in 1p and 13q in mantle cell lymphoma.

Flordal Thelander E; Ichimura K; Collins VP; Walsh SH; Barbany G; Hagberg A; Laurell A; Rosenquist R; Larsson C; Lagercrantz S
Article: MODERN PATHOLOGY. 2007;20(1):63-75

Genomic imbalances during transformation from follicular lymphoma to diffuse large B-cell lymphoma.

Berglund M; Enblad G; Thunberg U; Amini R-M; Sundström C; Roos G; Erlanson M; Rosenquist R; Larsson C; Lagercrantz S
Article: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2006;82(2):87-96

Evaluation of spectral karyotyping (SKY) in biodosimetry for the triage situation following gamma irradiation.

Szeles A; Joussineau S; Lewensohn R; Lagercrantz S; Larsson C
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;118(3):555-563

U-2940, a human B-cell line derived from a diffuse large cell lymphoma sequential to Hodgkin lymphoma.

Sambade C; Berglund M; Lagercrantz S; Sällström J; Reis RM; Enblad G; Glimelius B; Sundström C
Article: MODERN PATHOLOGY. 2005;18(3):331-339

Mantle cell lymphomas with clonal immunoglobulin V(H)3-21 gene rearrangements exhibit fewer genomic imbalances than mantle cell lymphomas utilizing other immunoglobulin V(H) genes.

Thelander EF; Walsh SH; Thorsélius M; Laurell A; Landgren O; Larsson C; Rosenquist R; Lagercrantz S
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2005;26(1):141-149

Molecular cytogenetic characterization of primary cultures and established cell lines from non-medullary thyroid tumors.

Foukakis T; Thoppe SR; Lagercrantz S; Dwight T; Weng W-H; Svensson A; Höög A; Zedenius J; Wallin G; Lui W-O; Larsson C
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2004;25(4):955-960

Molecular cytogenetic characterization shows higher genetic homogeneity in conventional renal cell carcinoma compared to other kidney cancers.

Alimov A; Sundelin B; Bergerheim U; Pavlenko M; Pisa P; Zetterberg A; Larsson C; Lagercrantz S
Article: GENES CHROMOSOMES & CANCER. 2004;41(2):133-144

Spontaneously immortalized human T lymphocytes develop gain of chromosomal region 2p13-24 as an early and common genetic event.

Siwicki JK; Berglund M; Rygier J; Pienkowska-Grela B; Grygalewicz B; Degerman S; Golovleva I; Chrzanowska KH; Lagercrantz S; Blennow E; Roos G; Larsson C
Article: CANCER GENETICS. 2003;141(1):43-48

Molecular cytogenetic characterization of four commonly used cell lines derived from Hodgkin lymphoma.

Berglund M; Flordal E; Gullander J; Lui W-O; Larsson C; Lagercrantz S; Enblad G
Article: BIOCHEMICAL PHARMACOLOGY. 2003;65(2):237-247

Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance.

Månsson E; Flordal E; Liliemark J; Spasokoukotskaja T; Elford H; Lagercrantz S; Eriksson S; Albertioni F
Article: CANCER GENETICS. 2002;139(1):38-43

Clonal development of a blastoid mantle cell lymphoma studied with comparative genomic hybridization.

Flordal E; Berglund M; Rosenquist R; Erlanson M; Enblad G; Roos G; Larsson C; Lagercrantz S
Article: LEUKEMIA & LYMPHOMA. 2002;43(11):2179-2189

A novel B-cell line (U-2932) established from a patient with diffuse large B-cell lymphoma following Hodgkin lymphoma.

Amini R-M; Berglund M; Rosenquist R; Von Heideman A; Lagercrantz S; Thunberg U; Bergh J; Sundström C; Glimelius B; Enblad G
Article: MODERN PATHOLOGY. 2002;15(8):807-816

Chromosomal imbalances in diffuse large B-cell lymphoma detected by comparative genomic hybridization.

Berglund M; Enblad G; Flordal E; Lui W-O; Backlin C; Thunberg U; Sundström C; Roos G; Allander SV; Erlanson M; Rosenquist R; Larsson C; Lagercrantz S
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2002;20(6):1161-1165

Aberrations of centrosomes in adrenocortical tumors.

