takahiro-seki.jpg

Takahiro Seki

Research Specialist

Research description

Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo. Du Q, Wu J, Fischer C, Seki T, Jing X, Gao J, He X, Hosaka K, Tong L, Yasue A, Miyake M, Sobajima M, Oyadomari S, Sun X, Yang Y, Zhou Q, Ge M, Tao W, Yao S, Cao Y Proc Natl Acad Sci U S A 2022 Oct;119(40):e2203307119

Brown-fat-mediated tumour suppression by cold-altered global metabolism. Seki T, Yang Y, Sun X, Lim S, Xie S, Guo Z, Xiong W, Kuroda M, Sakaue H, Hosaka K, Jing X, Yoshihara M, Qu L, Li X, Chen Y, Cao Y Nature 2022 08;608(7922):421-428

CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity. Liang YY, Bacanu S, Sreekumar L, Ramos AD, Dai L, Michaelis M, Cinatl J, Seki T, Cao Y, Coffill CR, Lane DP, Prabhu N, Nordlund P Cell Chem Biol 2022 04;29(4):572-585.e8

Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors. Hosaka K, Yang Y, Seki T, Du Q, Jing X, He X, Wu J, Zhang Y, Morikawa H, Nakamura M, Scherzer M, Sun X, Xu Y, Cheng T, Li X, Liu X, Li Q, Liu Y, Hong A, Chen Y, Cao Y Nat Commun 2020 07;11(1):3704

CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance. Langebäck A, Bacanu S, Laursen H, Mout L, Seki T, Erkens-Schulze S, Ramos AD, Berggren A, Cao Y, Hartman J, van Weerden W, Bergh J, Nordlund P, Lööf S Sci Rep 2019 12;9(1):19384

Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning. Seki T, Hosaka K, Fischer C, Lim S, Andersson P, Abe M, Iwamoto H, Gao Y, Wang X, Fong GH, Cao Y J Exp Med 2018 02;215(2):611-626

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance. Iwamoto H, Abe M, Yang Y, Cui D, Seki T, Nakamura M, Hosaka K, Lim S, Wu J, He X, Sun X, Lu Y, Zhou Q, Shi W, Torimura T, Nie G, Li Q, Cao Y Cell Metab 2018 Jul;28(1):104-117.e5

Dual roles of endothelial FGF-2-FGFR1-PDGF-BB and perivascular FGF-2-FGFR2-PDGFRβ signaling pathways in tumor vascular remodeling. Hosaka K, Yang Y, Nakamura M, Andersson P, Yang X, Zhang Y, Seki T, Scherzer M, Dubey O, Wang X, Cao Y Cell Discov 2018 ;4():3

A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning. Fischer C, Seki T, Lim S, Nakamura M, Andersson P, Yang Y, Honek J, Wang Y, Gao Y, Chen F, Samani NJ, Zhang J, Miyake M, Oyadomari S, Yasue A, Li X, Zhang Y, Liu Y, Cao Y Nat Commun 2017 12;8(1):2079

Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production. Nakamura M, Zhang Y, Yang Y, Sonmez C, Zheng W, Huang G, Seki T, Iwamoto H, Ding B, Yin L, Foukakis T, Hatschek T, Li X, Hosaka K, Li J, Yu G, Wang X, Liu Y, Cao Y Proc Natl Acad Sci U S A 2017 11;114(45):E9635-E9644

Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions. Yang X, Sui W, Zhang M, Dong M, Lim S, Seki T, Guo Z, Fischer C, Lu H, Zhang C, Yang J, Zhang M, Wang Y, Cao C, Gao Y, Zhao X, Sun M, Sun Y, Zhuang R, Samani NJ, Zhang Y, Cao Y JCI Insight 2017 02;2(4):e89044

Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism. Yang Y, Zhang Y, Iwamoto H, Hosaka K, Seki T, Andersson P, Lim S, Fischer C, Nakamura M, Abe M, Cao R, Skov PV, Chen F, Chen X, Lu Y, Nie G, Cao Y Nat Commun 2016 09;7():12680

Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat. Seki T, Hosaka K, Lim S, Fischer C, Honek J, Yang Y, Andersson P, Nakamura M, Näslund E, Ylä-Herttuala S, Sun M, Iwamoto H, Li X, Liu Y, Samani NJ, Cao Y Nat Commun 2016 08;7():12152

Pericyte-fibroblast transition promotes tumor growth and metastasis. Hosaka K, Yang Y, Seki T, Fischer C, Dubey O, Fredlund E, Hartman J, Religa P, Morikawa H, Ishii Y, Sasahara M, Larsson O, Cossu G, Cao R, Lim S, Cao Y Proc Natl Acad Sci U S A 2016 09;113(38):E5618-27

PlGF-induced VEGFR1-dependent vascular remodeling determines opposing antitumor effects and drug resistance to Dll4-Notch inhibitors. Iwamoto H, Zhang Y, Seki T, Yang Y, Nakamura M, Wang J, Yang X, Torimura T, Cao Y Sci Adv 2015 Apr;1(3):e1400244

Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues. Honek J, Seki T, Iwamoto H, Fischer C, Li J, Lim S, Samani NJ, Zang J, Cao Y Proc Natl Acad Sci U S A 2014 Oct;111(41):14906-11

VEGFR2-mediated vascular dilation as a mechanism of VEGF-induced anemia and bone marrow cell mobilization. Lim S, Zhang Y, Zhang D, Chen F, Hosaka K, Feng N, Seki T, Andersson P, Li J, Zang J, Sun B, Cao Y Cell Rep 2014 Oct;9(2):569-80

Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis. Dong M, Yang X, Lim S, Cao Z, Honek J, Lu H, Zhang C, Seki T, Hosaka K, Wahlberg E, Yang J, Zhang L, Länne T, Sun B, Li X, Liu Y, Zhang Y, Cao Y Cell Metab 2013 Jul;18(1):118-29

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay. Martinez Molina D, Jafari R, Ignatushchenko M, Seki T, Larsson EA, Dan C, Sreekumar L, Cao Y, Nordlund P Science 2013 Jul;341(6141):84-7

Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involves suppression of oxidative stress and inflammatory cytokines. Fang J, Seki T, Tsukamoto T, Qin H, Yin H, Liao L, Nakamura H, Maeda H Carcinogenesis 2013 Dec;34(12):2833-41

Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis. Hosaka K, Yang Y, Seki T, Nakamura M, Andersson P, Rouhi P, Yang X, Jensen L, Lim S, Feng N, Xue Y, Li X, Larsson O, Ohhashi T, Cao Y Nat Commun 2013 ;4():2129

Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice. Lim S, Honek J, Xue Y, Seki T, Cao Z, Andersson P, Yang X, Hosaka K, Cao Y Nat Protoc 2012 Mar;7(3):606-15

Tumour necrosis factor-alpha increases extravasation of virus particles into tumour tissue by activating the Rho A/Rho kinase pathway. Seki T, Carroll F, Illingworth S, Green N, Cawood R, Bachtarzi H, Subr V, Fisher KD, Seymour LW J Control Release 2011 Dec;156(3):381-9