Roshani L; Fujioka K; Auer G; Kjellman M; Lagercrantz S; Larsson C
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2001;8(6):681-689

Differential expression of multiple alternative spliceforms of the Men1 tumor suppressor gene in mouse.

Forsberg L; Zablewska B; Piehl F; Weber G; Lagercrantz S; Gaudray P; Höög C; Larsson C
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2001;145(4):415-420

Homozygous inactivation of the MEN1 gene as a specific somatic event in a case of secondary hyperparathyroidism.

Forsberg L; Villablanca A; Välimäki S; Farnebo F; Farnebo LO; Lagercrantz S; Larsson C
Article: GENES CHROMOSOMES & CANCER. 2001;32(1):43-49

Gain of 1q and loss of 9q21.3-q32 are associated with a less favorable prognosis in papillary thyroid carcinoma.

Kjellman P; Lagercrantz S; Höög A; Wallin G; Larsson C; Zedenius J
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2000;5(5):485-492

New chromosomal breakpoints in non-Hodgkin's lymphomas revealed by spectral karyotyping and G-banding.

Nordgren A; Sørensen AG; Tinggaard-Pedersen N; Blennow E; Larsson C; Lagercrantz S
Article: MAMMALIAN GENOME. 1999;10(4):376-380

Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene.

Ehrenborg E; Zazzi H; Lagercrantz S; Granqvist M; Hillerbrand U; Allander SV; Larsson C; Luthman H
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1998;247(2):357-360

Expression of the BCL6 gene in the pre- and postnatal mouse.

Bajalica-Lagercrantz S; Piehl F; Farnebo F; Larsson C; Lagercrantz J
Article: GENOMICS. 1998;50(2):275-280

Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG).

Peyrard M; Parveneh S; Lagercrantz S; Ekman M; Fransson I; Sahlén S; Dumanski JP
Article: MAMMALIAN GENOME. 1998;9(4):310-311

Mapping of the human Ca2+ channel beta 4 subunit to 2q22-23 and its expression in developing mouse.

Betz R; Leibiger B; Farnebo F; Lagercrantz S; Piehl F; Leibiger I; Larsson C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 1997;82(12):4258-4265

Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern.

Enmark E; Pelto-Huikko M; Grandien K; Lagercrantz S; Lagercrantz J; Fried G; Nordenskjöld M; Gustafsson JA
Article: GENOMICS. 1997;46(1):78-85

Cloning and characterization of freac-9 (FKHL17), a novel kidney-expressed human forkhead gene that maps to chromosome 1p32-p34.

Ernstsson S; Betz R; Lagercrantz S; Larsson C; Ericksson S; Cederberg A; Carlsson P; Enerbäck S
Article: GENOMICS. 1997;44(3):344-346

Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene.

Cederberg A; Betz R; Lagercrantz S; Larsson C; Hulander M; Carlsson P; Enerbäck S
Article: LEUKEMIA. 1997;11(4):594-598

Expression of LAZ3/BCL6 in follicular center (FC) B cells of reactive lymph nodes and FC-derived non-Hodgkin lymphomas.

Bajalica-Lagercrantz S; Piehl F; Lagercrantz J; Lindahl J; Weber G; Kerckeart JP; Porwit-MacDonald A; Nordenskjöld M
Article: GENOMICS. 1996;38(3):450-451

Localization of the human deoxyguanosine kinase gene (DGUOK) to chromosome 2p13.

Johansson M; Bajalica-Lagercrantz S; Lagercrantz J; Karlsson A
Article: GENOMICS. 1996;36(3):424-430

Primary structure of human 11-cis retinol dehydrogenase and organization and chromosomal localization of the corresponding gene.

Simon A; Lagercrantz J; Bajalica-Lagercrantz S; Eriksson U
Article: CANCER GENETICS. 1996;90(2):102-105

Duplication of 2q31-qter as a sole aberration in a case of non-Hodgkin's lymphoma.

Bajalica-Lagercrantz S; Tingaard Pedersen N; Sørensen AG; Nordenskjöld M
Article: CHROMOSOME RESEARCH. 1996;4(4):310-313

Mapping of a new MAP kinase activated protein kinase gene (3PK) to human chromosome band 3p21.2 and ordering of 3PK and two cosmid markers in the 3p22-p21 tumour-suppressor region by two-colour fluorescence in situ hybridization.

Szeles A; Bajalica-Lagercrantz S; Lindblom A; Lushnikova T; Kashuba VI; Imreh S; Nordenskjöld M; Klein G; Zabarovsky ER
Article: IUBMB LIFE. 1996;39(2):303-306

Nucleotide sequence of a cDNA clone (SUBT1) partly homologous to a human subtelomeric repeat sequence.

Lagercrantz J; Lagercrantz S
Article: GENOMICS. 1996;32(3):455-457

The gene for human glutaredoxin (GLRX) is localized to human chromosome 5q14.

Padilla CA; Bajalica S; Lagercrantz J; Holmgren A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1996;218(2):514-517

Chromosomal localization and 5' sequence of the human protein serine/threonine phosphatase 5' gene.

Xu X; Lagercrantz J; Zickert P; Bajalica-Lagercrantz S; Zetterberg A
Article: GENES CHROMOSOMES & CANCER. 1995;13(1):34-39

Characterization of add(1)(p36) in non-Hodgkin lymphomas by fluorescence in situ hybridization.

Bajalica S; Brøndum-Nielsen K; Sørensen AG; Pedersen NT; Kristoffersson U; Akerman M; Anderson M; Pisa P; Nordenskjöld M
Show more

All other publications

Review: CANCERS. 2022;14(19):4665

Pharmacogenomics for Prediction of Cardiovascular Toxicity: Landscape of Emerging Data in Breast Cancer Therapies.

Altena R; Bajalica-Lagercrantz S; Papakonstantinou A
Corrigendum: NATURE CANCER. 2022;3(5):649

Author Correction: The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Tamborero D; Dienstmann R; Rachid MH; Boekel J; Lopez-Fernandez A; Jonsson M; Razzak A; Braña I; De Petris L; Yachnin J; Baird RD; Loriot Y; Massard C; Martin-Romano P; Opdam F; Schlenk RF; Vernieri C; Masucci M; Villalobos X; Chavarria E; Cancer Core Europe consortium; Balmaña J; Apolone G; Caldas C; Bergh J; Ernberg I; Fröhling S; Garralda E; Karlsson C; Tabernero J; Voest E; Rodon J; Lehtiö J
Review: CANCERS. 2020;12(12):E3762-3762

Germline TP53 Testing in Breast Cancers: Why, When and How?

Evans DG; Woodward ER; Bajalica-Lagercrantz S; Oliveira C; Frebourg T
Letter: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(11):1483-1485

Reply to Kratz et al.

Frebourg T; Lagercrantz SB; Oliveira C; Magenheim R; Evans DG; European Reference Network GENTURIS
Letter: NATURE MEDICINE. 2020;26(7):992-994

Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal.

Tamborero D; Dienstmann R; Rachid MH; Boekel J; Baird R; Braña I; De Petris L; Yachnin J; Massard C; Opdam FL; Schlenk R; Vernieri C; Garralda E; Masucci M; Villalobos X; Chavarria E; Cancer Core Europe consortium; Calvo F; Fröhling S; Eggermont A; Apolone G; Voest EE; Caldas C; Tabernero J; Ernberg I; Rodon J; Lehtiö J
Letter: LEUKEMIA & LYMPHOMA. 2007;48(5):1038-1041

Establishment of a cell line from a chemotherapy resistant diffuse large B-cell lymphoma.

Berglund M; Thunberg U; Fridberg M; Wingren AG; Gullbo J; Leuchowius K-J; Amini R-M; Lagercrantz S; Horvat A; Enblad G; Söderberg O
Other: JOURNAL OF MEDICAL GENETICS. 1995;32(12):987-990

Partial disomy of Xp and the presence of SRY in a phenotypic female.

Bajalica S; Blennow E; Tşezou A; Galla-Voumvouraki A; Alevizaki M; Sinaniotis C; Kitsiou-Tzeli S

Employments

Adjunct Professor, Department of Oncology-Pathology, Karolinska Institutet, 2023-2027

Degrees and Education

Docent, Karolinska Institutet, 2003
University Medical Degree, Karolinska Institutet, 2001

About me

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI